Comparing the Effect of Dexmedetomidine and Etomidate Administration with Acute Height Stress on Spatial Memory in Male Mice

Abstract Background: Nowadays, anesthetic drugs are widely used in anesthesia and surgical procedures and their effects on memory have been the focus of attention for a very long time. The effects of these common drugs include Dexmedetomidine (DEX) and Etomidate (ETO), on memory are controversial. In this study, the effects of these two drugs, co-administrated with heights stress, were evaluated on short-term and long-term spatial memory. 48 male mice were divided into 6 experimental groups consisting of Control, Control+heightstress (H.S), ETO, ETO+H.S, DEX+H.S. Drugs were administered Intra-peritoneal with doses of 0.3-0.4 mg/kg and 11 mg/kg for DEX and ETO respectively, and spatial memory was assessed using the Barnes Model.Results: DEX improved acquisition and retention of spatial reference memory, whereas ETO showed no such effects. In addition, DEX and ETO showed excitatory effects on short-term spatial memory, however DEX was more effective than ETO.Conclusion: the results suggested the neuoprotective, synaptic plasticity and memory improving effects of DEX on spatial reference and working memory. However, the precise neuronal and molecular mechanisms of these effects and their relation to the anti-stress system is still unknown and requires further research.

Download Full-text

Short-term sleep deprivation disrupts the molecular composition of ionotropic glutamate receptors in entorhinal cortex and impairs the rat spatial reference memory

Behavioural Brain Research ◽

10.1016/j.bbr.2015.10.002 ◽

2016 ◽

Vol 300 ◽

pp. 70-76 ◽

Cited By ~ 10

Author(s):

Meilan Xie ◽

Chao Li ◽

Chao He ◽

Li Yang ◽

Gang Tan ◽

...

Keyword(s):

Sleep Deprivation ◽

Glutamate Receptors ◽

Entorhinal Cortex ◽

Reference Memory ◽

Molecular Composition ◽

Ionotropic Glutamate Receptors ◽

Short Term ◽

Spatial Reference ◽

Spatial Reference Memory

Download Full-text

Estrogen enhances the retention of spatial reference memory in the open field tower task, but disrupts the expression of spatial memory following a novel start position

Neurobiology of Learning and Memory ◽

10.1016/j.nlm.2012.11.002 ◽

2013 ◽

Vol 99 ◽

pp. 50-58 ◽

Cited By ~ 8

Author(s):

Olga Lipatova ◽

Donna J. Toufexis

Keyword(s):

Spatial Memory ◽

Open Field ◽

Reference Memory ◽

Start Position ◽

Spatial Reference ◽

Spatial Reference Memory

Download Full-text

Age-dependent effects of environmental enrichment on spatial reference memory in male mice

Behavioural Brain Research ◽

10.1016/j.bbr.2007.07.009 ◽

2007 ◽

Vol 185 (1) ◽

pp. 43-48 ◽

Cited By ~ 64

Author(s):

Lauren L. Harburger ◽

Talley J. Lambert ◽

Karyn M. Frick

Keyword(s):

Environmental Enrichment ◽

Reference Memory ◽

Male Mice ◽

Spatial Reference ◽

Spatial Reference Memory ◽

Age Dependent

Download Full-text

Selective H3 Antagonist (ABT-239) Differentially Modifies Cognitive Function Under the Impact of Restraint Stress

Frontiers in Systems Neuroscience ◽

10.3389/fnsys.2020.614810 ◽

2021 ◽

Vol 14 ◽

Author(s):

Emil Trofimiuk ◽

Przemysław Wielgat ◽

Halina Car

Keyword(s):

