scholarly journals Comparison of corneal optical quality after SMILE, wavefront-optimized LASIK and topography-guided LASIK for myopia and myopic astigmatism

Author(s):  
Yu Zhang ◽  
Xiaoxiao Sun ◽  
Yueguo Chen

Abstract Purpose: To compare visual outcomes and corneal optical quality after small incision lenticule extraction (SMILE) , wavefront-optimized (WFO) FS-LASIK and topography-guided customized ablation treat­ment (TCAT) FS-LASIK for myopia. Methods: This prospective study included 283 eyes of 283 myopic patients who underwent SMILE or FS-LASIK according to the patient's wishes. FS-LASIK patients were randomly assigned to use WFO or TCAT ablation. There were 102 eyes, 100 eyes and 81eyes in the SMILE group, WFO group and TCAT group, respectively. The combined corneal topographer and tomographer system (Sirius) was used to measure corneal aberrations and optical quality. Visual outcomes and corneal aberrations were compared among the three groups.Results: At postoperative 1 and 6 months, there were no significant differences in uncorrected distance visual acuity (UDVA) and corrected distance visual acuity (CDVA) among the three groups (P > .05). Postoperative manifest refractive spherical equivalent was similar among the groups (P > .05). There was statisti­cally significant difference in cylinder at 1 month among the three groups, with the highest mean value in TCAT group (P < .05). The corneal optical path difference (OPD), root mean square of corneal astigmatism and strehl ratio (SR) were the most superior in the TCAT group at postoperative 1 and 6 months (P < .05).Conclusion: SMILE, WFO FS-LASIK and TCAT FS-LASIK provided similar visual results. TCAT FS-LASIK could induce fewer corneal OPD and astigmatism, and higher SR than the others. However, a better algorithm for TCAT FS-LASIK is needed to decrease postoperative residual astigmatism.

2020 ◽  
Author(s):  
JUNJIE PIAO ◽  
Woong-Joo Whang ◽  
Choun-Ki Joo

Abstract Background This study clinically evaluated the visual outcomes after refractive surgery for myopia using femtosecond laser-assisted in situ keratomileusis (femto-LASIK) and epi-LASIK (flap-off). Methods In this prospective cohort study, 40 eyes of 27 patients were divided into two groups depending on the technique used for refractive surgery. Femto-LASIK flaps and epi-LASIK flaps (flap-off) were created using femtosecond laser and Epi-K TM epikeratome, respectively. Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), manifest refraction (MR), corneal asphericity (Q-value), and corneal higher-order aberrations (HOAs) were assessed pre- and postoperatively. Results The improvement in LogMAR UDVA after refractive surgery was statistically significant for both groups ( P < 0.001 for all groups); it was significantly improved in the femto-LASIK group, 1 day and 1 week postoperatively ( P < 0.001, P = 0.019, respectively). With regard to the front and total corneal HOAs, there were significant differences in spherical aberrations (Z 4,0 ) between the femto-LASIK and flap-off epi-LASIK groups ( P = 0.016 and P = 0.017, respectively). With regard to the back corneal HOAs, there were significant differences in vertical coma (Z 3,-1 ) aberration, 0.027 ± 0.027 μm (femto-LASIK) and 0.001 ± 0.034 μm (flap-off epipolis LASIK); horizontal secondary astigmatism (Z 4,2 ) aberration, -0.008 ± 0.012 μm (femto-LASIK) and 0.007 ± 0.018 μm (flap-off epipolis LASIK); oblique tetrafoil (Z 4,-4 ) aberration, -0.008 ± 0.029 μm (femto-LASIK) and 0.015 ± 0.026 μm (flap-off epi-LASIK), respectively ( P = 0.018, P = 0.007, and P = 0.022, respectively). However, the back corneal HOA changes did not have a significant effect on the total corneal HOA changes. Conclusion Femto-LASIK yielded better early visual outcomes than did flap-off epi-LASIK, but there was no significant difference between the outcomes of the two procedures, 1 week postoperatively.


