scholarly journals The Impact of Combined Cranberry Supplementation and Weight Loss Diet on Inflammatory, Antioxidant and Apoptosis Biomarkers in Patients with Non-Alcoholic Fatty Liver Disease

2021 ◽  
Author(s):  
Majid Mohammadshahi ◽  
Razie Hormoznejad ◽  
Fakher Rahim ◽  
Bijan Helli ◽  
Pezhman Alavinejad ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Weight Loss ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Serum Levels ◽  
Alcoholic Fatty Liver ◽  
Weight Loss Diet ◽  
Tnf Α ◽  
Alcoholic Fatty Liver Disease

Abstract Background Non-alcoholic fatty liver disease (NAFLD) is a prevalent chronic liver diseases. The aim of this study was to evaluate the effect of combined weight loss diet and cranberry supplementation on inflammatory, antioxidant and apoptosis biomarkers in patients with NAFLD. Methods In this randomized, double-blinded, controlled clinical trial, 41 NAFLD patients were supplemented with either a 288-mg cranberry tablet or a placebo tablet for 12 weeks. Both groups followed a diet of 500–1000 calories less than the estimated energy requirements. Serum levels of Total antioxidant capacity (TAC), Malondialdehyde (MDA), Cytokeratin 18-M30 (CK-18 M30), Chemokine C-C motif ligand 2 (CCL2) and Tumour necrosis factor alpha (TNF-α) were measured at both baseline and the end of the study. Results Significant improvements in TAC were observed in the cranberry group and between the two groups (p = 0.006 and p = 0.011 respectively), but the changes in the placebo group were not significant (p = 0.325). There were no statistically significant differences in the serum levels of MDA, CK-18 M30, CCL2 and TNF-α between the cranberry and the placebo groups (p > 0.05). Conclusions It seems that daily consumption of cranberry supplement would be beneficial in increasing serum levels of TAC. Further studies are needed to investigate the effects of anti-inflammatory and antioxidant properties of cranberry on NAFLD. Trial registration : Iranian Registry of Clinical Trial. http://www.irct.ir: IRCT20150124020765N2, January 2019.

The effects of DASH diet on weight loss and metabolic status in adults with non-alcoholic fatty liver disease: a randomized clinical trial

2015 ◽  
Vol 36 (4) ◽  
pp. 563-571 ◽  
Author(s):  
Mohsen Razavi Zade ◽  
Mohammad Hosein Telkabadi ◽  
Fereshteh Bahmani ◽  
Behnaz Salehi ◽  
Shima Farshbaf ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Weight Loss ◽  
Liver Disease ◽  
Fatty Liver ◽  
Randomized Clinical Trial ◽  
Fatty Liver Disease ◽  
Metabolic Status ◽  
Alcoholic Fatty Liver ◽  
Dash Diet ◽  
Alcoholic Fatty Liver Disease

scholarly journals Efeito do uso de probióticos, prebióticos e simbióticos na Doença Hepática Gordurosa Não Alcoólica

2020 ◽  
Vol 9 (8) ◽  
pp. e263982594
Author(s):  
Mickael de Paiva Sousa ◽  
Joyce Sousa Aquino Brito ◽  
Pedro Lucas Alves Ferreira ◽  
Suhelen Maria Brasil da Cunha Gama ◽  
Betânia de Jesus e Silva de Almendra Freitas
Keyword(s):  
Clinical Trial ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Nutritional Intervention ◽  
Alcoholic Fatty Liver ◽  
Tnf Α ◽  
Alcoholic Fatty Liver Disease

