Small Cell Carcinoma as an Independent Prognostic Factor for Cervical Cancer Patients: A Population-Based Analysis

2020 ◽  
Author(s):  
Wang Miao ◽  
Wu Qiuji ◽  
Congkuan Song ◽  
Liu Yixin ◽  
Wang Xulong ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Prognostic Factors ◽  
Cell Carcinoma ◽  
Multivariate Regression ◽  
Population Based ◽  
Small Cell ◽  
Seer Database ◽  
Multivariate Regression Model ◽  
Kaplan Meier ◽  
Before And After

Abstract Background: Small cell carcinoma (SmCC) of cervix was a rare neoplasm with little recognition. Population-based study describing difference in characteristics and outcomes between SmCC and squamous cell carcinoma (SCC), usual type, was limited. Here, we used the Surveillance, Epidemiology, and End Results (SEER) database to compare SmCC with SCC and investigated the prognostic values of the clinicopathological characteristics and survival outcomes in SmCC of cervix.Methods: Patients diagnosed with cervical SmCC and SCC in SEER database from 2004-2015 were enrolled in analysis. Propensity-score matching analysis (PSM) was used to balance baseline characteristics between patients who were cervical SmCC and those who were cervical SCC. Cox regression models and Kaplan-Meier methods were conducted to analyze survival data before and after PSM. Stratified analyses were performed to investigate the risk of mortality at different stage. Results: In total, 25345 patients including 287 cervical SmCC patients and 25058 cervical SCC patients were enrolled our analysis. Both histological subtypes were more common in unmarried women and in white populations. Compared with cervical SCC patients, cervical SmCC patients showed a higher rate of larger tumor size (tumor size ≥4 cm, 33.8% vs 51.9%, P<0.001), higher grade disease (grade III-IV, 32.2% vs 58.9%, P<0.001), regional lymph node involvement (22.5% vs 49.5%, P<0.001) and distant metastasis (10.3% vs 32.4%, P<0.001). Before PSM, multivariate regression model revealed that SmCC histology (P<0.001) and advanced FIGO stages (P<0.001) were principal prognostic factors of poor survival for cervical patients. After PSM, 1060 patients in SCC group were 4:1 matched with 278 patients in SmCC group. Multivariate regression model in PSM cohort showed histology and FIGO stage were crucial prognostic factors for survival. Kaplan-Meier survival curves clearly showed that cervical SmCC patients had worse survival than that of patients with SCC in all stages, stage I-II, III, IV before and after PSM analysis.Conclusion: Compared to patients with cervical SCC, those with cervical SmCC showed a worse survival before and after adjustment baseline characteristic in all stages. SmCC was an independent poor prognostic factor in cervical cancer patients.

scholarly journals Radiotherapy for small cell carcinoma of the esophagus: outcomes and prognostic factors from a retrospective study

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
Baoqing Chen ◽  
Han Yang ◽  
Huali Ma ◽  
Qiaoqiao Li ◽  
Bo Qiu ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Small Cell ◽  
Therapeutic Modality ◽  
Cancer Center ◽  
Lesion Length ◽  
Carcinoma Of The Esophagus ◽  
Kaplan Meier ◽  
Ecog Ps

Abstract Background Small cell carcinoma of the esophagus (SCCE) is characterized by its progressive feature and poor prognosis. There is no consensus on a standard therapeutic modality for SCCE. In this study, we aimed to characterize the outcomes of primary SCCE patients treated by radiation therapy as part of treatment and investigate prognostic factors. Methods We retrospectively analyzed the data of 42 SCCE patients who were treated by RT as part of treatment at the Sun Yat-sen University Cancer Center from 2001 to 2014. The Kaplan-Meier and log-rank method were used to analyze survival. Cox’s hazard regression model was applied to determine prognostic factors. Results Of the 42 enrolled patients, 25 had limited disease (LD) and 17 with extensive disease (ED). The overall response rate (CR + PR) was 60.0% (21/35). The median overall survival time (OS) for whole and LD group were 12.9 and 36.8 months. The 1-, 3- and 5-year OS rates of the whole cohort were 64.9, 31.3, and 13.9%, respectively. OS was significantly longer in patients with ECOG performance score (ECOG PS) < 2 (p = 0.001), lesion length ≤ 5 cm (p = 0.001), and LD (p = 0.049). In the patients with LD, multivariate analysis indicated that combined with chemotherapy (P = 0.046) and higher radiation dose (P = 0.027) predicted better prognosis in OS. The overall rate of grade 3–4 toxicities in the whole cohort was 37.5%. In total, 65% (17/26) patients with recurrent disease died with the metastasis with or without the primary recurrence. Conclusion RT was one of the effective and safe treatments for locoregional control of SCCE. Lower ECOG PS score, shorter lesion length, treated with chemotherapy, and a higher dose of RT were identified as favorable independent prognostic factors.

