Male sex is strongly associated with IgE-sensitization to airborne but not food allergens: results up to age 24 years from the BAMSE birth cohort

Abstract Background Up to half of the population in high-income countries has allergen-specific IgE antibodies. However, data regarding sex differences of IgE-sensitization from childhood to adulthood is limited. Objective To explore IgE-sensitization to common foods and airborne allergens in relation to sex over time in a population-based birth cohort followed up to young adulthood. Methods The Swedish population-based birth cohort BAMSE includes 4,089 subjects who have been followed regularly with questionnaires and clinical investigations. A recent 24-year follow-up included 3,069 participants (75%). Sera collected at 4, 8, 16 and 24 years were analyzed for IgE-antibodies to 14 common foods and airborne allergens. Results At 24 years sensitization to foods had decreased compared to previous follow-ups affecting 8.4%, while sensitization to airborne allergens was more common, affecting 42.2%. Male sex was associated with IgE-sensitization to airborne allergens at all ages (overall OR: 1.68, 95% CI 1.46 - 1.94) while there was no statistically significant association between sex and sensitization to food allergens (overall OR: 1.10, 95% CI 0.93 - 1.32). Levels of allergen-specific IgE did not differ significantly between males and females for any of the tested foods or airborne allergens at any age, following adjustment for multiple comparisons. Conclusion IgE-sensitization to airborne allergens increases with age up to young adulthood, whereas sensitization to food allergens seems to level off. Male sex is strongly associated with IgE-sensitization to airborne allergens from early childhood up to young adulthood. In contrast, there is little evidence for associations between sex and IgE-sensitization to foods.

Download Full-text

Machine learning to identify pairwise interactions between specific IgE antibodies and their association with asthma: A cross-sectional analysis within a population-based birth cohort

PLoS Medicine ◽

10.1371/journal.pmed.1002691 ◽

2018 ◽

Vol 15 (11) ◽

pp. e1002691 ◽

Cited By ~ 20

Author(s):

Sara Fontanella ◽

Clément Frainay ◽

Clare S. Murray ◽

Angela Simpson ◽

Adnan Custovic

Keyword(s):

Machine Learning ◽

Birth Cohort ◽

Specific Ige ◽

Population Based ◽

Cross Sectional ◽

Ige Antibodies ◽

Cross Sectional Analysis ◽

Pairwise Interactions ◽

Specific Ige Antibodies ◽

Sectional Analysis

Download Full-text

Male sex is strongly associated with IgE-sensitization to airborne but not food allergens: results up to age 24 years from the BAMSE birth cohort

Clinical and Translational Allergy ◽

10.1186/s13601-020-00319-w ◽

2020 ◽

Vol 10 (1) ◽

Cited By ~ 2

Author(s):

Erik Melén ◽

Anna Bergström ◽

Inger Kull ◽

Catarina Almqvist ◽

Niklas Andersson ◽

...

Keyword(s):

Birth Cohort ◽

Food Allergens ◽

Male Sex

Download Full-text

An Analysis Of Cytokine Profiles Associated with elevated Total And Allergen-specific IgE Levels In A Population-based birth Cohort At Age 18-20

10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a1332 ◽

2010 ◽

Author(s):

Edward Zoratti ◽

Suzanne Havstad ◽

Dennis R. Ownby ◽

Ganesa Wegienka ◽

Kevin R. Bobbitt ◽

...

Keyword(s):

Birth Cohort ◽

Specific Ige ◽

Population Based ◽

Cytokine Profiles

Download Full-text

Prediction of peanut allergy in adolescence by early childhood storage protein-specific IgE signatures: The BAMSE population-based birth cohort

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2016.12.973 ◽

2017 ◽

Vol 140 (2) ◽

pp. 587-590.e7 ◽

Cited By ~ 15

Author(s):

Anna Asarnoj ◽

Carl Hamsten ◽

Christian Lupinek ◽

Erik Melén ◽

Niklas Andersson ◽

...

Keyword(s):

Early Childhood ◽

Birth Cohort ◽

Storage Protein ◽

Peanut Allergy ◽

Specific Ige ◽

Population Based

Download Full-text

Food-Specific IgE and IgG Antibodies in Patients With Chronic Rhinosinusitis With Nasal Polyps: A Case–Control Study

Ear Nose & Throat Journal ◽

10.1177/0145561319867668 ◽

2019 ◽

pp. 014556131986766

Author(s):

Rafaela Veloso-Teles ◽

Rui Cerejeira ◽

Débora Rodrigues ◽

Rosa Roque-Farinha ◽

Christian von Buchwald

Keyword(s):

