scholarly journals Anchoring silver nanoparticles on imidazolium-based poly(ionic liquid)s with engineered nanopores as an efficient carrier for anticancer drug controlled delivery with antimicrobial effect

2022 ◽  
Author(s):  
Ehsan Aliakbari ◽  
Reza Eghdam Zamiri ◽  
Mehri Mahdavi ◽  
Vahid Yousefi
Keyword(s):  
Drug Delivery ◽  
Silver Nanoparticles ◽  
Ionic Liquid ◽  
Antimicrobial Effect ◽  
Antibacterial Activities ◽  
E Coli ◽  
Ft Ir ◽  
Poly Ionic Liquid

Abstract Due to the significance of drug delivery, the design of novel progressive nanomaterials for targeting drug delivery is a significant role in pharmacotherapy, as this method is supposed to reach a more exact target. One of the most distinguished materials by researchers is the poly ionic liquid (PIL), which have been used as anticancer drugs carriers and notably improve the antitumor effect and half-life. In this work, an efficient and stable nanocarrier containing silver nanoparticle, which were well distributed throughout the ionic liquid-based copolymer network (PILP-Ag), was reported for the drug delivery with antimicrobial effect. PILP was synthesized by radical silver nanoparticles was anchored into PIL voids by in-situ reduction, which enrich the adsorption capability of drug and antimicrobial effect of the nanocarrier. The synthesized nanomaterials were characterized by various techniques such as BET, TGA, SEM, TEM, AAS and FT-IR spectroscopy. The antibacterial activities of the silver-containing PIL against both S. aureus and E. coli were studied by determination of the minimum inhibitory concentration and Minimum Bactericidal Concentration.

scholarly journals Investigation of Mechanical, Chemical, and Antibacterial Properties of Electrospun Cellulose-Based Scaffolds Containing Orange Essential Oil and Silver Nanoparticles

Polymers ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 85
Author(s):  
Duy-Nam Phan ◽  
Muhammad Qamar Khan ◽  
Van-Chuc Nguyen ◽  
Hai Vu-Manh ◽  
Anh-Tuan Dao ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Essential Oil ◽  
Antibacterial Properties ◽  
Antibacterial Activities ◽  
E Coli ◽  
Multiple Processes ◽  
Controllable Release ◽  
Ft Ir ◽  
Orange Essential Oil

This study demonstrated a controllable release properties and synergistic antibacterial actions between orange essential oil (OEO) and silver nanoparticles (AgNPs) incorporated onto cellulose (CL) nanofibers. The preparation of AgNPs attached on CL nanofibers was conducted through multiple processes including the deacetylation process to transform cellulose acetate (CA) nanofibers to CL nanofibers, the in situ synthesis of AgNPs, and the coating of as-prepared silver composite CL nanofibers using OEO solutions with two different concentrations. The success of immobilization of AgNPs onto the surface of CL nanofibers and the incorporation of OEO into the polymer matrix was confirmed by SEM-EDS, TEM, XRD, and FT-IR characterizations. The tensile strength, elongation at break, and Young’s modulus of the nanofibers after each step of treatment were recorded and compared to pristine CA nanofibers. The high antibacterial activities of AgNPs and OEO were assessed against Gram-positive B. subtilis and Gram-negative E. coli microorganisms. The combined effects of two antimicrobials, AgNPs and OEO, were distinctively recognized against E. coli.

The Influence of Orange Essential Oil on Mechanical, Chemical, and Antibacterial Properties of Cellulose Nanofibers Containing Silver Nanoparticles

2021 ◽  
Author(s):  
Duy-Nam Phan ◽  
Muhammad Qamar Khan ◽  
Chuc Nguyen Van ◽  
Manh-Hai Vu ◽  
Anh-Tuan Dao ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Essential Oil ◽  
Cellulose Nanofibers ◽  
Antibacterial Properties ◽  
Antibacterial Activities ◽  
E Coli ◽  
Multiple Processes ◽  
Controllable Release ◽  
Orange Essential Oil

