scholarly journals Evaluation of Neurological Complications in Hospitalized COVID-19 Patients: A Cross-Sectional Study 2020

Author(s):  
Mojtaba Khazaei ◽  
Fatemeh Feizy ◽  
Salman Khazaei

Abstract Objective: The coronavirus (COVID-19) has been spreading around the world since December 2019. Neurological symptoms have been reported as a part of the clinical spectrum of the disease. This study aimed to determine the frequency of neurological complications in hospitalized patients with COVID-19.Methods: Electronic medical records in the hospital information system, laboratory findings, and radiological examinations were evaluated for all patients with laboratory-confirmed SARS-CoV-2 infection. The cases were referred to Shahid Beheshti Hospital affiliated to Hamadan University of Medical Sciences from February 20, 2020 to the end of the same year.Results: A total of 477 hospitalized COVID-19 patients were included in the analyses. Based on our results, 105 (22.02%) patients showed neurological manifestations. Ischemic stroke, decreased consciousness, and headache were the most frequent reported neurological symptoms with the rate of 34 (7.13%), 28 (5.88%), and13 (2.72%), respectively. Moreover, 54 (51.43%) cases were male, and the vast majority of the patients (66; 62.86%) had more than 60 years of age. Conclusions: SARS-CoV-2 may involve nervous system and cause brain tissue damage. The findings of this study provide more information on coronavirus disease, contributing to effective interventions for the control of the disease

2019 ◽  
Vol 8 ◽  
Author(s):  
Shaghayegh Zafarmand ◽  
Haniyeh Javanmardi ◽  
Maryam Amiri ◽  
Masoud Maneshi ◽  
Susan Mansouri-Mehrabadi ◽  
...  

Background: Pregnancy and postpartum are critical periods for patients with neurological complications. In this study, we aimed to evaluate the clinical characteristics and outcome of pregnant women with neurological conditions. Materials and Methods: This cross-sectional study reviewed pregnant women with neurological signs and symptoms, who were registered in the Medical Care Monitoring Center (MCMC) database of Shiraz University of Medical Sciences 2013-15. A questionnaire was designed to record each patient’s information including demographic variables, past medical history, clinical presentation, obstetric profile, and fetal/maternal outcomes. Results: Totally, 332 mothers were registered in the database. The main neurological complaints in our population were headache, seizure, unilateral neurological symptoms, multiple sclerosis, neuromuscular disorder, and brain tumor. More than half of the patients (54%) experienced headache during the pregnancy and postpartum period. Conclusion: Evaluating the neurological disorders separately, based on the time of symptom onset indicates the importance of follow-up of mothers during peripartum. Our findings suggest that decisions for pregnancy in women with neurological disorders should be based on risks outweighing for the mother and the fetus, particularly regarding the pharmacological side effects. [GMJ.2019;8:e1616]


2020 ◽  
Author(s):  
Daphne Carmen Erkelens ◽  
Frans H. Rutten ◽  
Loes T. Wouters ◽  
L. Servaas Dolmans ◽  
Esther de Groot ◽  
...  

Abstract Background: The Netherlands Triage Standard (NTS) is a widely used decision support tool for telephone triage at Dutch out-of-hours primary care services (OHS-PC), which, however, has never been validated against clinical outcomes. We aimed to determine the accuracy of the NTS urgency allocation for patients with neurological symptoms suggestive of a transient ischaemic attack (TIA) or stroke, with the clinical outcomes TIA, stroke, and other (neurologic) life-threatening events (LTEs) as the reference.Method: A cross-sectional study of telephone triage recordings of patients with neurological symptoms calling the OHS-PC between 2014 and 2016.The allocated NTS urgencies were derived from the electronic medical records of the OHS-PC. The clinical outcomes were retrieved from the electronic medical records of the patients’ own general practitioners. The accuracy of a high NTS urgency allocation (medical help within three hours) was calculated in terms of sensitivity, specificity, positive and negative predictive values (PPV and NPV) with the clinical outcomes TIA/stroke/other LTEs as the reference.Results: Of 1,269 patients, 635 (50.0%) received the diagnosis TIA/stroke (34.2% TIA/minor stroke, 15.8% major ischaemic or haemorrhagic stroke), and 4.8% other LTEs. For TIA/stroke/other LTEs, the sensitivity and specificity of the NTS urgency allocation were 0.72 (95%CI 0.68-0.75) and 0.48 (95%CI 0.43-0.52), and the PPV and NPV were 0.62 (95%CI 0.60-0.64) and 0.58 (95%CI 0.54-0.62).Conclusions: The NTS decision support tool used in Dutch OHS-PC performed poor to moderately regarding safety (sensitivity) and efficiency (specificity) in allocating adequate urgencies to patients with and without TIA/stroke/other LTEs.


2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Carlos E. Duran ◽  
Alejandro Ramírez ◽  
Juan G. Posada ◽  
Johanna Schweineberg ◽  
Liliana Mesa ◽  
...  

