scholarly journals Postoperative bleeding in a patient with appendiceal mucinous adenocarcinoma and liver dysfunction patient: A case-report

2021 ◽  
Author(s):  
MingKun Sun ◽  
Xiaohua Niu ◽  
Ying Tang ◽  
Wenzhong Mo ◽  
Haiyang Xin ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Liver Dysfunction ◽  
Mucinous Adenocarcinoma ◽  
Malignant Tumors ◽  
Postoperative Bleeding ◽  
Pathological Examination ◽  
Preoperative Imaging ◽  
Intraperitoneal Hyperthermic Chemotherapy ◽  
Hyperthermic Chemotherapy ◽  
Enhanced Computed Tomography

Abstract Background: Appendiceal malignant tumors are rare in the clinic, and the incidence rate of gastrointestinal tumors is only approximately 0.5%. Our aim is to describe our experience with this rare disease and to increase knowledge on the diagnosis and treatment of appendiceal malignant tumors. Case presentation: We report the case of a 69-year-old woman who was admitted to the hospital due to dyspepsia. The patient was a carrier of hepatitis B virus, and liver dysfunction was diagnosed preoperatively. Abdominal enhanced computed tomography and colonoscopy showed that the appendix was significantly enlarged and dilated, and effusion and appendicitis were observed. Mucinous adenocarcinoma and appendiceal abscesses were not excluded because of the lack of specificity, which makes it difficult to diagnose the disease before a surgery. Laparoscopic appendectomy was performed, and a rapid frozen pathological examination showed a mucinous tumor of the appendix. Intraperitoneal hyperthermic chemotherapy with cisplatin was administered. The patient had abdominal hemorrhage on the fifth day after the surgery. After active treatment, she was discharged from the hospital 19 days after the surgery.Conclusions: The diagnosis of appendiceal malignant tumors mainly depends on preoperative imaging and microscopic results,and highly suspected patients, rapid pathological examination is needed during the operation., and so on. Notably, for elderly patients with hepatitis B infection and liver dysfunction, there is a probability of postoperative bleeding.

Laparoscopic Surgery for Gallbladder Neuroendocrine Carcinoma: A Case Series and Literature Review

2020 ◽  
Author(s):  
Hongwu Chu ◽  
Ying Shi ◽  
Changwei Dou ◽  
Fangqiang Wei ◽  
Chengwu Zhang ◽  
...  
Keyword(s):  
Laparoscopic Surgery ◽  
Survival Time ◽  
Postoperative Bleeding ◽  
Case Series ◽  
Bile Leakage ◽  
Postoperative Chemotherapy ◽  
Pathological Examination ◽  
Preoperative Imaging ◽  
Wall Thickening ◽  
Free Survival

Abstract Background: Gallbladder neuroendocrine carcinomas (GB-NECs) are a group of rare and heterogeneous neoplasms. There are few reports regarding laparoscopic surgery for GB-NEC cases diagnosed at advanced stage.Case presentation: Three patients, two females and one male, were admitted to our hospital. Two patients had the chief complaint of upper quadrant pain and one patient was found to have gallbladder occupation during a routine health checkup. No patient complained jaundice, weight loss, or carcinoid syndrome-related symptoms including diarrhea, edema, flushing and wheezing. Contrast-enhanced computed tomography (CT) examination showed local wall thickening of the gallbladder. In addition, one patient showed focal liver parenchymal invasion, and none of the three patients' preoperative imaging examination revealed lymph nodes (LNs) metastases. All three patients underwent laparoscopic radical cholecystectomy according to intraoperative frozen pathological examination, and they were diagnosed as GB-NEC based on postoperative pathology and immunohistochemistry. TNM stages of these patients were ⅢA (T3N0M0), ⅢB (T3N1M0) and ⅣB (T3N2M0), respectively. Chromogranin A (CgA) and synaptophysin (Syn) were positive in all cases. No patient encountered postoperative bleeding, bile leakage, abdominal abscess, gastrointestinal fistulas or pulmonary complication. Two patients underwent postoperative chemotherapy with two cycles and seven cycles of etoposide plus cisplatin, respectively. Another patient did not receive postoperative chemotherapy due to his poor general condition. The overall survival time of three patients was 4.6 months, 16.8 months and 8.5 months, respectively. All three patients presented with liver and/or bile duct recurrence after surgery with the tumor-free survival time of 2.3 months, 3.3 months and 3.0 months, respectively.Conclusion: Laparoscopic surgery may be considered as a potential treatment for advanced GB-NEC in selected patients. However, further studies are needed to investigate the tumor-free survival benefit of laparoscopic surgery, and whether expanding the resection scope could reduce postoperative recurrence.

scholarly journals Postoperative Bleeding in a Patient with Appendiceal Mucinous Adenocarcinoma and Liver Dysfunction Patient: A Case-Report

2021 ◽  
Vol 04 (04) ◽  
Author(s):  
Xiaohua Niu ◽  
Chaoming Tang ◽  
Ling Qi ◽  
Wenzhong Mo ◽  
Haiyang Xin ◽  
...  
Keyword(s):  
Case Report ◽  
Liver Dysfunction ◽  
Mucinous Adenocarcinoma ◽  
Postoperative Bleeding

Malignant mesothelioma of the tunica vaginalis testis: A Rare Malignant Tumor without Asbestos Exposure

