FRACTIONAL DETERMINATIONS OF URINARY 17-KETOSTEROIDS IN HYPEREMESIS GRAVIDARUM

1962 ◽  
Vol 41 (1) ◽  
pp. 123-128 ◽  
Author(s):  
Pentti A. Järvinen ◽  
Sykkö Pesonen ◽  
Pirkko Väänänen
Keyword(s):  
Hyperemesis Gravidarum ◽  
First Trimester ◽  
Control Group ◽  
Before And After ◽  
Daily Urine ◽  
First Trimester Of Pregnancy ◽  
The Difference

ABSTRACT The fractional determination of 17-ketosteroids in the daily urine was performed in nine cases of hyperemesis gravidarum and in four control cases, in the first trimester of pregnancy both before and after corticotrophin administration. The excretion of total 17-KS is similar in the two groups. Only in the hyperemesis group does the excretion of total 17-KS increase significantly after corticotrophin administration. The fractional determination reveals no difference between the two groups of patients with regard to the values of the fractions U (unidentified 17-KS), A (androsterone) and Rest (11-oxygenated 17-KS). The excretion of dehydroepiandrosterone is significantly higher in the hyperemesis group than in the control group. The excretion of androstanolone seems to be lower in the hyperemesis group than in the control group, but the difference is not statistically significant. The differences in the correlation between dehydroepiandrosterone and androstanolone in the two groups is significant. The high excretion of dehydroepiandrosterone and low excretion of androstanolone in cases of hyperemesis gravidarum is a sign of adrenal dysfunction.

HORMONE ASSAYS DURING RECURRENT EXCESSIVE HAIRGROWTH IN PREGNANCY

1964 ◽  
Vol 45 (3) ◽  
pp. 447-456 ◽  
Author(s):  
Aarno Turunen ◽  
Sykkö Pesonen ◽  
Harry Zilliacus
Keyword(s):  
Placental Tissue ◽  
Normal Subjects ◽  
First Trimester ◽  
Control Group ◽  
Steroid Synthesis ◽  
Incubation Experiments ◽  
Before And After ◽  
Stimulation Tests ◽  
First Trimester Of Pregnancy ◽  
Hormone Excretion

ABSTRACT Three cases of recurrent excessive hairgrowth during pregnancy are described. The hormone excretion of two of these women was studied before and after stimulation tests. The patients received 40 IU of corticotrophin as an intravenous infusion and in addition a total of 3 mg fluorocortisone to produce suppression of the adrenals. Urinary steroids were determined before and during the stimulation tests. Four patients who were in the first trimester of pregnancy served as controls. After the legal termination of pregnancy incubation experiments with placental tissue were carried out to determine the ability of the placenta to convert the 17-OH-group of testosterone to the 17-keto-group. The results of these experiments were compared with those in normal subjects. In one case pregnancy had been legally terminated, and in the other the placenta was full-term. In both patients an increased 17-OH-progesterone secretion and some block in steroid synthesis were responsible for dysfunction. The excretion of total 17-ketosteroids, epiandrosterone and androsterone were higher in these patients than in the control group. In incubation experiments of placental tissue it was confirmed that the 17β-dehydrogenase activity of the patients was lower than in the control placenta. Hence, the inactivating capacity of testosterone was less than that of the control group. This phenomenon may be responsible for an increased level of testosterone in the plasma of the patients and of excessive hairgrowth during pregnancy. Of the six children born to the three mothers with recurrent excessive hairgrowth during pregnancy, three had severe congenital malformations, in one case of the heart and in two cases of the extremities.

Dynamics of cytochemical parameters of blood neutrophils in pregnant women with diffuse toxic goiter

2021 ◽  
pp. 40-43
Author(s):  
A. Z. Alieva ◽  
A. E. Esedova ◽  
M. M. Bakuev ◽  
Ya. Z. Zaydieva
Keyword(s):  
Pregnant Women ◽  
First Trimester ◽  
Control Group ◽  
Cationic Protein ◽  
Comparative Aspect ◽  
Blood Neutrophils ◽  
First Trimester Of Pregnancy ◽  
Toxic Goiter ◽  
Cytochemical Parameters

Introduction. Using cytochemical methods, the activity of myeloperoxidase (MPO), as well as the content of cationic proteins, glycogen and lipids in the blood neutrophils of pregnant women with diffuse toxic goiter (DTG) was studied in a comparative aspect.Goal. To study the dynamics of changes in the cytochemical parameters of neutrophils in women's blood during physiological pregnancy, as well as in pregnant patients with DTG.Material and methods. The study included 82 pregnant women aged 20-40 years old with Hashimoto's thyroiditis and graves' disease. The subject of the study was the determination of immunological indicators: the level of autoantibodies to TSH, TPO and TG; the content of populations and subpopulations of lymphocytes, and cytochemical indicators of blood: MPO activity; cationic protein content; glycogen content; lipid content. Results. The activity of MPO in the blood neutrophils of women with a physiological course of pregnancy (comparison group) is similar to that in the control group. In the first trimester of pregnancy, the percentage of neutrophils with a moderate to high content of colored granules tends to decrease, which is reflected in the value of the average cytochemical index.Conclusion. It should be noted that significant shifts in the content of components of the phagocytic defense system were found in the blood neutrophils of pregnant women with thyrotoxicosis syndrome.

