scholarly journals Maternal Vitamin D and Newborn Telomere Length

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 2012
Author(s):  
Lisa Daneels ◽  
Dries S. Martens ◽  
Soumia Arredouani ◽  
Jaak Billen ◽  
Gudrun Koppen ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cord Blood ◽  
Telomere Length ◽  
First Trimester ◽  
Maternal Serum ◽  
Adverse Outcomes ◽  
Dietary Vitamin ◽  
Maternal Vitamin ◽  
Vitamin D Intake ◽  
Diet Supplements

Nutrition is important during pregnancy for offspring health. Gestational vitamin D intake may prevent several adverse outcomes and might have an influence on offspring telomere length (TL). In this study, we want to assess the association between maternal vitamin D intake during pregnancy and newborn TL, as reflected by cord blood TL. We studied mother–child pairs enrolled in the Maternal Nutrition and Offspring’s Epigenome (MANOE) cohort, Leuven, Belgium. To calculate the dietary vitamin D intake, 108 women were asked to keep track of their diet using the seven-day estimated diet record (EDR) method. TL was assessed in 108 cord blood using a quantitative real-time PCR method. In each trimester of pregnancy, maternal serum 25-hydroxyvitamin D (25-OHD) concentration was measured. We observed a positive association (β = 0.009, p-value = 0.036) between newborn average relative TL and maternal vitamin D intake (diet + supplement) during the first trimester. In contrast, we found no association between average relative TL of the newborn and mean maternal serum 25-OHD concentrations during pregnancy. To conclude, vitamin D intake (diet + supplements), specifically during the first trimester of pregnancy, is an important factor associated with TL at birth.

scholarly journals Prenatal maternal and cord blood vitamin D concentrations and negative affectivity in infancy

2021 ◽  
Author(s):  
Sara Sammallahti ◽  
Elisa Holmlund-Suila ◽  
Runyu Zou ◽  
Saara Valkama ◽  
Jenni Rosendahl ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cord Blood ◽  
Negative Affectivity ◽  
Maternal Serum ◽  
Maternal Vitamin ◽  
Hydroxyvitamin D ◽  
Increased Risk ◽  
Standard Deviations ◽  
Temperamental Trait

AbstractHigher maternal vitamin D concentration during pregnancy is associated with better child mental health. Negative affectivity, an early-emerging temperamental trait, indicates an increased risk of psychopathology. We investigated if maternal early/mid-pregnancy 25-hydroxyvitamin D (25(OH)D) and neonatal cord blood 25(OH)D concentrations are associated with Negative affectivity in infancy. We studied term-born infants from the vitamin D Intervention in Infants study (VIDI, n = 777, follow-up rate 80%, Finland), and the Generation R Study (n = 1505, follow-up rate 40%, Netherlands). We measured maternal serum 25(OH)D at 6–27 weeks (VIDI) or 18–25 weeks (Generation R) of pregnancy, and cord blood 25(OH)D at birth (both cohorts). Caregivers rated infant Negative affectivity at 11.7 months (VIDI) or 6.5 months (Generation R) using the Revised Infant Behavior Questionnaire. Using linear regression, we tested associations between 25(OH)D and Negative affectivity adjusted for infant age, sex, season of 25(OH)D measurement, maternal age, education, smoking, and body-mass-index. Per 10 nmol/l increase in maternal early/mid-pregnancy 25(OH)D, infant Negative affectivity decreased by 0.02 standard deviations (95% confidence interval [CI] − 0.06, − 0.004) in VIDI, and 0.03 standard deviations (95% CI − 0.03, − 0.01) in Generation R. Cord blood 25(OH)D was associated with Negative affectivity in Generation R (− 0.03, 95% CI − 0.05, − 0.01), but not VIDI (0.00, 95% CI − 0.02, 0.02). Lower maternal 25(OH)D concentrations were consistently associated with higher infant Negative affectivity, while associations between cord blood 25(OH)D concentrations and Negative affectivity were less clear. Maternal vitamin D status during early- and mid-pregnancy may be linked with early-emerging differences in offspring behavior.

scholarly journals First-trimester maternal serum vitamin D and mode of delivery

2012 ◽  
Vol 108 (11) ◽  
pp. 1972-1975 ◽  
Author(s):  
Makrina D. Savvidou ◽  
Mahlatse Makgoba ◽  
Pedro T. Castro ◽  
Ranjit Akolekar ◽  
Kypros H. Nicolaides
Keyword(s):  
Vitamin D ◽  
Caesarean Section ◽  
Vaginal Delivery ◽  
Elective Caesarean Section ◽  
Mode Of Delivery ◽  
First Trimester ◽  
Maternal Serum ◽  
Emergency Caesarean Section ◽  
Maternal Vitamin ◽  
Vitamin D Levels

