scholarly journals Preoperative Neutrophil to Lymphocyte Ratio Predicts Complications After Esophageal Resection That Can Be Used as Inclusion Criteria for Enhanced Recovery After Surgery: a Multi-Center Observational Study

2021 ◽  
Author(s):  
Bowen Shi ◽  
Xinyu Wang ◽  
Yue Zhao ◽  
Xiang Fei ◽  
Ji Zhu ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Logistic Regression ◽  
Postoperative Complications ◽  
Enhanced Recovery ◽  
Enhanced Recovery After Surgery ◽  
Neutrophil To Lymphocyte Ratio ◽  
Inclusion Criteria ◽  
Multivariate Logistic Regression ◽  
Cancer Resection ◽  
Lymphocyte Ratio

Abstract BackgroundThe neutrophil to lymphocyte ratio (NLR) has been reported as an indicator for poor prognosis in many cancers including esophageal cancer. However, the relationship between the NLR and postoperative complications after esophageal cancer resection remains unclear. At present, enhanced recovery after surgery (ERAS) lacks an inclusion criteria. The aim of this study is to determine whether the preoperative NLR (preNLR) can predict complications after esophageal cancer resection, which could represent the criteria for ERAS. MethodsThis was a retrospective study on 171 patients who underwent esophagectomy at Hospital between November 2019 and November 2020(68 patients from Changhai Hospital, 65 patients from Shanghai General Hospital and 38 patients from Affiliated Hospital of Qingdao University). Univariate and multivariate logistic regression analyses were performed to demonstrate that the preNLR could predict complications after esophagectomy. ResultsA preNLR cutoff value of 2.30 was identified as having the greatest ability to predict complications with a sensitivity of 76% and specificity of 65%. Moreover, the Chi-squared test results showed that the preNLR was significantly associated with complications (x2=13.641, p<0.001), and multivariate logistic regression analysis showed that body mass index (BMI), p stage and preNLR were independent variables associated with the development of postoperative complications (p<0.05). ConclusionThe preNLR can predict complications after esophagectomy, and these predicted complications can represent the criteria for recruiting patients for ERAS.

scholarly journals Prognostic value of neutrophil-to-lymphocyte ratio, lactate dehydrogenase, D-dimer and CT score in patients with COVID-19

2020 ◽  
Author(s):  
Yu-Qing Cai ◽  
Hui-Qing Zeng ◽  
Xiao-Bin Zhang ◽  
Xiao-Jie Wei ◽  
Lan Hu ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Lactate Dehydrogenase ◽  
Independent Predictor ◽  
Neutrophil To Lymphocyte Ratio ◽  
Multivariate Logistic Regression ◽  
Laboratory Findings ◽  
Lymphocyte Ratio ◽  
Severe Group ◽  
High Level ◽  
D Dimer

Abstract Background To explore the significance of neutrophil-to-lymphocyte ratio (NLR), lactate dehydrogenase (LDH), D-dimer and CT score in evaluating the severity and prognosis of coronavirus disease – 2019 (COVID-19). Methods Patients with laboratory confirmed COVID-19 were retrospectively enrolled. The baseline data, laboratory findings, chest computed tomography (CT) results evaluating by CT score on admission, and clinical outcomes were collected and compared. The logistic regression was used to assess the independent relationship between the baseline level of four indicators (NLR, LDH, D-dimer, CT score) and the severity of COVID-19. Results Among 432 patients, 125 (28.94%) cases were divided into severe group, the remaining (n = 307, 71.06%) were in non-severe group. In multivariate logistic regression, high level of NLR, LDH were independent predictor of the severe group in COVID-19 (OR = 2.163; 95%CI = 1.162–4.026; p = 0.015 for NLR > 3.82; OR = 2.298; 95%CI = 1.327–3.979; p = 0.003 for LDH > 246U/L). Combining NLR > 3.82 and LDH > 246U/L increased the sensitivity of diagnosis in severe patients (NLR > 3.82 [50.40%] vs. Combined diagnosis [72.80%]; p = 0.0007; LDH > 246 [59.2%] vs. Combined diagnosis [72.80%]; p < 0.0001). Conclusions High levels of NLR and LDH in serum have potential value in the early identification of severe patients with COVID-19. The combination of LDH and NLR can improve the sensitivity of diagnosis.

scholarly journals Enhanced recovery after surgery nursing program, a protective factor for stoma-related complications in patients with low rectal cancer

