scholarly journals Evaluation of Symmetric Dimethylarginine and Doppler Ultrasonography in the Diagnosis of Gentamicin-Induced Acute Kidney Injury in Dogs

2021 ◽  
Author(s):  
Youssef Mohamed Yassein Elgazzar ◽  
Mohamed M. Ghanem ◽  
Yassein M. Abdel-Raof ◽  
Mohamed.M.M. Kandiel ◽  
Mahmoud Helal
Keyword(s):  
Acute Kidney Injury ◽  
Doppler Ultrasonography ◽  
Left Kidney ◽  
Resistive Index ◽  
Kidney Injury ◽  
Significant Morbidity ◽  
Serum Urea ◽  
Symmetric Dimethylarginine ◽  
Sodium Calcium ◽  
Gentamicin Sulphate

Abstract Acute kidney injury is a common problem in dogs and is associated with significant morbidity and mortality, so this study was aimed to evaluate Symmetric dimethylarginine (SDMA), Doppler ultrasonography including resistive index (RI) in the diagnosis of acute kidney injury in dogs. Ten healthy mongrel dogs were injected with gentamicin sulphate 10% at the dose of 30 mg/ kg body weight daily for ten days for induction of acute kidney injury. Clinical, Biochemical, Ultrasonographic, Doppler ultrasonographic examinations, and urinalysis were performed for all dogs on zero day before induction, on the 5th day, and the 10th day of induction. The results of the current study showed a significant increase in plasma level of SDMA, serum urea, creatinine, phosphorus, potassium, and a significant decrease in serum sodium, calcium, and chloride on the 5th day and 10th day of induction, there was an increase in renal cortical echogenicity of right and left kidney compared to adjacent liver and spleen, respectively. RI value showed a significant increase on the 5th day and 10th day of induction. This study showed that SDMA is a sensitive, and promising biomarker for diagnosis of acute kidney injury in dogs compared to routine biomarkers also, the RI of Doppler ultrasonography is useful for early identifying acute kidney injury when the only observable change is an increase in cortical echogenicity.

scholarly journals Doppler resistive index to reflect risk of acute kidney injury after major abdominal surgery: A prospective observational trial

2019 ◽  
Vol 63 (7) ◽  
pp. 551 ◽  
Author(s):  
Satyen Parida ◽  
Kavitha Muthukrishnan ◽  
SDeepak Barathi ◽  
AshokShankar Badhe ◽  
SandeepKumar Mishra
Keyword(s):  
Acute Kidney Injury ◽  
Abdominal Surgery ◽  
Resistive Index ◽  
Kidney Injury ◽  
Major Abdominal Surgery ◽  
Observational Trial

scholarly journals Bedside Renal Doppler Ultrasonography and Acute Kidney Injury after TAVR

2020 ◽  
Vol 9 (4) ◽  
pp. 905
Author(s):  
Marilou Peillex ◽  
Benjamin Marchandot ◽  
Sophie Bayer ◽  
Eric Prinz ◽  
Kensuke Matsushita ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Severe Aortic Stenosis ◽  
Resistive Index ◽  
Kidney Injury ◽  
Right Atrial ◽  
Renal Resistive Index ◽  
Serum Cystatin C ◽  
Systemic Hemodynamic ◽  
Dismal Prognosis ◽  
Renal Doppler

