Effect of Poor Glycemic Control Incognitive Performance Inthe Elderly With Type 2 Diabetes Mellitus: The Mexican Health and Aging Study

Abstract Background Cognitive impairment is twice more frequent in elderly with type 2 diabetes mellitus (DM). This study was conducted to determine the association between glycemic control and cognitive performance among community-dwelling elderly persons in Mexico. Methods Cross-sectional study conducted in individuals aged 60 years or elderly participating in the 2012 Mexican Health and Aging Study. Type 2 DM participants were classified in 3 groups according to their glycated hemoglobin levels (HbA1c): <7% (intensive control), 7-7.9% (standard control) or ≥ 8% (poor control), and cognitive performance: low (CCCE ≤ 44 points), intermediate (44.1-59.52 points), or high (≥ 59.53 points). Multinomial logistic regression models were constructed to determine this association. Results Out of 946 subjects, 216 were selected. Subjects in the low cognitive performance group were older (69.7 ± 6.6 vs 65.86 ± 5.18 years, p < .001) and had a lower educational level (2.5 ± 2.6 vs 7.44 ± 4.15 years, p < .000) when compared to the high cognitive performance participants. HbA1c ≥8% was associated with having low (OR 3.17, 95% CI 1.17–8.60, p = .024), and intermediate (OR 3.23, 95% CI 1.27–8.20, p = .014) cognitive performance; this trend was not found for HbA1c 7.0-7.9% group. Conclusions Glycemic control with a HbA1c ≥ 8% was associated with worse cognitive performance.

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Effect of poor glycemic control in cognitive performance in the elderly with type 2 diabetes mellitus: The Mexican Health and Aging Study

BMC Geriatrics ◽

10.1186/s12877-020-01827-x ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Alberto J. Mimenza-Alvarado ◽

Gilberto A. Jiménez-Castillo ◽

Sara G. Yeverino-Castro ◽

Abel J. Barragán-Berlanga ◽

Mario U. Pérez-Zepeda ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Glycemic Control ◽

Cognitive Performance ◽

Community Dwelling ◽

Poor Glycemic Control ◽

Elderly Persons ◽

Aging Study

Abstract Background Cognitive impairment is twice more frequent in elderly with type 2 diabetes mellitus (DM). This study was conducted to determine the association between glycemic control and cognitive performance among community-dwelling elderly persons in Mexico. Methods Cross-sectional study conducted in individuals aged 60 years or elderly participating in the 2012 Mexican Health and Aging Study. Type 2 DM participants were classified in 3 groups according to their glycated hemoglobin levels (HbA1c): < 7% (intensive control), 7–7.9% (standard control) or ≥ 8% (poor control), and cognitive performance: low (CCCE ≤44 points), intermediate (44.1–59.52 points), or high (≥59.53 points). Multinomial logistic regression models were constructed to determine this association. Results Two hundred sixteen community-dwelling adults aged 60 and older with type 2 diabetes were selected. Subjects in the low cognitive performance group were older (69.7 ± 6.6 vs 65.86 ± 5.18 years, p < .001) and had a lower educational level (2.5 ± 2.6 vs 7.44 ± 4.15 years, p < .000) when compared to the high cognitive performance participants. HbA1c ≥ 8% was associated with having low (Odds Ratio (OR) 3.17, 95% CI 1.17–8.60, p = .024), and intermediate (OR 3.23, 95% CI 1.27–8.20, p = .014) cognitive performance; this trend was not found for HbA1c 7.0–7.9% group. The multinomial regression analysis showed that the presence of HbA1c ≥ 8% (poor glycemic control) was associated with low (OR 3.17, 95% CI = 1.17–8.60, p = .024), and intermediate (OR 3.23, 95% CI = 1.27–8.20, p = .014) cognitive performance. After adjusting for confounding variables. Conclusions Glycemic control with a HbA1c ≥ 8% was associated with worse cognitive performance.