BMC Surgery ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Weiling Shao ◽  
Honggang Wang ◽  
Qun Chen ◽  
Wen Zhao ◽  
Yulian Gu ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Logistic Regression ◽  
Abdominoperineal Resection ◽  
Protective Factor ◽  
Enhanced Recovery ◽  
Enhanced Recovery After Surgery ◽  
Nursing Program ◽  
Low Rectal Cancer ◽  
Psychological Status ◽  
Multivariate Logistic Regression

Abstract Background This study aimed to investigate the association between enhanced recovery after surgery (ERAS) nursing program and stoma-related complications (SRCs) and prognosis in patients with low rectal cancer (LRC) undergoing abdominoperineal resection with sigmoidostomy. Methods LRC patients who underwent elective abdominoperineal resection with sigmoidostomy between May 2016 and May 2019 were retrospectively enrolled. The occurrence of early major or minor SRCs (within postoperative 30 days) was set as the primary end-point. Clinicopathological variables and laboratory tests were compared between patients with or without SRCs. The univariate and multivariate logistic regression analyses were performed to investigate risk factors for SRCs. Hospitalization satisfaction-related and prognosis-related variables were compared between LRC patients with or without ERAS nursing program. Results A total of 288 patients were enrolled and the incidence of SRCs was 26.7% (77/288). ERAS nursing program was the only independent risk factor for SRCs in LRC patients (OR 2.04, 95%CI 1.31–3.12, P = 0.016) by the multivariate logistic regression analysis. Moreover, ERAS nursing program was associated with higher hospitalization satisfaction rate, faster bowel function recovery, better psychological status, and higher quality of life. Conclusions ERAS nursing program was a protective factor for SRCs and associated with improved prognosis in LRC patients undergoing elective abdominoperineal resection with sigmoidostomy.

scholarly journals Correction to: The enhanced recovery after surgery (ERAS) protocol to promote recovery following esophageal cancer resection

Surgery Today ◽  
2020 ◽  
Vol 50 (5) ◽  
pp. 531-531
Author(s):  
Apurva Ashok ◽  
Devayani Niyogi ◽  
Priya Ranganathan ◽  
Sandeep Tandon ◽  
Maheema Bhaskar ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Enhanced Recovery ◽  
Enhanced Recovery After Surgery ◽  
Cancer Resection ◽  
Eras Protocol

scholarly journals The enhanced recovery after surgery (ERAS) protocol to promote recovery following esophageal cancer resection

Surgery Today ◽  
2020 ◽  
Vol 50 (4) ◽  
pp. 323-334
Author(s):  
Apurva Ashok ◽  
Devayani Niyogi ◽  
Priya Ranganathan ◽  
Sandeep Tandon ◽  
Maheema Bhaskar ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Enhanced Recovery ◽  
Enhanced Recovery After Surgery ◽  
Cancer Resection ◽  
Eras Protocol

scholarly journals Enhanced recovery after surgery nursing, a risk factor for stoma-related complications in patients with low rectal cancer

2020 ◽  
Author(s):  
Weiling Shao ◽  
Honggang Wang ◽  
Qun Chen ◽  
Wen Zhao ◽  
Yulian Gu ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Logistic Regression ◽  
Risk Factor ◽  
Abdominoperineal Resection ◽  
Enhanced Recovery ◽  
Enhanced Recovery After Surgery ◽  
Multivariate Logistic Regression Analysis ◽  
Low Rectal Cancer ◽  
Psychological Status ◽  
Multivariate Logistic Regression

Abstract Background: This study aimed to investigate the association between enhanced recovery after surgery (ERAS) nursing and stoma-related complications (SRCs) and prognosis in patients with low rectal cancer (LRC) undergoing abdominoperineal resection with sigmoidostomy.Methods: LRC patients who underwent elective abdominoperineal resection with sigmoidostomy between May 2016 and May 2019 were retrospectively enrolled. The occurrence of early major or minor SRCs (within postoperative 30 days) was set as the primary end-point. Clinicopathological variables and laboratory tests were compared between patients with or without SRCs. The univariate and multivariate logistic regression analyses were performed to investigate risk factors for SRCs. Hospitalization satisfaction-related and prognosis-related variables were compared between LRC patients with or without ERAS nursing.Results: A total of 288 patients were enrolled and the incidence of SRCs was 26.7% (77/288). ERAS nursing was the only independent risk factor for SRCs in LRC patients (OR: 2.04, 95%CI: 1.31-3.12, P=0.016) by the multivariate logistic regression analysis. Moreover, ERAS nursing was associated with higher hospitalization satisfaction rate, faster bowel function recovery, better psychological status, and higher quality of life.Conclusions: ERAS nursing was a risk factor for SRCs and associated with improved prognosis in LRC patients undergoing elective abdominoperineal resection with sigmoidostomy.

