scholarly journals Breast Cancer Survival in the Mammography Era in Brazil: A Population-Based Analysis of 2,715 Cases

2021 ◽  
Author(s):  
Juliana Fernandes ◽  
Beatriz Machado ◽  
Cassio Cardoso-Filho ◽  
Juliana Nativio ◽  
Cesar Cabello ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Survival ◽  
Survival Rates ◽  
Population Based ◽  
Breast Cancer Survival ◽  
Stage I ◽  
Current Status ◽  
Breast Cancers ◽  
Risk Of Death ◽  
Significant Difference

Abstract Background This study aims to assess breast cancer survival rates after one decade of mammography in a large urban area of Brazil. Methods It is a population-based retrospective cohort of women with breast cancer in Campinas, São Paulo, from 2010 to 2014. Age, vital status and stage were accessed through the cancer and mortality registry, and patients records. Statistics used Kaplan-Meier, log-rank and Cox's regression. Results Out of the 2,715 cases, 665 deaths (24.5%) were confirmed until early 2020. The mean age at diagnosis was 58.6 years. Women 50-69 years were 48.0%, and stage I the most frequent (25.0%). The overall mean survival was 8.4 years (8.2-8.5). The 5-year survival (5yOS) for overall, 40-49, 50-59, 60-69, 70-79 years was respectively 80.5%, 87.7%, 83.7%, 83.8% and 75.5%. The 5yOS for stages 0, I, II, III and IV was 95.2%, 92.6%, 89.4%, 71.1% and 47.1%. There was no significant difference in survival in stage I or II (p=0.058). Compared to women 50-59 years, death's risk was 2.3 times higher for women 70-79 years and 26% lower for women 40-49 years. Concerning stage I, the risk of death was 1.5, 4.1 and 8.6 times higher, and 34% lower, respectively, for stage II, III, IV and 0. Conclusions In Brazil, breast cancers are currently diagnosed in the early stages, although advanced cases persist. Survival rates may reflect improvements in screening, early detection and treatment. The results can reflect the current status of other regions or countries with similar health care conditions.

scholarly journals Survival rates of breast cancer and predictive factors: a hospital-based study from western Amazon area in Brazil

2019 ◽  
Vol 24 (1) ◽  
pp. 261-273 ◽  
Author(s):  
Ruth Helena Pimenta Fujimoto ◽  
Rosalina Jorge Koifman ◽  
Ilce Ferreira da Silva
Keyword(s):  
Breast Cancer ◽  
Cancer Survival ◽  
Cox Regression ◽  
Survival Rates ◽  
Breast Cancer Survival ◽  
Cancer Specific Survival ◽  
Risk Of Death ◽  
Kaplan Meier ◽  
Medical Reports ◽  
Survival Studies

Abstract Breast cancer survival in Latin America countries is below Central European countries. Hospital-based breast cancer survival studies in western Amazon, Brazil, are lacking. This article aims to estimate hospital-based breast cancer survival in Rio Branco, Acre, and predictor factors. Hospital-based cohort study of all women diagnosed with breast cancer (2007-2012) was proceeded. Information were obtained from medical reports, and follow-up was until 2013. One-, 2- and 5- years breast cancer specific-survival were estimated by Kaplan-Meier method. Crude and adjusted Harzards Ratios (HR) were estimated by proportional Cox regression model. One-, 2-, and 5-year overall breast cancer survival were 95.5%, 83.7%, and 87.3% respectively. Surgery combined to radiotherapy significantly affected 1-, 2-, and 5-year survival (99%, 94%, and 90.6%, respectively) as compared to other treatments (77%,57.1%, and 37.5%, respectively). Comparing to surgery combined to radiotherapy treatment, surgery alone increased the risk of death, independently of age and stage (HR = 7.23;95%CI:2.29-22.83). In Rio Branco, Acre, 5-year breast cancer survival is similar to more developed areas in Brazil. Surgery combined to radiotherapy was independently associated to a lower risk of death as compared to surgery alone and other treatment.

scholarly journals Comparison of survival in non-metastatic inflammatory and other T4 breast cancers: a SEER population-based analysis

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Dechuang Jiao ◽  
Jingyang Zhang ◽  
Jiujun Zhu ◽  
Xuhui Guo ◽  
Yue Yang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cox Model ◽  
Survival Rates ◽  
Tumor Grade ◽  
Population Based ◽  
Rank Test ◽  
Breast Cancers ◽  
Significant Independent Predictor ◽  
Cancer Specific Survival ◽  
7Th Edition

