scholarly journals Fatty Dihydropyridines With Anti-Hypertensive and Cardioprotective Potential During Ischemia and Reperfusion

2021 ◽  
Author(s):  
eduarda Santa-Helena ◽  
Joaquim de Paula Ribeiro ◽  
Carolina Rosa Gioda ◽  
Diego da Costa Cabrera ◽  
Marcelo G. Montes D’Oca ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Methyl Ester ◽  
Cardiac Function ◽  
Oxidative Status ◽  
Global Ischemia ◽  
Ischemia And Reperfusion ◽  
Standard Drug ◽  
Lipid Damage

Abstract In this study, three fatty dihydropyridines, were tested for their anti-hypertensive and cardioprotective properties. Dihydropyridines 2c, 8c, and 9a contain the oleic chain and the nitro unit, the oleic chain and the chlorine unit, and the palmitic chain and the chlorine unit, respectively. For the experiments, animals were treated with N(ω)-nitro-L-arginine methyl ester to induce hypertension and after treated with the new dihydropyridine compounds and the standard drug nifedipine. Then, the heart was removed and subjected to global ischemia and reperfusion. Analyses of cardiac parameters were performed to monitor cardiac functionality; lactate dehydrogenase values were quantified in perfusates. After ischemia and reperfusion were performed, analyses to check the oxidative status and lipid damage. The results of the present study suggest that the new fatty DHPs have anti-hypertensive effects offering protection against ischemia to the heart of rats, accomplished by increasing antioxidants that defend and prevent the decline in cardiac function.

scholarly journals Graded global ischemia and reperfusion. Cardiac function and lactate metabolism.

Circulation ◽  
1977 ◽  
Vol 55 (6) ◽  
pp. 864-872 ◽  
Author(s):  
C S Apstein ◽  
L Deckelbaum ◽  
M Mueller ◽  
L Hagopian ◽  
W B Hood
Keyword(s):  
Cardiac Function ◽  
Global Ischemia ◽  
Ischemia And Reperfusion ◽  
Lactate Metabolism

Homocyst(e)ine impairs endocardial endothelial function

1999 ◽  
Vol 77 (12) ◽  
pp. 950-957 ◽  
Author(s):  
Suresh C Tyagi ◽  
Lane M Smiley ◽  
Vibhas S Mujumdar
Keyword(s):  
Nitric Oxide ◽  
Methyl Ester ◽  
Cardiac Function ◽  
Vascular Function ◽  
Ex Vivo ◽  
Cardiac Contraction ◽  
Normal Male ◽  
Wistar Kyoto ◽  
Endocardial Endothelium ◽  
Endothelial Nitric Oxide

Homocyst(e)ine injured vascular endothelium and modulated endothelial-dependent vascular function. Endothelium plays an analogous role in both the vessel and the endocardium. Therefore, we hypothesized that homocyst(e)ine modulated endocardial endothelium (EE) dependent cardiac function. The ex vivo cardiac rings from normal male Wistar-Kyoto rats were prepared. The contractile responses of left and right ventricular rings were measured in an isometric myobath, using different concentrations of CaCl2. The response was higher in the left ventricle than right ventricle and was elevated in endocardium without endothelium. The half effective concentration (EC50) and maximum tension generated by homocyst(e)ine were 106 and 5-fold lower than endothelin (ET) and angiotensin II (AII), respectively. However, in endothelial-denuded endocardium, homocyst(e)ine response was significantly increased (p < 0.005, compared with intact endothelium) and equal to the response to ET and AII. To determine the physiological significance of ET, AII, homocyst(e)ine, and endothelial nitric oxide in EE function, cardiac rings were pretreated with AII (10-10 M) or ET (10-13 M) and then treated with homocyst(e)ine (10-8 M). Results suggested that at these concentrations AII, ET, or homocyst(e)ine alone had no effect on cardiac contraction. However, in the presence of 10-10 M AII or 10-13 M ET, the cardiac contraction to homocyst(e)ine (10-8 M) was significantly enhanced (p < 0.01, compared with without pretreatment) and further increased in the endocardium without endothelium. The pretreatment of cardiac ring with the inhibitor of nitric oxide, Nω-nitro-L-arginine methyl ester (L-NAME), increased contractile response to homocyst(e)ine. These results suggested that homocyst(e)ine impaired EE-dependent cardiac function and acted synergistically with AII and ET in enhancing the cardiac contraction.Key words: endocardial remodeling, homocyst(e)ine, contraction, endothelin, angiotensin, endothelial-derived relaxing factor (EDRF), Nω-nitro-L-arginine methyl ester (L-NAME), endothelial dysfunction, ex vivo cardiac function, heart failure.