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Effect of poor glycemic control in Cognitive Performance in the elderly with type 2 diabetes mellitus: The Mexican Health and Aging Study

10.21203/rs.3.rs-44732/v2 ◽

2020 ◽

Author(s):

Alberto J Mimenza-Aguilar ◽

Gilberto A Jimenez-Castillo ◽

Sara G Yeverino-Castro ◽

Abel Barragán-Berlanga ◽

Mario U Perez-Zepeda ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Glycemic Control ◽

Cognitive Performance ◽

Community Dwelling ◽

Poor Glycemic Control ◽

Elderly Persons ◽

Aging Study

Abstract BackgroundCognitive impairment is twice more frequent in elderly with type 2 diabetes mellitus (DM). This study was conducted to determine the association between glycemic control and cognitive performance among community-dwelling elderly persons in Mexico.MethodsCross-sectional study conducted in individuals aged 60 years or elderly participating in the 2012 Mexican Health and Aging Study. Type 2 DM participants were classified in 3 groups according to their glycated hemoglobin levels (HbA1c): <7% (intensive control), 7-7.9% (standard control) or ≥ 8% (poor control), and cognitive performance: low (CCCE ≤44 points), intermediate (44.1-59.52 points), or high (≥59.53 points). Multinomial logistic regression models were constructed to determine this association.Results216 community-dwelling adults aged 60 and older with type 2 diabetes were selected. Subjects in the low cognitive performance group were older (69.7 ± 6.6 vs 65.86 ± 5.18 years, p <.001) and had a lower educational level (2.5 ± 2.6 vs 7.44 ± 4.15 years, p <.000) when compared to the high cognitive performance participants. HbA1c ≥8% was associated with having low (Odds Ratio (OR) 3.17, 95% CI 1.17-8.60, p=.024), and intermediate (OR 3.23, 95% CI 1.27-8.20, p=.014) cognitive performance; this trend was not found for HbA1c 7.0-7.9% group.The multinomial regression analysis showed that the presence of HbA1c ≥8% (poor glycemic control) was associated with low (OR 3.17, 95% CI = 1.17-8.60, p=.024), and intermediate (OR 3.23, 95% CI = 1.27-8.20, p=.014) cognitive performance. After adjusting for confounding variables.ConclusionsGlycemic control with a HbA1c ≥ 8% was associated with worse cognitive performance.

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Glycemic control and disability-free survival in hypoglycemic agent-treated community-dwelling older patients with type 2 diabetes mellitus

Geriatrics and Gerontology International ◽

10.1111/ggi.12975 ◽

2017 ◽

Vol 17 (11) ◽

pp. 1858-1865 ◽

Cited By ~ 5

Author(s):

Takuro Morita ◽

Tazuo Okuno ◽

Taroh Himeno ◽

Keisuke Watanabe ◽

Kumie Nakajima ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Glycemic Control ◽

Older Patients ◽

Community Dwelling ◽

Free Survival ◽

Hypoglycemic Agent

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Metformin Pharmacogenetics: Effects of SLC22A1, SLC22A2, and SLC22A3 Polymorphisms on Glycemic Control and HbA1c Levels

Journal of Personalized Medicine ◽

10.3390/jpm9010017 ◽

2019 ◽

Vol 9 (1) ◽

pp. 17 ◽

Cited By ~ 6

Author(s):

Laith AL-Eitan ◽

Basima Almomani ◽

Ahmad Nassar ◽

Barakat Elsaqa ◽

Nesreen Saadeh

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Glycemic Control ◽

Multinomial Logistic Regression ◽

Incidence Rates ◽

P Value ◽

Nucleotide Polymorphisms ◽

Hba1c Levels

Type 2 diabetes mellitus (T2DM) constitutes a major portion of Jordan’s disease burden, and incidence rates are rising at a rapid rate. Due to variability in the drug’s response between ethnic groups, it is imperative that the pharmacogenetics of metformin be investigated in the Jordanian population. The objective of this study was to investigate the relationship between twenty-one single nucleotide polymorphisms (SNPs) in the SLC22A1, SLC22A2, and SLC22A3 genes and their effects on metformin pharmacogenetics in Jordanian patients diagnosed with type 2 diabetes mellitus. Blood samples were collected from 212 Jordanian diabetics who fulfilled the inclusion criteria, which were then used in SNP genotyping and determination of HbA1c levels. The rs12194182 SNP in the SLC22A3 gene was found to have a significant association (p < 0.05) with lower mean HbA1c levels, and this association more pronounced in patients with the CC genotype (i.e., p-value was significant before correcting for multiple testing). Moreover, the multinomial logistic regression analysis showed that SNP genotypes within the SLC22A1, SLC22A2, and SLC22A3 genes, body mass index (BMI) and age of diagnosis were significantly associated with glycemic control (p < 0.05). The results of this study can be used to predict response to metformin and other classes of T2DM drugs, making treatment more individualized and resulting in better clinical outcomes.

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