2019 ◽  
Author(s):  
Junjie Piao ◽  
Woong-Joo Whang ◽  
Choun-Ki Joo

Abstract Background This prospective cohort study clinically evaluated the visual outcomes after refractive surgery for myopia using femtosecond laser-assisted in situ keratomileusis (femto-LASIK) and epipolis LASIK (flap-off epi-LASIK).Methods Forty eyes of 27 patients were divided into 2 groups in this prospective cohort study. Femto-LASIK flaps were created using a femtosecond laser; epi-LASIK flaps (flap-off) were made using and Epi-K TM epikeratome. Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), manifest refraction (MR), corneal asphericity (Q-value), and corneal higher-order aberrations (HOAs) were assessed pre- and postoperatively.Results The improvement in LogMAR UDVA after refractive surgery was statistically significant for both groups ( P < 0.001 for all groups); it was significantly improved for femto-LASIK at 1 day and 1 week postoperatively ( P < 0.001, P = 0.019, respectively). In analysis of the front and total corneal HOAs, there were significant differences in spherical aberrations (Z 4,0 ) between the femto-LASIK and flap-off epi-LASIK groups ( P = 0.016 and P = 0.017, respectively). In analysis of the back corneal HOAs, there were significant differences in vertical coma (Z 3,-1 ) aberration 0.027 ± 0.027 (femto-LASIK) and 0.001 ± 0.034 (flap-off epi-LASIK); horizontal secondary astigmatism (Z 4,2 ) aberration -0.008 ± 0.012 (femto-LASIK) and 0.007 ± 0.018 (flap-off epi-LASIK); oblique tetrafoil (Z 4,-4 ) aberration -0.008 ± 0.029 (femto-LASIK) and 0.015 ± 0.026 (flap-off epi-LASIK), respectively ( P = 0.018, P = 0.007, and P = 0.022, respectively). However, the back corneal HOA changes did not have a significant effect on the total corneal HOA changes.Conclusion Femto-LASIK yielded better early visual outcomes than that by flap-off epi-LASIK, but there was no significant difference between the outcomes of the 2 procedures 1 week postoperatively.


2020 ◽  
Author(s):  
JUNJIE PIAO ◽  
Woong-Joo Whang ◽  
Choun-Ki Joo

Abstract Background This prospective cohort study clinically evaluated the visual outcomes after refractive surgery for myopia using femtosecond laser-assisted in situ keratomileusis (femto-LASIK) and epipolis LASIK (flap-off). Methods Forty eyes of 27 patients were divided into 2 groups in this prospective cohort study. Femto-LASIK flaps were created using a femtosecond laser; epipolis LASIK flaps (flap-off) were made using and Epi-K TM epikeratome. Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), manifest refraction (MR), corneal asphericity (Q-value), and corneal higher-order aberrations (HOAs) were assessed pre- and postoperatively. Results The improvement in LogMAR UDVA after refractive surgery was statistically significant for both groups ( P < 0.001 for all groups); it was significantly improved for femto-LASIK at 1 day and 1 week postoperatively ( P < 0.001, P = 0.019, respectively). In analysis of the front and total corneal HOAs, there were significant differences in spherical aberrations (Z 4,0 ) between the femto-LASIK and flap-off epipolis LASIK groups ( P = 0.016 and P = 0.017, respectively). In analysis of the back corneal HOAs, there were significant differences in vertical coma (Z 3,-1 ) aberration 0.027 ± 0.027 μm (femto-LASIK) and 0.001 ± 0.034 μm (flap-off epipolis LASIK); horizontal secondary astigmatism (Z 4,2 ) aberration -0.008 ± 0.012 μm (femto-LASIK) and 0.007 ± 0.018 μm (flap-off epipolis LASIK); oblique tetrafoil (Z 4,-4 ) aberration -0.008 ± 0.029 μm (femto-LASIK) and 0.015 ± 0.026 μm (flap-off epipolis LASIK), respectively ( P = 0.018, P = 0.007, and P = 0.022, respectively). However, the back corneal HOA changes did not have a significant effect on the total corneal HOA changes. Conclusion Femto-LASIK yielded better early visual outcomes than that by flap-off epipolis LASIK, but there was no significant difference between the outcomes of the 2 procedures 1 week postoperatively.


