Are Coworkers in the Italian Peripheral Areas Performing Better? A Counterfactual Analysis

Coworking spaces are “serendipity accelerators” designed to host creative people and entrepreneurs. While recent literature has started exploring the indirect effects of coworking spaces on the local context, little is still known on how coworking spaces may directly affect the coworkers’ economic performance and wellbeing. Using a novel dataset based on a survey of 326 CWs working in the Italian coworking spaces in 2018, this paper explores the potential economic impact for coworkers, depending on whether a coworking space is localized in a peripheral or an urban area. Through a propensity-score matching approach, we found that being located in a peripheral area for coworkers may represent an opportunity to earn more than working in an urban center. The same holds for the organization coworkers belong to.

Minimum temperature forecasting by stochastic techniques : An evidence of the heat island effect

This paper deals mainly with the forecasting of minimum temperatures (Tm) from an stochastic viewpoint. Some appropriate theoretical considerations lead to a choice of those variables significant connected to Tm. Modelling has been carried out for two nearby observatories, one in the centre of Madrid, the other one in the border (Barajas airport). The obtained models allow to show that the significant variables are the same for both locations, but performance in the peripheral area is of a rather inferior quality. It is shown, taking into account the characteristics of both places, that the difference between them can be allotted to the heat-island effect in the centre of Madrid.

Unlock Condensate Reserves by Peripheral Development of Giant Condensate

This paper addresses the development of peripheral area in order to maximize the condensate production in a giant Recycle Gas-Condensate Reservoir in UAE. The condensate reservoir is producing many years under recycling mode to maintain the pressure and maximize the gas condensate recovery. The producers and injector wells are in a line drive pattern where the injected fluid is lean gas to maintain 100% VRR. The condensate production declined through the years due to gradual pressure decrease as well as injected lean gas/N2 breakthrough. Several studies were done to increase condensate recovery and extend gas production plateau. The methodology adopted for this study is the developing of the peripheral area in the giant recycle reservoir as part of its full field development plan (FFDP) in order to provide more pressure support initially and to increase the sweep efficiency for more condensate recovery. In addition; it is worth to mention that peripheral wells will provide production relaxation from some gas produces which have lean gas and N2 breakthroughs. Pilot wells were drilled to examine and confirm the strategy assumed by analyzing the performance of those wells in terms of location, condensate production, CGR values and trajectory. Simulation modeling was as well used for matching purposes and future prediction and forecasting. Pilot wells were drilled in deferent peripheral area in the reservoir and completed as horizontal gas producers. By analyzing the current wells performance it has been approved that the wells are producing high condensate about (2000-2500) MMstb and producing high CGR values about (80-100). Simulation modeling were utilize for future prediction and confirmed that the development of peripheral area by drilling additional wells enhances the sweeping efficiency and participated in expected gain a multimillions of barrels of additional condensate with maintaining the same business plan gas production target. It was promising to have more incremental in case of ramping up the production. The paper discussed in detail about methodology adopted in order to unlock the condensate reserves by peripheral development and confirmed the results of the gain of condensate production and CGR from actual data and simulation modeling. The provided information is quite informative to be widely used and applied in similar reservoirs.

Employment or Development in a Semi-Peripheral Region: The Roadrunner Paradigm

This study observes the relationship between employment policies and the evolution of the productive system, applying the theoretical framework of local development to an average-sized town in a semi-peripheral area of the European Union, during the period from 1975 to 2015. To do so, a case analysis was made of the outcomes of employment policies via their effects on the variables impacting on the productive fabric. The following data sources were used: grey literature related to public policies; published statistics on demographic variables and economic activity; and local press reports. The following results were obtained: (a) the responses of economic agents owe more to the changes in the international scenario than to employment policies; (b) it is essential to analyse the evolution of demographic factors to properly interpret the relationship between labour supply and demand. We conclude that (a) corporate culture significantly influences the success or otherwise of employment policies, and (b) in the semi-peripheral area discussed, unemployment is an endemic problem that successive cohesion and employment policies have failed to resolve. Therefore, the use of innovation-oriented theoretical and practical approaches should be reconsidered.

