scholarly journals Talaromycosis Marneffei pada Pasien HIV

2020 ◽  
Vol 9 (3) ◽  
pp. 373
Author(s):  
Aulia Ihsani ◽  
Raveinal Raveinal

Talaromycosis marneffei adalah infeksi jamur yang disebabkan Talaromyces marneffei. Talaromikosis adalah salah satu infeksi oportunistik yang sering mengenai orang dengan infeksi Human Immunodeficiency Virus (HIV) stadium akhir di Asia Tenggara, India timur laut, Cina Selatan, Hongkong, dan Taiwan. Gejala klinis talaromikosis tidak spesifik, seperti demam, anemia, penurunan berat badan, hepatomegali, splenomegali, gangguan pernapasan dan manifestasi kulit. Diagnosis ditegakkan berdasarkan kecurigaan klinis dengan konfirmasi pemeriksaan histopatologi. Dilaporkan pasien laki-laki berusia 29 tahun, dirawat di Bagian Penyakit Dalam RSUP Dr. M. Djamil Padang, dengan keluhan utama muncul bintil-bintil berwarna kehitaman hampir diseluruh wajah sejak 3 bulan yang lalu. Pasien sudah dikenal menderita HIV sejak 4 bulan yang lalu dan sudah mendapat terapi antiretroviral (ARV). Didapatkan plak hiperpigmentasi pada wajah dan hepatomegali. Laboratorium didapatkan kadar hemoglobin 8,9 gr/dl, CD4 8 sel/uL dan pemeriksaan histopatologi yang menunjukkan massa sporis eosinofilik di intraseluler dan diantara stroma jaringan ikat. Pemberian ARV dilanjutkan dan juga diberikan antijamur.Kata kunci: human immunodeficiency virus, talaromycosis, talaromyces marneffei

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Xue Chen ◽  
Lin Jia ◽  
Yongfeng Wu ◽  
Jing Chang ◽  
Tong Zhang ◽  
...  

Abstract Background An upper abdominal mass without tenderness often indicates a benign or malignant tumor once liver or spleen hyperplasia has been excluded. A lymphadenopathic mass from Talaromyces marneffei infection is rare. Case presentation We report the case of a 29-year-old human immunodeficiency virus (HIV) infected man who presented with an upper abdominal mass and without any symptoms related with infection. Histopathology and next-generation sequencing (NGS) following biopsy of the mass confirmed T. marneffei-infected lymphadenopathy, and the patient was successfully treated with amphotericin B and itraconazole. Conclusions This case report suggests that potential fungal infection should be considered during the diagnostic workup of a mass in clinical practice.


2021 ◽  
Author(s):  
Juan He ◽  
Jia-Sheng Li ◽  
Yi-Qun Kuang ◽  
Jun Li ◽  
Hong-Bin Li ◽  
...  

Abstract Talaromycosis (penicilliosis) caused by Talaromyces marneffei is one of the most important opportunistic infection diseases in tropical countries of South and Southeast Asia. Most infections occurred in individuals with human immunodeficiency virus (HIV) and the primarily reason for the increase in the number of the cases is HIV pandemic. The pathogenesis of T. marneffei infection is unclear. There is still no ideal animal model for studying Talaromycosis. In this study, we developed a stable, safe and maneuverable murine model that mimics human T. marneffei disseminated infection using T. marneffei yeast intraperitoneal injected to BALB/c nude mice. We successfully observed symptoms similar to those seen in clinical patients in this murine model, including skin lesions, hepatosplenomegaly, pulmonary infection and mesenteric lesions. We further studied the pathological changes of various tissues and organs in the infected animals to help better understand the severity of the infection. This model may provide a good tool for studying disseminated infection induced by T. marneffei.


1987 ◽  
Vol 1 (3) ◽  
pp. 381-395 ◽  
Author(s):  
Beverly Ryan ◽  
Edward Connor ◽  
Anthony Minnefor ◽  
Frank Desposito ◽  
James Oleske

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