Author(s):  
Isaak R. Fischinger ◽  
Jascha Wendelstein ◽  
Kristin Tetz ◽  
Matthias Bolz ◽  
Manfred R. Tetz

Abstract Purpose To evaluate the influence of the type of the keratectasia and preoperative keratometry readings on the efficacy of implantation of iris-fixated phakic anterior chamber intraocular lenses (pIOL) in patients with keratoconus. Methods In this retrospective study, iris-fixated pIOLs (Artisan/Artiflex (Ophtec®), Verisyse/Veriflex (AMO®)) were implanted in 38 eyes of 22 patients with stable keratoconus. Thirty-six eyes underwent corneal crosslinking (CXL) prior to the lens implantation. The refractive outcome was evaluated 6 weeks postoperatively and the influence of preoperative refraction and topo- and tomographical factors were analyzed. Results The mean postoperative uncorrected distance visual acuity (UDVApost) was 0.25 ± 0.15 logMAR and was not statistically different from the mean preoperative corrected distance visual acuity (CDVApre), which was 0.24 ± 0.13 logMAR. Twenty-seven eyes (71%) reached UDVApost/CDVApre ≥ 1 (efficacy index), whereas patients with PMD-like ectasia (n = 14) showed significantly (p = 0.003) higher efficacy index (100%) than patients diagnosed with keratoconus (n = 24) (54%). Higher eccentricity of the maximum posterior elevation showed a significant beneficial influence on the efficacy index (p = 0.021). Furthermore, a higher Amsler-Krumeich stage and preoperative MAE were correlated with a worse UDVApost. The mean absolute spherical equivalent was significantly decreased from 5.71 ± 4.96 D to 1.25 ± 1.20 D (p < 0.001). No significant difference was found in endothelial cell count. Conclusion The results indicate that the implantation of phakic iris-fixated anterior chamber IOLs is a reasonable refractive option for patients with keratoconus. Keratoconus patients with a pellucidal marginal degeneration (PMD)-like appearance ectasia seem to benefit most from such procedures.


Photonics ◽  
2021 ◽  
Vol 8 (7) ◽  
pp. 262
Author(s):  
Diego de Ortueta ◽  
Dennis von Rüden ◽  
Samuel Arba-Mosquera

Is it possible to obtain good results in myopia of 2 or fewer diopters (D) with transepithelial photorefractive keratectomy (TransPRK) changing the optical zone and epithelium thickness? We retrospectively analyzed two groups of 296 eyes with a minimum follow-up of 4 months. Group A had 2 or less D, treated with an optical zone (OZ) 0.2 mm bigger than recommended, and a central epithelium thickness of 60 microns, and group B had 2 D to 5 D, with the recommended optical zone, and a 55-micron epithelium ablation at the center. The outcomes were not different between the two myopic ranges; the postop uncorrected distance visual acuity was 20/20 ± 4 in both groups (p = 0.2), which was −0.3 ± 0.8 lines worse than the preoperative corrected distance visual acuity in both groups (p = 0.5). The safety of the treatments resulted in a change of 0.0 ± 0.7 lines in the low myopia group, versus a gain of +0.1 ± 0.8 lines in the moderate myopia group (p = 0.1). The deviation from the intended target was −0.04 ± 0.33 D in the low myopia group and +0.07 ± 0.32 D in the moderate myopia group (p < 0.0001); the postoperative spherical equivalent was 0.00 ± 0.33 D in the low myopia group and +0.10 ± 0.31 D in the moderate myopia group (p < 0.0001). The postop refractive astigmatism was 0.32 ± 0.16 D in both groups (p = 0.5). In conclusion, the refractive and visual outcomes after TransPRK are comparable in low myopia changing the optical zone and epithelium thickness versus moderate myopia with standard optical zone and epithelium thickness.


2021 ◽  
Vol 10 (17) ◽  
pp. 3776
Author(s):  
Majid Moshirfar ◽  
Rachel Huynh ◽  
Nour Bundogji ◽  
Alyson N. Tukan ◽  
Thomas M. Sant ◽  
...  

Previous studies have demonstrated safety and efficacy using 6.0 and 6.5 mm optical zones in the WaveLight EX500 Excimer Laser System but have not evaluated if differing optical zone sizes influence refractive outcomes. This study examines visual outcomes between two study populations undergoing LASIK with either a 6.0 mm (1332 patients) or 6.5 mm (1332 patients) optical zone. Outcomes were further stratified by severity of myopia (low, moderate, and high) and astigmatism (low and high). Patients were matched by age and preoperative manifest sphere and cylinder. Postoperative measurements were then compared. The 6.5 mm group demonstrated better postoperative manifest refractive spherical equivalent (MRSE), manifest sphere, and absolute value of the difference in actual and target spherical equivalent refraction (|∆ SEQ|), within the total population, moderate myopia, and low astigmatism groups, but this did not lead to improved postoperative uncorrected distance visual acuity (UDVA) or best corrected distance visual acuity (CDVA). Though astigmatic correction and postoperative angle of error were similar between optical zone sizes, they were significantly worse with high myopia. Overall, this study demonstrates differences in visual outcomes between the 6.0 and 6.5 mm optical zone sizes that may warrant consideration; however, essentially, the results are comparable between them.


