Effect of semaphorin 3A expression on clinicopathological features and prognosis in oropharyngeal carcinoma

Abstract Semaphorin 3A (SEMA3A) is a well-known axon guidance molecule in the nervous system. It is also known as a tumor suppressor in various cancers. In the present study, we examined the relationships between SEMA3A and clinicopathologic features and neoangiogenesis and its prognostic significance for oropharyngeal cancer (OPC) patients. Thirty-two OPC patients who underwent biopsy and 17 normal patients who underwent tonsillectomy were analyzed for SEMA3A expression by immunohistochemical analysis. We also analyzed 22 OPC specimens for CD34 expression as a marker of neoangiogenesis. SEMA3A was significantly downregulated in OPC compared with normal tonsil tissues (p = 0.005). SEMA3A expression was negatively correlated with CD34 expression, which suggested that a higher microvascular density corresponded to a lower expression of SEMA3A (r = -0.466, p = 0.033). Moreover, the higher SEMA3A expression cohort showed better survival than the lower SEMA3A expression cohort regardless of human papillomavirus (HPV) status (p = 0.035). These results suggest that SEMA3A expression is a prognostic marker for survival and is associated with antiangiogenesis in OPC.

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Influences of Semaphorin 3A Expression on Clinicopathological Features, Human Papillomavirus Status, and Prognosis in Oropharyngeal Carcinoma

Microorganisms ◽

10.3390/microorganisms8091286 ◽

2020 ◽

Vol 8 (9) ◽

pp. 1286

Author(s):

Hai Thanh Pham ◽

Satoru Kondo ◽

Kazuhira Endo ◽

Naohiro Wakisaka ◽

Yoshitaka Aoki ◽

...

Keyword(s):

Human Papillomavirus ◽

Prognostic Marker ◽

Prognostic Significance ◽

Immunohistochemical Analysis ◽

Hpv Infection ◽

Etiologic Factor ◽

Oropharyngeal Carcinoma ◽

Semaphorin 3A ◽

Hpv Status ◽

Cd34 Expression

Human papillomavirus (HPV) infection is now identified as a major etiologic factor for oropharyngeal cancer (OPC), and HPV positivity is well established better prognostic marker in OPC. Now, predictable markers for the prognosis of the patients who are stratified by HPV has been investigated in. Semaphorin 3A (SEMA3A) is a well-known axon guidance molecule in the nervous system. It is also known as a tumor suppressor in various cancers. In the present study, we examined the relationships between SEMA3A and clinicopathologic features, especially HPV status, and neoangiogenesis, and its prognostic significance for OPC patients. Thirty-two OPC patients and 17 normal patients were analyzed for SEMA3A expression by immunohistochemical analysis. We also analyzed 22 OPC specimens for CD34 expression as a marker of neoangiogenesis. SEMA3A was significantly downregulated in OPC compared with chronic tonsillitis tissues (p = 0.005). SEMA3A expression was negatively correlated with CD34 expression (r = −0.466, p = 0.033). Moreover, the higher SEMA3A expression cohort showed better survival than the lower SEMA3A expression cohort regardless of HPV status (p = 0.035). These results suggest that SEMA3A expression is a prognostic marker for survival regardless of HPV status and is associated with anti-angiogenesis in OPC.

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Inhibitory effect of semaphorin-3A, a known axon guidance molecule, in the human thymocyte migration induced by CXCL12

Journal of Leukocyte Biology ◽

10.1189/jlb.0111031 ◽

2011 ◽

Vol 91 (1) ◽

pp. 7-13 ◽

Cited By ~ 25

Author(s):

Flavia Garcia ◽

Yves Lepelletier ◽

Salete Smaniotto ◽

Réda Hadj-Slimane ◽

Mireille Dardenne ◽

...

Keyword(s):

Axon Guidance ◽

Inhibitory Effect ◽

Semaphorin 3A ◽

Human Thymocyte ◽

Axon Guidance Molecule ◽

Guidance Molecule

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A Role of Staphyococcus aureus, Interleukin-18, Nerve Growth Factor and Semaphorin 3A, an Axon Guidance Molecule, in Pathogenesis and Treatment of Atopic Dermatitis

Allergy Asthma and Immunology Research ◽

10.4168/aair.2010.2.4.235 ◽

2010 ◽

Vol 2 (4) ◽

pp. 235 ◽

Cited By ~ 17

Author(s):

Zenro Ikezawa ◽

Junko Komori ◽

Yuko Ikezawa ◽

Yusuke Inoue ◽

Mio Kirino ◽

...

Keyword(s):

Atopic Dermatitis ◽

Nerve Growth Factor ◽

Growth Factor ◽

Axon Guidance ◽

Semaphorin 3A ◽

Interleukin 18 ◽

Nerve Growth ◽

Axon Guidance Molecule ◽

Guidance Molecule

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3GnT2 Maintains Adenylyl Cyclase-3 Signaling and Axon Guidance Molecule Expression in the Olfactory Epithelium

Journal of Neuroscience ◽

10.1523/jneurosci.0224-11.2011 ◽

2011 ◽

Vol 31 (17) ◽

pp. 6576-6586 ◽

Cited By ~ 16

Author(s):

T. R. Henion ◽

A. A. Faden ◽

T. K. Knott ◽

G. A. Schwarting

Keyword(s):

Axon Guidance ◽

Adenylyl Cyclase ◽

Olfactory Epithelium ◽

Axon Guidance Molecule ◽

Guidance Molecule

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The Beat generation: a multigene family encoding IgSF proteins related to the Beat axon guidance molecule in Drosophila

Development ◽

10.1242/dev.128.22.4545 ◽

2001 ◽

Vol 128 (22) ◽

pp. 4545-4552 ◽

Cited By ~ 1

Author(s):

G. C. Teg Pipes ◽

Qing Lin ◽

Stephanie E. Riley ◽

Corey S. Goodman

Keyword(s):

Axon Guidance ◽

Specific Growth ◽

Growth Cones ◽

Beat Generation ◽

Genetic Screen ◽

Genetic Interactions ◽

Membrane Bound ◽

Adhesive Factor ◽

Axon Guidance Molecule ◽

Guidance Molecule

A previous genetic screen led to the identification of the beaten path (beat Ia) gene in Drosophila. Beat Ia contains two immunoglobulin (Ig) domains and appears to function as an anti-adhesive factor secreted by specific growth cones to promote axon defasciculation. We identify a family of 14 beat-like genes in Drosophila. In contrast to beat Ia, four novel Beat-family genes encode membrane-bound proteins. Moreover, mutations in each gene lead to much more subtle guidance phenotypes than observed in beat Ia. Genetic interactions between beat Ic and beat Ia reveal complementary functions. Our data suggest a model whereby Beat Ic (and perhaps other membrane-bound family members) functions in a pro-adhesive fashion to regulate fasciculation, while Beat Ia (the original secreted Beat) functions in an anti-adhesive fashion to regulate defasciculation.

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