scholarly journals Fluid Status Changes During the Transition in Infants of Diabetic Mothers.

2021 ◽  
Author(s):  
Vincenzo Zanardo ◽  
Domenico Tortora ◽  
matteo Parotto ◽  
Valeria Manghina ◽  
lorenzo Severino ◽  
...  
Keyword(s):  
Body Weight ◽  
Cord Blood ◽  
Extracellular Fluid ◽  
Elective Cesarean Section ◽  
Control Group ◽  
Fluid Loss ◽  
Infants Of Diabetic Mothers ◽  
Fluid Status ◽  
Neonatal Life ◽  
Diabetic Mothers

Abstract BackgroundIn animal and human neonates, expansion of the extracellular fluid volume is associated with “wet” lung and poor respiratory outcomes.MethodsTo define fluid status changes during the transition from fetal to neonatal life in infants of diabetic mothers (IDM), we conducted a single centre (Policlinico Abano Terme, Abano Terme, Italy) study of 66 IDM and a 1:2 matched control group from January 1 to September 30, 2020. Fluid status changes were assessed by computing Δ Hct from umbilical cord blood at birth and capillary heel Hct at 48h, accounting for body weight decrease.ResultsIDM presented with significantly lower cord blood Hct levels in comparison to controls (47.33±4.52 vs 50.03±3.51%, p<0.001), mainly if delivered by elective cesarean section (45.01±3.77 vs 48.43±3.50%, p=0.001). Hct levels at 48h were comparable (55.18±5.42 vs 54.62±7.41%, p=0.703), concurrently with similar body weight decrease (-217.21±113.34 vs-217.51±67.28 g, p=0.614). This supports significantly higher ∆ Hct in IDM (5.13±5.24 vs 7.29±6.48, p<0.01) and extra circulating fluid loss of 2-3%.ConclusionGestational diabetes is associated with an excess of circulating fluids during the transition from fetal to neonatal life, challenging the current assumption that is per se at risk of wet lung.

scholarly journals Cardiorespiratory disorders of infants of diabetic mothers

2015 ◽  
Vol 143 (9-10) ◽  
pp. 567-572
Author(s):  
Ivan Hrabovski ◽  
Ljubomir Milasinovic ◽  
Mirjana Bogavac ◽  
Zorica Grujic ◽  
Ilija Grujic
Keyword(s):  
Body Weight ◽  
Glucose Homeostasis ◽  
Control Group ◽  
Average Weight ◽  
Microbiological Analysis ◽  
Respiratory Disorders ◽  
Infants Of Diabetic Mothers ◽  
Group I ◽  
The Impact ◽  
Diabetic Mothers

Introduction. One of the characteristics of modern era is the explosion of diabetes in the world. Today more than 400,000,000 people suffer from diabetes in the entire world. During the last decade the number of women with the disorder of glucose homeostasis is six to seven times greater than in the previous period. Therefore, the re-evaluation of the impact of glucose intolerance on the course and outcome of pregnancy is very current. Objective. The aim of the study was to evaluate the data on the influence of mothers? glucose homeostasis disturbances on the occurrence of cardiorespiratory disorders in newborns, as well as their influence on the perinatal outcome. Methods. Prospective examination included 102 newborns in total - 31 infants of mothers with glucose homeostasis disorder (Group I) and 71 infants of healthy mothers (Group II). Average age, body height, body weight, body mass index, parity and illness duration of the pregnant women had been determined, as well as the delivery method. Every newborn was provided with physical examination, Apgar score was calculated, body weight and body length were measured. Also, electrocardiography and brain ultrasound, as well as the basic hematology biochemical and microbiological analysis, were performed within the examinations of the infants. Results. The average weight and obesity incidence with diabetic women was higher than in the control group and their infants were heavier and with lower gestational age. Heart failures were diagnosed in five (16.1%) infants of diabetic mothers and in one (1.4%) infant of a healthy woman (p<0.01). Respiratory disorders were diagnosed in 48.4% infants of diabetic mothers and in 12.6% of healthy mothers (p<0.01). Forty-two percent of infants of diabetic mothers and 19.7% infants of healthy mothers needed additional oxygen. Conclusion. Congenital anomalies of the cardiovascular system and respiratory disorders in the infants of diabetic mothers were six to eight times more frequent than in the infants of healthy mothers.

