A Fabry-Pérot cavity coupled surface plasmon photodiode for electrical biomolecular sensing

Abstract Surface plasmon resonance (SPR) is a well-established technology for real-time highly sensitive label-free detection and measurement of binding kinetics between biological samples. A common drawback, however, of SPR detection is the necessity for far field angular resolved measurement of specular reflection, which increases the size as well as requiring precise calibration of the optical apparatus. Here we present an alternative optoelectronic approach in which the plasmonic sensor is integrated within a photovoltaic cell. Incident light generates an electronic signal that is sensitive to the refractive index (RI) of a solution via interaction with the plasmon. The photogenerated current is enhanced due to the coupling of the plasmon mode with Fabry-Pérot (FP) modes in the absorbing layer of the photovoltaic cell. The near field electrical detection of SPR we demonstrate will enable a new generation of cheap, compact and high throughput biosensors.

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A Fabry-Pérot cavity coupled surface plasmon photodiode for electrical biomolecular sensing

Nature Communications ◽

10.1038/s41467-021-26652-7 ◽

2021 ◽

Vol 12 (1) ◽

Author(s):

Giles Allison ◽

Amrita Kumar Sana ◽

Yuta Ogawa ◽

Hidemi Kato ◽

Kosei Ueno ◽

...

Keyword(s):

Surface Plasmon Resonance ◽

Surface Plasmon ◽

Plasmon Resonance ◽

Specular Reflection ◽

Incident Light ◽

Photovoltaic Cell ◽

Label Free ◽

Plasmonic Sensor ◽

Label Free Detection ◽

Fabry Perot

AbstractSurface plasmon resonance is a well-established technology for real-time highly sensitive label-free detection and measurement of binding kinetics between biological samples. A common drawback, however, of surface plasmon resonance detection is the necessity for far field angular resolved measurement of specular reflection, which increases the size as well as requiring precise calibration of the optical apparatus. Here we present an alternative optoelectronic approach in which the plasmonic sensor is integrated within a photovoltaic cell. Incident light generates an electronic signal that is sensitive to the refractive index of a solution via interaction with the plasmon. The photogenerated current is enhanced due to the coupling of the plasmon mode with Fabry-Pérot modes in the absorbing layer of the photovoltaic cell. The near field electrical detection of surface plasmon resonance we demonstrate will enable a next generation of cheap, compact and high throughput biosensors.

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Quantitative Surface Plasmon Interferometry via Upconversion Photoluminescence Mapping

Research ◽

10.34133/2019/8304824 ◽

2019 ◽

Vol 2019 ◽

pp. 1-12 ◽

Cited By ~ 1

Author(s):

Anxiang Yin ◽

Hao Jing ◽

Zhan Wu ◽

Qiyuan He ◽

Yiliu Wang ◽

...

Keyword(s):

Surface Plasmon ◽

Incident Light ◽

Near Field ◽

Specific Antigen ◽

Far Field ◽

Label Free ◽

Environment Change ◽

Label Free Detection ◽

Rare Earth Doped

Direct far-field visualization and characterization of surface plasmon polaritons (SPPs) are of great importance for fundamental studies and technological applications. To probe the evanescently confined plasmon fields, one usually requires advanced near-field techniques, which is typically not applicable for real-time, high-throughput detecting or mapping of SPPs in complicated environments. Here, we report the utilization of rare-earth-doped nanoparticles to quantitatively upconvert invisible, evanescently confined SPPs into visible photoluminescence emissions for direct far-field visualization of SPPs in a complicated environment. The observed interference fringes between the SPPs and the coherent incident light at the metal surface provide a quantitative measurement of the SPP wavelength and the SPP propagating length and the local dielectric environments. It thus creates a new signaling pathway to sensitively transduce the local dielectric environment change into interference periodicity variation, enabling a new design of directly measurable, spectrometer-free optical rulers for rapid, ultrasensitive label-free detection of various biomolecules, including streptavidin and prostate-specific antigen, down to the femtomolar level.

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A sandwich-like strategy for the label-free detection of oligonucleotides by surface plasmon fluorescence spectroscopy (SPFS)

The Analyst ◽

10.1039/c6an01129b ◽

2016 ◽

Vol 141 (20) ◽

pp. 5784-5791 ◽

Cited By ~ 4

Author(s):

Qiang Su ◽

Gilbert Nöll

Keyword(s):

Fluorescence Spectroscopy ◽

Surface Plasmon ◽

Molecular Beacons ◽

Label Free ◽

Background Fluorescence ◽

Detection Strategy ◽

Cutting Surface ◽

Label Free Detection ◽

Lower Background

Cutting surface-bound optical molecular beacons results in a sandwich-like detection strategy with lower background fluorescence.

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Trends in SPR Cytometry: Advances in Label-Free Detection of Cell Parameters

Biosensors ◽

10.3390/bios8040102 ◽

2018 ◽

Vol 8 (4) ◽

pp. 102 ◽

Cited By ~ 8

Author(s):

Richard Schasfoort ◽

Fikri Abali ◽

Ivan Stojanovic ◽

Gestur Vidarsson ◽

Leon Terstappen

Keyword(s):

Surface Plasmon Resonance ◽

Surface Plasmon ◽

Plasmon Resonance ◽

Mammalian Cells ◽

Living Cells ◽

Label Free ◽

Intact Cells ◽

Cell Parameters ◽

Spr Imaging ◽

Label Free Detection

SPR cytometry entails the measurement of parameters from intact cells using the surface plasmon resonance (SPR) phenomenon. Specific real-time and label-free binding of living cells to sensor surfaces has been made possible through the availability of SPR imaging (SPRi) instruments and researchers have started to explore its potential in the last decade. Here we will discuss the mechanisms of detection and additionally describe the problems and issues of mammalian cells in SPR biosensing, both from our own experience and with information from the literature. Finally, we build on the knowledge and applications that has already materialized in this field to give a forecast of some exciting applications for SPRi cytometry.

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