scholarly journals Synthesis of Poly(methacrylic acid-co-butyl acrylate) Grafted onto Functionalized Carbon Nanotube Nanocomposites for Drug Delivery

Polymers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 533 ◽  
Author(s):  
Josué A. Torres-Ávalos ◽  
Leonardo R. Cajero-Zul ◽  
Milton Vázquez-Lepe ◽  
Fernando A. López-Dellamary ◽  
Antonio Martínez-Richa ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Methacrylic Acid ◽  
Butyl Acrylate ◽  
Chemical Vapor ◽  
Vis Spectroscopy ◽  
Ir And Raman Spectroscopies ◽  
Ft Ir

Design of a smart drug delivery system is a topic of current interest. Under this perspective, polymer nanocomposites (PNs) of butyl acrylate (BA), methacrylic acid (MAA), and functionalized carbon nanotubes (CNTsf) were synthesized by in situ emulsion polymerization (IEP). Carbon nanotubes were synthesized by chemical vapor deposition (CVD) and purified with steam. Purified CNTs were analyzed by FE-SEM and HR-TEM. CNTsf contain acyl chloride groups attached to their surface. Purified and functionalized CNTs were studied by FT-IR and Raman spectroscopies. The synthesized nanocomposites were studied by XPS, 13C-NMR, and DSC. Anhydride groups link CNTsf to MAA–BA polymeric chains. The potentiality of the prepared nanocomposites, and of their pure polymer matrices to deliver hydrocortisone, was evaluated in vitro by UV–VIS spectroscopy. The relationship between the chemical structure of the synthesized nanocomposites, or their pure polymeric matrices, and their ability to release hydrocortisone was studied by FT-IR spectroscopy. The hydrocortisone release profile of some of the studied nanocomposites is driven by a change in the inter-associated to self-associated hydrogen bonds balance. The CNTsf used to prepare the studied nanocomposites act as hydrocortisone reservoirs.

Ti3C2MXenes modified with in situ grown carbon nanotubes for enhanced electromagnetic wave absorption properties

2017 ◽  
Vol 5 (16) ◽  
pp. 4068-4074 ◽  
Author(s):  
Xinliang Li ◽  
Xiaowei Yin ◽  
Meikang Han ◽  
Changqing Song ◽  
Hailong Xu ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Electromagnetic Wave ◽  
Chemical Vapor Deposition ◽  
Vapor Deposition ◽  
Chemical Vapor ◽  
Absorption Properties ◽  
Electromagnetic Wave Absorption ◽  
Catalytic Chemical Vapor Deposition ◽  
Wave Absorption

Ti3C2TxMXenes modified within situgrown carbon nanotubes (CNTs) are fabricatedviaa simple catalytic chemical vapor deposition (CVD) process.

In Situ Observation of Nucleation and Growth of Carbon Nanotubes from Iron Carbide Nanoparticles

2008 ◽  
Vol 1142 ◽  
Author(s):  
Hideto Yoshida ◽  
Seiji Takeda ◽  
Tetsuya Uchiyama ◽  
Hideo Kohno ◽  
Yoshikazu Homma
Keyword(s):  
Carbon Nanotubes ◽  
Iron Carbide ◽  
Bulk Diffusion ◽  
Chemical Vapor ◽  
Nucleation And Growth ◽  
Atomic Scale ◽  
In Situ Observation ◽  
Transmission Electron ◽  
Cvd Growth

ABSTRACTNucleation and growth processes of carbon nanotubes (CNTs) in iron catalyzed chemical vapor deposition (CVD) have been observed by means of in-situ environmental transmission electron microscopy. Our atomic scale observations demonstrate that solid state iron carbide (Fe3C) nanoparticles act as catalyst for the CVD growth of CNTs. Iron carbide nanoparticles are structurally fluctuated in CVD condition. Growth of CNTs can be simply explained by bulk diffusion of carbon atoms since nanoparticles are carbide.