Introdução: A Doença Hepática Gordurosa Não Alcoólica (DHGNA) é um espectro de doenças hepáticas crônicas, sendo a mais comum devido à prevalência de obesidade em todo o mundo. Nesse contexto, há estudos existentes na literatura que ratificam os potenciais efeitos de microrganismos frente às complicações da DHGNA. Objetivo: A presente revisão se propõe a verificar as evidências sobre o efeito de probióticos, prebióticos e simbióticos na  (DHGNA). Metodologia: Realizou-se uma busca de artigos publicados nas bases de dados Science Direct, PubMed e Cochrane, utilizando-se a combinação de descritores cadastrados nos Descritores em Ciências da Saúde (DeCS): non- alcoholic fatty liver disease; microbiome; nutritional intervention; clinical trial. Quinze artigos originais entre os anos de 2012 e 2018 foram elegidos. Resultados: Estudos que utilizaram probióticos, prebióticos e simbiótico na DHGNA observaram melhora em alguns parâmetros que contribuem para progressão da doença, como: ação de enzimas pró-oxidantes, redução da adiposidade, inflamação e fibrose no fígado, regulação da flora bacteriana intestinal, entre outros. Se tratando de bactérias probióticas, estudos relatam que as mesmas previnem o dano hepático, melhora o acúmulo de gordura visceral e a sensibilidade à insulina. Entre os efeitos dos prebióticos, destacam-se a atenuação da extensão da DHGNA, restaurando a homeostase da microbiota intestinal e a função da barreira epitelial intestinal. Os simbióticos, por sua vez, diminuíram significativamente os níveis de alanina aminotransferase, um marcador de lesão no fígado, e os níveis séricos de TNF-α e PCR. Conclusão: Terapias direcionadas à microbiota intestinal têm se tornado importantes ferramentas para o tratamento da DHGNA, uma vez que existem na literatura, relatos experimentais que destacam uma série de benefícios por meio do uso de probióticos, prebióticos e simbióticos. No entanto, são necessários mais estudos acerca do presente tema.

scholarly journals Improvements in clinical characteristics of patients with non-alcoholic fatty liver disease, after an intervention based on the Mediterranean lifestyle: a randomised controlled clinical trial

2018 ◽  
Vol 120 (2) ◽  
pp. 164-175 ◽  
Author(s):  
Christina N. Katsagoni ◽  
George V. Papatheodoridis ◽  
Panagiota Ioannidou ◽  
Melanie Deutsch ◽  
Alexandra Alexopoulou ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Weight Loss ◽  
Liver Disease ◽  
Fatty Liver ◽  
Mediterranean Diet ◽  
Fatty Liver Disease ◽  
Liver Stiffness ◽  
Alcoholic Fatty Liver ◽  
Randomised Controlled ◽  
Alcoholic Fatty Liver Disease

AbstractLifestyle interventions remain the cornerstone therapy for non-alcoholic fatty liver disease (NAFLD). This randomised controlled single-blind clinical trial investigated the effect of Mediterranean diet (MD) or Mediterranean lifestyle, along with weight loss, in NAFLD patients. In all, sixty-three overweight/obese patients (50 (sd11) years, BMI=31·8 (sd4·5) kg/m2, 68 % men) with ultrasonography-proven NAFLD (and elevated alanine aminotransferase (ALT) and/or γ-glutamyl transpeptidase (GGT) levels) were randomised to the following groups: (A) control group (CG), (B) Mediterranean diet group (MDG) or (C) Mediterranean lifestyle group (MLG). Participants of MDG and MLG attended seven 60-min group sessions for 6 months, aiming at weight loss and increasing adherence to MD. In the MLG, additional guidance for increasing physical activity and improving sleep habits were given. Patients in CG received only written information for a healthy lifestyle. At the end of 6 months, 88·8 % of participants completed the study. On the basis of intention-to-treat analysis, both MDG and MLG showed greater weight reduction and higher adherence to MD compared with the CG (allP<0·05) at the end of intervention. In addition, MLG increased vigorous exercise compared with the other two study groups (P<0·001) and mid-day rest/naps compared with CG (P=0·04). MLG showed significant improvements in ALT levels (i.e. ALT<40 U/l (P=0·03) and 50 % reduction of ALT levels (P=0·009)) and liver stiffness (P=0·004) compared with CG after adjusting for % weight loss and baseline values. MDG improved only liver stiffness compared with CG (P<0·001) after adjusting for the aforementioned variables. Small changes towards the Mediterranean lifestyle, along with weight loss, can be a treatment option for patients with NAFLD.

