Retinal Nerve Fiber Layer Analysis in Children with Migraine with and without Aura using Optical Coherence Tomography: A Case-Control Study

2021 ◽  
Author(s):  
Daniela Rego-Lorca ◽  
Barbara Burgos-Blasco ◽  
Cristina Gines-Gallego ◽  
Mario Carrasco-Lopez-Brea ◽  
Maria Teresa de Santos-Moreno ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Case Control Study ◽  
Case Control ◽  
Healthy Controls ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Rnfl Thickness ◽  
Control Study

Abstract PurposeTo evaluate retinal nerve fiber layer (RNFL) thickness in children with migraine, with and without aura, compared to healthy controls using optical coherence tomography (OCT).MethodsCross-sectional case-control study. Peripapillary RNFL thickness was measured using optical coherence tomography (OCT) in a group of children diagnosed with migraine with aura (MwA) (n=9) and migraine without aura (MwoA) (n=11), and in a group of healthy controls (n=20). Age, sex, duration of migraine in months, number of episodes per month, duration of episodes in hours, and use of prophylactic treatment with magnesium were recorded. Groups were matched by age, sex and refractive error. All participants underwent complete neurological and pediatric examination.ResultsNo significant differences were found when comparing all migraine patients with healthy controls. However, children with MwA showed statistically significant reductions in RNFL thickness in the temporal (mean difference 7.83; CI95% 0.52-15.14, P=0.027) and inferior-temporal (mean difference 16.06; CI95% 1.95-30.16, P=0.027) sectors compared to patients with MwoA. None of the other sectors showed statistically significant differences between groups (all P>0.05).ConclusionAura in migraine may be associated with a RNFL thickness decrease in children.

scholarly journals Nerve fiber layer in glaucomatous hemifield loss: a case-control study with time- and spectral-domain optical coherence tomography

2012 ◽  
Vol 75 (1) ◽  
pp. 53-58 ◽  
Author(s):  
Alexandre Soares Castro Reis ◽  
Kallene Summer Moreira Vidal ◽  
André Carvalho Kreuz ◽  
Mario Luiz Ribeiro Monteiro ◽  
Marcelo Teixeira Nicolela ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Nerve Fiber ◽  
Case Control Study ◽  
Case Control ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Control Study ◽  
Hemifield Loss

Peripapillary Retinal Nerve Fiber Layer Changes in Patients with Diabetes Mellitus: A Case-control Study

2020 ◽  
Vol 35 (4) ◽  
pp. 257-260
Author(s):  
Irini Chatziralli ◽  
Aristotelis Karamaounas ◽  
Eleni Dimitriou ◽  
Dimitrios Kazantzis ◽  
George Theodossiadis ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Case Control Study ◽  
Case Control ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Patients With Diabetes ◽  
Control Study ◽  
Retinal Nerve Fiber

Retinal Nerve Fiber Layer Imaging with Spectral-domain Optical Coherence Tomography (OCT)—A Review of the Cirrus HD-OCT

2011 ◽  
Vol 04 (01) ◽  
pp. 12 ◽  
Author(s):  
Elaine To ◽  
Dennis Lam ◽  
Christopher Kai-shun Leung ◽  
◽  
◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Spectral Domain Oct ◽  
Rnfl Thickness ◽  
Retinal Nerve Fiber

High-speed, high-resolution imaging of the retinal nerve fiber layer (RNFL) with spectral-domain optical coherence tomography (OCT) has become an essential tool for evaluation of glaucoma. The Cirrus HD-OCT (Carl Zeiss Meditec, Inc. Dublin, CA) is a spectral-domain OCT that provides visualization of the distribution pattern and measurement of RNFL abnormalities in a 6x6mm2optic disc region. Analysis of the RNFL thickness deviation map—a color-coded map displaying areas of RNFL abnormalities—detects glaucoma with high sensitivity and specificity. Trend analysis of average and sectorial RNFL thicknesses, and event analysis of the RNFL thickness maps and the RNFL thickness profiles can be used to detect and follow diffuse and focal RNFL progression. RNFL measurement with spectral-domain OCT could provide important information for use in formulating treatment plans and evaluating disease prognosis in the management of glaucoma.

scholarly journals A comparison of retinal nerve fiber layer (RNFL) thickness obtained with frequency and time domain optical coherence tomography (OCT)

2009 ◽  
Vol 17 (5) ◽  
pp. 3997 ◽  
Author(s):  
Donald C. Hood ◽  
Ali S. Raza ◽  
Kristine Y. Kay ◽  
Shlomit F. Sandler ◽  
Daiyan Xin ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Time Domain ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Rnfl Thickness ◽  
Retinal Nerve Fiber

