Precision Follicular Self-Measurement Using a Pocket-Sized Transabdominal Ultrasound Device
Abstract Background: The purpose of this study was to determine the comparability of follicle diameters measured using a pocket-size transabdominal ultrasound (TAUS) device that produces images for self-assessment versus those measured using a conventional transvaginal ultrasound (TVUS) device. The pocket-sized device is fitted with a probe that can be connected to an electronic tablet for patient use and outputs follicle images for patient review.Methods: A prospective study was performed in 25 women (50 follicles) who underwent in vitro fertilization (IVF)/intracytoplasmic sperm injection between November 2019 and March 2020 to treat infertility. Patients were first provided with guidance from a doctor; then, they used the probe attached to the pocket-sized TAUS device to acquire the follicle images. The doctor then measured the follicle diameter using a TVUS device and compared the measurements with those obtained by viewing the images taken by the patient. The transverse cross-sectional follicle diameter measured on transabdominal images was defined as the abdominal transverse (AT) diameter. The sagittal and coronal cross-sectional follicle diameters measured on transvaginal images were defined as the vaginal sagittal (VS) and vaginal coronal (VC) diameters, respectively. The mean values of each parameter and the variance ratio of the difference between the TAUS and TVUS measurements were evaluated.Results: The results showed that the difference between AT-VS in the two imaging types was -0.382 mm (95% CI: -1.097-0.333 mm, P=0.288), whereas the difference between AT-VC was 0.342 mm (95% CI: -0.345-1.029 mm, P=0.322), and that between VS-VC was 0.724 mm (95% CI: 0.152-1.296 mm, P=0.014). The variance ratios for the differences between the TAUS and TVUS measurements and for the differences between the two TVUS cross-sectional measurements were σAT-VS2/σVS-VC2=1.56 and σAT-VC2/σVS-VC2=1.44, respectively.Conclusion(s): Despite the presence of some differences in precision due to differences in the method of imaging when patients performed follicular self-measurement using pocket-sized devices, there was little scattering. Therefore, this method can be used to measure follicle diameter at a precision that presents no issues at the clinical level.Trial Registration: Medical Park Shonan (2019001, 25 October 2019)