Acute kidney injury (AKI) following transcatheter aortic valve replacement (TAVR) is associated with a dismal prognosis. Elevated renal resistive index (RRI), through renal Doppler ultrasound (RDU) evaluation, has been associated with AKI development and increased systemic arterial stiffness. Our pilot study aimed to investigate the performance of Doppler based RRI to predict AKI and outcomes in TAVR patients. From May 2018 to May 2019, 100 patients with severe aortic stenosis were prospectively enrolled for TAVR and concomitant RDU evaluation at our institution (Nouvel Hôpital Civil, Strasbourg University, France). AKI by serum Creatinine (sCr-AKI) was defined according to the VARC-2 definition and AKI by serum Cystatin C (sCyC-AKI) was defined as an sCyC increase of greater than 15% with baseline value. Concomitant RRI measurements as well as renal and systemic hemodynamic parameters were recorded before, one day, and three days after TAVR. It was found that 10% of patients presented with AKIsCr and AKIsCyC. The whole cohort showed higher baseline RRI values (0.76 ± 0.7) compared to normal known and accepted values. AKIsCyC had significant higher post-procedural RRI one day (Day 1) after TAVR (0.83 ± 0.1 vs. 0.77 ± 0.6, CI 95%, p = 0.005). AUC for AKIsCyC was 0.766 and a RRI cut-off value of ≥ 0.795 had the most optimal sensitivity/specificity (80/62%) combination. By univariate Cox analysis, Mehran Risk Score, higher baseline right atrial pressure at baseline >0.8 RRI values one day after TAVR (HR 6.5 (95% CI 1.3–32.9; p = 0.021) but not RRI at baseline were significant predictors of AKIsCyC. Importantly, no significant impact of baseline biological parameters, renal or systemic parameters could be demonstrated. Doppler-based RRI can be helpful for the non-invasive assessment of AKI development after TAVR.

scholarly journals Serum symmetric dimethylarginine concentration in healthy horses and horses with acute kidney injury

2020 ◽  
Vol 16 (1) ◽  
Author(s):  
Natalia Siwinska ◽  
Agnieszka Zak ◽  
Malwina Slowikowska ◽  
Artur Niedzwiedz ◽  
Urszula Paslawska
Keyword(s):  
Acute Kidney Injury ◽  
Body Weight ◽  
Serum Creatinine ◽  
Healthy Adult ◽  
Small Animal ◽  
Kidney Injury ◽  
Blood Analysis ◽  
Advanced Degree ◽  
Kidney Dysfunction ◽  
Symmetric Dimethylarginine

Abstract Background There are limited options to diagnose acute kidney injury (AKI) in horses. Symmetric dimethylarginine (SDMA) is routinely used in human and small animal medicine. The aim of this study was to assess serum SDMA concentrations in healthy horses and horses with AKI. The objective of this study was to evaluate the association of: 1) age, 2) sex, 3) body weight and 4) serum creatinine and urea levels on serum SDMA concentrations. Fifty-three healthy horses, including 17 foals (2–6 months of age) and 36 adult horses (3–29 years of age), and 23 horses with AKI were included in the study based on history, physical examination, blood analysis, urinalysis and an ultrasonographic examination of the urinary tract. Serum SDMA concentrations were measured using a non-species specific commercial ELISA test. Results In healthy adult horses, the value of SDMA was 0.53 ± 0.14 μmol/L. The value was higher in foals (1.5 ± 0.4 μmol/L, P < 0.001). Horses with AKI had significantly higher concentrations of SDMA compared to healthy horses (1.76 ± 1.05 μmol/L, P < 0.001). In the healthy adult horses, there was no association of sex, age or body weight on SDMA. However, a significant positive relationship was found between serum creatinine and SDMA concentrations. Conclusions Healthy adult horses had SDMA values similar to those of other species. Foals had higher SDMA values. Therefore, different reference values should be created for them. The study confirmed an increased SDMA in horses with AKI. This, as well as the low influence of extrarenal factors on the SDMA values, may confirm its usefulness in the diagnosis of kidney dysfunction. Higher SDMA values may also indicate a more advanced degree of kidney dysfunction. Further research is required to determine whether SDMA could be used to detect kidney dysfunction in the asymptomatic stage of AKI.