scholarly journals Population-based analysis of small cell carcinoma of the esophagus using the SEER database

2020 ◽  
Vol 12 (7) ◽  
pp. 3529-3538
Author(s):  
Jiangyan Li ◽  
Jun Ma ◽  
Hao Wang ◽  
Jianyong Niu ◽  
Lin Zhou
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Population Based ◽  
Small Cell ◽  
Seer Database ◽  
Carcinoma Of The Esophagus

scholarly journals Role of Surgical Treatment in Primary Intestinal Non-Hodgkin Lymphomas: A SEER Population-Based Survival Analysis

2021 ◽  
Author(s):  
Cuifen Zhang ◽  
Xiaohong Zhang ◽  
Zeyu Liu ◽  
Jiahao Tao ◽  
Lizhu Lin ◽  
...  
Keyword(s):  
Multivariate Regression ◽  
Multivariate Regression Analysis ◽  
Population Based ◽  
Confounding Factors ◽  
Seer Database ◽  
Cancer Specific Survival ◽  
Non Hodgkin Lymphoma ◽  
Before And After ◽  
Specific Impact

Abstract Evidence regarding the need for surgery for primary intestinal non-Hodgkin lymphoma (PINHL) patients with chemotherapy is limited and controversial. We aimed to investigate the specific impact of surgery on survival of PINHL patients. Data from PINHL patients (aged >18 years) with chemotherapy between 1983 and 2015 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. We concerned about overall survival (OS) and improved cancer-specific survival (CSS). Propensity score matching (PSM) analysis was also used to explore the reliability of the results to further control for confounding factors. Finally, we screened 3537 patients. Multivariate regression analysis showed that patients with surgery and chemotherapy had better OS (hazard ratio [HR], 0·83; 95% confidence interval [CI], 0·75–0·93; P=0·0009) and CSS (HR, 0·87; 95% CI, 0·77–0·99; P=0·0404) compared with the non-operation group after adjusting for confounding factors. After PSM analysis, compared with non-surgery, surgery remained associated with improved OS (HR, 0·77; 95% CI, 0·68–0·87; P<0·0001) and improved CSS (HR, 0·82; 95% CI, 0·72–0·95; P=0·008) adjusted for baseline differences. In the large cohort of PINHL patients with chemotherapy older than 18 years, surgery was associated with significantly improved OS and CSS before and after PSM analysis.

Population-based study of the incidence, mortality and prognostic factors of small cell carcinoma of the cervix: Analysis of the Surveillance, Epidemiology and End Results database

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 5546-5546
Author(s):  
J. Chen ◽  
O. K. MacDonald ◽  
D. K. Gaffney
Keyword(s):  
Prognostic Factors ◽  
Lymph Node ◽  
Cell Carcinoma ◽  
Figo Stage ◽  
Lymph Node Involvement ◽  
Population Based ◽  
Small Cell ◽  
Cervix Uteri ◽  
Population Based Study ◽  
Node Involvement

5546 Background: Small cell carcinoma (SmC) is a rare histology of the cervix uteri that is generally associated with a poor prognosis. This is a population-based study of SmC using the Surveillance, Epidemiology and End Results (SEER). Methods: From 1977 to 2003, 290 women with SmC of the cervix uteri were identified. In addition, 27,527 patients with squamous cell carcinoma (SC) and 5231 with adenocarcinoma (AC) of the cervix were identified for comparison. The annual incidence of each histology was determined and examined for trend. The patient and disease characteristics at diagnosis were examined for each histology, and prognostic factors were evaluated for SmC. Mortality rates of SmC and other histologies were compared via log-rank tests. Results: Mean annual incidence of SmC was 0.03 per 100,000 women compared to 3.5 and 0.62 for SC and AC. A significant change in incidence was identified for SC and AC (p<0.05), but not for SmC (p=0.595). Patients with SmC were more likely to be treated with radiotherapy and to present with more advanced stage, lymph node involvement and distant metastasis than SC and AC (p<0.05). Survival rates for SmC at 2 and 5 years were 46.8% and 35.7%, which were worse compared to SC (HR 0.45; 95% CI: 0.36–0.57) and AC (HR 0.31; 95% CI: 0.25–0.39). The difference in survival is predominantly in patients with early stage, localized disease, and those treated with surgery ( Table ). Multivariate analysis of SmC, race, FIGO stage, age and hysterectomy alone significantly impacted prognosis (p<0.05), while year of diagnosis, lymph node involvement, tumor size, marital status and other treatment modality did not. Conclusions: SmC is an uncommon histologic variant of cervix cancer associated with a worse prognosis compared to SC and AC with a predilection for metastasis at diagnosis. FIGO stage, age and race are prognostic factors for survival. [Table: see text] No significant financial relationships to disclose.