Development of a porcine hard-to-heal wound model: evaluation of a bromelain-based enzymatic debriding agent

Aims: We describe the development of a novel porcine eschar model and compare the debridement efficacy of various concentrations of a novel bromelain-based enzymatic agent with collagenase. Methods: Full thickness excisional wounds were created on pigs and injected intradermally with various doses of doxorubicin. Wounds were monitored for a period of 46 days for the development of eschar and wound closure. After determining the optimal concentration and dose of doxorubicin resulting in non-healing eschars, these conditions were used to create additional wounds on another set of animals. The resulting eschars were treated with various concentrations of a novel bromelain-based enzymatic agent (EscharEx-02) or collagenase. The primary endpoint was greater than 95% removal of the central eschar. Results: Consistent eschars composed of two distinct areas (a central area of exudate and slough representing the hard-to-heal wound bed, and a peripheral area of full-thickness mummified necrosis) were seen after injection of doxorubicin (0.5 ml/cm2 of stock solution 0.75mg/ml) at one and six days after wound creation. Complete removal of the central eschar was achieved in all wounds after five and eight treatments with 5% and 2% EscharEx-02 respectively. Complete removal of the central eschar with collagenase was achieved in 0% and 82% of the wounds after 10 and 16 treatments respectively. Conclusions: We describe a porcine model for creating eschars similar to hard-to-heal wounds in humans. A novel bromelain-based enzymatic debridement agent was more effective than a commercially available collagenase in removing eschars in this wound model.

RUSC2 and WDR47 oppositely regulate kinesin-1–dependent distribution of ATG9A to the cell periphery

Autophagy-related protein 9 (ATG9) is a transmembrane protein component of the autophagy machinery that cycles between the trans-Golgi network (TGN) in the perinuclear area and other compartments in the peripheral area of the cell. In mammalian cells, export of the ATG9A isoform from the TGN into ATG9A-containing vesicles is mediated by the adaptor protein 4 (AP-4) complex. However, the mechanisms responsible for the subsequent distribution of these vesicles to the cell periphery is unclear. Herein we show that the AP-4–accessory protein RUSC2 couples ATG9A-containing vesicles to the plus-end-directed microtubule motor kinesin-1 via an interaction between a disordered region of RUSC2 and the kinesin-1 light chain (KLC). This interaction is counteracted by the microtubule-associated WD40-repeat domain 47 protein (WDR47). These findings uncover a mechanism for the peripheral distribution of ATG9A-containing vesicles, involving the function of RUSC2 as a kinesin-1 adaptor and WDR47 as a negative regulator of this function.

Effect of Temperature Gradient of Grain Storage on Migration and Distribution of Three Pests

Temperature gradients were set at the opposite sides of the grain storage: 25°C-30°C, 20°C-30°C, 20°C-35°C, 30°C-30°C. The migration and distribution of imago of Sitophilus oryzae, Rhizopertha dominica and Tribolium castaneum in the grain storage were observed. The results showed significant differences that the distribution trends of imago of Sitophilus oryzae, Rhizopertha dominica and Tribolium castaneum within a certain grain storage temperature gradient (p < 0.05). The temperature gradient of grain storage is 25°C-30°C. Tribolium castaneum tends to gather in the 30°C side area of grain storage, while Sitophilus oryzae has no obvious trend, while Rhizopertha dominica tends to gather in the 25°C. The temperature gradient of grain storage is 20°C-30°C. Both Tribolium castaneum and Sitophilus oryzae tend to gather in the 30°C side area of grain storage, while Rhizopertha dominica tends to gather in the 20°C. The temperature gradient of grain storage is 20°C-35°C. Tribolium castaneum, Sitophilus oryzae and Rhizopertha dominica all tend to gather in the area on the side of grain storage at 35°C. The temperature gradient of grain storage is 30°C-30°C, and there is no obvious trend for Tribolium castaneum. Rhizopertha dominica tends to gather in the 30°C area on the left side of grain storage, while Sitophilus oryzae tends to gather in the 30°C area on the right side of grain storage. After cooling down, it was found that Sitophilus oryzae tended to gather in the center of the grain storage, while the Tribolium castaneum had no obvious trend, and the Rhizopertha dominica tended to gather in the peripheral area of the grain storage.

BIOSOCIAL DIVERSITY OF SCOTS PINE (PINUS SYLVESTRIS L.) IN A TREE STAND IN RELATION TO CHOSEN HYDRAULIC CONDUCTIVITY INDICATORS OF THE STEM

The research focused in determining the lignification indicator of fresh needled springs and the mass of fresh needles in reference to the lignin content in tracheid walls of peripheral area of the stem (MFT/LC and MFN/LC) of Scots pine differentiated as far as its biosocial position within the community expressed by Kraft’s classification. The material for the analysis came from mature pine stands growing on North European Plain, on the territory of Poland. Chemical and structural analyses of wood encompassed the area of mature sapwood, i.e. thickness of the last 10 annual rings located at 1.3 m (DBH). It seems that the noticed differences values of both indicators (MFT/LC and MFN/LC) in pines belonging to the first three Kraft’s biological classes are connected with physiological, physical and structural conditionings of water transport with minerals in xylem and are closely connected with competition for sunlight, water, nutrients and living space.