Changes in Platelet Aggregability after Ovariectomy

1979 ◽  
Vol 42 (04) ◽  
pp. 1332-1339 ◽  
Author(s):  
Hiroh Yamazaki ◽  
Takeshi Motomiya ◽  
Minoru Sonoda ◽  
Noboru Miyagawa
Keyword(s):  
Platelet Count ◽  
Platelet Activation ◽  
Ovarian Hormones ◽  
Control Group ◽  
Platelet Aggregability ◽  
Appearance Rate ◽  
Before And After ◽  
The Difference ◽  
Induced Aggregation ◽  
Observation Period

SummaryChanges in platelets in 48 patients with uterine myoma before and after hysterectomy with and without ovariectomy were examined. Bilateral ovariectomy in 25 cases (ovariec-tomized group) and unilateral or non-ovariectomy in 23 cases (control group) were performed at the hysterectomy. Platelet count and an appearance rate of secondary aggregation decreased at one day after and increased at one week after the operation, similarly in both the ovariectomized and the control group. The appearance rate of secondary aggregation was reflected in an intensity of aggregation at 5 min after the addition of reagent to PRP. At one month after the operation, the appearance rate of secondary aggregation induced by 3 μM ADP showed a statistically significant decrease in comparison with the preoperation value (P <0.05) and the enhancement of 5-min aggregation was still observed in the control group, while ceased in the ovariectomized group. The difference between the two groups was significant (P < 0.05). There was almost no change in the speed and intensity of primary and secondary aggregation during the observation period. No significant differences in collagen-induced aggregation were noted between the two groups. The results suggest that ovarian hormones, mainly estrogen, facilitate platelet activation which is mediated by the so-called secondary aggregation.

PENGARUH TERAPI TERTAWA TERHADAP PENURUNAN TEKANAN DARAH LANSIA DI UPT PANTI WREDHA BUDHI DHARMA YOGYAKARTA

2019 ◽  
Vol 13 (1) ◽  
Author(s):  
Niken Setyaningrum ◽  
Andri Setyorini ◽  
Fachruddin Tri Fitrianta
Keyword(s):  
Blood Pressure ◽  
Data Analysis ◽  
The Elderly ◽  
Control Group ◽  
Group Comparison ◽  
Control Blood Pressure ◽  
Men And Women ◽  
Treatment Of Hypertension ◽  
Before And After ◽  
The Difference

ABSTRACTBackground: Hypertension is one of the most common diseases, because this disease is suffered byboth men and women, as well as adults and young people. Treatment of hypertension does not onlyrely on medications from the doctor or regulate diet alone, but it is also important to make our bodyalways relaxed. Laughter can help to control blood pressure by reducing endocrine stress andcreating a relaxed condition to deal with relaxation.Objective: The general objective of the study was to determine the effect of laughter therapy ondecreasing elderly blood pressure in UPT Panti Wredha Budhi Dharma Yogyakarta.Methods: The design used in this study is a pre-experimental design study with one group pre-posttestresearch design where there is no control group (comparison). The population in this study wereelderly aged over> 60 years at 55 UPT Panti Wredha Budhi Dharma Yogyakarta. The method oftaking in this study uses total sampling. The sample in this study were 55 elderly. Data analysis wasused to determine the difference in blood pressure before and after laughing therapy with a ratio datascale that was using Pairs T-TestResult: There is an effect of laughing therapy on blood pressure in the elderly at UPT Panti WredhaBudhi Dharma Yogyakarta marked with a significant value of 0.000 (P <0.05)

Method for the simultaneous quantification of n-hexane metabolites: application to n-hexane metabolism determination

1996 ◽  
Vol 15 (6) ◽  
pp. 497-503 ◽  
Author(s):  
T. Soriano ◽  
M. Menéndez ◽  
P. Sanz ◽  
M. Repetto
Keyword(s):  
Similar Pattern ◽  
Analytical Procedure ◽  
Daily Basis ◽  
Practical Application ◽  
Simultaneous Quantification ◽  
Exposed Workers ◽  
Before And After ◽  
Time Requirements ◽  
The Difference