Magnesium, Total Calcium, Phosphorus, Copper, and Zinc in Plasma and Erythrocytes of Venous Cord Blood from Infants of Diabetic Mothers: Comparison with a Reference Group by Logistic Discriminant Analysis

1992 ◽  
Vol 38 (10) ◽  
pp. 2002-2007 ◽  
Author(s):  
M Speich ◽  
A Murat ◽  
J L Auget ◽  
B Bousquet ◽  
P Arnaud
Keyword(s):  
Cord Blood ◽  
Gestational Age ◽  
Comparison Group ◽  
Reference Group ◽  
Total Calcium ◽  
Infants Of Diabetic Mothers ◽  
Calcium Phosphorus ◽  
The Mean ◽  
Diabetic Mothers ◽  
Apparently Healthy

Abstract Concentrations of magnesium (Mg), total calcium (Ca), phosphorus (P), copper (Cu), and zinc (Zn) were investigated in plasma (Pl) and erythrocytes (Erc) of venous cord blood of 44 infants of diabetic mothers (IDMs). These same concentrations plus total glycohemoglobin and fructosamine were determined at delivery in a subset of 15 mothers of these infants. Mineral results for IDMs were compared with those for 66 apparently healthy newborns. The duration of gestation in the two groups was significantly different (P &lt; 0.001). After adjustment for gestational age, the mean (+/- SD) differences between groups were significant for birth weight, head circumference, Erc-Mg (1.71 +/- 0.17 for IDMs vs 1.76 +/- 0.15 mmol/L for control subjects), Pl-Ca (1.96 +/- 0.32 vs 2.48 +/- 0.22 mmol/L), Pl-P (1.99 +/- 0.40 vs 1.57 +/- 0.25 mmol/L), and Erc-Cu (10.9 +/- 2.41 vs 12.9 +/- 3.00 mumol/L), but not for Erc-Zn (33.0 +/- 18.3 vs 40.4 +/- 13.6 mumol/L). The variable that best discriminated between the two infant groups after adjustment for gestational age was Pl-Ca. In the 15 mothers, Pl-Mg (0.67 +/- 0.07 mmol/L) and Pl-Ca (1.66 +/- 0.21 mmol/L) concentrations were low, Pl-Zn (9.81 +/- 3.40 mumol/L) was normal, and Pl-Cu (33.5 +/- 10.7 mumol/L) was above normal. Correlations between total glycohemoglobin and mineral values of the mothers or paired IDM mineral values were not significant. The concentration of Pl-Ca was positively correlated with Erc-Cu (P &lt; 0.001) and Pl-Cu (P &lt; 0.05) in the comparison group newborns but not in the IDMs.

ALPHA1-FETOPROTEIN AND CARBONIC ANHYDRASE B AND C CONCENTRATION IN CORD BLOOD FROM NEWBORN INFANTS OF DIABETIC MOTHERS

1974 ◽  
Vol 77 (3_Suppl) ◽  
pp. S81-S86 ◽  
Author(s):  
B. Nørgaard-Pedersen ◽  
J. G. Klebe
Keyword(s):  
Carbonic Anhydrase ◽  
Cord Blood ◽  
Gestational Age ◽  
Newborn Infants ◽  
Infants Of Diabetic Mothers ◽  
Carbonic Anhydrase B ◽  
Erythrocyte Carbonic Anhydrase ◽  
Diabetic Mothers

ABSTRACT Erythrocyte carbonic anhydrase (CA) concentration B and C and the α1-fetoprotein (AFP) concentration was determined in cord blood from 45 newborn infants of diabetic mothers (IDM). The concentration of these quantities has separately been compared with the corresponding concentration in cord blood from normal newborn infants with the same gestational age. No difference was found except for AFP, where a significantly (P < 0.05) higher concentration was found in some infants of insulin treated diabetic mothers.

scholarly journals 643 Elevated Acetoacetate, Oxidative Stress and Mcp-1 Levels in Cord Blood of Infants of Diabetic Mothers

2012 ◽  
Vol 97 (Suppl 2) ◽  
pp. A186-A187
Author(s):  
D. Kurepa ◽  
A. Pramanik ◽  
L. Groome ◽  
J. Bocchini ◽  
S. Jain
Keyword(s):  
Oxidative Stress ◽  
Cord Blood ◽  
Infants Of Diabetic Mothers ◽  
Diabetic Mothers

scholarly journals Influence of glucose homeostasis on maturation and ontogenesis of fetus

2011 ◽  
Vol 64 (11-12) ◽  
pp. 552-556
Author(s):  
Ivan Hrabovski ◽  
Ljubomir Milasnovic ◽  
Zorica Grujic ◽  
Ilija Grujic
Keyword(s):  
Body Weight ◽  
Glucose Homeostasis ◽  
Body Height ◽  
Control Group ◽  
Average Weight ◽  
Microbiological Analysis ◽  
Respiratory Disorders ◽  
Group I ◽  
Brain Ultrasound ◽  
Diabetic Mothers

Introduction. The aim of the paper is to examine the incidence and the rate of cardio respiratory disorders in mothers of newborns with diabetes mellitus in pregnancy as well as their influence on the perinatal outcome. Material and methods. A prospective and random study included 102 newborns, 31 newborns of mothers with glucose homeostasis disorder (group I) and 71 newborns of healthy mothers (group II). The average age, body height, body weight, body mass index, parity and illness duration of the pregnant women were recorded as well as the delivery method. Every newborn underwent physical examination in order to determine the Apgar score, body weight and length. Electrocardiogram, brain ultrasound and the basic hematology biochemical and microbiological analysis were done as well. Results. The average weight and obesity incidence were higher in diabetic women than in the control group and their newborns were heavier and of lower gestational age.Heart failures were diagnosed in 5 (1612%) newborns of diabetic mothers and in 1 (1.4%) of a healthy pregnant woman (p<0.01). Respiratory disorders were diagnosed in 48.4% of newborns of diabetic mothers and 12.64% of healthy mothers (p<0.01). Additional oxygen was needed by 42% of newborns of diabetic mothers and 19.7% of newborns of healthy mothers. Conclusion. Congenital anomalies of cardiovascular system and respiratory disorders were 6-8 times more frequent in newborns of diabetic mothers than in newborns of healthy mothers.

