scholarly journals Pulsed Electromagnetic Fields Protect Against Brain Injury After Intracerebral Hemorrhage: Involvement Of Anti-Inflammatory Processes And Hematoma Clearance Via CD36

2021 ◽  
Author(s):  
Yuefan Yang ◽  
Pan Wang ◽  
Anlai Liu ◽  
Xiuquan Wu ◽  
Zedong Yan ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Electromagnetic Fields ◽  
Neurological Deficits ◽  
Pulsed Electromagnetic Fields ◽  
Hematoma Volume ◽  
Bv2 Cells ◽  
Inflammatory Processes ◽  
Anti Inflammatory ◽  
Pulsed Electromagnetic ◽  
Proinflammatory Factors

Abstract Background: Intracerebral hemorrhage causes high mortality and morbidity, but its therapy methods are limited. In the present study, pulsed electromagnetic fields (PEMFs) were demonstrated to have beneficial effects on an intracerebral hemorrhage (ICH) model. This study explored the effects and underlying mechanism of PEMFs in a mouse model of ICH and cultured BV2 cells.Methods: PEMFs were applied 24 hours after collagenase-induced ICH and 4 hours per day for seven consecutive days. The levels of proinflammatory factors were assessed by ELISA kits and western blotting. Hematoma volume was measured by histological analysis. The effects of PEMFs on phagocytosis of the erythrocytes was observed in cultured BV2 cells.Results: Seven days after ICH, the hematoma volume was significantly reduced in PEMF-treated animals compared to nontreated mice. We found that PEMFs decreased the hematoma volume and the levels of proinflammatory factors after ICH. To evaluate the mechanisms underlying the effects of PEMFs on ICH, we analyzed the transcriptome profile three days after ICH, and we found that PEMFs reversed the changes in inflammation-related pathways and alleviated neurological deficits. Furthermore, PEMFs enhanced the erythrophagocytosis of microglia via CD36. Thus, the PEMF-mediated promotion of neurological functions may at least partly involve anti-inflammatory processes and hematoma clearance.Conclusions: These results suggest that PEMF treatment is a possible adjuvant therapy for ICH patients.

scholarly journals Adenosine Receptors as a Biological Pathway for the Anti-Inflammatory and Beneficial Effects of Low Frequency Low Energy Pulsed Electromagnetic Fields

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Katia Varani ◽  
Fabrizio Vincenzi ◽  
Annalisa Ravani ◽  
Silvia Pasquini ◽  
Stefania Merighi ◽  
...  
Keyword(s):  
Electromagnetic Fields ◽  
Adenosine Receptors ◽  
Biological Effects ◽  
Low Frequency ◽  
Low Energy ◽  
Membrane Receptors ◽  
Pulsed Electromagnetic Fields ◽  
Inflammatory Status ◽  
Anti Inflammatory ◽  
Pulsed Electromagnetic

Several studies explored the biological effects of low frequency low energy pulsed electromagnetic fields (PEMFs) on human body reporting different functional changes. Much research activity has focused on the mechanisms of interaction between PEMFs and membrane receptors such as the involvement of adenosine receptors (ARs). In particular, PEMF exposure mediates a significant upregulation ofA2Aand A3ARs expressed in various cells or tissues involving a reduction in most of the proinflammatory cytokines. Of particular interest is the observation that PEMFs, acting as modulators of adenosine, are able to increase the functionality of the endogenous agonist. By reviewing the scientific literature on joint cells, a double role for PEMFs could be hypothesized in vitro by stimulating cell proliferation, colonization of the scaffold, and production of tissue matrix. Another effect could be obtained in vivo after surgical implantation of the construct by favoring the anabolic activities of the implanted cells and surrounding tissues and protecting the construct from the catabolic effects of the inflammatory status. Moreover, a protective involvement of PEMFs on hypoxia damage in neuron-like cells and an anti-inflammatory effect in microglial cells have suggested the hypothesis of a positive impact of this noninvasive biophysical stimulus.

