Effect of Prenatal Exposure to Bisphenols on Newborn Leucocyte Telomere Length: A Prospective Birth Cohort Study in China

2021 ◽  
Author(s):  
Jun Liang ◽  
Yantao Shao ◽  
Dongping Huang ◽  
Chunxiu Yang ◽  
Tao Liu ◽  
...  
Keyword(s):  
Cord Blood ◽  
Telomere Length ◽  
Birth Cohort ◽  
Prenatal Exposure ◽  
Positive Association ◽  
Fold Increase ◽  
Later Life ◽  
Maternal Serum ◽  
Birth Cohort Study ◽  
Bisphenol S

Abstract Telomere length (TL) at birth is related to future diseases and long-term health. Bisphenols exhibit toxic effects and can cross the placenta barrier. However, the effect of prenatal exposure to bisphenols on newborn TL remains unknown. We aimed to explore the effects of prenatal exposure to bisphenols (i.e., bisphenol A (BPA), bisphenol B (BPB), bisphenol F (BPF), bisphenol S (BPS), and tetrabromobisphenol A (TBBPA)) on relative TL in newborns. A total of 801 mother–infant pairs were extracted from the Guangxi Zhuang Birth Cohort (GZBC). The relationships between bisphenol levels in maternal serum and relative TL in cord blood were examined by generalized linear models and restricted cubic spline (RCS) models. After adjusting for confounders, we observed a 3.19% (95% CI: -6.08%, -0.21%) reduction in relative cord blood TL among mothers ≥ 28 years with each 1-fold increase of BPS. However, each 1-fold increase of TBBPA, a 3.31% (95% CI: 0.67%, 6.01%) increased in relative cord blood TL among mothers < 28 years. The adjusted RCS models also revealed similar results (P overall < 0.05, P non-linear > 0.05). This is the first study to show a positive association between serum TBBPA levels and newborn relative TL among younger mothers. However, BPS levels were inversely correlated with TL in fetus born to older mothers. The results suggest fetuses of older pregnant women are more sensitivity to BPS exposure and accelerated aging or BPS-related diseases in later life may stem from early-life exposure.

scholarly journals Prenatal Exposure to Phthalates and Newborn Telomere Length: A Birth Cohort Study in Wuhan, China

2019 ◽  
Vol 127 (8) ◽  
pp. 087007 ◽  
Author(s):  
Lulu Song ◽  
Bingqing Liu ◽  
Mingyang Wu ◽  
Lina Zhang ◽  
Lulin Wang ◽  
...  
Keyword(s):  
Cohort Study ◽  
Telomere Length ◽  
Birth Cohort ◽  
Prenatal Exposure ◽  
Birth Cohort Study

Association of prenatal exposure to arsenic with newborn telomere length: Results from a birth cohort study

2019 ◽  
Vol 175 ◽  
pp. 442-448 ◽  
Author(s):  
Lulu Song ◽  
Bingqing Liu ◽  
Lina Zhang ◽  
Mingyang Wu ◽  
Lulin Wang ◽  
...  
Keyword(s):  
Cohort Study ◽  
Telomere Length ◽  
Birth Cohort ◽  
Prenatal Exposure ◽  
Birth Cohort Study

scholarly journals Prenatal exposure to perfluoroalkyl substances and thyroid hormone concentrations in cord plasma in a Chinese birth cohort

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Hong Liang ◽  
Ziliang Wang ◽  
Maohua Miao ◽  
Youping Tian ◽  
Yan Zhou ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Hormones ◽  
Cord Blood ◽  
Birth Cohort ◽  
Prenatal Exposure ◽  
Perfluoroalkyl Substances ◽  
Birth Cohort Study ◽  
Free T4 ◽  
Cord Plasma ◽  
Fetal Thyroid

Abstract Background Evidence of associations between prenatal exposure to perfluoroalkyl substances (PFASs) and fetal thyroid hormones (THs) is controversial, and few studies have estimated the associations, while addressing the high correlations among multiple PFASs. We aimed to examine the associations between prenatal PFAS exposure and thyroid hormone concentrations in cord blood. Methods A total of 300 mother-infant pairs from the Shanghai-Minhang Birth Cohort Study were included. We measured the concentrations of eight PFASs in maternal plasma samples collected at 12–16 gestational weeks, as well as those of total thyroxine (T4), free T4 (FT4), total triiodothyronine (T3), free T3 (FT3), and thyroid stimulating hormone (TSH) in cord plasma. We estimated the associations between maternal PFAS concentrations and TH concentrations using linear regression and Bayesian kernel machine regression (BKMR) models. Results In BKMR models, higher PFAS mixture concentrations were associated with increased T3 concentrations, and there were suggestive associations with increased FT3 concentrations. For single-exposure effects in BKMR models, a change in PFDA, PFUdA, and PFOA concentrations from the 25th to 75th percentile was associated with a 0.04 (95%CrI: − 0.01, 0.09), 0.02 (95%CrI: − 0.03, 0.07), and 0.03 (95%CrI: − 0.001, 0.06) nmol/L increase in T3 concentrations, respectively. PFOA, PFNA, and PFDA were the predominant compounds in PFASs-FT3 associations, and the corresponding estimates were 0.11 (95% CrI: 0.02, 0.19), − 0.17 (95% CrI: − 0.28, − 0.07), and 0.12 (95% CrI: − 0.004, 0.24) pmol/L, respectively. A change in PFNA and PFOA concentrations from the 25th to 75th percentile was associated with a − 1.69 (95% CrI: − 2.98, − 0.41) μIU/mL decrease and a 1.51 (95% CrI: 0.48, 2.55) μIU/mL increase in TSH concentrations. The associations of PFOA and PFNA with T3/FT3 were more pronounced in boys, while those with TSH were more pronounced in girls. Conclusion Our results suggest that prenatal exposure to multiple PFASs was associated with thyroid hormones in cord blood. However, individual PFAS had varied effects—differing in magnitude and direction—on fetal thyroid hormones.