scholarly journals Prognostic value of the neutrophil-to-lymphocyte ratio in acute organophosphorus pesticide poisoning

2021 ◽  
Vol 16 (1) ◽  
pp. 703-710
Author(s):  
Yuhang Mu ◽  
Boqi Hu ◽  
Nan Gao ◽  
Li Pang
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Hospital Mortality ◽  
Logistic Regression Analysis ◽  
Poor Prognosis ◽  
Prognostic Value ◽  
Organophosphorus Pesticide ◽  
Neutrophil To Lymphocyte Ratio ◽  
Pesticide Poisoning ◽  
Lymphocyte Ratio

Abstract This study investigates the ability of blood neutrophil-to-lymphocyte ratio (NLR) to predict acute organophosphorus pesticide poisoning (AOPP). Clinical data of 385 patients with AOPP were obtained within 24 h of admission, and NLR values were calculated based on neutrophil and lymphocyte counts. The patients were divided into two groups – good and poor – based on prognosis. Poor prognosis included in-hospital death and severe poisoning. The factors affecting prognosis were analyzed by logistic regression analysis, and the prognostic value of NLR was evaluated using the area under the receiver operating characteristic curve (AUC). Univariate logistic regression analysis showed that NLR levels, serum cholinesterase, and creatinine levels were good predictors of AOPP. Multivariate logistic regression analysis showed that high NLR was an independent risk factor for severe poisoning (adjusted odds ratio [AOR], 1.13; 95% CI, 1.10–1.17; p < 0.05) and in-hospital mortality (AOR, 1.07; 95% CI, 1.03–1.11; p < 0.05). NLR values >13 and >17 had a moderate ability to predict severe poisoning and in-hospital mortality, respectively (AUC of 0.782 [95% CI, 0.74–0.824] and 0.714 [95% CI, 0.626–0.803], respectively). Our results show that high NLR at admission is an independent indicator of poor prognosis in AOPP and can be used to optimize treatment and manage patients.

scholarly journals Neutrophil-to-Lymphocyte Ratio at Hospital Admission as a Novel Predictor of Early Growth of Intraparenchymal Haemorrhage in Patients With Traumatic Brain Injury

2020 ◽  
Author(s):  
Dongzhou Zhuang ◽  
Jiangtao Sheng ◽  
Guoyi Peng ◽  
Tian Li ◽  
Shirong Cai ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Multivariate Logistic Regression Analysis ◽  
Final Analysis ◽  
Early Growth ◽  
Neutrophil To Lymphocyte Ratio ◽  
Roc Curve Analysis ◽  
Cerebral Contusion ◽  
Lymphocyte Ratio ◽  
Intraparenchymal Haemorrhage ◽  
Development And Validation

Abstract BackgroundThis study aimed to explore the association between the neutrophil-to-lymphocyte ratio (NLR) and early growth of traumatic intraparenchymal haemorrhage (tICH) in patients with traumatic brain injury.MethodsA multicentre, observational cohort study was conducted at four hospitals and included patients with cerebral contusion undergoing baseline computed tomography (CT) for haematoma volume analysis within 6 hours after primary injury and who had follow-up visits within 48 hours. Routine blood tests were performed upon admission and analysed with early PIH. Logistic regression and receiver operating characteristic (ROC) analysis was used to explore the predictive value of the NLR for haematoma expansion. ResultsThe final analysis included 1003 patients in the retrospective development and validation cohorts. In the retrospective development cohort, the NLR were higher in the PIH group than in the non-PIH group (P<0.0001). Multivariate logistic regression analysis revealed that a higher NLR was independently associated with PIH (P<0.0001). ROC curve analysis showed that the NLR had a sensitive ability for predicting PIH (AUC, 0.91 [95% CI, 0.88-0.94]). In the validation study, the NLR had a similar ability to predict PIH. ConclusionThe NLR can be used to easily assess the growth of tICH and calculated using routine laboratory tests. A high NLR is independently predictive of early growth of tICH and may aid in risk stratification of patients with tICH on admission.

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