scholarly journals Autoimmune encephalitis with antibodies against Leucinie-rich Glioma Inactivated 1 and γ-aminobutyric acid-beta-receptor: case report and literature review

2020 ◽  
Author(s):  
Yi Xie ◽  
Jia Wen ◽  
Zhihua Zhao ◽  
Hongbo Liu ◽  
Nanchang Xie
Keyword(s):  
Case Report ◽  
Clinical Practice ◽  
Literature Review ◽  
Autoimmune Encephalitis ◽  
Steroid Treatment ◽  
Aminobutyric Acid ◽  
Slow Response ◽  
Beta Receptor ◽  
Serum Test ◽  
Moderate Diffusion

Abstract A 60-year-old man presented with slow response and psychosis. Apart from hyponatremia, serum test also showed positive anti-Leucinie-rich Glioma Inactivated 1 (anti-LGI1) and anti-γ-aminobutyric acid-beta-receptor (anti-GABABR), and electroencephalogram exhibited moderate diffusion abnormality. The patient responded well to steroid treatment. Here we report the first autoimmune encephalitis(AE) characterized by positive anti-LGI1 and anti-GABABR, as well as summarizing AE with multiple auto-antibodies reported so far, hopefully to provide experience for clinical practice.

scholarly journals Autoimmune encephalitis with coexistent LGI1 and GABABR1 antibodies: case report

BMC Neurology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yi Xie ◽  
Jia Wen ◽  
Zhihua Zhao ◽  
Hongbo Liu ◽  
Nanchang Xie
Keyword(s):  
Clinical Manifestations ◽  
Autoimmune Encephalitis ◽  
Behavioral Changes ◽  
Aminobutyric Acid ◽  
Slow Response ◽  
Case Presentation ◽  
Positive Serum ◽  
Supplement Therapy ◽  
Moderate Diffusion

Abstract Background Autoimmune encephalitis (AE) with multiple auto-antibodies is of great clinical significance because its complex clinical manifestations and atypical imaging increase the difficulty of diagnosis, differential diagnosis and treatment, which may aggravate the disease, increase the recurrence rate and mortality. The coexistence of anti-Leucinie-rich Glioma Inactivated 1 (LGI1) and anti-γ-aminobutyric acid-beta-receptor 1 (GABABR1) has not been published before. Case presentation We herein present the case of a 60-year-old man with slow response, behavioral changes, psychosis and sleep disorders. Laboratory test included serum hyponatremia, positive serum LGI1 and GABABR1 antibodies using transfected cell-based assays. Electroencephalogram exhibited moderate diffusion abnormality. The patient responded well to steroid impulse treatment and sodium supplement therapy, and did not recur during the follow-up. Conclusions Here we report the first AE characterized by positive LGI1 and GABABR1 antibodies, as well as summarizing AE with multiple auto-antibodies reported so far, hopefully to provide experience for clinical practice.

scholarly journals Case Report: Presentation of an unusual cause of carpal tunnel syndrome with accompanying literature review

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 319
Author(s):  
Paul Patiniott ◽  
Matheesha Herath ◽  
Peter Riddell
Keyword(s):  
Case Report ◽  
Clinical Practice ◽  
Carpal Tunnel Syndrome ◽  
Literature Review ◽  
Carpal Tunnel ◽  
Arteriovenous Malformations ◽  
High Flow ◽  
Complex Issue ◽  
Tunnel Syndrome ◽  
Report Presentation

Background: Carpal tunnel syndrome (CTS) is a condition seen commonly in clinical practice; high-flow arteriovenous malformations (AVM) can be a rare but important cause. Case Report: We discuss a case of a patient who had developed left CTS in the fifth decade of life as the result of a progressively enlarging congenital peripheral AVM affecting his left upper limb. This case illustrates the clinical challenges encountered in the surgical and interventional management of this complex issue. Discussion:High-flow AVMs affecting the extremities may be comprised of a convoluted network of vessels in high-flow, low-resistance systems that often recur despite intervention. Conclusion: Peripheral AVM affecting the hand can be a rare and therapeutically challenging cause of carpal tunnel syndrome that warrants multidisciplinary team discussion.

scholarly journals Chikungunya associated vulvitis: case report and literature review

2021 ◽  
Author(s):  
Isabel Cristina Chulvis do Val Guimarães ◽  
Svitrigaile Grinceviciene ◽  
Susana Cristina Aidé Viviani Fialho ◽  
Renata do Val Guimarães ◽  
Guilherme Amaral Calvet
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Chikungunya Virus ◽  
Steroid Treatment ◽  
Oral Steroid ◽  
Caucasian Woman ◽  
Transmitted Infection ◽  
Labia Minora ◽  
Gynecological Examination ◽  
Unusual Symptoms

Introduction: Chikungunya virus is spreading worldwide due to migration and globalization and could be presented with systemic and with unusual symptoms. Objective: To report a case of virus-transmitted infection detected in a woman during the gynecological examination at a vulvar clinic. Case report: A 73-year-old Caucasian woman attended a vulvar clinic because of dyspareunia and vulvar burning. Ulcers were observed on labia minora and perineum. A Chikungunya was diagnosed by seroconversion in paired specimens. She was prescribed prednisolone 40 mg once a day for 10 days. After oral steroid treatment, the woman had no body rashes or lesions on her genitals. Conclusion: This study emphasized that rare signs of unusual vulvitis with ulcers could be associated with Chikungunya infection.

