ADVERSE PREGNANCY OUTCOMES AND CORRELATION OF \r\nPREGNANCY GINGIVITIS WITH SUSPECTED \r\nPERIODONTOPATHOGENS

Background: Conflicting data exist regarding the influence of thiopurines exposure on adverse pregnancy outcomes in female patients with inflammatory bowel disease (IBD). Objective: The aim of this study was to provide an up-to-date and comprehensive assessment of the safety of thiopurines in pregnant IBD women. Methods: All relevant articles reporting pregnancy outcomes in women with IBD received thiopurines during pregnancy were identified from the databases (PubMed, Embase, Cochrane Library, and ClinicalTrials.gov) with the publication data up to April 2020. Data of included studies were extracted to calculate the relative risk (RR) of multiple pregnancy outcomes: congenital malformations, low birth weight (LBW), preterm birth, small for gestational age (SGA), and spontaneous abortion. The meta-analysis was performed using the random-effects model. Results: Eight studies matched with the inclusion criteria and a total of 1201 pregnant IBD women who used thiopurines and 4189 controls comprised of women with IBD received drugs other than thiopurines during pregnancy were included. Statistical analysis results demonstrated that the risk of preterm birth was significantly increased in the thiopurine-exposed group when compared to IBD controls (RR, 1.34; 95% CI, 1.00-1.79; p=0.049; I 2 =41%), while no statistically significant difference was observed in the incidence of other adverse pregnancy outcomes. Conclusion: Thiopurines’ use in women with IBD during pregnancy is not associated with congenital malformations, LBW, SGA, or spontaneous abortion, but appears to have an association with an increased risk of preterm birth.

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The Need for Personalized Risk-Stratified Approaches to Treatment for Gestational Diabetes: A Narrative Review

Seminars in Reproductive Medicine ◽

10.1055/s-0041-1723778 ◽

2021 ◽

Author(s):

Shamil D. Cooray ◽

Jacqueline A. Boyle ◽

Georgia Soldatos ◽

Shakila Thangaratinam ◽

Helena J. Teede

Keyword(s):

Gestational Diabetes ◽

Pregnancy Outcomes ◽

Population Based ◽

Adverse Pregnancy Outcomes ◽

Therapeutic Interventions ◽

Clinical Prediction Model ◽

Increased Risk ◽

Adverse Pregnancy ◽

The Individual ◽

Personalized Risk

AbstractGestational diabetes mellitus (GDM) is common and is associated with an increased risk of adverse pregnancy outcomes. However, the prevailing one-size-fits-all approach that treats all women with GDM as having equivalent risk needs revision, given the clinical heterogeneity of GDM, the limitations of a population-based approach to risk, and the need to move beyond a glucocentric focus to address other intersecting risk factors. To address these challenges, we propose using a clinical prediction model for adverse pregnancy outcomes to guide risk-stratified approaches to treatment tailored to the individual needs of women with GDM. This will allow preventative and therapeutic interventions to be delivered to those who will maximally benefit, sparing expense, and harm for those at a lower risk.

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Association between COVID-19 infection at the time of admission for birth and adverse pregnancy outcomes: evolving evidence to aid decision-making

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2021.06.088 ◽

2021 ◽

Author(s):

Jan VAN DER MEULEN ◽

Asma KHALIL

Keyword(s):

Decision Making ◽

Pregnancy Outcomes ◽

Adverse Pregnancy Outcomes ◽

Adverse Pregnancy ◽

Aid Decision ◽

Time Of Admission

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Assisted Reproductive Technologies and Their Association With Adverse Pregnancy Outcomes and Long-Term Cardiovascular Disease: Implications for Counseling Patients

Current Treatment Options in Cardiovascular Medicine ◽

10.1007/s11936-021-00932-3 ◽

2021 ◽

Vol 23 (8) ◽

Author(s):

Ki Park ◽

Emily Allard-Phillips ◽

Gregory Christman ◽

Michelle Dimza ◽

Alice Rhoton-Vlasak

Keyword(s):

Cardiovascular Disease ◽

Pregnancy Outcomes ◽

Assisted Reproductive Technologies ◽

Reproductive Technologies ◽

Adverse Pregnancy Outcomes ◽

Adverse Pregnancy

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Advanced maternal age and adverse pregnancy outcomes: A cohort study

Taiwanese Journal of Obstetrics and Gynecology ◽

10.1016/j.tjog.2020.11.018 ◽

2021 ◽

Vol 60 (1) ◽

pp. 119-124

Author(s):

M. Guarga Montori ◽

A. Álvarez Martínez ◽

C. Luna Álvarez ◽

N. Abadía Cuchí ◽

P. Mateo Alcalá ◽

...

Keyword(s):

Cohort Study ◽

Pregnancy Outcomes ◽

Maternal Age ◽

Advanced Maternal Age ◽

Adverse Pregnancy Outcomes ◽

Adverse Pregnancy

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Assessing the relationship between pregravid body mass index and risk of adverse maternal pregnancy and neonatal outcomes: prospective data in Southwest China

Scientific Reports ◽

10.1038/s41598-021-87135-9 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Yue Chen ◽

Ke Wan ◽

Yunhui Gong ◽

Xiao Zhang ◽

Yi Liang ◽

...

Keyword(s):

Body Mass Index ◽

Cesarean Delivery ◽

Body Mass ◽

Gestational Age ◽

Pregnancy Outcomes ◽

Maternal Age ◽

Southwest China ◽

Adverse Pregnancy Outcomes ◽

Relative Importance ◽

Adverse Pregnancy

AbstractThe relevance of pregestational body mass index (BMI) on adverse pregnancy outcomes remained unclear in Southwest China. This study aimed to investigate the overall and age-category specific association between pre-gestational BMI and gestational diabetes mellitus (GDM), preeclampsia, cesarean delivery, preterm delivery, stillbirth, macrosomia, and small-for-gestational age (SGA) or large-for-gestational age (LGA) neonates in Southwest China. Furthermore, it explores the relative importance of influence of pregravid BMI and maternal age on pregnancy outcomes. 51,125 Chinese singleton pregnant women were recruited as study subjects. Multiple logistic regression models were used to examine the influence of pre-pregnancy BMI on adverse pregnancy outcomes. Gradient boosting machine was used to evaluate the relative importance of influence of pregravid BMI and maternal age on pregnancy outcomes. It is found that women who were overweight or obese before pregnancy are at higher risk of adverse pregnancy outcomes except for SGA neonates, while pre-pregnancy underweight is a protective factor for GDM, preeclampsia, cesarean delivery, macrosomia and LGA, but not SGA. Younger mothers are more susceptible to GDM and macrosomia neonates, while older mothers are more prone to preeclampsia. Pre-pregnancy BMI has more influence on various pregnancy outcomes than maternal age. To improve pregnancy outcomes, normal BMI weight as well as relatively young maternal ages are recommended for women in child-bearing age.

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