scholarly journals A Novel Brachytherapy Biliary Drainage Catheter Loaded With 125I Seeds in Patients With Malignant Obstructive Jaundice: Preliminary Results Versus Iodine-125 Seed Strands Placement

2020 ◽  
Author(s):  
Zhaonan Li ◽  
Dechao Jiao ◽  
Xinwei Han ◽  
Xueliang Zhou ◽  
Yahua Li
Keyword(s):  
Obstructive Jaundice ◽  
Biliary Drainage ◽  
Control Group ◽  
Metallic Stent ◽  
Stent Patency ◽  
Malignant Obstructive Jaundice ◽  
Drainage Catheter ◽  
125I Seeds ◽  
Irradiation Group ◽  
Iodine 125

Abstract Background The placement of 125I seeds was a safe method for treating cholangiocarcinoma .The purpose of this study was to compare a novel brachytherapy biliary drainage catheter (BBDC) with an Iodine-125 (125I) seed strand after self-expandable metallic stent(SEMs) implantation in terms of safety and efficacy, as treatments for patients with cholangiocarcinoma of malignant obstructive jaundice (MOJ). Methods From September 2016 to December 2018, We retrospectively enrolled patients with biliary stent implantation after receiving either BBDC loaded with 125I seeds (double-strands irradiation group) or an 125I seed strand treatment (single-strand irradiation group, control group). The outcomes were analyzed regarding the relief of obstructive jaundice, interventional-related complications, stent patency and survival time. ResultsThe success rate of interventional therapy in both groups was 100% and all patients with MOJ were alleviated . The overall complication rates of BBDC group and control group were 23.1% (9 / 39) and 26.5% (9/ 34), respectively (P > 0.05). The median and mean overall stent patency of the BBDC group and the control group were (207 days versus 180 days, 204.212 days versus 186.278 days, p = 0.043). The median and mean overall survivals in the BBDC group were higher than those in the control group (245 days versus 212 days, 244.883 days versus 221.844 days, p = 0.030). ConclusionsThis interim analysis showed that BBDC (double-stranded irradiation) can prolong the stent patency time compared with 125I seed strand treatment (single-stranded irradiation) and had the advantage of reducing jaundice, which seemed to extend survival period.

Percutaneous Transhepatic Biliary Drainage in Malignant Obstructive Jaundice

1983 ◽  
Vol 69 (2) ◽  
pp. 161-165 ◽  
Author(s):  
Aldo Severini ◽  
Guido Cozzi ◽  
Massimo Bellomi ◽  
Maria Chiara Castoldi ◽  
Roberto Doci
Keyword(s):  
Prognostic Factors ◽  
Surgical Treatment ◽  
Liver Function ◽  
Obstructive Jaundice ◽  
Biliary Drainage ◽  
Biliary Obstruction ◽  
Percutaneous Transhepatic Biliary Drainage ◽  
Malignant Obstructive Jaundice ◽  
High Operative Risk ◽  
Transhepatic Biliary Drainage

Results obtained in 70 patients with neoplastic (primary or metastatic) biliary obstruction and submitted to percutaneous transhepatic biliary drainage indicate the effectiveness of the technique in relieving jaundice, improving general conditions and restoring liver function. In 25.4% of cases, the drainage allowed the patients to undergo surgical treatment of the neoplasm. In 74.6%, the drainage was left in place as definitive palliation. The complication rate was very low and similar to that described in the literature. At this time it is difficult to identify prognostic factors and foresee the results of percutaneous transhepatic biliary drainage, but the procedure is always indicated in patients at high operative risk or inoperable.

scholarly journals Biliary self-expandable metallic stent combined with Iodine-125 seeds strand in the treatment of hilar malignant biliary obstruction

2019 ◽  
Vol 48 (4) ◽  
pp. 030006051988784
Author(s):  
Chuanguo Zhou ◽  
Hui Li ◽  
Qiang Huang ◽  
Jianfeng Wang ◽  
Kun Gao
Keyword(s):  
Overall Survival ◽  
Biliary Obstruction ◽  
Median Overall Survival ◽  
Malignant Biliary Obstruction ◽  
Group Differences ◽  
Complication Rates ◽  
Metallic Stent ◽  
Stent Patency ◽  
Expandable Metallic Stent ◽  
Iodine 125

Objective To assess the safety and effectiveness of a self-expandable metallic stent (SEMS) combined with Iodine-125 seeds strand to treat hilar malignant biliary obstruction (MBO). Methods This retrospective study included patients who had received SEMS with 125I seeds strand (seeds group) or SEMS alone (controls) to treat hilar MBO. Demographic, biochemical, stent patency, overall survival and complications data were extracted and analysed. Results A total of 76 patients were included (seeds group, n = 40; controls, n = 36), with a total of 608 seeds deployed in the seeds group (mean, 15.2 ± 4.1 [range, 8–25] seeds per patient). Statistically significant between-group differences were shown in median stent patency time (seeds group, 387.0 ± 27.9 days [95% confidence interval {CI} 332.4, 441.6] versus controls, 121.0 ± 9.1 days [95% CI 103.2, 138.8]) and in median overall survival (seeds group, 177.0 ± 17.9 days [95% CI 141.8, 212.2] versus controls, 123.0 ± 20.4 [95% CI 83.0, 163.0]). There were no statistically significant between-group differences in complication rates. Conclusion SEMS combined with 125I seeds strand is safe, feasible, and tolerable in treating patients with hilar MBO, and may be effective in prolonging stent patency time and overall survival.

scholarly journals How to Choose Between Percutaneous Transhepatic and Endoscopic Biliary Drainage in Malignant Obstructive Jaundice: An Updated Systematic Review and Meta-analysis

In Vivo ◽  
2020 ◽  
Vol 34 (4) ◽  
pp. 1701-1714
Author(s):  
ALESSANDRO RIZZO ◽  
ANGELA DALIA RICCI ◽  
GIORGIO FREGA ◽  
ANDREA PALLONI ◽  
STEFANIA DE LORENZO ◽  
...  
Keyword(s):  
Systematic Review ◽  
Obstructive Jaundice ◽  
Biliary Drainage ◽  
Meta Analysis ◽  
Endoscopic Biliary Drainage ◽  
Malignant Obstructive Jaundice

Malignant obstructive jaundice in situs inversus: demonstration of precut and biliary drainage

2015 ◽  
Vol 81 (4) ◽  
pp. 1018-1019 ◽  
Author(s):  
Amy Tyberg ◽  
Taeyoon Lee ◽  
Kunal Karia ◽  
Supriya Suresh ◽  
Dong Choon Kim ◽  
...  
Keyword(s):  
Obstructive Jaundice ◽  
Situs Inversus ◽  
Biliary Drainage ◽  
Malignant Obstructive Jaundice
Sign in / Sign up

Export Citation Format

Share Document