Abstract Background Previous studies have reported poor survival rates in inflammatory breast cancer (IBC) patients than non-inflammatory local advanced breast cancer (non-IBC) patients. However, until now, the survival rate of IBC and other T4 non-IBC (T4-non-IBC) patients remains unexplored. Methods Surveillance, Epidemiology, and End Results (SEER) database was searched to identify cases with confirmed non-metastatic IBC and T4-non-IBC who had received surgery, chemotherapy, and radiotherapy between 2010 and 2015. IBC was defined as per the American Joint Committee on Cancer (AJCC) 7th edition. Breast Cancer-Specific Survival (BCSS) was estimated by plotting the Kaplan-Meier curve and compared across groups by using the log-rank test. Cox model was constructed to determine the association between IBC and BCSS after adjusting for age, race, stage of disease, tumor grade and surgery type. Results Out of a total of 1986 patients, 37.1% had IBC and mean age was 56.6 ± 12.4. After a median follow-up time of 28 months, 3-year BCSS rate for IBC and T4-non-IBC patients was 81.4 and 81.9%, respectively (log-rank p = 0.398). The 3-year BCSS rate in HR−/HER2+ cohort was higher for IBC patients than T4-non-IBC patients (89.5% vs. 80.8%; log-rank p = 0.028), and in HR−/HER2- cohort it was significantly lower for IBC patients than T4-non-IBC patients (57.4% vs. 67.5%; log-rank p = 0.010). However, it was identical between IBC and T4-non-IBC patients in both HR+/HER2- (85.0% vs. 85.3%; log-rank p = 0.567) and HR+/HER2+ (93.6% vs. 91.0%, log-rank p = 0.510) cohorts. After adjusting for potential confounding variables, we observed that IBC is a significant independent predictor for survival of HR−/HER2+ cohort (hazards ratio [HR] = 0.442; 95% CI: 0.216–0.902; P = 0.025) and HR−/HER2- cohort (HR = 1.738; 95% CI: 1.192–2.534; P = 0.004). Conclusions Patients with IBC and T4-non-IBC had a similar BCSS in the era of modern systemic treatment. In IBC patients, the HR−/HER2+ subtype is associated with a better outcome, and HR−/HER2- subtype is associated with poorer outcomes as compared to the T4-non-IBC patients.

Breast cancer survival rates among Chinese women born in East Asia and the United States

2005 ◽  
Vol 15 (8) ◽  
pp. 634-634
Author(s):  
S CHUANG ◽  
W CHEN ◽  
M HASHIBE ◽  
G LI ◽  
P GANZ ◽  
...  
Keyword(s):  
Breast Cancer ◽  
United States ◽  
East Asia ◽  
Cancer Survival ◽  
Chinese Women ◽  
Survival Rates ◽  
The United States ◽  
Breast Cancer Survival

scholarly journals Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort

2008 ◽  
Vol 10 (3) ◽  
Author(s):  
Elizabeth M Azzato ◽  
Kristy E Driver ◽  
Fabienne Lesueur ◽  
Mitul Shah ◽  
David Greenberg ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Genetic Variation ◽  
Cancer Survival ◽  
Cell Cycle Control ◽  
Population Based ◽  
Breast Cancer Survival

Time trends in population-based breast cancer survival in Estonia: Analysis by age and stage

2013 ◽  
Vol 53 (2) ◽  
pp. 226-234 ◽  
Author(s):  
Aleksei Baburin ◽  
Tiiu Aareleid ◽  
Peeter Padrik ◽  
Vahur Valvere ◽  
Kaire Innos
Keyword(s):  
Breast Cancer ◽  
Time Trends ◽  
Cancer Survival ◽  
Population Based ◽  
Breast Cancer Survival

Screening status, tumour subtype, and breast cancer survival: a national population-based analysis

2018 ◽  
Vol 172 (1) ◽  
pp. 133-142 ◽  
Author(s):  
Katie M. O’Brien ◽  
Therese Mooney ◽  
Patricia Fitzpatrick ◽  
Linda Sharp
Keyword(s):  
Breast Cancer ◽  
Cancer Survival ◽  
Population Based ◽  
Breast Cancer Survival ◽  
National Population

scholarly journals Breast cancer survival in sub‐Saharan Africa by age, stage at diagnosis and human development index: A population‐based registry study

2019 ◽  
Vol 146 (5) ◽  
pp. 1208-1218 ◽  
Author(s):  
Walburga Y. Joko‐Fru ◽  
Adalberto Miranda‐Filho ◽  
Isabelle Soerjomataram ◽  
Marcel Egue ◽  
Marie‐Therese Akele‐Akpo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Development Index ◽  
Cancer Survival ◽  
Population Based ◽  
Breast Cancer Survival ◽  
Sub Saharan Africa ◽  
Stage At Diagnosis ◽  
Registry Study ◽  
Sub Saharan ◽  
Population Based Registry

S-phase fraction is a prognostic factor in stage I breast carcinoma.

1993 ◽  
Vol 11 (9) ◽  
pp. 1717-1722 ◽  
Author(s):  
O Stål ◽  
M Dufmats ◽  
T Hatschek ◽  
J Carstensen ◽  
C Klintenberg ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
Dna Content ◽  
Cancer Survival ◽  
Prognostic Significance ◽  
Breast Cancer Survival ◽  
S Phase ◽  
Stage I ◽  
Phase Fraction ◽  
Breast Cancer Patients

PURPOSE AND METHODS The prognostic significance of cell proliferation, estimated as cytometric S-phase fraction (SPF), was investigated in node-negative breast cancer patients with small tumors (T1, NO). The 219 stage I patients originated from two series and were diagnosed either from 1978 to 1981 or from 1981 to 1985. The tumors were analyzed for estrogen receptors (ERs) by isoelectric focusing and for cellular DNA content by static cytofluorometry or flow cytometry. RESULTS A high SPF correlated with the absence of ERs and abnormal DNA content, and was less often found in tumors smaller than 11 mm compared with those with a diameter between 11 and 20 mm. Among the variables age, tumor size, DNA ploidy, ER status, and SPF, only SPF showed a significant association with distant recurrence and breast cancer survival in systemically untreated patients. The relative recurrence rate for patients with an SPF of 10% or greater was three times that for patients with lower SPFs. Estimated 8-year breast cancer survival rates for the same groups were 72% and 91%, respectively. CONCLUSION This study suggests that cytometric SPF has prognostic significance in stage I breast carcinoma.

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