A Study of Retinal Nerve Fiber Layer Thickness by using Spectral Domain Optical Coherence Tomography in Older Adults with Diabetes Mellitus

2019 ◽  
Vol 15 (1) ◽  
pp. 17-21
Author(s):  
Devendra Sharma ◽  
Arvind Chauhan ◽  
Avisha Mathur
Keyword(s):  
Optical Coherence Tomography ◽  
Diabetic Retinopathy ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Macular Thickness ◽  
Spectral Domain ◽  
Diabetic Patients ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Rnfl Thickness

Introduction: Peripapillary retinal nerve fiber layer (RNFL) thinning occurs in the diabetic patients earlier than the detectable diabetic retinopathy. We conducted this study to evaluate the RNFL thickness and macular thickness in elderly diabetic patients using optical coherence tomography in comparison to healthy controls. Material and methods: One fifty study participants were divided in 3 groups (50 each): normal subjects, patients with diabetes with no detectable diabetic retinopathy (NDR) and patients with diabetic retinopathy (DR) of differing severity. The RNFL thickness and macular thickness was measured using spectral-domain optical coherence tomography (SD OCT). Results: The RNFL thickness around the optic disc differed significantly among all the 3 groups and tended to become thinner as the patient develops DR in elderly subjects. The mean, superior-temporal and upper nasal peripapillary RNFL thickness differed among all the 3 groups. We observed that, mean superior, temporal, inferior and nasal RNFL tended to be thinner as the patient develops DR. Conclusion: The RNFL thickness, macular thickness and ganglion cell complex thinning differed significantly between the healthy group and diabetic group without clinical DR. The RNFL thinning (measured by Spectral-domain OCT) is an early neurodegenerative ocular change in diabetic patients even before onset of diabetic retinopathy.

scholarly journals Time-Domain and Spectral-Domain Optical Coherence Tomography of Retinal Nerve Fiber Layer in MS Patients and Healthy Controls

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Alex P. Lange ◽  
Reza Sadjadi ◽  
Jameelah Saeedi ◽  
Janette Lindley ◽  
Fiona Costello ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Time Domain ◽  
Disease Duration ◽  
Healthy Controls ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
History Of

Objective. The aim of this study was to compare retinal nerve fiber layer thickness (RNFLT) between spectral-domain (SD-) and time-domain optical coherence tomography (TD-OCT) in MS patients and healthy controls (HC). Furthermore, RNFLT between MS eyes with and without optic neuritis (ON) and HC should be explored. Finally, the relationship between RNFLT, disease duration, EDSS, and disease modifying therapy (DMT) should be established.Design. Prospective, cross-sectional study.Participants. 28 MS patients and 35 HC.Methods. Both groups underwent TD- and SD-OCT measurements. RFNLT was correlated between the two machines and between MS eyes with and without ON and HC. Furthermore, RNFLT was correlated to disease duration, EDSS and DMT.Results. A strong correlation (Pearson’sr=0.921,P<0.001), but a statistically significant difference of 2 μm (P<0.001), was found between the two devices. RNFLT was significantly different between MS eyes with history of ON (mean RFNLT (SD) 72.21 μm (15.83 μm)), MS eyes without history of ON 93.03 μm (14.25 μm), and HC 99.07 μm (7.23 μm) (P<0.001).Conclusions. The measurements between different generation of OCT machines are not interchangeable, which should be taken into account if comparing results between different machines and switching OCT machine in longitudinal studies.

The Effect of Peripapillary Detachment on Retinal Nerve Fiber Layer Measurement by Spectral Domain Optical Coherence Tomography in High Myopia

2015 ◽  
Vol 233 (3-4) ◽  
pp. 209-215 ◽  
Author(s):  
Radua Kamal Salah ◽  
Maria José Morillo-Sánchez ◽  
Antonio García-Ben ◽  
Francisca Rius-Diaz ◽  
Ángel Cilveti-Puche ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Rnfl Thickness ◽  
Group A ◽  
Group B ◽  
Retinal Nerve Fiber