Abstract This study demonstrates a controllable release properties and synergistic antibacterial actions between orange essential oil and silver nanoparticles incorporated onto cellulose nanofibers. The preparation of silver nanoparticles (AgNPs) attached on cellulose nanofibers was conducted through multiple processes including the deacetylation process to transform cellulose acetate nanofibers to cellulose nanofibers, the in-situ synthesis of AgNPs, and the coating of as-prepared silver composite cellulose nanofibers using orange essential oil (OEO) solutions with two different concentrations. The success of immobilization of AgNPs onto the surface of cellulose nanofibers and the incorporation of OEO into the polymer matrix was confirmed by SEM-EDS, TEM, XRD, and FTIR characterizations. The tensile strength, elongation at break, and Young’s modulus of the nanofibers after each step of treatment were recorded and compared to pristine CA nanofibers. The high antibacterial activities of AgNPs and OEO were assessed against gram-positive B. subtilis and gram-negative E. coli microorganisms. The combination effects of two antimicrobials, AgNPs and OEO, were distinctively recognized against B. subtilis.

scholarly journals Synthesis of Poly(methacrylic acid-co-butyl acrylate) Grafted onto Functionalized Carbon Nanotube Nanocomposites for Drug Delivery

Polymers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 533 ◽  
Author(s):  
Josué A. Torres-Ávalos ◽  
Leonardo R. Cajero-Zul ◽  
Milton Vázquez-Lepe ◽  
Fernando A. López-Dellamary ◽  
Antonio Martínez-Richa ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Methacrylic Acid ◽  
Butyl Acrylate ◽  
Chemical Vapor ◽  
Vis Spectroscopy ◽  
Ir And Raman Spectroscopies ◽  
Ft Ir

Design of a smart drug delivery system is a topic of current interest. Under this perspective, polymer nanocomposites (PNs) of butyl acrylate (BA), methacrylic acid (MAA), and functionalized carbon nanotubes (CNTsf) were synthesized by in situ emulsion polymerization (IEP). Carbon nanotubes were synthesized by chemical vapor deposition (CVD) and purified with steam. Purified CNTs were analyzed by FE-SEM and HR-TEM. CNTsf contain acyl chloride groups attached to their surface. Purified and functionalized CNTs were studied by FT-IR and Raman spectroscopies. The synthesized nanocomposites were studied by XPS, 13C-NMR, and DSC. Anhydride groups link CNTsf to MAA–BA polymeric chains. The potentiality of the prepared nanocomposites, and of their pure polymer matrices to deliver hydrocortisone, was evaluated in vitro by UV–VIS spectroscopy. The relationship between the chemical structure of the synthesized nanocomposites, or their pure polymeric matrices, and their ability to release hydrocortisone was studied by FT-IR spectroscopy. The hydrocortisone release profile of some of the studied nanocomposites is driven by a change in the inter-associated to self-associated hydrogen bonds balance. The CNTsf used to prepare the studied nanocomposites act as hydrocortisone reservoirs.

An in-situ extraction–preconcentration method using ionic liquid-based surfactants for the determination of organic contaminants contained in marine sediments

Talanta ◽  
2012 ◽  
Vol 99 ◽  
pp. 972-983 ◽  
Author(s):  
Bárbara Delgado ◽  
Verónica Pino ◽  
Jared L. Anderson ◽  
Juan H. Ayala ◽  
Ana M. Afonso ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Marine Sediments ◽  
Organic Contaminants ◽  
In Situ Extraction ◽  
Preconcentration Method ◽  
Extraction Preconcentration

scholarly journals Synthesis of silver nanoparticles from extracts of Scytonema geitleri HKAR-12 and their in vitro antibacterial and antitumor potentials

2019 ◽  
Vol 8 (3) ◽  
pp. 576-585
Keyword(s):  
Silver Nanoparticles ◽  
Coli Strain ◽  
X Ray Diffraction ◽  
Xrd Pattern ◽  
E Coli ◽  
Vis Spectroscopy ◽  
Shape Structure ◽  
Actual Size