scholarly journals Mean Platelet Volume and Ischemia Modified Albumin Levels in Cord Blood of Infants of Diabetic Mothers

2014 ◽  
Vol 55 (6) ◽  
pp. 455-458 ◽  
Author(s):  
Naci Topaloğlu ◽  
Şule Yıldırım ◽  
Mustafa Tekin ◽  
Nazan Kaymaz ◽  
Funda Tütüncüler ◽  
...  
Keyword(s):  
Cord Blood ◽  
Mean Platelet Volume ◽  
Platelet Volume ◽  
Ischemia Modified Albumin ◽  
Infants Of Diabetic Mothers ◽  
Diabetic Mothers

Levels of Glucagon-like Peptide 1 are Decreased in Macrosomic Neonates from Non-Diabetic Mothers

2018 ◽  
Vol 223 (01) ◽  
pp. 48-53
Author(s):  
Ayla Aktulay ◽  
Yaprak Engin-Ustun ◽  
Ozlem Yasar ◽  
Canan Yilmaz ◽  
Salim Erkaya ◽  
...  
Keyword(s):  
Birth Weight ◽  
Cord Blood ◽  
Gestational Age ◽  
Binary Logistic Regression ◽  
Control Group ◽  
Binary Logistic Regression Analysis ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Maternal Bmi ◽  
Diabetic Mothers

AbstractGlucagon-like peptide 1 (GLP-1) is a gut-derived peptide with insulin-like effects. Our aim was to analyze cord blood GLP-1 levels of macrosomic and appropriate-gestational-age (AGA) neonates from non-diabetic mothers. A case-control study was conducted with 22 term macrosomic neonates (birth weight≥4000 g) and 22 AGA (birth weight>10th percentile and<4000 g) pregnancies. Cord blood GLP-1 levels of neonates were measured. There were no significant differences in maternal age, gestational age and gravida between the 2 groups. Umbilical cord blood GLP-1 levels were significantly lower in macrosomic neonates (6.9±2.9 pg/mL) compared with control group (10.3±3.7 pg/mL) (p=0.002). Binary logistic regression analysis showed only the maternal BMI to be an independent statistically significant predictor of macrosomia (odds ratio=2.459; 95% CI, 1.170–5.170; P=0.018). The results of our study revealed decreased GLP-1 levels in macrosomic neonates, and maternal BMI was an independent predictor of macrosomia.

A Randomized Controlled Trial of Intact Cord Milking versus Immediate Cord Clamping in Term Infants Born by Elective Cesarean Section

2019 ◽  
Author(s):  
Vincenzo Zanardo ◽  
Pietro Guerrini ◽  
Lorenzo Severino ◽  
Alphonse Simbi ◽  
Matteo Parotto ◽  
...  
Keyword(s):  
Body Weight ◽  
Cord Blood ◽  
Cesarean Delivery ◽  
Controlled Trial ◽  
Elective Cesarean Section ◽  
Safe Procedure ◽  
Elective Cesarean Delivery ◽  
Clinical Trial Registration ◽  
Cord Clamping ◽  
Elective Cesarean

Abstract Objective We evaluated whether intact umbilical cord milking (UCM) is more effective than immediate cord clamping (ICC) in enhancing placental transfusion after elective cesarean delivery. Study Design In a randomized trial, volume of placental transfusion was assessed by Δ hematocrit (Hct) between neonatal cord blood and capillary heel blood at 48 hours of age, corrected for the change in body weight. Results There were no significant differences in cord blood mean Hct values at birth (UCM, 44.5 ± 4.8 vs. ICC, 44.9 ± 4.2%, p = 0.74). Conversely, at 48 hours of age, the UCM group had significantly higher capillary heel Hct values (UCM, 53.7 ± 5.9 vs. ICC, 49.8 ± 4.6%, p < 0.001), supporting a higher placental transfusion volume (Δ Hct, UCM 9.2 ± 5.2 vs. ICC 4.8 ± 4.7, p < 0.001), despite comparable neonatal body weight decrease (UCM, −7.3 vs. ICC, −6.8%, p = 0.77). Conclusion Higher Δ Hct between cord blood at birth and capillary heel blood at 48 hours of age, corrected for the change in body weight, suggests that intact UCM is an efficacious and safe procedure to enhance placental transfusion among neonates born via elective cesarean delivery. Clinical Trial Registration ClinicalTrials.gov, www.clinicaltrials.gov, NCT03668782.

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