2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Xiao Wang ◽  
Haixia Tu ◽  
Yong Wang

Purpose. To compare the short-term visual outcomes and intraocular optical performance of a rotationally asymmetric multifocal intraocular lens (MIOL) (SBL-3, Lenstec, Inc., Christ Church, Barbados) and an apodized diffractive MIOL (the Acrysof IQ ResTOR SN6AD1, Alcon Laboratories, Inc., Fort Worth, Texas, United States). Methods. A prospective, comparative, nonrandomized, and single-center study. Sixty-eight age-related cataract patients (81 eyes) after phacoemulsification cataract surgery and in-the-bag MIOL implantation were enrolled. Thirty-eight eyes received SBL-3, and 43 eyes received SN6AD1. Ophthalmological evaluation included uncorrected distance visual acuity (UDVA), uncorrected intermediate visual acuity (UIVA), uncorrected near visual acuity (UNVA), corrected distance visual acuity (CDVA), modulation transfer function (MTF), Strehl ratio (SR), intraocular aberrations (4 mm optical zone), and defocus curve at 3 months postoperatively. The Chinese version of the visual function index-14 (VF-12-CN) and spectacle independence were assessed in all patients. Results. There was no statistically significant difference between groups in postoperative UDVA (p=0.186). Postoperative UIVA and UNVA were significantly better for the SBL-3 group than for the SN6AD1 group (p<0.01). Statistically significant differences were revealed in defocus levels from –3.50 D to −4.00 D with better visual acuities for the SBL-3 group (p<0.01). For intraocular optical quality outcomes, statistically significant differences between groups were observed in RMS of intraocular total aberrations, coma, and trefoil high-order aberrations, presenting significantly higher values of these parameters in the eyes of the SBL-3 group (p < 0.01). Statistically significant differences were revealed in the MTF values at spatial frequencies of 5 and 10 cycles/degree between groups. There were no significant differences in scores of VF-12-CN, and spectacle independence between the groups (p>0.05). Conclusions. Both MIOLs were able to successfully restore visual function after cataract surgery. SBL-3 provided better UIVA and UNVA with a wider range of intermediate vision.


2019 ◽  
Author(s):  
Amin Faisal Ellakwa ◽  
Marwa Ali Zaki ◽  
Rana Mohammed Ashour

Abstract Objectives:to compare the efficacy, safety and predictability of corneal wavefront guided (WFG) and aberration free ablation in single-step transepithelial photorefractive keratectomy (TransPRK) in myopic patients with high pre-existing corneal higher order aberrations (HOAs). Background: Corneal WFG and aberration free treatments have been proposed as methods to achieve better visual, refractive, and optical outcomes. Methods:Non-randomized controlled trialwas conducted in El-HekmaEye-LASIK center, Menoufia governorate, Egypt during the period from January 2017 to December 2017. TransPRK was performed to eligible myopic patients with or without astigmatism with corneal HOAs ≥ 0.35 µmat 6 mm diameter utilizing either optimized (aberration free) or corneal WFG patterns (SCHWIND eye-tech-solutions, Kleinostheim, Germany). Uncorrected distance visual acuity (UDVA), manifest and cycloplegic refractions, best spectacle corrected distance visual acuity (CDVA), thorough slit lamp examination and corneal topography were assessed and repeated six months postoperatively. Results: Six months postoperatively, 97.6% and 100% of patients achieved MRSE within ± 1D with 76.2% and 66.67% of patients achieved UDVA of ≥20/20 in aberration free and corneal WFG groups respectively. Both groups showed increase in spherical and total corneal HOAs, with no significant difference in corneal WFG (p=0.08, p=0.28 respectively) while significantly higher postoperatively in aberration free group (p<0.001, p=0.001 respectively). Coma and trefoil aberrations declined after corneal WFG technique, yet increased after aberration free one. Conclusions: both aberration free and corneal WFG TransPRK were safe, effective and predictable in treatment of myopia in patients with high pre-existing corneal HOAs at 6 mm diameter with better aberrometric outcomes in corneal WFG group.