2020 ◽  
Vol 02 ◽  
Author(s):  
Hayder Makki Al-Masari ◽  
Reham Ainawi ◽  
Abdulwahid Alwahedi ◽  
Heba Nofal ◽  
Yaser Asad
Keyword(s):  
Malignant Mesothelioma ◽  
Preoperative Diagnosis ◽  
Asbestos Exposure ◽  
Clinical Manifestations ◽  
Pathological Examination ◽  
Tunica Vaginalis ◽  
Intraperitoneal Hyperthermic Chemotherapy ◽  
Tunica Vaginalis Testis ◽  
Hyperthermic Chemotherapy ◽  
Oncology Center

: Malignant mesothelioma of the tunica vaginalis testis is an extremely rare and often a deadly tumor. Preoperative diagnosis is very difficult due to lack of specific clinical manifestations, mainly including hydrocele formation and painless inguinal mass. In this abstract we present a case of a young patient with hydrocele and dull pain of left testes, was planned for laparoscopic repair of left inguinal hernia, during which a mass attached to the scrotal cord was discovered. Dissection and release of the mass from the cord structure were done, and postoperative pathological examination revealed a malignant mesothelioma arising from the left tunica vaginalis testis. Case was then referred to oncology center where intraperitoneal hyperthermic chemotherapy with cytoreductive surgery were done.

Liver dysfunction related to hepatitis B and C in patients with inflammatory bowel disease treated with immunosuppressive therapy

Gut ◽  
2010 ◽  
Vol 59 (10) ◽  
pp. 1340-1346 ◽  
Author(s):  
C. Loras ◽  
J. P. Gisbert ◽  
M. Minguez ◽  
O. Merino ◽  
L. Bujanda ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Hepatitis B ◽  
Immunosuppressive Therapy ◽  
Liver Dysfunction ◽  
Bowel Disease ◽  
Inflammatory Bowel

Intraperitoneal Hyperthermic Chemotherapy in Gastric Cancer: Rationale for a new Approach

1998 ◽  
Vol 84 (4) ◽  
pp. 483-488 ◽  
Author(s):  
Federico Bozzetti ◽  
Maurizio Vaglini ◽  
Marcello Deraco
Keyword(s):  
Gastric Cancer ◽  
Peritoneal Carcinomatosis ◽  
Intraperitoneal Chemotherapy ◽  
Randomized Clinical Trials ◽  
Locally Advanced ◽  
Preliminary Evidence ◽  
Favorable Effect ◽  
Tumor Spread ◽  
Intraperitoneal Hyperthermic Chemotherapy ◽  
Hyperthermic Chemotherapy

There is preliminary evidence from experience in the treatment of various abdominal malignancies that intraperitoneal chemotherapy alone or combined with hyperthermia may attain a role in the therapeutic strategy. This paper considers the rationale for such an approach, as well as its current results and potential indications in patients with gastric cancer. The literature is critically reviewed, with special emphasis on specific topics such as patterns of tumor spread, mechanisms of local recurrence, the rationale for intraperitoneal chemotherapy and intraperitoneal hyperthermic chemotherapy, toxicity, and results from non-controlled as well as randomized clinical trials in patients with gastric cancer. There is some evidence that intraperitoneal hyperthermic chemotherapy has a favorable effect on clinical outcome in patients with limited peritoneal carcinomatosis or malignant ascitis and in those at risk of future peritoneal spread, such as patients with pT3-pT4 cancers or with positive cytology of the peritoneal fluid. Hyperthermic chemotherapy should be considered a promising approach in limited or impending peritoneal carcinomatosis, and should be included in the multidisciplinary approach to the treatment of locally advanced gastric cancer.

scholarly journals Pseudomyxoma peritonei: A Review

2013 ◽  
Vol 7 (2) ◽  
pp. 88-92 ◽  
Author(s):  
S M Kamal ◽  
Md Abu Bakar ◽  
Md Yusuf Ali ◽  
Md Abdul Ahad
Keyword(s):  
Peritoneal Cavity ◽  
Pseudomyxoma Peritonei ◽  
Goblet Cells ◽  
Low Grade ◽  
Ovarian Malignancy ◽  
Rare Clinical Entity ◽  
Debulking Surgery ◽  
Intraperitoneal Hyperthermic Chemotherapy ◽  
Hyperthermic Chemotherapy ◽  
Abdominal Masses

Pseudomyxoma peritonei (PMP) is rare clinical entity characterized by abundant extracellular mucinous material in the peritoneal cavity and tumoural implants on the peritoneal surfaces. The origin of PMP is controversial. It often arises from the goblet cells of large bowel or appendix. There is increase in MUC-2 secreting cells and accumulation of excessive mucin secreted by these cells in the peritoneal cavity. A ruptured appendiceal mucinous adenoma is the most common origin. Low grade ovarian malignancy is often associated. Patient may present with growing abdominal masses associated with abdominal pain, nausea, vomiting, fatigue and weight loss. Ultrasonogram and CT scan of the abdomen have role in diagnosis but diagnosis is often difficult before laparotomy or laparoscopy. Debulking surgery with intraperitoneal hyperthermic chemotherapy is the treatment. DOI: http://dx.doi.org/10.3329/fmcj.v7i2.13523 Faridpur Med. Coll. J. 2012;7(2):88-92

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