Introduction. In Colombia, the genetic background of the populations was shaped by different levels of admixture between Natives, European, and Africans. Approximately 35.363 patients have diagnosed chronic kidney disease and according to population studies, 10.4% of these patients are Afro-descendant. We aim to assess the frequency of APOL1 variants G1 and G2 in Afro-descendant patients with ESRD treated at la Fundacion Valle del Lili University Hospital in Cali, Colombia. Methods. This is an observational cross-sectional study. Afro-descendant patients with ESRD in waitlist or recipients of kidney transplant were evaluated. Clinical data were collected from the electronic medical records. Genotyping was carried out by amplification of the exon 7 of the APOL1 gene. For the identification of risk genotypes, the bioinformatics tool BLAST was used. Results. We enrolled 102 participants. The frequency of APOL1 risk variants was 67.2%, in which 24.5% (n = 25) were G1 heterozygous and 5.8% (n = 6) were G2 heterozygous and 37% of the patients had high-risk status with two alleles in homozygous (G1/G1 = 21 and G2/G2 = 3) or compound heterozygote (G1/G2 = 14) form.


Author(s):  
Mehrdad Karajizadeh ◽  
Reza Nikandish ◽  
Omid Yousefianzadeh ◽  
Zahra Hamedi ◽  
Hamid Reza Saeidnia

Aim: This study was conducted to determine the usability of the rapid response team (RRT) electronic medical records (EMRs) system at an Abu-Ali-Sina organ transplant hospital, Shiraz, Iran. Method: This cross-sectional study was carried out in partnership with 25 direct members of RRT includes nurses and anesthesia technicians who were on the shift during the data collection for two months. To evaluate, the Questionnaire for User Interaction Satisfaction (QUIS) version 7 was used. Data were analyzed by SPSS version 19. Results: A total of 20 out of 25 questionnaires were obtained. Seven (25.0 %) of 27 sections were higher than seven, and all areas were higher than five. The highest rankings were for 1) reading characters on the computer screen 2) highlighting on the screen simplify task 3) overall reactions: wonderful and learning to operate the system. Conclusion: This study demonstrates the usability of the hospital RRT for the EMRs system and over the moderate. However, the flexibility and capability of the rapid response for EMRs tool require to be improved.


2020 ◽  
Author(s):  
Daphne Carmen Erkelens ◽  
Frans H. Rutten ◽  
Loes T. Wouters ◽  
L. Servaas Dolmans ◽  
Esther de Groot ◽  
...  

Abstract BackgroundThe Netherlands Triage Standard (NTS) is a widely used decision support tool for telephone triage at Dutch out-of-hours primary care services (OHS-PC), which, however, has never been validated against clinical outcomes. We aimed to determine the accuracy of the NTS urgency allocation for patients with neurological symptoms suggestive of a transient ischaemic attack (TIA) or stroke, with the clinical outcomes TIA, stroke, and other (neurologic) life-threatening events (LTEs) as the reference.MethodA cross-sectional study of telephone triage recordings of patients with neurological symptoms calling the OHS-PC between 2014 and 2016.The allocated NTS urgencies were derived from the electronic medical records of the OHS-PC. The clinical outcomes were retrieved from the electronic medical records of the patients’ own general practitioners. The accuracy of a high NTS urgency allocation (medical help within three hours) was calculated in terms of sensitivity, specificity, positive and negative predictive values (PPV and NPV) with the clinical outcomes TIA/stroke/other LTEs as the reference.ResultsOf 1,269 patients, 635 (50.0%) received the diagnosis TIA/stroke (34.2% TIA/minor stroke, 15.8% major ischaemic or haemorrhagic stroke), and 4.8% other LTEs. For TIA/stroke/other LTEs, the sensitivity and specificity of the NTS urgency allocation were 0.72 (95%CI 0.68–0.75) and 0.48 (95%CI 0.43–0.52), and the PPV and NPV were 0.62 (95%CI 0.60–0.64) and 0.58 (95%CI 0.54–0.62).ConclusionsThe NTS decision support tool used in Dutch OHS-PC performed poor to moderately regarding safety (sensitivity) and efficiency (specificity) in allocating adequate urgencies to patients with and without TIA/stroke/other LTEs.Trial registration: the Netherlands National Trial Register, identification number NTR7331.


2020 ◽  
Author(s):  
Rui Li ◽  
Yue Niu ◽  
Sarah Robbins Scott ◽  
Chu Zhou ◽  
Lan Lan ◽  
...  

BACKGROUND With the proliferation of electronic medical records systems (EMRs), there is an increasing interest in utilizing EMRs data for medical research, yet there is no quantitative research on EMRs data utilization for medical research purposes. OBJECTIVE Understand the current status of clinical data utilization in clinical research activities, including trends in recent years and differences between different populations, to find out the present problems in the use of EMR data for research, and provide a reference for promoting the utilization of EMR data in scientific research. METHODS For this descriptive, cross-sectional study, the utilization of EMRs data by staff at Xuanwu Hospital in Beijing, China between 2016 and 2019 was analyzed. The utilization of EMRs data was described as the number of requests, the proportion of requesters, and the frequency of requests per capita. The comparison by year, professional title, and age was conducted by double-sided chi square test. RESULTS From 2016 to 2019, EMRs data utilization was poor, as the proportion of requesters was 5.8% and the frequency was 0.1 times / person / year. The frequency per capita gradually slowed and more older, senior level staff used EMRs data compared to younger staff. CONCLUSIONS The value of using EMRs data for research purposes does not get enough attention among researchers in Chinese hospitals. Ensuring equal availability of EMRs data and highlighting the benefits of such systems can help promote its use in research settings. Future research should focus on mechanisms that encourage data utilization, ensure fair data availability, and promote data sharing.


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