Vaginal microbiota and cytokine levels predict preterm delivery in Asian women

Abstract Background: Preterm birth (PTB) is the most common cause of neonatal morbidity and mortality worldwide. Approximately half of PTBs are linked with microbial etiologies, including pathologic changes to the vaginal microbiota, which vary according to ethnicity. Globally more than 50% of PTBs occur in Asia, but studies of the vaginal microbiome and its association with pregnancy outcomes in Asian women are lacking. This study aimed to characterize the vaginal microbiome and cytokine environment of 18 Karen and Burman pregnant women who delivered preterm and 36 matched controls delivering at full term. Results: Using 16S ribosomal RNA gene sequencing we identified a predictive vaginal microbiota signature for PTB that was detectable as early as the first trimester of pregnancy, characterized by higher levels of Prevotella buccalis , and lower levels of Lactobacillus crispatus and Finegoldia , accompanied by decreased levels of cytokines including IFNγ, IL-4 and TNFα. Conclusion: Our findings highlight new opportunities to predict PTB in Asian women in low-resource settings who are at highest risk of adverse outcomes from unexpected PTB, as well as in Burman/Karen ethnic minority groups in high-resource regions.

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Vaginal Microbiota and Cytokine Levels Predict Preterm Delivery in Asian Women

Frontiers in Cellular and Infection Microbiology ◽

10.3389/fcimb.2021.639665 ◽

2021 ◽

Vol 11 ◽

Author(s):

Manoj Kumar ◽

Selvasankar Murugesan ◽

Parul Singh ◽

Marwa Saadaoui ◽

Duaa Ahmed Elhag ◽

...

Keyword(s):

Preterm Birth ◽

Minority Groups ◽

Neonatal Morbidity ◽

First Trimester ◽

Adverse Outcomes ◽

Vaginal Microbiota ◽

Asian Women ◽

Vaginal Microbiome ◽

High Resource ◽

Cytokine Levels

Preterm birth (PTB) is the most common cause of neonatal morbidity and mortality worldwide. Approximately half of PTBs is linked with microbial etiologies, including pathologic changes to the vaginal microbiota, which vary according to ethnicity. Globally more than 50% of PTBs occur in Asia, but studies of the vaginal microbiome and its association with pregnancy outcomes in Asian women are lacking. This study aimed to longitudinally analyzed the vaginal microbiome and cytokine environment of 18 Karen and Burman pregnant women who delivered preterm and 36 matched controls delivering at full term. Using 16S ribosomal RNA gene sequencing we identified a predictive vaginal microbiota signature for PTB that was detectable as early as the first trimester of pregnancy, characterized by higher levels of Prevotella buccalis, and lower levels of Lactobacillus crispatus and Finegoldia, accompanied by decreased levels of cytokines including IFNγ, IL-4, and TNFα. Differences in the vaginal microbial diversity and local vaginal immune environment were associated with greater risk of preterm birth. Our findings highlight new opportunities to predict PTB in Asian women in low-resource settings who are at highest risk of adverse outcomes from unexpected PTB, as well as in Burman/Karen ethnic minority groups in high-resource regions.

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Impact of impaired vaginal microbiota on the mast cell population of the decidua in the first trimester of pregnancy

Voprosy ginekologii akušerstva i perinatologii ◽

10.20953/1726-1678-2019-2-76-82 ◽

2019 ◽

Vol 18 (2) ◽

pp. 76-82

Author(s):

E.V. En’kova ◽

◽

O.V. Khoperskaya ◽

O.V. Gayskaya ◽

D.A. Atyakshin ◽

...

