The Risk of Cardiac-related Mortality in Stage IIIA-N2 Non-small Cell Lung Cancer: Analysis of the Surveillance, Epidemiology, and End Results Database
Abstract Background: We aimed to investigate the association between postoperative radiotherapy (PORT) and cardiac-related mortality for patients with ⅢA-N2 non-small cell lung cancer (NSCLC) by the Surveillance, Epidemiology, and End Results (SEER) database.Methods: The United States (US) population based SEER database were queried for cardiac-related mortality among patients with ⅢA-N2 NSCLC. Cardiac-related mortality was compared between PORT and Non-PORT group. Accounting for mortality from other causes, Gray’s test compared cumulative incidences of cardiac-related mortality between both groups. Univariate and multivariate analysis were performed using the competing risk model.Results: From 1988 to 2016, 7290 patients met the inclusion criteria: 3386 patients treated with PORT and 3904 patients treated with Non-PORT. The 5-year overall incidence of cardiac-related mortality was 3.01% in PORT group and 3.26% in Non-PORT group. Older age, male sex, squamous cell lung cancer, earlier year of diagnosis and earlier T stage were independent adverse factors for cardiac-related mortality. However, PORT use wasn’t associated with an increase in the hazard for cardiac-related mortality (subdistribution hazard ratio [SHR]=0.99, 95% confidence interval [95% CI], 0.78–1.24, p=0.91). When evaluating cardiac-related mortality in each time period, the overall incidence of cardiac-related mortality was decreased over time. There were no statistically significant differences based on PORT use in all time periods.Conclusions: With a median follow-up of 25 months, no significant differences were found in cardiac-related mortality between PORT and Non-PORT for ⅢA-N2 NSCLC patients.