scholarly journals Delayed onset of liver injury after intentional chloroform overdose: a case report and literature review

2019 ◽  
Vol 18 (3) ◽  
pp. 192-196
Author(s):  
Maria Panetta ◽  
◽  
Alex Brightmore ◽  
W Stephen Waring ◽  
◽  
...  
Keyword(s):  
Case Report ◽  
Clinical Practice ◽  
Liver Injury ◽  
Literature Review ◽  
Toxic Effect ◽  
Acute Liver Injury ◽  
Transaminase Activity ◽  
Liver Transaminase ◽  
Delayed Onset ◽  
Conscious Level

Chloroform is a recognised cause of acute liver injury, although now rarely encountered in clinical practice. We present a case of inhalational chloroform self-poisoning in a 47-year-old man that presented to hospital initially with reduced conscious level and later developed acute liver injury that was treated with intravenous acetylcysteine. This paper reviews the existing literature and presents a summary of the mechanisms of chloroform hepatotoxicity. Published cases show that there is a characteristic delay of 24 to 48 hours between chloroform exposure and elevation of liver transaminase activity. Therefore, clinicians need to provide an appropriate duration of monitoring in order to detect the occurrence of this important toxic effect.

scholarly journals Endoscopic removal of pedunculated leiomyoma of the sigmoid colon (case report and literature review of dignostic and treatment options)

2006 ◽  
Vol 53 (1) ◽  
pp. 87-89 ◽  
Author(s):  
I. Jovanovic ◽  
T. Cvejic ◽  
D. Popovic ◽  
M. Micev
Keyword(s):  
Case Report ◽  
Clinical Practice ◽  
Literature Review ◽  
Sigmoid Colon ◽  
Female Patient ◽  
Treatment Options ◽  
Endoscopic Removal

Colonic leiomyoma are remarkably rare cause of colonic symptoms in clinical practice. They constitute only 3% of gastrointestinal leiomyomas and complete endoscopic removal of the tumor can be a problem because of its submucosal origin. We describe a 62-year female patient with a 8 mm leiomyoma of sigmoid colon that was successfully removed by conventional endoscopic snare electrocauterisation, without complications.

Severe acute hypokalaemia associated with piperacillin/tazobactam in an HIV-infected patient under antiretroviral therapy with tenofovir alafenamide: case report and literature review

Sexual Health ◽  
2020 ◽  
Vol 17 (2) ◽  
pp. 194 ◽  
Author(s):  
Cheng-Chun Tai ◽  
Ruey-Yi Chou ◽  
Jiun-Yu Guo ◽  
Hsin-Pai Chen
Keyword(s):  
Adverse Effect ◽  
Case Report ◽  
Clinical Practice ◽  
Antiretroviral Therapy ◽  
Literature Review ◽  
Antimicrobial Agent ◽  
Infected Patient ◽  
Hospital Acquired Infection ◽  
Tenofovir Alafenamide ◽  
Hospital Acquired

Piperacillin/tazobactam is a commonly prescribed antimicrobial agent. Tenofovir alafenamide (TAF) is increasingly being used in antiretroviral therapy (ART) of HIV. Herein we report a case of a 57-year-old male with AIDS receiving TAF-containing ART in whom severe refractory hypokalaemia developed after coadministration of piperacillin/tazobactam for suspected hospital-acquired infection. Upon withdrawal of piperacillin/tazobactam, serum potassium concentrations returned to normal within 2 days. Hypokalaemia is a rare adverse effect of piperacillin/tazobactam and may be aggravated with the underlying use of TAF. We also reviewed past reported cases of hypokalaemia after piperacillin/tazobactam administration. We want to highlight that a more cautious approach should be considered when combining piperacillin/tazobactam and TAF in clinical practice.

GIANT OVARIAN FIBROMA WITH ASSOCIATED PSEUDO-MEIGS' SYNDROME: A CASE REPORT AND LITERATURE REVIEW

2021 ◽  
pp. 4-6
Author(s):  
Michael Tyodoo Maanongun ◽  
Andrea Avershima Ornguze ◽  
Babarinde Ojo
Keyword(s):  
Case Report ◽  
Clinical Practice ◽  
Pleural Effusion ◽  
Literature Review ◽  
Gold Standard ◽  
Rare Condition ◽  
Solid Tumours ◽  
Ovarian Fibroma

Meigs' syndrome is a rare condition characterized by the presence of a benign broma of the ovary, ascites and pleural effusion. When either of ascites or pleural effusion is associated with the broma it is termed pseudo-Meigs' syndrome. Though bromas are the most common benign solid tumours of the ovary, they rarely present in clinical practice and diagnosis is made difcult by symptoms that usually mimic disseminated malignancy. The gold standard of treatment is laparotomy, denitive diagnosis is by histology, and by denition of the syndrome, the symptoms resolve after removal of the tumour and the patients become asymptomatic. We present a patient with a giant ovarian broma with associated pseudo Meigs syndrome who was successfully managed without any complications.

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