In Vitro and In Vivo Drug Release from a Novel In Situ Forming Drug Delivery System

2007 ◽  
Vol 25 (6) ◽  
pp. 1347-1354 ◽  
Author(s):  
Heiko Kranz ◽  
Erol Yilmaz ◽  
Gayle A. Brazeau ◽  
Roland Bodmeier
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
In Situ Forming

scholarly journals CHEMICAL MODIFICATION, CHARACTERIZATION AND EVALUATION OF MUCOADHESIVE POTENTIALITY OF ASSAM BORA RICE STARCH

2017 ◽  
Vol 9 (9) ◽  
pp. 132 ◽  
Author(s):  
Abdul Baquee Ahmed ◽  
Iman Bhaduri
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Sustained Release ◽  
Chemical Modification ◽  
Ex Vivo ◽  
Rice Starch ◽  
Modified Starch ◽  
Native Starch ◽  
Ft Ir

Objective: The objective of the present study was to chemical modification, characterization and evaluation of mucoadhesive potentiality of Assam bora rice starch as potential excipients in the sustained release drug delivery system. Methods: The starch was isolated from Assam bora rice and esterified using thioglycolic acid and characterized by Fourier transform infrared spectroscopy (FT-IR), Differential scanning calorimetry (DSC) and Nuclear magnetic resonance (NMR). The 10% w/v gel formulation based on modified bora rice starch loaded with irinotecan (0.6%) was prepared and evaluated for various rheological properties, ex-vivo mucoadhesion using goat intestine and in vitro drug release study in phosphate buffer pH 6.8.Results: The chemical modification was confirmed by FT-IR and NMR studies with the presence of the peak at 2626.74 cm-1 and a singlet at 2.51 respectively due to–SH group. Ex-vivo mucoadhesion studies showed 6.6 fold increases in mucoadhesion of the modified starch with compared to native starch (46.3±6.79g for native starch; 308.7±95.31g for modified starch). In vitro study showed 89.12±0.84 % of drug release after 6 h in phosphate buffer pH 6.8 and the release kinetics followed Non-Fickian diffusion.Conclusion: The modified Assam bora rice starch enhanced a mucoadhesive property of the native starch and thus, can be explored in future as a potential excipient for the sustained release mucoadhesive drug delivery system.

scholarly journals Formulation and characterization of flurbiprofen loaded microsponge based gel for sustained drug delivery

2019 ◽  
Vol 10 (4) ◽  
pp. 2765-2776
Author(s):  
Naresh Kshirasagar ◽  
Goverdhan Puchchakayala ◽  
Balamurgan K
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Drug Release ◽  
Diffusion Method ◽  
Skin Delivery ◽  
Sustained Action ◽  
Release Studies ◽  
Ft Ir ◽  
Polymer Ratio

The new investigation in this present work is to develop microsponges constructed novel drug delivery system for sustained action of Flurbiprofen. Quai-emulsion solvent diffusion method was engaged using Ethyl cellulose and Eudragit RS100 with drug: polymer ratio for development of microsponges. For optimization purposes, several factors are considered in the investigation. Several evaluation studies for the formed microsponges were carried out FT-IR, SEM, DSC, X-RD, particle size analysis, morphology, drug loading and In vitro drug release studies were carried out. Finally, it was concluded that there is no drug-polymer interaction as per DSC & FT-IR. Encapsulation efficiency, particle size and drug content showed a higher impact on alteration of drug-polymer ratio. SEM studies showed that morphological microsponges are spherical and porous in nature and with the mean particle size of 38.86 μm. The gel loaded with microsponges, were followed by In vitro and Ex vivo drug release studies by modified Franz diffusion cell. Skin delivery of optimized formulation enhanced the drug residence time and maintained therapeutic concentration for an extended period of time, which is possible to show sustained action of the drug.

In-Situ Characterization of Carbon Nanotube-Polystyrene Composite Deformation

2000 ◽  
Vol 6 (S2) ◽  
pp. 40-41
Author(s):  
D. Qian ◽  
E. C. Dickey ◽  
R. Andrews ◽  
T. Rantell ◽  
B. Safadi
Keyword(s):  
Carbon Nanotubes ◽  
Load Transfer ◽  
Electronic Materials ◽  
Composite Films ◽  
Chemical Vapor ◽  
Ex Situ ◽  
In Situ Tem ◽  
Multiwalled Carbon ◽  
Young’S Moduli

Carbon nanotubes (NTs) have novel electronic properties and exceptionally high Young's moduli on the order of TPa. so NTs have potential applications in advanced composite materials such as conductive polymers, electromagnetic-radio frequency interference (EMI/RFI) shielding material and opto-electronic materials. The utility of the nanotubes in composite applications depends strongly on the ability to disperse the NTs homogeneously throughout the matrix without destroying the integrity of the NTs. Furthermore, interfacial bonding between the NT and matrix is necessary to achieve load transfer across the interface, which is desirable for improving the mechanical properties of polymer composites.In this work, aligned multiwalled carbon nanotubes (MWNTs) produced by continuous chemical vapor deposition (CVD) (see Fig.l), were homogeneously dispersed in polystyrene (PS) matrices by a simple solution-evaporation method. Using this procedure, we made uniform MWNT-PS composite films ∼0.4mm thick for ex-situ mechanical tensile test and very thin films, ∼100nm, for in-situ TEM tests, as shown in Fig.2.