scholarly journals Prenatal exposure to metals and neurodevelopment in infants at six months: Rio Birth Cohort Study of Environmental Exposure and Childhood Development (PIPA Project).

2021 ◽  
Author(s):  
Monica Seefelder de Assis Araujo ◽  
Nataly Damasceno de figueiredo ◽  
Jorge Fonte de Rezende Flho ◽  
Joffre Amim Junior ◽  
Marlos Melo Martins ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cord Blood ◽  
Birth Cohort ◽  
Umbilical Cord ◽  
Prenatal Exposure ◽  
Umbilical Cord Blood ◽  
Blood Lead ◽  
Maternal Blood ◽  
Childhood Development ◽  
Birth Cohort Study

Abstract The PIPA Project is a prospective birth cohort study based in Rio de Janeiro, Brazil, whose pilot study was carried out between October 2017 and August 2018. Arsenic (As), cadmium (Cd), lead (Pb), and mercury (Hg) concentrations were determined in maternal (n = 49) and umbilical cord blood (n = 46). The Denver Developmental Screening Test II (DDST-II) was applied in 50 six-month-old infants. Metals were detected in 100% of the mother and newborn samples above the limits of detection. Maternal blood lead concentrations were higher in premature newborns (GM: 5.72 µg/dL; p = 0.05). One-third of the infants (17–33%) exhibited at least one fail in the neurodevelopment evaluation (fail group). Maternal blood arsenic concentrations were significantly (p = 0.02) higher in the "fail group" (GM: 11.85 µg /L) compared to infants who did not fail (not fail group) (GM: 8.46 µg /L). Maternal and umbilical cord blood arsenic concentrations were higher in all Denver Test’s domains (except personal/social) in the “fail group”, albeit non-statistically significant. These findings indicate the need to further investigate the toxic effects of prenatal exposure to metals on infant neurodevelopment.

scholarly journals Maternal Vitamin D and Newborn Telomere Length

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 2012
Author(s):  
Lisa Daneels ◽  
Dries S. Martens ◽  
Soumia Arredouani ◽  
Jaak Billen ◽  
Gudrun Koppen ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cord Blood ◽  
Telomere Length ◽  
First Trimester ◽  
Maternal Serum ◽  
Adverse Outcomes ◽  
Dietary Vitamin ◽  
Maternal Vitamin ◽  
Vitamin D Intake ◽  
Diet Supplements

Nutrition is important during pregnancy for offspring health. Gestational vitamin D intake may prevent several adverse outcomes and might have an influence on offspring telomere length (TL). In this study, we want to assess the association between maternal vitamin D intake during pregnancy and newborn TL, as reflected by cord blood TL. We studied mother–child pairs enrolled in the Maternal Nutrition and Offspring’s Epigenome (MANOE) cohort, Leuven, Belgium. To calculate the dietary vitamin D intake, 108 women were asked to keep track of their diet using the seven-day estimated diet record (EDR) method. TL was assessed in 108 cord blood using a quantitative real-time PCR method. In each trimester of pregnancy, maternal serum 25-hydroxyvitamin D (25-OHD) concentration was measured. We observed a positive association (β = 0.009, p-value = 0.036) between newborn average relative TL and maternal vitamin D intake (diet + supplement) during the first trimester. In contrast, we found no association between average relative TL of the newborn and mean maternal serum 25-OHD concentrations during pregnancy. To conclude, vitamin D intake (diet + supplements), specifically during the first trimester of pregnancy, is an important factor associated with TL at birth.

scholarly journals Prenatal exposure to arsenic and lung function in children from the New Hampshire Birth Cohort Study

2021 ◽  
Vol 155 ◽  
pp. 106673
Author(s):  
Antonio J. Signes-Pastor ◽  
Pablo Martinez-Camblor ◽  
Emily Baker ◽  
Juliette Madan ◽  
Margaret F. Guill ◽  
...  
Keyword(s):  
Cohort Study ◽  
Lung Function ◽  
Birth Cohort ◽  
New Hampshire ◽  
Prenatal Exposure ◽  
Birth Cohort Study
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