Case Control Study ◽

Specific Ige ◽

Food Allergens ◽

Igg Antibodies ◽

Ige Antibodies ◽

Specific Ige Antibodies ◽

Specific Igg ◽

Food Specific Ige ◽

Control Study ◽

Specific Igg Antibodies

EPOS 2012 states that investigation is needed to study a possible role for food allergy in the initiation and perpetuation of chronic rhinosinusitis with nasal polyps (CRSwNP). Our main goal was to compare serum levels of food-specific immunoglobulin G (IgG) and IgE antibodies in patients with CRSwNP and controls. A prospective case–control study with 33 patients with CRSwNP and 31 controls without CRS was carried out. Clinical data were gathered through a systematic interview and blood sample was collected. Enzyme-linked immunosorbent assay tests using OmegaDiagnostics kit with 40 food allergens for detection of specific IgG antibodies were performed and food-specific IgE antibodies were determined by immunoassay using ImmunoCAP. Immunoglobulin classes and IgG subclasses levels were also evaluated. Statistical analysis was performed using SPSS v.23. The overall sum of food IgG antibodies was significantly lower in CRSwNP compared to control group, and this difference was also observed for different specific IgG antibodies (corn, soya, grain legumes, pear and apple, berries, citric fruit). In controls, a positive correlation between IgG1 and the sum of food IgG antibodies was seen, but in CRSwNP group a negative correlation was found. In addition, a significant higher level of IgG1 and lower IgG2 and IgG3 was found among patients with CRSwNP. Levels of serum-specific IgE antibodies against multiallergen food mix (fx5) and against shrimp, strawberry, orange, rye, or egg yolk, as well as the sum of food IgE antibodies, did not differ significantly between the groups. These findings suggest that food allergy does not have an important role in CRSwNP etiopathogenesis, whether it is IgG or IgE mediated. Moreover, the observed suppression of specific IgG antibodies against food allergens, its negative correlation with IgG1 and the IgG1 switching in CRSwNP, can be related to deviated IgG responses against other targets (eg, airborne particles) and warrants future investigation.

Download Full-text

Food allergy in early childhood increases the risk of pollen-food allergy syndrome

10.22541/au.164143253.38970625/v1 ◽

2022 ◽

Author(s):

Kun Baek Song ◽

Min Jee Park ◽

Eom Ji Choi ◽

Sungsu Jung ◽

Ji-Sun Yoon ◽

...

Keyword(s):

Early Childhood ◽

Food Allergy ◽

Birth Cohort ◽

Age At Onset ◽

Allergic Diseases ◽

Population Based ◽

Food Allergens ◽

History Of ◽

Skin Prick Tests ◽

Inhalant Allergens

Abstract Background: The level of pollen in Korea has increased over recent decades. Research suggests that pollen-food allergy syndrome (PFAS) may be more frequent in childhood than previously recognized. We aimed to investigate the prevalence and characteristics of PFAS in children aged 6–10 years from a general population-based birth cohort. Methods: We analyzed 930 children from the COhort for Childhood Origin of Asthma and allergic diseases (COCOA) birth cohort. Allergic diseases were diagnosed annually by pediatric allergists. The skin prick tests were performed with 14 common inhalant allergens and four food allergens for children aged 3 and 7 years. Results: Of the 930 eligible children, 44 (4.7%) aged 6–10 years were diagnosed with. The mean age at onset was 6.74 years. PFAS prevalence was 7.2% among children with allergic rhinitis (AR) and 19.1% among those with pollinosis, depending on comorbidity. PFAS was more prevalent in schoolchildren with atopic dermatitis, food allergy, and sensitization to food allergens and grass pollen in early childhood. In schoolchildren with AR, only a history of food allergy before 3 years increased the risk of PFAS (aOR 2.971, 95% CI: 1.159–7.615). Conclusion: Food allergy and food sensitization in early childhood was associated with PFAS in schoolchildren with AR. Further study is required to elucidate the mechanism by which food allergy in early childhood affects the development of PFAS.

Download Full-text

Sensibilization Spectrum in Preschool Children with Atopic Dermatitis

Педиатрическая фармакология ◽

10.15690/pf.v18i4.2292 ◽

2021 ◽

Vol 18 (4) ◽

pp. 286-291

Author(s):

Tat'yana S. Kashinskaya ◽

Natal'ya V. Shahova ◽

Yurij F. Lobanov ◽

Natal'ya K. Bishevskaya

Keyword(s):

Staphylococcus Aureus ◽

Atopic Dermatitis ◽

Milk Proteins ◽

Specific Ige ◽

Cow’S Milk ◽

Food Allergens ◽

Positive Correlation ◽

Weak Positive Correlation ◽

Staphylococcus Aureus Enterotoxins ◽

Airborne Allergens

Background. Atopic dermatitis (AD) is an allergodermathosis that is widespread in children and adult populations. Sensibilization to food allergens prevails in children of early age, and to airborne allergens in older age. Impairments of skin barrier lead to increase in Staphylococcus aureus colonization and finally aggravate the course of AD and the sensibilization level.Objective. The aim of the study is to estimate the sensibilization spectrum in 3-6 years old children with AD and its correlation with severity.Methods. It was cross sectional study with two independent cohorts of 3-6 years old children with and without (healthy) AD. Estimation of sensibilization spectrum and revealing of correlation with disease severity were performed.Results. The study includes 106 children aged 4.4 ± 1.2 year (58.5% boys and 41.5% girls). Polysensibilization was revealed in 28.3% of children. According to our data: 3-6 years old children with AD most often had sensibilization to the cat epithelium (34.9%), cow's milk proteins (22.6%), Dermatophagoides pteronyssinus mite (16.0%). Sensibilization to enterotoxins of Staphylococcus aureus was revealed in 7.5% children. We have recorded weak positive correlation between the AD severity and the level of specific IgE to airborne and food allergens. There was no statistically significant correlation between the AD severity and the level of specific IgE to Staphylococcus aureus enterotoxins A and B. Conclusion. The most common sensibilization type among 3-6 years old children with AD was one to airborne allergens. Sensibilization to the cat epithelium prevails among airborne allergens, to the cow's milk proteins — among food allergens. The weak positive correlation between the AD severity and the level of specific IgE to airborne and food allergens was revealed. The weak negative correlation with the level of specific IgE to Staphylococcus aureus enterotoxins A and B was revealed, thus the data was statistically insignificant.

Download Full-text