scholarly journals Wide-field Swept-source OCT Analysis of Interocular Symmetry of Choroidal Thickness in Subjects with Uncomplicated Pachychoroid

2021 ◽  
Author(s):  
Min-Su Kim ◽  
Hyung-Bin Lim ◽  
Woo-Hyuk Lee ◽  
Yeo-Kyoung Won ◽  
Gi-Yup Nam ◽  
...  
Keyword(s):  
Choroidal Thickness ◽  
Anatomical Variation ◽  
Correlation Coefficients ◽  
Wide Field ◽  
Macular Area ◽  
Clinical Factor ◽  
Swept Source ◽  
Peripheral Area ◽  
Peripheral Areas ◽  
The Right

Abstract Purpose: To study the bilateral choroidal thickness (CT) symmetry and difference in uncomplicated pachychoroid subjects using wide-field swept-source optical coherence tomography (SS-OCT).Methods: All subjects underwent a wide-field 16-mm 1-line scan using SS-OCT. Bilateral CT was measured at, and compared among, the following 12 points: 3 points at 900-µm intervals from the nasal optic disc margin (nasal peripapillary area), 1 point at the subfovea, 6 points at 900-µm intervals from the fovea to the nasal and temporal areas (macular area), and 2 peripheral points 5,400 and 8,100 µm from the fovea (peripheral area). Associations between interocular CT differences in the various measurement areas and clinical factors were analyzed.Results: There was no statistically significant differences in CT between the right and left eyes in any area (all p > 0.05); they all showed significant positive correlations (all p < 0.01). However, the correlation coefficients (ρ) were smaller for the nasal peripapillary and peripheral areas compared to the macular area. In addition, the interocular axial length differences were significantly associated with interocular CT differences in the macular area, but not in the nasal peripapillary or peripheral area. No other clinical factor was associated with interocular CT differences in any area.Conclusions: The CTs in each region were bilaterally symmetrical in subjects with uncomplicated pachychoroid. However, interocular difference in CT increased from the center to the periphery, indicating that the anatomical variation of the nasal peripapillary and peripheral choroid was greater than that of the macula.

scholarly journals Wide-Field Swept-Source OCT Analysis of Interocular Symmetry of Choroidal Thickness in Subjects with Uncomplicated Pachychoroid

2021 ◽  
Vol 10 (18) ◽  
pp. 4253
Author(s):  
Min-Su Kim ◽  
Hyung-Bin Lim ◽  
Woo-Hyuk Lee ◽  
Yeo-Kyoung Won ◽  
Ki-Yup Nam ◽  
...  
Keyword(s):  
Choroidal Thickness ◽  
Anatomical Variation ◽  
Correlation Coefficients ◽  
Wide Field ◽  
Macular Area ◽  
Swept Source ◽  
Swept Source Oct ◽  
Peripheral Areas ◽  
Positive Correlations ◽  
The Right

Background: We aimed to study the bilateral choroidal thickness (CT) symmetry and difference in uncomplicated pachychoroid subjects using wide-field swept-source optical coherence tomography (SS-OCT). Methods: All subjects underwent a wide-field 16-mm one-line scan using SS-OCT. Bilateral CT was measured at, and compared among, the following 12 points: three points at 900-µm intervals from the nasal optic disc margin (nasal peripapillary area), one point at the subfovea, six points at 900-µm intervals from the fovea to the nasal and temporal areas (macular area), and two peripheral points 5400 and 8100 µm from the fovea (peripheral area). Results: There were no statistically significant differences in CT between the right and left eyes in any area (all p > 0.05); they all showed significant positive correlations (all p < 0.01). However, the correlation coefficients (ρ) were smaller for the nasal peripapillary and peripheral areas compared to the macular area. Conclusions: The CTs in each region were bilaterally symmetrical in subjects with uncomplicated pachychoroid. However, interocular difference in CT increased from the center to the periphery, indicating that the anatomical variation of the nasal peripapillary and peripheral choroid was greater than that of the macula.

scholarly journals Combined 60° Wide-Field Choroidal Thickness Maps and High-Definition En Face Vasculature Visualization Using Swept-Source Megahertz OCT at 1050 nm

