Absence of WDR13 in p53-Null Mice Increases Longevity
Keyword(s):
Abstract Absence of WDR13 is known to be involved in pancreatic, colon and uterine hyperproliferation. However, a recent study showed its antiproliferative role liver regeneration in response to hepatotoxins. These findings intrigued to study the role of WDR13-null condition in Trp53 knockout mouse to study the tumour predisposition and survival. We report absence of Wdr13 in Trp53-null background alleviates the tumour load, in turn increasing total survival in mouse model.
2008 ◽
Vol 37
(3)
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pp. 651-657
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2008 ◽
Vol 36
(9)
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pp. 1840-1845
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2014 ◽
Vol 93
(5-6)
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pp. 252-266
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2004 ◽
Vol 314
(3)
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pp. 849-853
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2014 ◽
Vol 13
(6)
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pp. 2771-2782
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2011 ◽
Vol 51
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pp. S33-S34