In the present study silver nanoparticles (AgNPs) have been synthesized through the cell-free extracts of the rooftop dwelling cyanobacterium Scytonema geitleri HKAR-12. UV-VIS spectroscopy, FTIR, X-ray diffraction, SEM and TEM were used for the determination of morphological, structural and optical properties of synthesized AgNPs. Extracts of Scytonema geitleri HKAR-12 have the ability to reduce AgNO3 to Ag0. Sharp peak at 422 nm indicated the rapid synthesis of AgNPs. FTIR results showed the presence of different groups responsible for the reduction of AgNO3 to AgNPs. XRD pattern confirmed the crystalline nature of AgNPs. SEM showed the bead shape structure of AgNPs. TEM confirmed the actual size of AgNPs to be ranging between 9-17 nm. AgNPs showed antibacterial activity against Pseudomonas aeruginosa, Escherichia coli strain1 and E. coli strain 2 and 11 μg/mL of AgNPs effectively inhibited the growth of MCF-7 cells. Hence, Scytonema geitleri HKAR-12, isolated from the rooftop could serve as a desirable biological candidate for convenient and cheap production of AgNPs having antimicrobial and anti-cancerous properties.

Dissociation of zinc phthalocyanine aggregation on bacterial surface is key for photodynamic antimicrobial effect

2018 ◽  
Vol 22 (09n10) ◽  
pp. 925-934 ◽  
Author(s):  
Dafeng Liu ◽  
Linsen Li ◽  
Jincan Chen ◽  
Zhuo Chen ◽  
Longguang Jiang ◽  
...  
Keyword(s):  
Antimicrobial Effect ◽  
Antibacterial Activities ◽  
Surface Hydrophobicity ◽  
The Other ◽  
Zinc Phthalocyanine ◽  
Bacterial Surface ◽  
E Coli ◽  
Bacterial Signaling ◽  
Bacterial Uptake ◽  
Key Parameter

Antimicrobial photodynamic therapy (aPDT) is an effective mean for killing bacteria in this era of increasing multi-antibiotic resistance, and possesses a number of unique advantages. Much effort has been devoted to the development a key component of aPDT photosensitizers (PSs). We synthesized a series of PSs with different positive charges (ZnPc(Lys)[Formula: see text], where [Formula: see text] 3, 5, 7, and studied their antibacterial activities and mechanisms against Escherichia coli (E. coli). Interestingly, the ZnPc(Lys)[Formula: see text] derivative showed stronger antibacterial effect (MIC = 25.3 [Formula: see text]M) than the other two PSs (MICs = 50.6 [Formula: see text]M), even though this PS did not have the highest uptake on bacteria among these PSs. It was ZnPc(Lys)[Formula: see text] that possessed the highest bacterial uptake. ZnPc(Lys)[Formula: see text] was found to have the highest monomeric fractions (62.0%) on bacteria surface than the other two PSs (37.9% for [Formula: see text] 3 and 33.9% [Formula: see text] = 7). These results clearly demonstrate that PS conformation on bacterial surface as a key parameter determining antibacterial efficacy of PSs. Other mechanistic aspects of photodynamic effects, including PS binding kinetics, bacterial surface hydrophobicity, zeta potential of bacteria, membrane permeability and bacterial signaling pathways were also studied.

scholarly journals Determination of the Lewis acidity of amide–AlCl3 based ionic liquid analogues by combined in situ IR titration and NMR methods

RSC Advances ◽  
2018 ◽  
Vol 8 (24) ◽  
pp. 13248-13252 ◽  
Author(s):  
Pengcheng Hu ◽  
Wei Jiang ◽  
Lijuan Zhong ◽  
Shu-Feng Zhou
Keyword(s):  
Ionic Liquid ◽  
Lewis Acidity ◽  
Nmr Analysis ◽  
In Situ Ir ◽  
Nmr Methods

The Lewis acidic strength and amount of amide–AlCl3 IL analogues are determined by the combination of in situ IR titration and NMR analysis.

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