Acute kidney injury in the cancer patient

2015 ◽  
Author(s):  
Gilbert W. Moeckel ◽  
Veena Manjunath ◽  
Mark A. Perazella
Keyword(s):  
Acute Kidney Injury ◽  
Cancer Patients ◽  
Clinical Presentation ◽  
Kidney Tissue ◽  
Hospital Setting ◽  
Kidney Injury ◽  
Direct Effects ◽  
Significant Morbidity ◽  
Adequate Treatment ◽  
Kidney Lesions

Acute kidney injury in cancer patients is a complicated clinical condition associated with significant morbidity and mortality, especially in the hospital setting. Cancer patients may develop a variety of different kidney lesions that impair not only immediate survival but also limit the adequate treatment of the underlying malignant process. This poses a significant challenge for clinicians.The mechanisms that lead to acute kidney injury in cancer patients are similar to those seen in non-cancer patients. Moreover, significant morbidity is seen in association with chemotherapy, as well as through direct effects of the cancer on the kidney (i.e. obstruction, infiltrate).This chapter reviews the clinical presentation of the most common malignancies that affect the kidney, discusses their pathologic manifestations in kidney tissue, and reviews options for the clinical management of cancer patients with acute kidney injury.

Semiquantitative Power Doppler Ultrasound Score to Predict Acute Kidney Injury in Patients With Sepsis or Cardiac Failure: A Prospective Observational Study

2019 ◽  
Vol 36 (1) ◽  
pp. 115-122 ◽  
Author(s):  
Hai Jun Zhi ◽  
Jing Zhao ◽  
Shen Nie ◽  
Yun Jie Ma ◽  
Xiao Ya Cui ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Doppler Ultrasound ◽  
Cardiac Failure ◽  
Power Doppler ◽  
Resistive Index ◽  
Kidney Injury ◽  
Renal Resistive Index ◽  
Power Doppler Ultrasound ◽  
Predictive Values ◽  
Ultrasound Score

Background: Diagnosing acute kidney injury (AKI) stage 3 in critically ill patients may help physicians in making treatment decisions. This diagnosis relies chiefly on urinary output and serum creatinine, which may be of limited value. This study aimed to explore the diagnostic performance of renal resistive index (RRI) and semiquantitative power Doppler ultrasound (PDU) scores in predicting AKI stage 3 in patients with sepsis or cardiac failure. Methods: This study is a prospective observational study that included 83 patients (40 with sepsis and 43 with cardiac failure). Renal resistive index and semiquantitative PDU scores were measured within 6 hours following admission to the intensive care unit. Acute kidney injury was defined according to the criteria set by Kidney Disease Improving Global Outcomes. Results: The predictive values of RRI (area under the curve [AUC] = 0.772, 95% confidence interval [CI] = 0.658-0.886) and PDU score (AUC = 0.780, 95% CI = 0.667-0.892) were similar in all patients. Power Doppler ultrasound score (AUC = 0.910, 95% CI = 0.815-1.000) could effectively predict AKI stage 3 in the cardiac failure subgroup, and the optimal cutoff for this parameter was ≤ 1 (sensitivity = 87.5%, specificity = 92.6%, Youden index = 0.801, accuracy in our population = 90.7%). However, PDU scores (AUC = 0.620, 95% CI = 0.425-0.814) could not predict AKI stage 3 in the sepsis subgroup. The predictive values of RRI for AKI stage 3 in the cardiac failure (AUC = 0.820, 95% CI = 0.666-0.974) and sepsis (AUC = 0.724, 95% CI = 0.538-0.910) subgroups were similar. Conclusions: Power Doppler ultrasound scores could effectively predict AKI stage 3 in patients with cardiac failure but not in patients with sepsis. Renal resistive index is a poor predictor of AKI stage 3 in patients with sepsis or cardiac failure.

scholarly journals Intraoperative renal resistive index threshold as an acute kidney injury biomarker

2020 ◽  
Vol 61 ◽  
pp. 109626 ◽  
Author(s):  
Anne D. Cherry ◽  
Jennifer N. Hauck ◽  
Benjamin Y. Andrew ◽  
Yi-Ju Li ◽  
Jamie R. Privratsky ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Resistive Index ◽  
Kidney Injury ◽  
Renal Resistive Index
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