Non-Alcoholic Fatty Liver Disease in Overweight Children and its Relationship with Retinol Serum Levels

2008 ◽  
Vol 78 (1) ◽  
pp. 27-32 ◽  
Author(s):  
Suano de Souza ◽  
Silverio Amancio ◽  
Saccardo Sarni ◽  
Sacchi Pitta ◽  
Fernandes ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Liver Disease ◽  
Fatty Liver ◽  
Lipid Profile ◽  
Fatty Liver Disease ◽  
Thiobarbituric Acid ◽  
Serum Levels ◽  
Control Group ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Objectives: To evaluate the frequency of non-alcoholic fatty liver disease, the retinol serum levels, lipid profile, and insulin resistance in overweight/obese children. To relate these biochemical variables with the risk of this disease in the population studied. Methods: The study was cross-sectional and prospective, with 46 overweight/obese school children (28 female, 18 male; mean age 8.6 years). The control group consisted of 45 children, paired by age and gender. Hepatic steatosis, evaluated by ultrasound, was classified as normal, mild, moderate, or severe. Also evaluated were serum retinol levels; thiobarbituric acid reactive substances; lipid profile; and fasting glucose and serum insulin levels, used for the calculation of the Homeostasis Model Assessment. Results: Hepatic ultrasound alterations were found in 56.5% and 48,9% of the overweight/obese and control group children, respectively. Presence of obesity was associated with high levels of triglycerides (OR = 4.6; P = 0.002). In the studied children, the risk of steatosis was related to a trend to a higher percentage of retinol inadequacy (OR = 2.8; p = 0.051); there was no association with thiobarbituric acid reactive substances, lipid profile, or insulin resistance. Conclusions: The high frequency of non-alcoholic fatty liver disease in both groups, evaluated by hepatic ultrasound, in low-socioeconomic level children, independent of nutritional condition and without significant association with insulin resistance, emphasizes that especially in developing countries, other risk factors such as micronutrient deficiencies (e.g. vitamin A) are involved.

scholarly journals Patient disease knowledge, attitudes and behaviours related to non-alcoholic fatty liver disease: a qualitative study

2021 ◽  
Vol 8 (1) ◽  
pp. e000634
Author(s):  
Monica A Tincopa ◽  
Jane Wong ◽  
Michael Fetters ◽  
Anna S Lok
Keyword(s):  
Social Support ◽  
Weight Loss ◽  
Liver Disease ◽  
Fatty Liver ◽  
Health Behaviour ◽  
Fatty Liver Disease ◽  
Primary Therapy ◽  
Alcoholic Fatty Liver ◽  
Medical Comorbidities ◽  
Alcoholic Fatty Liver Disease

ObjectiveDespite clear evidence that weight loss via nutritional and physical activity changes improves histological outcomes in non-alcoholic fatty liver disease (NAFLD), many patients struggle to implement and maintain these health behaviour changes. The aim of this study was to characterise disease knowledge, attitudes and behaviours among persons with NAFLD and to identify the factors driving these health behaviours and perceptions.DesignWe conducted semistructured interviews among patients with NAFLD. We used purposeful sampling to enroll equivalent percentages based on age and sex, and enrolled approximately one-third of patients with cirrhosis to capture those perspectives. Interviews were conducted until thematic saturation was achieved. Transcripts were coded using NVivo software to identify themes and subthemes.ResultsA total of 29 patient interviews were completed. Ambiguity about the diagnosis and aetiology of their liver disease was a key theme, though the vast majority of patients were aware that weight loss via nutrition and exercise was the primary therapy. Most patients were asymptomatic, diagnosed incidentally, and reported low level of concern regarding their diagnosis. The primary barriers and facilitators to health behaviour change were the presence of social support, competing medical comorbidities and low motivation to change behaviours.ConclusionsAlthough patients are aware that lifestyle interventions are the primary therapy for NAFLD, there is a gap in knowledge about the condition. The presence of social support and competing medical comorbidities were the most consistent facilitators and barriers to lifestyle change. Tailoring treatment recommendations to provide relevant disease education, specific nutrition and exercise regimens, and personalised approaches based on specific individual barriers and facilitators will likely aid in uptake and maintenance of first-line therapy for NAFLD.

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