Effect of pulsed electromagnetic fields on maturation of regenerate bone in a rabbit limb lengthening model

2005 ◽  
Vol 24 (1) ◽  
pp. 2-10 ◽  
Author(s):  
Kenneth F. Taylor ◽  
Nozumu Inoue ◽  
Bahman Rafiee ◽  
John E. Tis ◽  
Kathleen A. McHale ◽  
...  
Keyword(s):  
Electromagnetic Fields ◽  
Limb Lengthening ◽  
Pulsed Electromagnetic Fields ◽  
Pulsed Electromagnetic

Effects of Pulsed Electromagnetic Fields on Rat Eye

1999 ◽  
Vol 18 (2) ◽  
pp. 157-164
Author(s):  
Gianluca Giavaresi ◽  
Francesco Broccoli ◽  
Milena Fini ◽  
Paola Torricelli ◽  
Paola Versura ◽  
...  
Keyword(s):  
Electromagnetic Fields ◽  
Pulsed Electromagnetic Fields ◽  
Pulsed Electromagnetic

scholarly journals Anti-inflammatory genes in PBMCs post-spontaneous intracerebral hemorrhage

2021 ◽  
Vol 12 (1) ◽  
pp. 58-66
Author(s):  
Doan Nguyen ◽  
Vi Tran ◽  
Alireza Shirazian ◽  
Cruz Velasco-Gonzalez ◽  
Ifeanyi Iwuchukwu
Keyword(s):  
Intracerebral Hemorrhage ◽  
Negative Correlation ◽  
Mononuclear Cells ◽  
Inflammatory Cells ◽  
Favorable Outcome ◽  
Hospital Length Of Stay ◽  
Spontaneous Intracerebral Hemorrhage ◽  
Hematoma Volume ◽  
Peripheral Blood Mononuclear ◽  
Anti Inflammatory

Abstract Background Neuroinflammation is important in the pathophysiology of spontaneous intracerebral hemorrhage (ICH) and peripheral inflammatory cells play a role in the clinical evolution and outcome. Methodology Blood samples from ICH patients (n = 20) were collected at admission for 5 consecutive days for peripheral blood mononuclear cells (PBMCs). Frozen PBMCs were used for real-time PCR using Taqman probes (NFKB1, SOD1, PPARG, IL10, NFE2L2, and REL) and normalized to GAPDH. Data on hospital length of stay and modified Rankin score (MRS) were collected with 90-day MRS ≤ 3 as favorable outcome. Statistical analysis of clinical characteristics to temporal gene expression from early to delayed timepoints was compared for MRS groups (favorable vs unfavorable) and hematoma volume. Principle findings and results IL10, SOD1, and REL expression were significantly higher at delayed timepoints in PBMCs of ICH patients with favorable outcome. PPARG and REL increased between timepoints in patients with favorable outcome. NFKB1 expression was not sustained, but significantly decreased from higher levels at early onset in patients with unfavorable outcome. IL10 expression showed a negative correlation in patients with high hematoma volume (>30 mL). Conclusions and significance Anti-inflammatory, pro-survival regulators were highly expressed at delayed time points in ICH patients with a favorable outcome, and IL10 expression showed a negative correlation to high hematoma volume.

scholarly journals Effects of pulsed electromagnetic fields on cartilage apoptosis signalling pathways in ovariectomised rats

2011 ◽  
Vol 35 (12) ◽  
pp. 1875-1882 ◽  
Author(s):  
Shasha Li ◽  
Qinglu Luo ◽  
Liqun Huang ◽  
Yujun Hu ◽  
Qingjie Xia ◽  
...  
Keyword(s):  
Electromagnetic Fields ◽  
Signalling Pathways ◽  
Pulsed Electromagnetic Fields ◽  
Pulsed Electromagnetic ◽  
Ovariectomised Rats
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