Spatial Memory ◽

Restraint Stress ◽

Reference Memory ◽

Control Group ◽

Memory Impairments ◽

Spatial Reference ◽

Spatial Reference Memory ◽

Pre Treatment ◽

New Compounds ◽

The Impact

Background: A considerable number of competitive antagonists/inverse agonists of histamine H3 receptor (H3R) have progressed to clinical assessment, with pitolisant approved for the treatment of narcolepsy. H3R, highly expressed in the CNS, is regarded as a relevant target in CNS disorders. At the same time, new compounds including ABT-239 H3R antagonist (ABT; benzonitrile, 4-[2-[2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl]-5-benzofuranyl]-) are continually being tested. The study aimed to test ABT-239 as a prophylactic agent in stress-induced memory impairments.Methods: Stressed and non-stressed rats were pre-treated with ABT-239 and subsequently subjected to several behavioral tests aimed at assessing the animals’ working and spatial reference memory [Morris water maze (MWM), Barnes maze (BM)], assessing the locomotor function and anxiety-like behavior [Open field (OF), elevated “plus” maze—EPM].Results: Chronically stressed rats displayed a significant decline in spatial (working and reference) memory. In the MWM test, we observed an improvement in spatial reference memory in stressed animals and a positive after ABT-239 pre-treatment. In the BM test, the effect of ABT-239 administration on spatial memory changed in successive attempts, from negative initially to favorable in subsequent attempts, and negative in the last trial of the test in the control group of rats. However, a beneficial effect is noted in the group of stressed animals, which remained throughout the entire testing period.Conclusions: Presented findings demonstrate that ABT-239 shows the potential to abolish or prevent restraint stress-induced spatial memory impairments and cognitive deficits. However, in conditions of appetitive modulation, it could increase damage to memory (unstressed animals).

Download Full-text

Stingless Bee Honey Improves Spatial Memory in Mice, Probably Associated with Brain-Derived Neurotrophic Factor (BDNF) and Inositol 1,4,5-Triphosphate Receptor Type 1 (Itpr1) Genes

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2019/8258307 ◽

2019 ◽

Vol 2019 ◽

pp. 1-11 ◽

Cited By ~ 2

Author(s):

Mohd Zulkifli Mustafa ◽

Fairuz Nabila Zulkifli ◽

Ivanna Fernandez ◽

Abdul Razak Mariatulqabtiah ◽

Muthuraju Sangu ◽

...

Keyword(s):

Gene Expression ◽

Working Memory ◽

Spatial Memory ◽

Spatial Working Memory ◽

Reference Memory ◽

Stingless Bee ◽

Synaptic Function ◽

Control Group ◽

Spatial Reference ◽

Spatial Reference Memory

This study was conducted to evaluate the effects of stingless bee honey (SBH) supplementation on memory and learning in mice. Despite many studies that show the benefits of honey on memory, reports on the nootropic effects of SBH are still lacking, and their underlying mechanism is still unclear. SBH is a honey produced by the bees in the tribe of Meliponini that exist in tropical countries. It features unique storage of honey collected in cerumen pots made of propolis. This SBH may offer a better prospect for therapeutic performance as the previous report identifies the presence of antioxidants that were greater than other honey produced by Apis sp. In this study, SBH was tested on Swiss albino mice following acute (7 days) and semichronic (35 days) supplementation. Experiments were then conducted using Morris water maze (MWM) behaviour analysis, RT-PCR for gene expression of mice striatum, and NMR for metabolomics analysis of the honey. Results indicate spatial working memory and spatial reference memory of mice were significantly improved in the honey-treated group compared with the control group. Improved memory consolidations were also observed in prolonged supplementation. Gene expression analyses of acutely treated mice demonstrated significant upregulation of BDNF and Itpr1 genes that involve in synaptic function. NMR analysis also identified phenylalanine, an essential precursor for tyrosine that plays a role at the BDNF receptor. In conclusion, SBH supplementation for seven days at 2000 mg/kg, which is equivalent to a human dose of 162 mg/kg, showed strong capabilities to improve spatial working memory. And prolonged intake up to 35 days increased spatial reference memory in the mice model. The phenylalanine in SBH may have triggered the upregulation of BDNF genes in honey-treated mice and improved their spatial memory performance.

Download Full-text