scholarly journals Small cell carcinoma as an independent prognostic factor for cervical cancer patients: a population-based analysis

2021 ◽  
Author(s):  
Wang Miao ◽  
Wu Qiuji ◽  
Song Congkuan ◽  
Liu Yixin ◽  
Wang Xulong ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Prognostic Factor ◽  
Cell Carcinoma ◽  
Cancer Patients ◽  
Small Cell Carcinoma ◽  
Cox Regression ◽  
Small Cell ◽  
Poor Prognostic Factor ◽  
Gynecology And Obstetrics ◽  
Before And After

Aim: To compare cervical small cell carcinoma (SmCC) with squamous cell carcinoma (SCC) in patient characteristics and survival outcomes. Methods: Cervical SmCC and SCC patients in Surveillance, Epidemiology, and End Results database from 2004 to 2015 were enrolled. Propensity-score matching analysis (PSM) paired subjects with similar background variables. Cox regression, Kaplan–Meier and stratified analyses were conducted before and after PSM. Results: Cervical SmCC patients showed a higher rate of larger tumor size, advanced grade disease, lymph node involvement and distant metastasis (p < 0.001). Before and after PSM, SmCC histology and advanced Federation International of Gynecology and Obstetrics stages (p < 0.001) were principal prognostic factors of survival, and cervical SmCC was associated with worse survival in all stages (stage I–IV). Conclusion: SmCC was an independent poor prognostic factor in cervical cancer patients.

Trends in glassy cell cervical cancer in the United States from 1973-2015: Analysis based on SEER database.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e17502-e17502
Author(s):  
Anahat Kaur ◽  
Shuai Wang ◽  
Tarek N. Elrafei ◽  
Lewis Steinberg ◽  
Abhishek Kumar
Keyword(s):  
United States ◽  
Cervical Cancer ◽  
Overall Survival ◽  
Cell Carcinoma ◽  
Small Sample Size ◽  
Black Population ◽  
The United States ◽  
Small Sample ◽  
Cervix Uteri ◽  
Kaplan Meier

e17502 Background: Glassy cell carcinoma of cervix (GCCC) is a rare histological subtype of cervical cancer which has historically been associated with rapidly progressive disease, early development of metastases and overall poor prognosis. We attempt to define real-world trends in GCCC in the United States based on data from SEER (Surveillance, Epidemiology and End Results) database. Methods: We extracted data from the US National Cancer Institute's SEER 2018 dataset using ICD-O code for ‘Cervix Uteri Glassy Cell Carcinoma’. All patients who were diagnosed between 1973-2015 were included. Statistical analysis was done using SPSS 26. Kaplan Meier curve was used for survival analysis. Results: Data for a total of 57 patients with GCCC was available from 1975 to 2017. Median age at diagnosis was 38 years (range 30.5-44.5). Increased frequency of cases was noted in white females (77.2%) as compared to black population (22.2%). Most cases initially presented with localized or regional spread (47.4% and 40.4% respectively) with distant metastasis seen in only 10.5% patients. Data analysis revealed that 63.2% patients had Grade III poorly differentiated carcinoma, 66.7% received radiation therapy, 57.9% underwent chemotherapy and 59.6% had cancer direceted surgery performed. Calculated mean overall survival was 121.9 months. We were unable to calculate 5 year and 10 year median overall survival due to small sample size and censored data. Conclusions: GCCC is a rare histologic type of cervical cancer that presents at a younger age, is more frequently seen in white females and is commonly associated with localized or regional spread at time of initial presentation.[Table: see text]

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