1 The described analytical procedure permits the simultaneous determination of the main n-hexane meta bolites in urine. 2-Hexanone, 2-hexanol, 2, 5-hexanediol and 2, 5-hexanedione, were chosen to dose the rats used in this study. All urine samples were collected and analysed on a daily basis, before and after acidic hydrolysis (pH 0.1) by GC/MS. 2-Hexanone, 2, 5-dimethylfurane, γ-valerolac tone and 2, 5-hexanedione were determined before hydro lysis ; 2-hexanol and 2, 5-hexanediol, after hydrolysis; and 5-hydroxy-2-hexanone and 4, 5-dihydroxy-2-hexanone were calculated by the difference between γ-valerolactone and 2, 5-hexanedione with and without hydrolysis, respectively. 2 A metabolic scheme was proposed reflecting the biotransformations undergone by the four compounds assayed. We consider 2, 5-dimethylfurane as a 'true metabolite' because the quantities detected were always greater before hydrolysis. 3 It has been reported that human and rat n-hexane metabolism follow a similar pattern. Therefore, as a practical application and without increasing either sample or time requirements, the simultaneous quantifi cation of the different metabolites and their excretion profile could provide better information about the metabolic situation of exposed workers than the determi nation of 2, 5-hexanedione alone. According to our experimental results, 4, 5-dihydroxy-2-hexanone itself would be a good toxicity indicator.

scholarly journals The difference in saliva pH before and after brushing with fluoride containing toothpaste and without toothpaste

2008 ◽  
Vol 20 (3) ◽  
Author(s):  
Samuel Setiawan ◽  
Edeh Rolleta Haroen ◽  
Dede Hadidjah
Keyword(s):  
Drinking Water ◽  
Research Method ◽  
Control Group ◽  
Research Subjects ◽  
Male And Female ◽  
Significant Difference ◽  
Salivary Ph ◽  
Before And After ◽  
Quasi Experimental ◽  
The Difference

In administering fluoride through drinking water there is the risk of overdose, higher cost and inadequate availability of drinking water containing fluoride in developing countries like Indonesia. A safe fluoride source is contained in toothpaste. The purpose of this research was to obtain data concerning difference in saliva pH before and after brushing with toothpaste containing fluoride and without toothpaste. The research method used was the quasi-experimental method. Samples were collected by the way of purposive sampling, conducted on 43 male and female research subjects. The data were analyzed by statistical analysis using the t test at 95% confidence level. In this research a control group consisting of 43 people was used. Research results indicated that the average saliva pH before brushing was 7.174; after brushing with fluoride containing toothpaste salivary pH was 7.593. Result research of brushing without toothpaste showed an average saliva of 7.163 before brushing and 7.379 after brushing without toothpaste. The average changes in saliva pH before and after brushing using fluoride containing toothpaste was 0.216. The conclusion of this research was that there was significant difference in saliva pH before and after brushing with toothpaste containing fluoride; there was significant difference in saliva pH before and after brushing without toothpaste, and there was significant difference in saliva pH before and after brushing with toothpaste containing fluoride and without toothpaste.

scholarly journals OHIS Differences on Primary School Students in Relation to Little Dentist Training

2021 ◽  
Author(s):  
Asep Arifin Senjaya ◽  
Ni Made Sirat ◽  
I Nyoman Wirata ◽  
Ni Ketut Ratmini
Keyword(s):  
Treatment Group ◽  
Primary School ◽  
Oral Hygiene ◽  
Dental Health ◽  
Control Group ◽  
Primary School Students ◽  
School Students ◽  
Significant Difference ◽  
Before And After ◽  
The Difference

Dental healthcare is very important since dental and oral hygiene should be maintained. Statistics showed that more than 80% of children in developed and developing countries suffer from dental disease. This study aimed to see the safety of OHIS (Oral Hygiene Index Simplified) in primary school students who got and did not get little dentist cadre training in Bangli Regency in 2019. The study was done in an experimental design: pre and post-test with control design, which was conducted in August-September 2019. The sample in this study is 366 students. The difference in OHIS scores before and after treatment in the control group and treatment group was carried out by the bivariate Mann Whitney U Test. The results of the study showed that before dental health training was conducted, there were 54.3% of primary school students in the treatment group with good OHIS score criteria, and after the training was carried out as many as 98.4% of the students in the treatment group had a good OHIS. Additionally, prior to the training, 57.5% of the control group had fair OHIS criteria score. Then, after the training was carried out, 73.7% of the control group had good OHIS score. Hence, the study concluded that there was a significant difference in the OHIS of primary school students who got little doctor training prior to and after the training. Also, there was a significant difference in the OHIS of the students who did not get such treatment before and after the training.

scholarly journals ANALISIS PERBEDAAN ABNORMAL RETURN DAN TRADING VOLUME ACTIVITY SEBELUM DAN SESUDAH PERISTIWA PENETAPAN UNDANG-UNDANG TAX AMNESTY