Differential cardioprotective effects of cardiac and non-cardiac adenosine during global ischemia and reperfusion

2007 ◽  
Vol 42 (6) ◽  
pp. S201-S202
Author(s):  
Anwar S. Abd-Elfattah ◽  
Mai Ding ◽  
S. Jamal Mustafa ◽  
Magda A. Mansour ◽  
Farid R. Nomair
Keyword(s):  
Global Ischemia ◽  
Ischemia And Reperfusion ◽  
Cardioprotective Effects

scholarly journals Comparison of two methods to automatically quantify infarct size in rat isolated hearts following global ischemia and reperfusion (1154.6)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Matthias Riess ◽  
Sushrut Shidham ◽  
Raha Nabbi ◽  
Wolfgang Gaggl ◽  
Alexandra Lerch‐Gaggl
Keyword(s):  
Infarct Size ◽  
Global Ischemia ◽  
Ischemia And Reperfusion ◽  
Isolated Hearts

LC-MS/MS profiling and neuroprotective effects of Mentat® against transient global ischemia and reperfusion–induced brain injury in rats

Nutrition ◽  
2015 ◽  
Vol 31 (7-8) ◽  
pp. 1008-1017 ◽  
Author(s):  
Gollapalle Lakshminarayanashastry Viswanatha ◽  
Lakkavalli Mohan Sharath Kumar ◽  
Mohamed Rafiq ◽  
Kethaganahalli Jayaramaiah Kavya ◽  
Agadi Hiremath Thippeswamy ◽  
...  
Keyword(s):  
Brain Injury ◽  
Global Ischemia ◽  
Ischemia And Reperfusion ◽  
Neuroprotective Effects ◽  
Transient Global Ischemia

scholarly journals EFFECT OF CIMETIDINE ON NITRO-OXIDATIVE STRESS IN A RAT MODEL OF PERIODONTITIS

2014 ◽  
Vol 87 (3) ◽  
pp. 177-181 ◽  
Author(s):  
Carina Culic ◽  
Alina Elena Parvu ◽  
Sandu Florin Alb ◽  
Camelia Alb ◽  
Angela Pop
Keyword(s):  
Oxidative Stress ◽  
Methyl Ester ◽  
Rat Model ◽  
Low Dose ◽  
Oxidative Status ◽  
Stress Index ◽  
Oxidative Stress Index ◽  
Total Antioxidant ◽  
Total Oxidative Status ◽  
And Oxidative Stress

Background and aims. Periodontitis is a chronic inflammation that involves nitro-oxidative stress with damaging periodontal structural effects. We aimed to evaluate the consequences of low-dose cimetidine on nitro-oxidative stress in periodontitis. Methods. A rat model of ligature-induced periodontitis was used. After two weeks, the periodontitis groups were treated with cimetidine, aminoguanidine, N-nitro-L-arginine methyl ester and trolox for one week. On day 21, blood was drawn and the serum analyzed for measurement of total nitrites and nitrates, total oxidative status, total antioxidant response, and oxidative stress index. Results. Cimetidine had an inhibitory effect on the synthesis of nitric oxide (p=0.001), total oxidative status (p=0.01) and oxidative stress index (p=0.01). Total antioxidant reactivity was increased by cimetidine (p=0.01). The effects of cimetidine were almost like those of aminoguanidine, NG-nitro-L-arginine methyl ester, and trolox. Conclusions. Low-dose cimetidine can be used as adjunctive host modulatory therapy in chronic periodontitis because it reduces nitro-oxidative stress.

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