Effect of 8 Weeks of Vitamin D Supplementation and Water-Based Exercise on Cardiometabolic Profile in Women With Type 2 Diabetes

2021 ◽  
Author(s):  
Mona Salarinia ◽  
Mohammad Azizi ◽  
Worya Tahmasebi ◽  
Hadi Khalvandi
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Protein Profile ◽  
Vitamin D Supplementation ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Water Exercise ◽  
Vitamin D 3 ◽  
Cardiometabolic Profile

Abstract BackgroundSince type 2 diabetes is the most common metabolic disease, it is necessary to know the factors affecting on the complications of this disease. The aim of this study was to investigate the Effect of 8 weeks of vitamin D supplementation and water exercise on cardiometabolic profile in women with type 2 diabetes.Methods40 women with type 2 diabetes participated in this study voluntarily and randomly divided to four groups: 1) vitamin D+ water exercise, 2) vitamin D, 3) water exercise, and 4) control groups. Water exercise groups (groups 1 and 3) performed 3 sessions of water training per week during 8 weeks (15 minutes of warm-up, 45 to 60 minutes of main activity with a Borg scale of 14 and 10 minutes of cooling). Vitamin D groups (groups 1 and 2) received 50,000 (IU) vitamin D supplements once a week. Levels of fasting blood sugar (FBS), insulin, hemoglobin A1c (HbA1c), C- reactive protein (CRP) levels, as well as lipid protein profile (triglyceride, total cholesterol, high and low density lipoproteins (LDL and HDL)) were measured before and after intervention. Insulin resistance was also obtained by calculating HOMA-IR.ResultsWeight, waist circumference, and body fat mass were significantly decrease after intervention in Vitamin D+ water exercise group (P= 0.001, 0.001, 0.032, and 0.013 respectively), as well as CRP, glycemic and lipid profile were significantly improved after intervention in water exercise group.ConclusionThe results of the present study showed that water exercise plus vitamin D supplementation had synergism beneficial effects on anthropometric indices and cardiometabolic status of type 2 diabetic patients and can be used as a non-pharmacological and non-invasive method to reduce complications of type 2 diabetes. Iranian Clinical Trials Registry number: IRCT20201223049811N1, data of registration: 12.01.2021; https://en.irct.ir/trial/53230

scholarly journals Effect of Vitamin D supplementation on vascular functions and oxidative stress in type 2 diabetic patients with Vitamin D deficiency

2017 ◽  
Vol 21 (4) ◽  
pp. 555 ◽  
Author(s):  
Sandhiya Selvarajan ◽  
Nishanthi Anandabaskar ◽  
StevenAibor Dkhar ◽  
SadishKumar Kamalanathan ◽  
Kadhiravan Tamilarasu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Vitamin D Supplementation ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
And Oxidative Stress ◽  
Type 2 Diabetic

scholarly journals Calcium-Vitamin D Cosupplementation Influences Circulating Inflammatory Biomarkers and Adipocytokines in Vitamin D-Insufficient Diabetics: A Randomized Controlled Clinical Trial

2014 ◽  
Vol 99 (12) ◽  
pp. E2485-E2493 ◽  
Author(s):  
Maryam Tabesh ◽  
Leila Azadbakht ◽  
Elham Faghihimani ◽  
Marjan Tabesh ◽  
Ahmad Esmaillzadeh
Keyword(s):  
Type 2 Diabetes ◽  
Clinical Trial ◽  
Vitamin D ◽  
Vitamin D Supplementation ◽  
Inflammatory Biomarkers ◽  
Hypoglycemic Agents ◽  
Controlled Clinical Trial ◽  
Diabetic Patients ◽  
Tnf Α