Hemostatic Effect of Aminated Multiwalled Carbon Nanotubes/Oxidized Regenerated Cellulose Nanocomposites

2019 ◽  
Vol 19 (11) ◽  
pp. 7410-7415 ◽  
Author(s):  
Baode Zhang ◽  
Ali Nabipour Chakoli ◽  
Jin Mei He ◽  
Yu Dong Huang ◽  
Andrey N. Aleshin
Keyword(s):  
Carbon Nanotubes ◽  
Multiwalled Carbon Nanotubes ◽  
Regenerated Cellulose ◽  
Oxidized Regenerated Cellulose ◽  
Multiwalled Carbon ◽  
Hemostatic Effect ◽  
Pristine Mwcnts ◽  
Ft Ir ◽  
Cellulose Nanocomposites

We have investigated the covalent conjugation of aminated multiwalled carbon nanotubes (MWCNTNH2)s with Oxidized Regenerated Cellulose (ORC) in order to enhance the hemostatic effect. The MWCNT-NH2s were prepared by functionalization of pristine MWCNTs (pMWCNTs) using amine groups. Neat ORC gauze and MWCNT-NH2s were reacted using glutamic acid as cross linking bridge. We investigated an amination of pMWCNTs as well as the dispersion of MWCNT-NH2s in the ORC gauze as matrix and their interfacial interactions by SEM and FT-IR. The results revealed that relatively strong interaction exists between aminated MWCNTs and the ORC macromolecules. The hydrophilicity test results in the significant increment of water uptake of MWCNT-NH2s/ORC composites with increasing the concentration of MWCNT-NH2s in composite. The in-vitro procoagulation test shows that the MWCNT-NH2s/ORC gauzes have significant procoagulant activity. The hemostatic evaluation of MWCNT-NH2s/ORC composites on rabbits shows that the aminated MWCNTs increase the rate of blood stopping and hence they decrease the blood loosing from injured sites. Hemostatic evaluation indicates that the MWCNT-NH2s/ORC gauze has a valuable hemostatic performance. The products of platelets release reaction, activated platelets glycoprotein and activated clotting enzymes were increased simultaneously. The mechanism of the hemostasis for MWCNT-NH2s/ORC gauze is discussed.

The role of platinum on the NOx storage and desorption behavior of ceria: An online FT-IR study combined with in situ Raman and UV-Vis spectroscopy

2020 ◽  
Author(s):  
Anastasia Filtschew ◽  
Pablo Beato ◽  
Søren Birk Rasmussen ◽  
Christian Hess
Keyword(s):  
Gas Phase ◽  
Phase Analysis ◽  
Room Temperature ◽  
Storage Mechanism ◽  
In Situ Raman ◽  
Vis Spectroscopy ◽  
Ft Ir ◽  
Ir Study

The role of platinum on the room temperature NOx storage mechanism and the NOx desorption behavior of ceria was investigated by combining online FT-IR gas-phase analysis with in situ Raman...

Study on the Synthesis and Characterization of PANi/Nano-CeO2 Composites

2007 ◽  
Vol 124-126 ◽  
pp. 287-290 ◽  
Author(s):  
Fei Liu ◽  
Yong Jun He ◽  
Jeung Soo Huh
Keyword(s):  
In Situ Polymerization ◽  
Solid Phase ◽  
Polymerization Reaction ◽  
Solid Phase Reaction ◽  
Phase Reaction ◽  
Vis Spectroscopy ◽  
Ft Ir ◽  
Average Size

The nano-CeO2 was synthesized by two-step solid-phase reaction. The image of TEM showed that nano-CeO2 with an average size of about 70 nm. The series of polyaniline/nano-CeO2 composites with different PANi: CeO2 ratios were prepared by in-situ polymerization in the presence of hydrochloric acid (HCl) as dopant by adding nano-CeO2 into the polymerization reaction mixture of aniline. The composites obtained were characterized by FT-IR and UV-vis spectroscopy analysis. The FT-IR spectra of nanocomposites indicate different blue-shifts, attributed to C–N stretching mode for benzenoid unit. The UV-vis spectra of nanocomposites display einstein-shifts compared with PANi at 620nm. The conductivity properties of the composites are also changed compare to the pure PANi. These results suggest that the interactions between the polymer matrix and nanoparticles take place in polyaniline/nano- CeO2 composites.

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