Preliminary application of brachytherapy with double-strand 125I seeds and biliary drainage for malignant obstructive jaundice

2021 ◽  
Author(s):  
Zong-Ming Li ◽  
De-Chao Jiao ◽  
Xin-Wei Han ◽  
Qin-Yu Lei ◽  
Xue-Liang Zhou ◽  
...  
Keyword(s):  
Obstructive Jaundice ◽  
Biliary Drainage ◽  
Malignant Obstructive Jaundice ◽  
125I Seeds ◽  
Preliminary Application

scholarly journals A Novel Brachytherapy Biliary Drainage Catheter Loaded With 125I Seeds in Patients With Malignant Obstructive Jaundice: Preliminary Results Versus Iodine-125 Seed Strands Placement

2020 ◽  
Author(s):  
Zhaonan Li ◽  
Dechao Jiao ◽  
Xinwei Han ◽  
Xueliang Zhou ◽  
Yahua Li
Keyword(s):  
Obstructive Jaundice ◽  
Biliary Drainage ◽  
Control Group ◽  
Metallic Stent ◽  
Stent Patency ◽  
Malignant Obstructive Jaundice ◽  
Drainage Catheter ◽  
125I Seeds ◽  
Irradiation Group ◽  
Iodine 125

Abstract Background The placement of 125I seeds was a safe method for treating cholangiocarcinoma .The purpose of this study was to compare a novel brachytherapy biliary drainage catheter (BBDC) with an Iodine-125 (125I) seed strand after self-expandable metallic stent(SEMs) implantation in terms of safety and efficacy, as treatments for patients with cholangiocarcinoma of malignant obstructive jaundice (MOJ). Methods From September 2016 to December 2018, We retrospectively enrolled patients with biliary stent implantation after receiving either BBDC loaded with 125I seeds (double-strands irradiation group) or an 125I seed strand treatment (single-strand irradiation group, control group). The outcomes were analyzed regarding the relief of obstructive jaundice, interventional-related complications, stent patency and survival time. ResultsThe success rate of interventional therapy in both groups was 100% and all patients with MOJ were alleviated . The overall complication rates of BBDC group and control group were 23.1% (9 / 39) and 26.5% (9/ 34), respectively (P > 0.05). The median and mean overall stent patency of the BBDC group and the control group were (207 days versus 180 days, 204.212 days versus 186.278 days, p = 0.043). The median and mean overall survivals in the BBDC group were higher than those in the control group (245 days versus 212 days, 244.883 days versus 221.844 days, p = 0.030). ConclusionsThis interim analysis showed that BBDC (double-stranded irradiation) can prolong the stent patency time compared with 125I seed strand treatment (single-stranded irradiation) and had the advantage of reducing jaundice, which seemed to extend survival period.

Percutaneous Transhepatic Biliary Drainage in Malignant Obstructive Jaundice

1983 ◽  
Vol 69 (2) ◽  
pp. 161-165 ◽  
Author(s):  
Aldo Severini ◽  
Guido Cozzi ◽  
Massimo Bellomi ◽  
Maria Chiara Castoldi ◽  
Roberto Doci
Keyword(s):  
Prognostic Factors ◽  
Surgical Treatment ◽  
Liver Function ◽  
Obstructive Jaundice ◽  
Biliary Drainage ◽  
Biliary Obstruction ◽  
Percutaneous Transhepatic Biliary Drainage ◽  
Malignant Obstructive Jaundice ◽  
High Operative Risk ◽  
Transhepatic Biliary Drainage

Results obtained in 70 patients with neoplastic (primary or metastatic) biliary obstruction and submitted to percutaneous transhepatic biliary drainage indicate the effectiveness of the technique in relieving jaundice, improving general conditions and restoring liver function. In 25.4% of cases, the drainage allowed the patients to undergo surgical treatment of the neoplasm. In 74.6%, the drainage was left in place as definitive palliation. The complication rate was very low and similar to that described in the literature. At this time it is difficult to identify prognostic factors and foresee the results of percutaneous transhepatic biliary drainage, but the procedure is always indicated in patients at high operative risk or inoperable.

scholarly journals How to Choose Between Percutaneous Transhepatic and Endoscopic Biliary Drainage in Malignant Obstructive Jaundice: An Updated Systematic Review and Meta-analysis

In Vivo ◽  
2020 ◽  
Vol 34 (4) ◽  
pp. 1701-1714
Author(s):  
ALESSANDRO RIZZO ◽  
ANGELA DALIA RICCI ◽  
GIORGIO FREGA ◽  
ANDREA PALLONI ◽  
STEFANIA DE LORENZO ◽  
...  
Keyword(s):  
Systematic Review ◽  
Obstructive Jaundice ◽  
Biliary Drainage ◽  
Meta Analysis ◽  
Endoscopic Biliary Drainage ◽  
Malignant Obstructive Jaundice

Malignant obstructive jaundice in situs inversus: demonstration of precut and biliary drainage

2015 ◽  
Vol 81 (4) ◽  
pp. 1018-1019 ◽  
Author(s):  
Amy Tyberg ◽  
Taeyoon Lee ◽  
Kunal Karia ◽  
Supriya Suresh ◽  
Dong Choon Kim ◽  
...  
Keyword(s):  
Obstructive Jaundice ◽  
Situs Inversus ◽  
Biliary Drainage ◽  
Malignant Obstructive Jaundice

scholarly journals The impact of preoperative biliary drainage on postoperative outcomes in patients with malignant obstructive jaundice: a retrospective analysis of 290 consecutive cases at a single medical center

2022 ◽  
Vol 20 (1) ◽  
Author(s):  
Zhihui Gao ◽  
Jie Wang ◽  
Sheng Shen ◽  
Xiaobo Bo ◽  
Tao Suo ◽  
...  
Keyword(s):  
Postoperative Complications ◽  
Obstructive Jaundice ◽  
Biliary Drainage ◽  
Medical Center ◽  
Radical Resection ◽  
Preoperative Biliary Drainage ◽  
Malignant Obstructive Jaundice ◽  
Link Type ◽  
Study Population ◽  
The Impact

Abstract Background The efficacy of preoperative biliary drainage (PBD) has been debated for several decades, and yet indications for PBD remain controversial. The aim of this study was to compare the postoperative morbidity and mortality in patients with malignant obstructive jaundice undergoing direct surgery versus surgery with PBD. Methods All consecutive patients with malignant obstructive jaundice who underwent radical resection between June 2017 and December 2019 at Zhongshan Hospital were analyzed retrospectively. The study population was divided into two groups: PBD group (PG) and direct surgery group (DG). The subgroups were chosen based on the site of obstruction. Perioperative indicators and postoperative complications were compared and analyzed. Results A total of 290 patients were analyzed. Postoperative complications occurred in 134 patients (46.4%). Patients in the PG group had a lower overall rate of postoperative complications compared with the DG group, with perioperative total bilirubin (TB) identified as an independent risk factor in multivariate analysis (hazard ratio = 1.004; 95% confidence interval 1.001–1.007; P = 0.017). Subgroup analysis showed that PBD reduced the complication rate in patients with proximal obstruction. In the proximal-obstruction subgroup, a preoperative TB level > 162 μmol/L predicted postoperative complications. Conclusions PBD may reduce the overall rate of postoperative complications among patients with proximal malignant obstructive jaundice. Trial registration ClinicalTrials.gov, 2018ZSLC 24. Registered May 17, 2018, https://clinicaltrials.gov/.

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