The Application of Augmented Reality in Craniofacial Bone Fracture Reduction: Study Protocol For a Randomized Controlled Trial.

Abstract Background: Augmented reality (AR) is a new technology that increases users’ perception of the real world. The purpose of this study is to evaluate the efficacy and safety of augmented reality navigation system in treatment with craniofacial fracture reduction.Methods: This will be a single-center prospective randomized controlled trial. Twenty-two patients will be assigned to two groups of 11 and those with zygomaticomaxillary complex fractures will undergo preoperative three-dimensional CT modeling and have operational plans designed. The control team will use traditional optical navigation to perform the surgery and the experimental team will use an AR navigation system. The primary outcome measures will be the accuracy of the key points of surgical area between the preoperational surgical plan and post-operation. The secondary outcome measures will be the blood loss, operation time, bone reduction time, hospital time and complication rate. The findings obtained through this study are expected to evaluate efficacy and safety of the augmented reality navigation system in the treatment of zygomaticomaxillary complex fractures.Discussion: This controlled trial of augmented reality navigation system in treatment with zygomaticomaxillary complex fracture reduction is expected to clarify the efficacy and safety of this technology by measuring the accuracy of the key points of surgical area and blood loss, operation and bone reduction times, hospital stay duration and complication rates. This is a single-center study, and the results are expected to promote the application of augmented reality in craniofacial fracture reduction to improve surgery accuracy and efficacy.Trial registration: Trial registration: Chinese Clinical Trial Registry: No. ChiCTR1900022626. Registered on April 19, 2019.

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A phase II, single-center, double-blind, randomized placebo-controlled trial to explore the efficacy and safety of intravenous melatonin in patients with COVID-19 admitted to the intensive care unit (MelCOVID study): a structured summary of a study protocol for a randomized controlled trial

Trials ◽

10.1186/s13063-020-04632-4 ◽

2020 ◽

Vol 21 (1) ◽

Cited By ~ 3

Author(s):

Miguel Rodríguez-Rubio ◽

Juan Carlos Figueira ◽

Darío Acuña-Castroviejo ◽

Alberto M. Borobia ◽

Germaine Escames ◽

...

Keyword(s):

Intensive Care Unit ◽

Randomized Controlled Trial ◽

Intensive Care ◽

Phase Ii ◽

Study Protocol ◽

Controlled Trial ◽

Efficacy And Safety ◽

Single Center ◽

Double Blind ◽

Randomized Controlled

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Does An Augmented Reality-based Portable Navigation System Improve the Accuracy of Acetabular Component Orientation During THA? A Randomized Controlled Trial

Clinical Orthopaedics and Related Research ◽

10.1097/corr.0000000000001083 ◽

2020 ◽

Vol 478 (5) ◽

pp. 935-943 ◽

Cited By ~ 2

Author(s):

Hiroyuki Ogawa ◽

Kenji Kurosaka ◽

Atsuko Sato ◽

Naoyuki Hirasawa ◽

Masaaki Matsubara ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Augmented Reality ◽

Acetabular Component ◽

Navigation System ◽

Controlled Trial ◽

Randomized Controlled ◽

Portable Navigation ◽

Component Orientation

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Efficacy and safety of using premedication with simethicone/Pronase during upper gastrointestinal endoscopy examination with sedation: A single center, prospective, single blinded, randomized controlled trial

Digestive Endoscopy ◽

10.1111/den.12952 ◽

2017 ◽

Vol 30 (1) ◽

pp. 57-64 ◽

Cited By ~ 2

Author(s):

Ling‐Ye Zhang ◽

Wen‐Yan Li ◽

Ming Ji ◽

Fu‐Kun Liu ◽

Guang‐Yong Chen ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Gastrointestinal Endoscopy ◽

Controlled Trial ◽

Upper Gastrointestinal Endoscopy ◽

Efficacy And Safety ◽

Single Center ◽

Randomized Controlled ◽

Upper Gastrointestinal

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A controlled study of the efficacy and safety of tandospirone citrate combined with escitalopram in the treatment of vascular depression: A pilot randomized controlled trial at a single-center in China

Journal of Psychiatric Research ◽

10.1016/j.jpsychires.2019.04.024 ◽

2019 ◽

Vol 114 ◽

pp. 133-140 ◽

Cited By ~ 1

Author(s):

Hongbin Chen ◽

Qianwen Lin ◽

Ting Lin ◽

Yongsen Lin ◽

Xiaohui Lin ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Controlled Trial ◽

Controlled Study ◽

Efficacy And Safety ◽

Single Center ◽

Vascular Depression ◽

Randomized Controlled ◽

Pilot Randomized Controlled Trial

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The Efficacy and Safety of Two Low-Dose Peri-Operative Dexamethasone in Total Hip Arthroplasty: A Single-Center Randomized Controlled Trial

10.21203/rs.3.rs-257598/v1 ◽

2021 ◽

Author(s):

fulin Li ◽

dong yin ◽

yu Huang ◽

Xiao Huang ◽

Wenwen Huang

Keyword(s):

Randomized Controlled Trial ◽

Total Hip Arthroplasty ◽

Low Dose ◽

Controlled Trial ◽

Perioperative Period ◽

Efficacy And Safety ◽

Single Center ◽

Blank Group ◽

Randomized Controlled ◽

Vas Score

Abstract Objective To evaluate the efficacy and safety of two low-dose dexamethasone in the perioperative period of total hip arthroplasty (THA) with a single-center randomized controlled trial.Method 98 patients who underwent THA received two low-dose (10 mg) IV-dexamethasone (group dexa) or IV- isotonic saline group (The placebo).The post-operative day 24 h,48 h,72 h c reactive protein (CRP) and interleukin-6(IL-6), the pain VAS scores at rest and mobilization, the incidence of postoperative nausea and vomiting (PONV), nausea VAS score, postoperative fatigue rating and analgesia and antiemetic, the postoperative lengh of stay (PLOS), wound problems and complications were recorded and compared.Results The inflammatory markers (CRP, IL - 6) level postoperative 24,48,72 hours in dexa group of was lower than the placebo group (P<0.05).The 24 hours of rest and dynamic pain VAS score in dexa group was lower than those in blank group (P<0.05).The incidence of PONV, nausea VAS score, fatigue ICFS score in dexa group was lower than the blank group (P<0.05) and the dosage of analgesic and antiemetic were decreased significantly (P<0.05).In addition, the PLOS of dexa group was shorter than the blank group (P< 0.05).There was no significant difference in perioperative complications between the two groups (P> 0.05).Conclusion The application of two low-dose dexamethasone in the perioperative period of THA can effectively reduce the postoperative CRP and IL-6 levels, reduce pain, nausea, postoperative fatigue and the use of opioid analgesics, shorten the PLOS, without increasing the risk of incision infection or gastrointestinal hemorrhage.

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