Purpose: The aim of this study was to investigate the repercussions of peripapillary detachment on retinal nerve fiber layer (RNFL) measurements in patients with highly myopic eyes. Methods: A total of 244 highly myopic eyes underwent a complete ophthalmologic examination that included optical coherence tomography (OCT) to analyze the peripapillary retina and RNFL thickness. Based on the OCT findings, patients were grouped as follows: group A: eyes with a peripapillary intrachoroidal cavitation (PIC); group B: eyes with a peripapillary neurosensory retinal detachment (PNRD), and group C: eyes without a peripapillary detachment. Results: The OCT scans identified a peripapillary detachment in 42 eyes (17.21%). Out of these 42 eyes, 22 showed PIC (52.38%; group A) and 20 had a PNRD (47.62%; group B). The average overall RNFL thickness in groups A, B and C was 74.11 ± 10.88, 88.26 ± 25.72 and 72.75 ± 16.24 μm, respectively (ANOVA test, p = 0.00). Conclusion: Eyes with a PNRD had a significantly greater average RFNL thickness than those without peripapillary detachment in pathologic myopia due to a misidentification of the outer profile of the RFNL. This fact makes the interpretation of RNFL thickness in highly myopic eyes more challenging.

scholarly journals Assessment of retinal nerve fiber layer thickness in migraine patients measured with optical coherence tomography

2018 ◽  
Vol 5 (1) ◽  
pp. 21
Author(s):  
Alireza Khosravi ◽  
Kourosh Shahraki ◽  
Afsaneh Moghaddam
Keyword(s):  
Optical Coherence Tomography ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Control Group ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Rnfl Thickness ◽  
Standard Value ◽  
Retinal Nerve Fiber

Background: Headache is one of the most disturbing symptoms with common neurological signs. Variations in optic nerve perfusion quality or retinal microcirculation may end up in peripapillary retinal nerve fiber layer (RNFL) thickness in patients with migraine. The aim of this study was to investigate the retinal nerve fiber layer (RNFL) thickness in patients with migraine.Methods: This cross-sectional study was conducted by including thirty patients diagnosed with migraine and thirty normal individuals. Patients were evaluated in groups including migraine with and without aura and controls. Retinal nerve fiber layer (RNFL) thickness was measured using stratus optical coherence tomography (OCT) and then was compared in case and control groups. All data were analyzed using SPSS software version 16.Results: RNFL thickness was significantly thinner in migraine patients compared to the control group. Symmetricity of RNFL showed significantly reduction in patients with migraine compared to standard value (95% vs 68%). Comparison of NRR area between patients and standard value showed significantly reduced values (P=0.0001). Mean value of optic disc area showed significantly reduced value compared to standard value about 2.35 m2 (P=0.0001).Conclusions: This study suggests that migraine leads to a reduction in the peripapillary RNFL thickness and to thinning in choroidal structures. These findings can be explained by a chronic ischemic insult related to migraine pathogenic mechanisms.

Association of Retinal Nerve Fiber Layer (RNFL) Thickness with Smoking Using Optical Coherence Tomography (OCT) in Pakistani Population

2020 ◽  
Keyword(s):  
Optical Coherence Tomography ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Rnfl Thickness ◽  
History Of ◽  
Group B ◽  
Retinal Nerve Fiber

Background: Smoking has multisystem effects on human body due to hypoxia and systemic inflammation, which it produces. This contributory effect is observed in ocular tissues as well. The aim of the study was to evaluate retinal nerve fiber layer (RNFL) thickness in healthy individuals with a history of smoking, using optical coherence tomography (OCT). Methods: Patients healthy eyes n=300 were examined. Two groups were made; Group A with history of smoking (n=50) and Group B with no history of smoking (n=250). Subjects with a history of diabetes, hypertension, raised intra ocular pressure (IOP >21 mmHg), any neurological disease or family history of glaucoma were excluded from the study. Independent t-test was used to assess the thickness variation with smoking status. ANOVA was used to analyze the differences in both groups. p value <0.05 was taken as significant. Results: The mean retinal nerve fiber layer (RNFL) thickness was found to be 96.44 ± 9.32 μm in Group A eyes. It was found to be significantly increased (p=0.02) in Group B 99.54 ± 9.32 μm. The mean RNFL thickness 93.52 ± 8.60 μm in smokers with history of more than 10 years was found decreased compared to the thickness 98.66 ± 3.96 μm in those with history of smoking less than 10 years. Conclusion: Retinal nerve fiber layer (RNFL) was found to be decreased in subjects with positive history of smoking. This difference signifies that smoking is associated with ocular pathologies. Future protocols may be included in screening for RNFL thickness in smokers for early detection and prevention of optical diseases. Keywords: Smoking; Retina; Retinal Nerve Fiber Layer (RNFL); Retinal Damage; Optical Coherence Tomography (OCT).

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