Low maternal vitamin D levels have been associated with adverse pregnancy outcome. A recent study has suggested that low maternal vitamin D levels at the time of delivery are also associated with an almost fourfold increase in caesarean section risk. The aim of the present study was to investigate whether there is a difference in maternal serum 25-hydroxyvitamin D (25(OH)D) levels at 11–13 weeks' gestation according to the mode of delivery. Maternal serum 25(OH)D levels were measured at 11–13 weeks' gestation in 995 singleton pregnancies resulting in the birth of phenotypically normal neonates at term. The measured 25(OH)D levels were adjusted for maternal age, BMI, racial origin, smoking, method of conception and season of blood testing, and the adjusted levels (multiple of the median; MoM) were compared between those who subsequently delivered vaginally and those that delivered by caesarean section. Delivery was vaginal in 79·6 % of cases, by emergency caesarean section in 11·6 % and by elective caesarean section in 8·8 %. The median 25(OH)D level in our population was 46·82 (interquartile range (IQR) 27·75–70·13) nmol/l. The adjusted maternal median 25(OH)D levels in the emergency and elective caesarean section groups (0·99, IQR 0·71–1·46 MoM and 0·96, IQR 0·73–1·27 MoM, respectively) were not significantly different from the vaginal delivery group (0·99, IQR 0·71–1·33 MoM; P = 0·53 and P = 0·81, respectively). First-trimester maternal serum 25(OH)D levels are similar between women who subsequently have a vaginal delivery and those who deliver by elective or emergency caesarean section.

scholarly journals Predicted vitamin D status during pregnancy in relation to offspring forearm fractures in childhood: a study from the Danish National Birth Cohort

2015 ◽  
Vol 114 (11) ◽  
pp. 1900-1908 ◽  
Author(s):  
Sesilje B. Petersen ◽  
Marin Strøm ◽  
Ekaterina Maslova ◽  
Charlotta Granström ◽  
Peter Vestergaard ◽  
...  
Keyword(s):  
Vitamin D ◽  
Birth Cohort ◽  
Dietary Vitamin ◽  
Vitamin D Status ◽  
Forearm Fractures ◽  
Maternal Vitamin ◽  
Vitamin D Intake ◽  
Danish National Birth Cohort ◽  
Tanning Bed ◽  
Maternal Vitamin D Status

AbstractIn a prospective cohort study, the association between maternal vitamin D status during pregnancy and offspring forearm fractures during childhood and adolescence was analysed in 30 132 mother and child pairs recruited to the Danish National Birth Cohort between 1996 and 2002. Data on characteristics, dietary factors and lifestyle factors were collected on several occasions during pregnancy. We analysed the association between predicted vitamin D status, based on a subsample with 25-hydroxyvitamin D (25(OH)D) biomarker measurements (n 1497) from gestation week 25, and first-time forearm fractures among offspring between birth and end of follow-up. Diagnoses were extracted from the Danish National Patient Register. Multivariable Cox regression models using age as the underlying time scale indicated no overall association between predicted vitamin D status (based on smoking, season, dietary and supplementary vitamin D intake, tanning bed use and outdoor physical activity) in pregnancy and offspring forearm fractures. Likewise, measured 25(OH)D, tanning bed use and dietary vitamin D intake were not associated with offspring forearm fractures. In mid-pregnancy, 91 % of the women reported intake of vitamin D from dietary supplements. Offspring of women who took >10 µg/d in mid-pregnancy had a significantly increased risk for fractures compared with the reference level of zero intake (hazard ratios (HR) 1·31; 95 % CI 1·06, 1·62), but this was solely among girls (HR 1·48; 95 % CI 1·10, 2·00). Supplement use in the peri-conceptional period exhibited similar pattern, although not statistically significant. In conclusion, our data indicated no protective effect of maternal vitamin D status with respect to offspring forearm fractures.

scholarly journals The effect of the maternal vitamin D level on the risk of spontaneous pregnancy loss in the first trimester

2021 ◽  
Vol 10 (6) ◽  
pp. 2215
Author(s):  
Sharmin Ferdous ◽  
Farhat Hussain ◽  
Samira Hayee ◽  
Nahreen Akhtar ◽  
Suraiya Khanam ◽  
...  
Keyword(s):  
Vitamin D ◽  
Pregnancy Loss ◽  
Serum Vitamin ◽  
First Trimester ◽  
Maternal Serum ◽  
Control Group ◽  
Case Group ◽  
Maternal Vitamin ◽  
Serum Vitamin D ◽  
Spontaneous Pregnancy