Context: To the best of our knowledge, no study has examined the effects of vitamin D-calcium cosupplementation on inflammatory biomarkers and adipocytokines in vitamin D-insufficient type 2 diabetics. Objective: This study was performed to assess the effects of vitamin D and calcium supplementation on inflammatory biomarkers and adipocytokines in vitamin D-insufficient people with type 2 diabetes. Methods: Totally, 118 diabetic patients were enrolled in this randomized, placebo-controlled clinical trial. After matching for age, sex, body mass index, type and dose of hypoglycemic agents, and duration of diabetes, subjects were randomly assigned into 4 groups receiving the following: 1) 50000 IU/wk vitamin D + calcium placebo; 2) 1000 mg/d calcium + vitamin D placebo; 3) 50 000 IU/wk vitamin D + 1000 mg/d calcium; or 4) vitamin D placebo + calcium placebo for 8 weeks. Blood sampling was done for the quantification of inflammatory biomarkers and adipocytokines at the study baseline and after 8 weeks of intervention. Results: Calcium (changes from baseline: −75±19 ng/ml, P = .01) and vitamin D alone (−56 ± 19 ng/mL, P = .01) and joint calcium-vitamin D supplementation (−92 ± 19 ng/mL, P = .01) resulted in a significant reduction in serum leptin levels compared with placebo (−9 ± 18 ng/mL). This was also the case for serum IL-6, such that calcium (−2 ± 1 pg/mL, P < .001) and vitamin D alone (−4 ± 1 pg/mL, P < .001) and their combination (−4 ± 1 pg/mL, P < .001) led to significant reductions compared with placebo (3 ± 1 pg/mL). After adjustment for potential confounders, individuals in the calcium (−3.1 ± 1.3, P < .05), vitamin D (−3.1 ± 1.3, P < .05), and joint calcium-vitamin D groups (−3.4 ± 1.3, P < .05) had greater reductions in serum TNF-α concentrations compared with placebo (0.1 ± 1.2). Individuals who received joint calcium-vitamin D supplements tended to have a decrease in serum high-sensitivity C-reactive protein levels compared with placebo after controlling for baseline levels (−1.14 ± 0.25 vs 0.02 ± 0.24 ng/mL, P = .09). Conclusion: Joint calcium-vitamin D supplementation might improve systemic inflammation through decreasing IL-6 and TNF-α concentrations in vitamin D-insufficient people with type 2 diabetes.

scholarly journals VITAMIN D SUPPLEMENTATION AND HBA1C LEVELS IN TYPE 2 DIABETIC PATIENTS

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Mahesh Kumar Singh
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Vitamin D Supplementation ◽  
Diabetic Patients ◽  
Inverse Association ◽  
Natural Diet ◽  
Vitamin D Levels ◽  
Tertiary Center ◽  
Hba1c Levels

Introduction: Type 2 diabetes mellitus (T2DM) is a major public health problem, with an estimated 65 million patients in India. Studies shown that low serum 25(OH)D concentrations are associated with an increased risk of type 2 diabetes and shown the beneficial effect of vitamin D supplementation on insulin sensitivity. Vitamin D is formed in humans by subcutaneous photosynthesis from its precursor, 7-dehydrocholesterol by exposing themselves to the sun. older age is associated with a decrease in 7-dehydrocholesterol concentration in the human skin. This lifestyle habit and their natural diet of low vitamin D consumption may cause poor glucose control in diabetic patients. The purpose of this study was to examine the association between serum 25(OH)D and glycosylated hemoglobin (HbA1c) levels. Material and Methods: This was a prospective observational study of T2DM patients aged 18 and above who attended the outpatient clinics of a tertiary center. The following variables were collected from the cases: age, sex, type of diabetes, HbA1c result. Baseline HbA1c and vitamin D levels were recorded prior to supplementation and after a period of 6 months of supplementation with vitamin D, HbA1c and vitamin D levels were recorded once again.  Results: A total of 169 patients were included in the study and whose follow up was completed at the end of 6 months. Mean age of the study population was 46.87 ± 15.99. there were 74(43.79%) male and 95(56.21%) female.  Mean HbA1c pre-supplementation (%) was   9.58 ± 2.41 while post supplementation was 7.21 ± 1.08. There was a significant reduction of HbA1c of T2DM (P < 0.0001). Vitamin D levels pre-supplementation (nmol/L) (mean ± SD) was 38.54 ± 29.54 while, Vitamin D levels post-supplementation (nmol/L) (mean ± SD) was 38.54  ± 29.54. There was a significant increase of vitamin D levels of T2DM (P < 0.0001). Conclusion: Significant inverse association between vitamin levels D and HbA1c in T2DM patients was observed. Also there was significant reduction in HbA1c as vitamin D levels increased. Regular screening of vitamin levels D and HbA1c in T2DM patients is advised. Keywords: Vitamin D, diabetes, T2DM, 25-hydroxyvitamin D

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