2019 ◽  
Author(s):  
JUNJIE PIAO ◽  
Young-Sik Yoo ◽  
Woong-Joo Whang ◽  
Choun-Ki Joo

Abstract Purpose This study was to clinically evaluate the visual outcomes after refractive surgery for myopia using femtosecond laser-assisted in situ keratomileusis (femto-LASIK) and epipolis LASIK (flap-off epi-LASIK). Methods Forty eyes of 27 patients were divided into 2 groups in a retrospective study. Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), manifest refraction (MR),corneal asphericity (Q-value) and corneal higher-order aberrations (HOAs) were assessed pre- and postoperatively. Results The pre- and postoperative changes in flattest keratometry reading(K1), steepest keratometry reading(K2), central corneal thickness(CCT), and only Q-value of the anterior surface was statistically significant for both groups (femto-LASIK: P=0.014, P=0.03, P<0.001, P=0.001, respectively; epi-LASIK: all P<0.001). The postoperative corneal thickness spatial profile (CTSP) were statistically significant thinner than preoperative CTSP in both procedures (all P<0.05), and the epi-LASIK was significant thinner than femto-LASIK at 6 mm ring of CTSP (P=0.039). The improvement in LogMAR UDVA after refractive surgery was statistically significant for both groups (P<0.001 for all groups); it was significantly improved for femto-LASIK on day 1 and at 1 week postoperatively (P<0.001, P=0.019, respectively). In analysis of corneal HOAs, there were significant reduction of vertical coma aberration and horizontal secondary astigmatism aberration, and induction of spherical aberration in the front corneal HOAs after femto-LASIK (P=0.021, P=0.001, P=0.001, respectively); in the total corneal HOAs changes were the same pattern as the front corneal HOAs (P=0.007, P=0.004, P<0.001, respectively), but in the back corneal HOAs changes, a few significant induction of vertical coma aberration, and reduction of oblique trefoil aberration and oblique tetrafoil aberration (all P<0.05). In flap-off epi-LASIK, there were only significant induction of SA in the front and total corneal HOAs after surgery (all P<0.05); in the back corneal HOAs, a few significant induced horizontal secondary astigmatism aberration and reduced SA aberration (P=0.027, P=0.011, respectively), however, the back corneal HOAs changes were not significant effect on the total corneal HOAs changes. Conclusion Femto-LASIK showed better early visual outcomes than that noted by epi-LASIK, but there was no significant difference between the outcomes of the 2 procedures 1 week postoperatively.


2019 ◽  
Author(s):  
Lingying Ye ◽  
Tianyu Chen ◽  
Zhixiang Hu ◽  
Qiudong Su ◽  
Jin Li

Abstract AIM To compare the visual performance of asymmetric refractive multifocal intraocular lenses (MIOLs) with all optic zone diffractive MIOLs.METHODS A prospective study. Patients underwent phacoemulsification were divided into two groups according to the type of MIOLs: 25 patients were implanted with asymmetric refractive MIOLs and 25 patients with all optic zone diffractive MIOLs. Visual acuity, refraction, defocus curves, objective optical quality and the questionnaire of life quality were measured 3 months after surgery.RESULTS There was no significant difference between two groups in uncorrected distance visual acuity、uncorrected near visual acuity、best corrected distance visual acuity or distance corrected near visual acuity. However, the uncorrected intermediate visual acuity was 0.24±0.10 in refractive group and 0.31±0.13 in diffractive group (P<0.05); the distance corrected intermediate visual acuity was 0.22±0.09 in refractive group and 0.31±0.14 in diffractive group (P<0.05). Defocus curves showed two crests in both groups. However, the curve between two crests of refractive group was smoother than diffractive group. The Modulated transfer function cut-off frequency was (22.74±12.29)c/d in refractive group and(30.50±10.04)c/d in diffractive group (P<0.05); the OQAS values 100% (OV100%) were 0.75±0.41 in refractive group and 1.02±0.34 in diffractive group(P<0.05),OV20% were 0.52±0.34 in refractive group and 0.71±0.25 in diffractive group (P<0.05).There was no significant difference between two groups at overall satisfaction, independence spectacles ratio or visual interference phenomenon.CONCLUSIONS Both MIOLs achieve good visual acuity at distance and near. The asymmetric refractive MIOLs show better intermediate visual acuity, and the all optic zone diffractive MIOLs appear to have better objective visual quality.


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