Keyword(s):

Mast Cell ◽

Cell Population ◽

First Trimester ◽

Vaginal Microbiota ◽

First Trimester Of Pregnancy ◽

Mast Cell Population

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Maternal serum cytokine levels in women with hyperemesis gravidarum in the first trimester of pregnancy

Fertility and Sterility ◽

10.1016/s0015-0282(02)04699-x ◽

2003 ◽

Vol 79 (3) ◽

pp. 498-502 ◽

Cited By ~ 28

Author(s):

Petek Balkanli Kaplan ◽

Fatih Gücer ◽

N.Cenk Sayin ◽

Mahmut Yüksel ◽

M.Ali Yüce ◽

...

Keyword(s):

Hyperemesis Gravidarum ◽

First Trimester ◽

Maternal Serum ◽

Serum Cytokine ◽

Cytokine Levels ◽

First Trimester Of Pregnancy

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Detection of interleukin-6 and interleukin-8 in serum from women with recurrent spontaneous abortion

Baghdad Science Journal ◽

10.21123/bsj.7.3.1181-1186 ◽

2010 ◽

Vol 7 (3) ◽

pp. 1181-1186

Author(s):

Baghdad Science Journal

Keyword(s):

Serum Level ◽

Pregnant Women ◽

Spontaneous Abortion ◽

First Trimester ◽

Recurrent Spontaneous Abortion ◽

Sufficient Evidence ◽

Cytokine Levels ◽

Elisa Technique ◽

First Trimester Of Pregnancy

To investigate the role of IL-6 and IL-8 in the immune-regulatory mechanisms involved in the recurrent spontaneous abortion of the first trimester of pregnancy. Serum level of IL-6 and IL-8 were determined in 25 women of age (20-35) years who had a spontaneous abortion of unknown aetiology during the first trimester of pregnancy .They were compared with the corresponding levels of 20 pregnant and non-pregnant women as control groups .cytokine levels were measured by (ELISA) technique .The women with spontaneous abortion had highly significant (P < 0.01) increased serum level of IL-8 and highly significant (P < 0.01 ) decreased level of IL-6 compared to those with normal pregnant and non-pregnant women. The results of this study may be related to the underlying aetiopathogenetic mechanisms , however , There is sufficient evidence for their use as predictive markers of pregnancy outcome.

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Hyperglycosylated chorionic gonadotropin – prognostic criteria development of complications of pregnancy

HEALTH OF WOMAN ◽

10.15574/hw.2017.121.82 ◽

2017 ◽

pp. 82-85

Author(s):

N.V. Pehnyo ◽

Keyword(s):

Pregnant Women ◽

Chorionic Gonadotropin ◽

Human Chorionic Gonadotropin ◽

Prognostic Significance ◽

Neonatal Morbidity ◽

First Trimester ◽

Trophoblast Invasion ◽

Placental Dysfunction ◽

Hyperglycosylated Human Chorionic Gonadotropin ◽

First Trimester Of Pregnancy

The objective: to assess the prognostic significance of the level of serum hyperglycosylated human chorionic gonadotropin (gHCG) reative to the development of pregnancy complications that lead to impaired fetal conditions. Materials and methods. 382 pregnant women were examined who were on the register, were hospitalized in case of complications of pregnancy and gave birth to KCMH №2 (Kiev). All pregnant women were evaluated serum gCGG in the period of 8-10 weeks gestation, evaluated the course and result of pregnancy. Results. Reduction in the level of gHCG is a marker of insufficient trophoblast invasion, which is likely to lead to the formation of placental dysfunction and the development of a variety of obstetric pathology complicating the course of pregnancy and a risk factor for antenatal loss and neonatal morbidity. The conclusion. Determination of the level of hyperglycosylated human chorionic gonadotropin in the first trimester of pregnancy will make it possible to identify pregnant women at risk for the formation of placental dysfunction and propose a set of monitoring activities aimed at early detection of violations of pregnancy and their timely removal. This helps prevent the formation of severe pathological conditions during pregnancy in both the mother and the fetus, which corresponds to the current trends in the development of medical care, namely: prediction, prevention and individual approach. Key words: hyperglycosylated chorionic gonadotrophin, complications of pregnancy, disturbed fetal condition.