Background: Pregnancy loss in the first trimester is one of the most disappointing matters for a mother. But spontaneous pregnancy loss in the first trimester is the most common negative outcome of pregnancy. It's estimated that about 10% of known pregnancies are lost in the first trimester whereas fewer than 4% of pregnancies miscarry in the second trimester. Aim of current study was to assess the effect of the maternal vitamin D level on the risk of spontaneous pregnancy loss in the first trimester.Methods: It was a case-control study conducted in the department of obstetrics and gynecology, Sir Salimullah medical college Mitford hospital, Dhaka, Bangladesh during the period of September 2018 to August 2019. A total of 100 patients were included in this study. Statistical analyses of the results were obtained by using window-based computer software devised with SPSS version 22.0.Results: In analyzing the association of serum vitamin D status with first-trimester pregnancy state it was observed that more than half (52.0%) patients had severe deficiency (<10 ng/ml) in the case group and 14 (28.0%) patients in the control group. In total 24 (48.0%) patients had deficiency (10-20 ng/ml) in case and 35 (70.0%) in control group. Only 1 (2.0%) patient had insufficiency (21-29 ng/ml) in control group. The difference was statistically significant (p<0.05) between the two groups.Conclusions: Maternal serum vitamin D deficiency was significantly associated with early spontaneous pregnancy loss in the first trimester.

Maternal vitamin D intake during pregnancy increases gene expression of ILT3 and ILT4 in cord blood

2009 ◽  
Vol 40 (5) ◽  
pp. 786-794 ◽  
Author(s):  
M. K. Rochat ◽  
M. J. Ege ◽  
D. Plabst ◽  
J. Steinle ◽  
S. Bitter ◽  
...  
Keyword(s):  
Gene Expression ◽  
Vitamin D ◽  
Cord Blood ◽  
Maternal Vitamin ◽  
Vitamin D Intake

scholarly journals Relationship between maternal vitamin D status in the first trimester of pregnancy and maternal and neonatal outcomes: a retrospective single center study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Meng Ni ◽  
Qianqian Zhang ◽  
Jiuru Zhao ◽  
Qianwen Shen ◽  
Dongting Yao ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
First Trimester ◽  
Maternal Serum ◽  
Neonatal Outcomes ◽  
Vitamin D Status ◽  
Maternal Vitamin ◽  
Serum Vitamin D ◽  
First Trimester Of Pregnancy

Abstract Background This study aimed to investigate the relationship between maternal serum vitamin D status in the first trimester of pregnancy and maternal as well as neonatal outcomes, considered the prevalence of vitamin D deficiency (serum 25(OH)D < 50 nmol/L) around the world, especially in the pregnant women. Methods From January 2015 to December 2016, in this cross-sectional retrospective study, we enrolled women receiving regular prenatal examinations and giving birth in the International Peace Maternity and Child Health Hospital. Cases confirmed as multiple pregnancy, incomplete medical records, and vitamin D level recorded after 13 weeks of gestation were excluded. A total of 23,394 mother-infant pairs were included ultimately. Obstetric and neonatal information were extracted from the database. Maternal serum vitamin D concentration was measured by chemiluminescence microparticle immunoassay. Logistic regression analysis (unadjusted and adjusted models) was used to analyze the association between vitamin D and maternal and neonatal outcomes. Results The average 25(OH) D concentration was 43.20 ± 0.10 nmol/L; 67.09% of patients were vitamin D deficient(25(OH) D < 50.00 nmol/L), 29.84% were vitamin D insufficient (50 nmol/L ≤ 25(OH)D < 75 nmol/L), 3.07% were sufficient (25(OH)D ≥ 75 nmol/L). The maternal 25(OH)D levels varied with age, pre-pregnancy BMI, season when blood sample was collected, number of previous-pregnancy. Notably, newborns delivered by women with deficient vitamin D status had a higher incidence rate of admission to NICU (Deficiency: 12.20% vs Insufficiency: 10.90% vs Sufficiency: 11.70%, Pbonferroni = .002) and a longer stay (deficiency: 6.2 ± 4.1 days vs insufficiency: 5.9 ± 3.1 days vs sufficiency: 5.1 ± 2.1 days, Pbonferroni = .010). Moreover, maternal vitamin D deficiency was a dependent risk factor for admission to NICU (unadjusted OR = 1.35, 95% CI,1.05–1.74 Pbonferroni = .022; adjusted OR = 1.31, 95% CI,1.010–1.687 Pbonferroni = .042). Conclusions Maternal vitamin D deficiency (25(OH) D < 50 nmol/L) was prevalent in eastern coastal China. The incidence rate of GDM as well as preeclampsia was higher in vitamin D insufficient group while vitamin D deficiency group was liable to intrauterine infection when compared with the other two groups. Most importantly, low vitamin D status in the first trimester of pregnancy was a dependent risk factor for admission to NICU. More well-designed perspective researches are necessary to clarify the role of vitamin D in the early stage of pregnancy.

