Impact of ALDH2 Gene Polymorphism on Coronary Artery lesions in Ethnic Hakka Population with Acute Myocardial Infarction

Abstract Background: Aldehyde dehydrogenase 2 (ALDH2) contributes to converting acetaldehyde into acetate, thus plays a key role in the ethanol metabolism and oxidation of acetaldehyde. The aim of this study is to investigate the impact of Aldehyde dehydrogenase 2 (ALDH2) gene polymorphism on coronary artery lesions in ethnic Hakka patients with acute myocardial infarction (AMI). Methods: A total of 312 patients (male = 241, female = 71) with acute myocardial infarction (AMI) suffered ≥ 50% stenosis of at least one major coronary artery were recruited into the study. Lesions of AMI patients carried different ALDH2 genotypes were analyzed. Results: The incidence of multivessel lesions was higher in the ALDH2 mutation group (90.6%) than the ALDH2 wild group (80.3%) with reaching statistical significance (p = 0.009). Compare to the single lesion group, multivessel lesions group were more likely to be lower DBP (77.3 ± 14.1 versus 86.4 ± 13.8, p = 0.004), older (66.1 ± 12.2 versus 59 ± 12.1, p = 0.009), have hypertension (55.7% versus 30.8%, p = 0.023) in the ALDH2 wild patients. In the ALDH2 mutation patients, multivessel lesions group also tend to be elderly (65.9 ± 11.3 versus 58.5 ± 11.3, p = 0.011). In the addition, the multivessel lesions group presented higher levels of the TG and lower levels of the LDL-C than the single lesion group, but it is no statistical differences. The logistics regression showed that age and ALDH2 mutation were vulnerable to the multivessel lesions the ethnic Hakka population with AMI. Conclusions: The AMI patients in ethnic Hakka population carrying mutated ALDH2 allele was vulnerable to multiple coronary artery lesions. ALDH2 allele was associated with multiple coronary artery lesions in AMI patients among ethnic Hakka population. Key words: ALDH2 mutated allele, coronary artery lesions, acute myocardial infarction

Download Full-text

Influence of APOA5 (rs662799 and rs3135506) gene polymorphism in acute myocardial infarction patients and its association with basic coronary artery disease risk factors

Journal of Applied Pharmaceutical Science ◽

10.7324/japs.2015.50602 ◽

2015 ◽

pp. 008-014 ◽

Cited By ~ 1

Author(s):

Rohit Srivastava ◽

Pratibha Singh ◽

Pratima Verma ◽

Rishi Sethi ◽

Arti Verma ◽

...

Keyword(s):

Risk Factors ◽

Myocardial Infarction ◽

Coronary Artery Disease ◽

Acute Myocardial Infarction ◽

Coronary Artery ◽

Gene Polymorphism ◽

Disease Risk ◽

Coronary Artery Disease Risk ◽

Artery Disease

Download Full-text

Clinical Study on Characteristics and Risk Factors of Coronary Artery Lesions in Young Patients with Acute Myocardial Infarction

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2021/5716410 ◽

2021 ◽

Vol 2021 ◽

pp. 1-7

Author(s):

Hua Liu ◽

Jiangang Zhang ◽

Zengcai Ma ◽

Zesheng Xu

Keyword(s):

Risk Factors ◽

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Coronary Artery ◽

Elderly Patients ◽

Collateral Circulation ◽

Young Patients ◽

Coronary Artery Lesions ◽

Dominant Type ◽

Factors Affecting

Epidemiological evidence suggests that the incidence of acute myocardial infarction (AMI) among people under 40 years of age has an increasing trend in recent years. Smoking, hypertension, diabetes mellitus, family history, and gender (male) are considered as classic risk factors for CHD, but the pathogenesis of CHD in young people is not exactly the same. Moreover, the relationship between the pattern of coronary artery disease and risk factors in young patients with acute myocardial infarction is inconclusive. In this study, we retrospectively studied the clinical data of 150 AMI patients treated in our hospital from January 2020 to May 2021. The patients were divided into the young group and elderly group according to the difference in age. The number of coronary artery lesions, the degree of coronary artery stenosis, the distribution dominance typing, the position of the lesions, and the presence of collateral circulation were observed and compared between the two groups. Multivariate logistic regression analysis was used to investigate the risk factors affecting coronary artery lesions in young patients with AMI. The results showed that the number of coronary lesions in young patients with AMI was mainly single-vessel, and the dominant type of distribution was mainly right dominant type. The stenosis degree is lighter than that of elderly patients, and the incidence of collateral circulation is lower than that of elderly patients, but the position of the lesions has no obvious regular. Smoking, staying up late, HDL-C, and LDL-C/ApoB were independent factors affecting the number of coronary artery lesions, and the changes of HDL-C and LDL-C/ApoB had an important influence on the degree of coronary stenosis in young patients. This provides a new idea for clinical treatment.

Download Full-text

Study On The Application Value of Thromboelastic Graph in The Condition Assessment of Patients With Acute Myocardial Infarction

10.21203/rs.3.rs-153879/v1 ◽

2021 ◽

Author(s):

Kaiyang Wang ◽

Yunjie Teng ◽

Tingting Wu ◽

Yitong Ma ◽

Xiang Xie

Keyword(s):

Myocardial Infarction ◽

Coronary Artery Disease ◽

Acute Myocardial Infarction ◽

Coronary Artery ◽

Condition Assessment ◽

Clinical Treatment ◽

Gensini Score ◽

Coronary Artery Lesions ◽

The Difference ◽

Artery Disease

Abstract Background:To explore the application value of thromboelastic graph (TEG) in the assessment of patients with acute myocardial infarction (AMI).Results: 1.R time (min), K time (min) and LY30(%) in the STEMI group were lower than those in the NSTEMI group, and the differences were statistically significant (P<0.05). The Angle(°) and MA values in the STEMI group were higher than those in the NSTEMI group, and the difference between the two groups was statistically significant (P<0.05). 2.R time(min), K time(min) and LY30(%) gradually decreased with the increase of the number of coronary artery lesions, while Angle(°) and MA value(mm) gradually increased. 3. R time (min), K time (min) and LY30(%) gradually decreased with the aggravation of coronary artery lesions, while Angle(°) and MA value (mm) gradually increased. 4. R time (min), K time (min) and LY30(%) were negatively correlated with Gensini score (r=-0.456, -0.418, -0.483, P<0.001).Angle(°) and MA value(mm) were positively correlated with Gensini score (r=0.531, 0.569, P<0.001).Conclusion: Thromboelastic graph (TEG) can be used as an effective indicator for predicting the condition of patients with acute myocardial infarction (AMI), evaluating the severity of coronary artery disease, and guiding clinical treatment.

Download Full-text