scholarly journals Regulation of MicroRNA 103 and 107 in Obese T2DM Patients Maintained on Metformin

2021 ◽  
Author(s):  
Nahla E. El-Ashmawy ◽  
Amr M. Gawaly ◽  
Hala A. EL Batanony ◽  
Naglaa F. Khedr
Keyword(s):  
Insulin Resistance ◽  
Serum Insulin ◽  
Glycosylated Hemoglobin ◽  
Serum Levels ◽  
Diabetic Control ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Diagnostic Biomarkers ◽  
Type 2 Diabetic

Abstract Metformin increases insulin sensitivity in obese type 2 diabetic patients (T2DM) by different mechanisms. The current study was conducted to estimate the levels of miRNA-103 and 107 in obese non diabetic subjects as well as obese T2DM patients maintained on metformin, and to correlate between the levels of miR 103 and 107 and the development of insulin resistance. Ninety subjects were equally recruited into three groups; obese non diabetic control (OC), obese newly diagnosed diabetic (ONDD) and obese type 2 diabetic treated with metformin (MetD). Serum levels of blood glucose, insulin, lipid profile, glycosylated hemoglobin (HbA1c), miR103&107 expression and DICER-1 were analyzed. Serum levels of HbA1c, FBG, HOMA-IR, T.ch, TG, LDL-C and VLDL-C were increased in ONDD (p˂0.0001) compared to OC and MetD. Significant increase of HDL-C (p = 0.022) was observed in MetD compared to OC and ONDD. Serum insulin was increased (p = 0.004) and miR 103 & 107 gene expression (p < 0.0001) in ONDD and significant down-regulation in MetD compared to OC group. DlCER-1 levels were decreased (p < 0.0001) in ONDD group and increased in MetD group compared to OC group. Both miR 103 and 107 were positively correlated with insulin and HOMA-IR, but negatively correlated with DICER-1. Depending on the estimated cutoff-values of area under receiver curve (AUC), miR 103 and 107 were excellent diagnostic biomarkers for insulin resistance. Our findings indicated the clinical utility of miR103 and miR 107 in diagnosis and treatment of insulin resistance. Moreover, metformin can affect miR 103 and miR 107 through modulation of DICER-1 level.

scholarly journals Adiponectin serum levels correlate with insulin resistance in type 2 diabetic patients

2015 ◽  
Vol 23 (3) ◽  
pp. 250-256 ◽  
Author(s):  
Shereen Aleidi ◽  
Ala Issa ◽  
Haidar Bustanji ◽  
Mohammad Khalil ◽  
Yasser Bustanji
Keyword(s):  
Insulin Resistance ◽  
Serum Levels ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

scholarly journals Glycaemic status and insulin resistance in diabetic peripheral neuropathy

2016 ◽  
Vol 11 (2) ◽  
pp. 54-58
Author(s):  
Taslima Akter ◽  
Qazi Shamima Akhter ◽  
Mezbahur Rahman ◽  
Sabrina Fahmida Azim ◽  
Fouzia Farid
Keyword(s):  
Insulin Resistance ◽  
Peripheral Neuropathy ◽  
Serum Insulin ◽  
Glycosylated Hemoglobin ◽  
Diabetic Patients ◽  
Model Assessment ◽  
Fasting Serum ◽  
Type 2 Diabetic Patients ◽  
Study Results

Background: Complication of diabetes mellitus includes peripheral neuropathy which causes ischemic foot ulceration. Hyperglycemia and insulin resistance may accelerate the development of diabetic peripheral neuropathy.Objective: To assess the glycaemic status and insulin resistance for development of peripheral neuropathy in type 2 diabetes mellitus.Methods: This control case control study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka from July 2014 to June 2015. A total number of 150 Type 2 diabetic patients of both sexes were selected with age ranging 40 to 50 years. Among them, 75 patients with peripheral neuropathy were included in study group and 75 patients without peripheral neuropathy were control. For evaluation of glycaemic status, fasting serum glucose (FSG), Glycosylated hemoglobin (HbA1c) and to calculate insulin resistance by homeostatic model assessment for insulin resistance (HOMA-IR), fasting serum insulin (FSI), were estimated. For statistical analysis, unpaired Student’s ‘t’ test was done.Results: In this study, significant increase in FSG, HbA1c, FSI, HOMA-IR were found in diabetic subjects with peripheral neuropathy in comparison to control group.Conclusion: From the study results, it is concluded that poor glycaemic control and greater insulin resistance may be associated with diabetic peripheral neuropathy.Bangladesh Soc Physiol. 2016, December; 11(2): 54-58

The effect of insulin resistance on postprandial triglycerides in Korean type 2 diabetic patients

2012 ◽  
Vol 51 (1) ◽  
pp. 15-22 ◽  
Author(s):  
Kyeong Hye Park ◽  
Kwang Joon Kim ◽  
Byung-Wan Lee ◽  
Eun Seok Kang ◽  
Bong Soo Cha ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Postprandial Triglycerides ◽  
Korean Type ◽  
Type 2 Diabetic

Effect of propolis on glycemic control in patients with type 2 diabetes: an updated systematic review and meta-analysis of randomized controlled trials

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Zahra Mosallanezhad ◽  
Cain Clark ◽  
Fatemeh Bahreini ◽  
Zahra Motamed ◽  
Abdolhamid Mosallanezhad ◽  
...  
Keyword(s):  
Systematic Review ◽  
Serum Insulin ◽  
Meta Analysis ◽  
Diabetic Patients ◽  
Controlled Trials ◽  
Type 2 Diabetic Patients ◽  
Content Type ◽  
Randomized Controlled ◽  
Type 2 Diabetic

Purpose The purpose of this systematic review and meta-analysis was to investigate the efficacy of propolis on glycemic indices in type 2 diabetic patients. Design/methodology/approach Web of science (ISI), Embase, Scopus and PubMed were systematically searched to find randomized controlled trials (RCTs) assessing the effects of propolis intake on glycemic controls in type 2 diabetic patients, from inception up to September 1, 2020. A random-effects model was used to pool weighted mean difference (WMD). Meta-regression was performed to detect the potential sources of inter-study heterogeneity. Findings Seven trials were included in the meta-analysis. Compared to controls, propolis intake significantly improved serum fasting blood sugar (FBS) (WMD = −13.62 mg/dl, 95% CI = [−23.04, −4.20], P = 0.005, I2 = 58.5%) and hemoglobin A1C (HbA1c) (WMD = −0.52%, 95% CI = [−0.86, −0.18], P = 0.002, I2 = 64.0%). In contrast, receiving propolis did not change serum insulin (WMD = −1.46 (uIU/ml), 95% CI = [−2.94, 0.02], P = 0.05, I2 = 75.0%) and homeostatic model assessment for insulin resistance (HOMA-IR) (WMD = −0.98 (%), 95% CI = [−2.00, 0.04], P = 0.06, I2 = 82.3%) compared to controls. Originality/value The present meta-analysis demonstrated that propolis intake significantly reduces serum FBS and HbA1c in diabetic patients but does not alter serum insulin and HOMA-IR. Further large-scale RCT’s are needed to approve these effects.

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