2015 ◽  
Vol 56 (11) ◽  
pp. 6284 ◽  
Author(s):  
Kathrin J. Mohler ◽  
Wolfgang Draxinger ◽  
Thomas Klein ◽  
Jan Philip Kolb ◽  
Wolfgang Wieser ◽  
...  
Keyword(s):  
Choroidal Thickness ◽  
Wide Field ◽  
High Definition ◽  
Swept Source ◽  
En Face

Choroidal Thickness and Structural Glaucoma Parameters in Glaucomatous, Preperimetric Glaucomatous, and Healthy Eyes using Swept-Source OCT

2017 ◽  
Vol 27 (5) ◽  
pp. 548-554 ◽  
Author(s):  
Handan Akil ◽  
Mayss Al-Sheikh ◽  
Khalil Ghasemi Falavarjani ◽  
Brian Francis ◽  
Vikas Chopra
Keyword(s):  
Nerve Fiber ◽  
Choroidal Thickness ◽  
Wide Field ◽  
Inner Plexiform Layer ◽  
Fiber Layer ◽  
Swept Source ◽  
Nerve Fiber Layer ◽  
Rnfl Thickness ◽  
The Mean ◽  
Healthy Eyes

Purpose To evaluate choroidal thickness (CT) and its relationship with retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer thickness (GCIPLT) in glaucomatous, preperimetric glaucomatous, and healthy eyes using swept-source optical coherence tomography (SS-OCT). Methods Fifty eyes with primary open-angle glaucoma, 20 eyes with preperimetric glaucoma, and 20 age-matched healthy eyes were enrolled. Three-dimensional wide-field (12 × 9 mm) images were obtained using a SS-OCT instrument. Peripapillary CT and RNFL thickness, as well as macular CT and GCIPLT, were recorded. The correlation of the CT with nerve fiber layer and GCIPLT measurements was assessed. The association between CT and potential confounding variables including age, sex, axial length, intraocular pressure, and central corneal thickness was also examined. Results Mean peripapillary CTs were 111.7 ± 41.7, 127.7 ± 40.1, and 120.8 ± 35.4 μm in glaucomatous, preperimetric glaucomatous, and normal eyes, respectively. There was statistically significant but weak correlation for the mean RNFL and mean peripapillary CT in glaucomatous subjects (r = 0.341, p = 0.04). There was a significant correlation between RNFL thickness and peripapillary CT in 1, 2, 5, and 6 clock hours of glaucomatous eyes (r = 0.410, p = 0.005; r = 0.316, p = 0.03; r = 0.346, p = 0.02; r = 0.35, p = 0.04, respectively). Mean macular CT was 181.5 ± 70.5, 187.4 ± 65.5, and 185.4 ± 76.4 μm in glaucomatous, preperimetric glaucomatous, and healthy eyes, respectively (p = 0.7). There was no statistically significant correlation between the mean GCIPLT and mean macular CT in all subjects (p>0.05). Conclusions Choroidal thinning and its correlation with other parameters in patients with glaucoma should be further investigated with the proprietary software of SS-OCT.

Choroidal thickness and vessel pattern in myopic eyes with dome-shaped macula

2021 ◽  
pp. bjophthalmol-2021-319066
Author(s):  
Pierre Negrier ◽  
Aude Couturier ◽  
David Gaucher ◽  
Sara Touhami ◽  
Guillaume Le Guern ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Retrospective Study ◽  
Retinal Detachment ◽  
Choroidal Thickness ◽  
Serous Retinal Detachment ◽  
Wide Field ◽  
Macular Area ◽  
The Mean ◽  
Choroidal Vessels ◽  
Bulge Height