2021 ◽  
Vol 10 (3) ◽  
pp. 186-198
Author(s):  
I Komang Wisnu Wardhana ◽  
Hermanto Hermanto ◽  
I Nyoman Nugraha AP
Keyword(s):  
Abnormal Return ◽  
Trading Volume ◽  
Secondary Data ◽  
Volume Activity ◽  
Analytical Technique ◽  
Tax Amnesty ◽  
Average Abnormal Return ◽  
Before And After ◽  
The Difference

The purpose of this study was to determine the difference in the average abnormal return and trading volume activity before and after the enactment of the tax amnesty law on the LQ-45 index. The type of data used in this study is secondary data with data collection techniques using the documentation method. Determination of the sample in this study using purposive sampling method with certain criteria so as to obtain 45 samples. The analytical technique used in this research is paired sample t-test with an observation period of 10 days. The results of this study indicate that: (1) There is no difference in the average abnormal return before and after the enactment of the tax amnesty law. (2) There is no difference in the average trading volume activity before and after the enactment of the tax amnesty law. 

scholarly journals Aplikasi Digital Risalah Ilmu Tajwid dalam Meningkatkan Kemampuan Baca Alquran

2018 ◽  
Vol 11 (2) ◽  
pp. 145-157
Author(s):  
Khairul Khairul ◽  
Muhammad Haramain
Keyword(s):  
Learning Environment ◽  
Research Design ◽  
Empirical Data ◽  
Control Group ◽  
Control Group Design ◽  
Text Book ◽  
Research Results ◽  
Group Design ◽  
Before And After ◽  
The Difference

This article discusses the using of risalah of tajwid digital apps in increasing the students of SMA Negeri 4 Pinrang abilities in reading al-Qur’an. The using of risalah of tajwid digital apps was by optimazing the technology of computer that running by risalah of tajwid digital apps, that able to create the learning environment to prepare the options that can stimulated the students to use the potential cognitive. The objectives of this research was to get the empirical data about the students’ ability in reading Alquran before and after taught by using risalah digital of tajwid science and to get the empirical data about students’ ability in reading Alquran before and after using text book as well as to get the information about the difference in students’ level of ability in reading Alquran at the experiment class and the control class. The research design is used nonequivalent control group design, it means that in this design the experiment class nor the control class was not selected randomly.The research results are: (1) The level of students’ ability in reading Alquran in the experiment class before the treatment was classified in poor category, however, after given the treatment it was in good category. (2) The level of students’ ability in reading Alquran in the control class before the treatment was in poor category, however, after given the treatment it was in good category. (3) There are difference of students’ level ability in reading Alquran in the experiment class and the control class.

scholarly journals THE EFFECT OF BASIC LIFE ASSISTANCE TRAINING (BHD) ON MOTIVATION AND DEMEANOUR OF CLASS XI STUDENTS IN RESCUING TRAFFIC ACCIDENTS IN SMA NEGERI 2 TENGGARONG

2019 ◽  
Vol 7 (1) ◽  
pp. 39-47
Author(s):  
Indah Nur Imamah ◽  
Alfi Ari Fakhrur Rizal ◽  
Milkhatun Kalimantan Milkhatun
Keyword(s):  
Traffic Accidents ◽  
Life Support ◽  
Sampling Technique ◽  
T Test ◽  
Control Group ◽  
P Value ◽  
Public Attention ◽  
The Public ◽  
Before And After ◽  
The Difference

Traffic accidents are one of the public health problems that affect all sectors of life. The phenomenon of traffic accidents so far has not received much public attention as a cause of death. The increase in mortality rates that occur on the highway is very high and quite a concern and vigilance for the community. This usually happens one of them because the Indonesian people do not know how to help victims who are good and right when finding victims. As a result most of actions is wrong, so  it can add to injury and  death. This study aims to determine the effect of basic life support (BLS) training on the motivation and demeanour of class XI students in rescuing  traffic accidents in SMA Negeri 2 Tenggarong. This study uses a quasy experimental method of pre and post design with a control group. Proportional stratified random sampling technique with a sample of 78 students and data collection using a questionnaire sheet. Data that was analyzed by paired t test in each group showed a p-value of 0,000 <0.05, meaning that there was a statistically change in motivation and attitude between before and after treatment in the form of BLS training for class XI students at SMAN 2 Tenggarong.  The result is not much different from the independent t test which showed p-value 0,000 <0.05, which means there is a statistically different demeanour between the difference before and after treatment in the form of BLS training in the control and intervention groups. The results showed that there was a statistically significant change in motivation and demeanour between before and after the BLS training was given to the motivation and demeanour of class XI students at SMAN 2 Tenggarong with a p-value of 0,000 <0.05.

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