Association of vitamin D with incident glaucoma: findings from the Women’s Health Initiative

2021 ◽  
pp. jim-2020-001645
Author(s):  
Laura D Carbone ◽  
Karen Johnson ◽  
Joseph C Larson ◽  
Fridtjof Thomas ◽  
Jean Wactawski-Wende ◽  
...  
Keyword(s):  
Vitamin D ◽  
Women's Health ◽  
Postmenopausal Women ◽  
Serum Levels ◽  
Dietary Vitamin ◽  
Health Initiative ◽  
Vitamin D Intake ◽  
Vitamin D Supplements ◽  
Dietary Vitamin D ◽  
The Women’S Health Initiative

The relationship between vitamin D and glaucoma is controversial. The objective of this study was to examine women from the Women’s Health Initiative (WHI) to determine if there is an association between vitamin D and incident glaucoma in postmenopausal women. We examined the association between dietary vitamin D intake, vitamin D supplements and serum 25 hydroxyvitamin D (25(OH)D) levels and the risk of developing glaucoma. 143,389 postmenopausal women from the WHI including a subset with serum 25(OH) D measurements were examined to determine the association of dietary, supplemental and serum levels of vitamin D to the development of glaucoma. Dietary intakes of vitamin D, use of vitamin D supplements and serum levels of 25(OH) D were predictors examined for the main outcome of incident glaucoma. In multivariable models adjusted for demographic, clinical variables and medication use, dietary vitamin D, vitamin D supplements, total vitamin D intake (diet plus supplements) and serum 25 (OH) D measurements were not significantly associated with incident glaucoma. In the CaD placebo-controlled intervention clinical trial, there was also no association in the active intervention arm with glaucoma. We conclude that dietary vitamin D intake, supplements and serum levels are not significantly related to the risk of developing glaucoma in postmenopausal women.

scholarly journals High Prevalence of Vitamin D Inadequacy During Late Postpartum in Canadian Mothers

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 790-790
Author(s):  
Sarah Montgomery ◽  
Angella Lee ◽  
Nasime Sarbar ◽  
Deborah Zibrik ◽  
Yvonne Lamers
Keyword(s):  
Vitamin D ◽  
British Columbia ◽  
Dietary Intake ◽  
Dietary Vitamin ◽  
Nutrient Deficiencies ◽  
Cross Sectional ◽  
Convenience Sample ◽  
Vitamin D Intake ◽  
Pregnancy And Postpartum ◽  
Dietary Vitamin D

Abstract Objectives To assess maternal dietary intake and adequacy at postpartum and to determine whether lifestyle characteristics and breastfeeding status are related to nutrient intakes. Methods We analyzed cross-sectional data from a convenience sample of 129 mothers at 18-mo postpartum, whose families were enrolled into a randomized toddler intervention trial, in the Lower Mainland, British Columbia, Canada. The Canadian Diet History Questionnaire II (C-DHQ II) was used to estimate usual dietary intake in the mothers during the preceding 12 months (i.e., between 6- to 18-mo postpartum). Implausible energy intakes were defined as &lt;600 kcal/day or &gt;3500 kcals/day, and excluded from analysis. Demographic and lifestyle characteristic data about the pregnancy and postpartum time period were collected using a questionnaire. Results Maternal mean (SD) age at birth was 33.5 (4.0) years and most women were of European (46%) or Asian (38%) ethnicity, and had Bachelor's degree or higher education (70%). About 75%, 88%, and 89% did not meet their dietary requirements (i.e., intake below the EAR) for fiber, potassium, and vitamin D intakes, from food only, respectively. Considering total dietary intake from food and supplements, the prevalence of dietary vitamin D inadequacy was 25%. Women of European ethnicity had higher vitamin D intake (median (IQR) in mg/1000kcal/day: 19.5 (7.26,101)) compared to Asian women (10.8 (3.87, 21.1); P &lt; 0.05). Dietary vitamin D intake was higher in breastfeeding (i.e., providing breastmilk as primary milk source, i.e., ³2 times/day, to their 18-mo old toddlers) compared to non- or occasionally breastfeeding mothers (20.0 (10.5, 61.1) versus 14.9 (4.28, 26.7) mg/1000kcal/day; P &lt; 0.05). Conclusions While most Canadian mothers in this sample met the EARs for most nutrients, the prevalence of dietary inadequacy was very high for vitamin D, potassium, and fiber. Some population groups may be especially at risk of developing nutrient deficiencies in this period of life characterized by postpartum recovery and transition; targeted public health strategies may be needed to address these deficiencies. Funding Sources This study is supported by The University of British Columbia, and the British Columbia Children's Hospital Research Institute, Canada, and is funded by Société des Produits Nestlé S.A.

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