AimTo analyse the choroidal thickness (CT) and vessel pattern of myopic patients with dome-shaped macula (DSM) and their association with the DSM axis and serous retinal detachment (SRD).MethodsRetrospective study. The CT and vessel pattern were assessed on optical coherence tomography (OCT), OCT-angiography and ultra-wide-field photography.Results27 eyes of 18 subjects (mean age: 65 years) were included. Compared with the 11 eyes (41%) with horizontal DSM, the 16 eyes (59%) with vertical DSM had a shorter axial length (25.8±2 mm vs 28.3±2.5 mm; p=0.01), a higher mean macular bulge height (624.4±207 µm vs 255.4±160.3 µm; p=0.0001) and a thicker CT (183.1±91.1 µm vs 72±38.3 µm; p<0.001). Large choroidal vessels crossed the macular area in 75% of eyes with vertical DSM vs 27% of eyes with horizontal DSM (p=0.02), whereas a watershed zone framing the macula was more often seen in horizontal DSM (72% vs 25%, p=0.02). Thirteen eyes (48%) had an SRD that was not associated with the DSM axis, the mean bulge height, the CT or the vessel pattern.ConclusionThe presence of an SRD did not correlate with the DSM axis, the CT or the vessel pattern. However, the rate of large choroidal vessels crossing the macula was higher in vertical DSM than in horizontal DSM.

Wide-field swept-source optical coherence tomography angiography in the assessment of retinal microvasculature and choroidal thickness in patients with myopia

2021 ◽  
pp. bjophthalmol-2021-319540
Author(s):  
Jade Y. Moon ◽  
Itika Garg ◽  
Ying Cui ◽  
Raviv Katz ◽  
Ying Zhu ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Choroidal Thickness ◽  
Optical Coherence Tomography Angiography ◽  
Foveal Avascular Zone ◽  
Systemic Hypertension ◽  
Wide Field ◽  
Optical Coherence ◽  
Swept Source ◽  
Retinal Microvasculature ◽  
Capillary Plexus

Background/aimsPathological myopia (PM) is a leading cause of blindness worldwide. We aimed to evaluate microvascular and chorioretinal changes in different stages of myopia with wide-field (WF) swept-source (SS) optical coherence tomography angiography (OCTA).MethodsThis prospective cross-sectional observational study included 186 eyes of 122 patients who had undergone imaging between November 2018 and October 2020. Vessel density (VD) and vessel skeletonised density (VSD) of superficial capillary plexus, deep capillary plexus and whole retina, as well as foveal avascular zone parameters, retinal thickness (RT) and choroidal thickness (CT), were calculated.ResultsThis study evaluated 75 eyes of 48 patients with high myopia (HM), 43 eyes of 31 patients with mild to moderate myopia and 68 eyes of 53 age-matched controls. Controlling for age and the presence of systemic hypertension, we found that HM was associated with decrease in VD and VSD in all layers on 12×12 mm² scans. Furthermore, HM was associated with a VD and VSD decrease in every Early Treatment Diabetic Retinopathy Study grid, with a larger decrease temporally (βVD=−0.39, βVSD=−10.25, p<0.01). HM was associated with decreased RT and CT. Reduction in RT was outside the macular region, while reduction in CT was in the macular region.ConclusionUsing WF SS-OCTA, we identified reduction in microvasculature and structural changes associated with myopia. Decrease in VD and VSD was greater in the temporal quadrant, and reductions in RT and CT were uneven across the retina. Further work may help identify risk factors for the progression of PM and associated vision-threatening complications.

scholarly journals Deep learning algorithms to segment and quantify the choroidal thickness and vasculature in swept-source optical coherence tomography images

2020 ◽  
pp. 2140002
Author(s):  
Gu Zheng ◽  
Yanfeng Jiang ◽  
Ce Shi ◽  
Hanpei Miao ◽  
Xiangle Yu ◽  
...  
Keyword(s):  
Deep Learning ◽  
Choroidal Thickness ◽  
Automatic Segmentation ◽  
Learning Algorithms ◽  
Intraclass Correlation ◽  
Correlation Coefficients ◽  
Practical Method ◽  
Training Data ◽  
Validation Data ◽  
Swept Source

Accurate segmentation of choroidal thickness (CT) and vasculature is important to better analyze and understand the choroid-related ocular diseases. In this paper, we proposed and implemented a novel and practical method based on the deep learning algorithms, residual U-Net, to segment and quantify the CT and vasculature automatically. With limited training data and validation data, the residual U-Net was capable of identifying the choroidal boundaries as precise as the manual segmentation compared with an experienced operator. Then, the trained deep learning algorithms was applied to 217 images and six choroidal relevant parameters were extracted, we found high intraclass correlation coefficients (ICC) of more than 0.964 between manual and automatic segmentation methods. The automatic method also achieved great reproducibility with ICC greater than 0.913, indicating good consistency of the automatic segmentation method. Our results suggested the deep learning algorithms can accurately and efficiently segment choroid boundaries, which will be helpful to quantify the CT and vasculature.