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Nature and frequency of diagnosis of different forms of glomerulonephritis as cause of development and progression of chronic kidney disease in different regions of world, according to clinical and morphological studies with renal biopsy

Medical alphabet ◽

10.33667/2078-5631-2021-25-20-25 ◽

2021 ◽

pp. 20-25

Author(s):

N. V. Teplova ◽

G. A. Chervyakova ◽

A. G. Vardanyan ◽

S. E. Arakelov ◽

A. G. Dzheksembekov ◽

...

Keyword(s):

Arterial Hypertension ◽

Antihypertensive Therapy ◽

Pregnant Patient ◽

First Trimester ◽

Adverse Outcomes ◽

Diagnostic Methods ◽

Complete Analysis ◽

Morphological Studies ◽

Modern Classification ◽

First Trimester Of Pregnancy

Hypertensive disorders in pregnant women are a significant factor in the development of complications leading to maternal and perinatal mortality. However, most cases of adverse outcomes are preventable. The choice of drug therapy in this group of patients should be made on the basis of a complete analysis and risk stratification.Purpose of work. Consideration of modern classification, diagnostic methods and rational antihypertensive therapy of chronic arterial hypertension on the example of a clinical case of a pregnant patient in a therapeutic hospital.Case description. The presented work describes a case of severe arterial hypertension during the first trimester of pregnancy, poorly amenable to drug correction.Conclusion. The features of this clinical observation are the problems associated with the selection of antihypertensive therapy for severe arterial hypertension during low gestational age pregnancy, taking into account comorbidities

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Catheter Directed Thrombolysis for Deep Vein Thrombosis during the First Trimester of Pregnancy: Two Case Reports

Journal of the Korean Radiological Society ◽

10.3348/jkrs.2008.58.2.127 ◽

2008 ◽

Vol 58 (2) ◽

pp. 127

Author(s):

Kum Rae Kim ◽

Won Kyu Park ◽

Jae Woon Kim ◽

Woo Hyung Kwun ◽

Bo Yang Suh ◽

...

Keyword(s):

Deep Vein Thrombosis ◽

Case Reports ◽

First Trimester ◽

Vein Thrombosis ◽

Catheter Directed Thrombolysis ◽

First Trimester Of Pregnancy ◽

Deep Vein

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FRACTIONAL DETERMINATIONS OF URINARY 17-KETOSTEROIDS IN HYPEREMESIS GRAVIDARUM

Acta Endocrinologica ◽

10.1530/acta.0.0410123 ◽

1962 ◽

Vol 41 (1) ◽

pp. 123-128 ◽

Cited By ~ 6

Author(s):

Pentti A. Järvinen ◽

Sykkö Pesonen ◽

Pirkko Väänänen

Keyword(s):

Hyperemesis Gravidarum ◽

First Trimester ◽

Control Group ◽

Before And After ◽

Daily Urine ◽

First Trimester Of Pregnancy ◽

The Difference

ABSTRACT The fractional determination of 17-ketosteroids in the daily urine was performed in nine cases of hyperemesis gravidarum and in four control cases, in the first trimester of pregnancy both before and after corticotrophin administration. The excretion of total 17-KS is similar in the two groups. Only in the hyperemesis group does the excretion of total 17-KS increase significantly after corticotrophin administration. The fractional determination reveals no difference between the two groups of patients with regard to the values of the fractions U (unidentified 17-KS), A (androsterone) and Rest (11-oxygenated 17-KS). The excretion of dehydroepiandrosterone is significantly higher in the hyperemesis group than in the control group. The excretion of androstanolone seems to be lower in the hyperemesis group than in the control group, but the difference is not statistically significant. The differences in the correlation between dehydroepiandrosterone and androstanolone in the two groups is significant. The high excretion of dehydroepiandrosterone and low excretion of androstanolone in cases of hyperemesis gravidarum is a sign of adrenal dysfunction.

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