scholarly journals Comparison of peripapillary and subfoveal choroidal thickness in normal versus primary open-angle glaucoma (POAG) subjects using spectral domain optical coherence tomography (SD-OCT) and swept source optical coherence tomography (SS-OCT)

2019 ◽  
Vol 4 (1) ◽  
pp. e000258 ◽  
Author(s):  
Swetha Komma ◽  
Jay Chhablani ◽  
Mohammed Hasnat Ali ◽  
Chandra S Garudadri ◽  
Sirisha Senthil
Keyword(s):  
Optical Coherence Tomography ◽  
Choroidal Thickness ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Normal Subjects ◽  
Optical Coherence ◽  
Macular Area ◽  
Swept Source ◽  
Sd Oct ◽  
Peripapillary Area

ObjectiveTo elucidate the difference between choroidal thickness (CT) in primary open-angle glaucoma (POAG) and normal subjects and to compare the CT measured using spectral domain optical coherence tomography (SD-OCT) and swept source optical coherence tomography (SS-OCT).Methods and analysisThis cross-sectional observational study included 25 eyes of 17 POAG subjects (cases) and 31 eyes of 20 normal subjects (controls). All the patients underwent complete ophthalmologic examination, enhanced depth imaging, SD-OCT and SS-OCT. In both controls and cases, the CT was measured in seven predetermined points in macular and peripapillary area and were compared.ResultsChoroid was significantly thicker on SS-OCT compared with SD-OCT in peripapillary and macular area in both cases and controls, except for inferior peripapillary in controls. The CT was not different from glaucoma and controls in peripapillary or macular area on SD-OCT (p>0.05), however, the CT was significantly thicker in glaucoma compared with controls in peripapillary area on SS-OCT (p<0.05) except inferior peripapillary (p=0.13). There was good intraobserver (±20 µm) and interobserver (±55 µm and ±45 µm) agreement on both SD-OCT and SS-OCT respectively.On SD-OCT, choroid was thinnest at the temporal peripapillary and thickest at subfoveal location in controls. In POAG, choroid was thinnest at inferior peripapillary region and thickest (500 µm) nasal to the fovea. On SS-OCT, choroid was thinnest at inferior peripapillary and thickest at the temporal peripapillary area in both cases and controls.ConclusionCT measurements on SS-OCT were higher than the SD-OCT measurements possibly due to better delineation of the sclerochoroidal junction on SS-OCT. CT was significantly thicker in glaucoma subjects compared with controls in peripapillary area on SS-OCT but not in macular area.

Carotid endarterectomy in patients with foetal-type posterior circle of Willis: Is there an indication for local anaesthesia?

VASA ◽  
2011 ◽  
Vol 40 (5) ◽  
pp. 404-407
Author(s):  
Maras ◽  
Tzormpatzoglou ◽  
Papas ◽  
Papanas ◽  
Kotsikoris ◽  
...  
Keyword(s):  
Carotid Endarterectomy ◽  
Local Anaesthesia ◽  
Anatomical Variation ◽  
Anatomical Variations ◽  
Circle Of Willis ◽  
Variable Degree ◽  
Operative Complications ◽  
The Right ◽  
Ica Stenosis ◽  
Symptomatic Stenosis

Foetal-type posterior circle of Willis is a common anatomical variation with a variable degree of vessel asymmetry. In patients with this abnormality, carotid endarterectomy (CEA) may create cerebral hypo-perfusion intraoperatively, and this may be underestimated under general anaesthesia. There is currently no evidence that anatomical variations in the circle of Willis represent an independent risk factor for stroke. Moreover, there is a paucity of data on treating patients with such anatomical variations and co-existing ICA stenosis. We present a case of CEA under local anaesthesia (LA) in a 52-year-old female patient with symptomatic stenosis of the right ICA and coexistent foetal-type posterior circle of Willis. There were no post-operative complications and she was discharged free from symptoms. She was seen again 3 months later and was free from complications. This case higlights that LA should be strongly considered to enable better intra-operative neurological monitoring in the event of foetal-type posterior circle of Willis.

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