scholarly journals Prognostic Effect of Glycemic Management In Acute First-Ever Ischemic Stroke On Stroke Recurrence And Mortality For Patients Without Previous Diabetes: A Longitudinal Cohort Study

Author(s):  
Hsi- Hsing Yang ◽  
Wu-Chien Chien ◽  
Jen-Jiuan Liaw ◽  
Chia-Chen Yang ◽  
Chi-Hsiang Chung ◽  
...  

Abstract Objective This study aimed to investigate the short- and long-term prognostic effects of glycemic management on stroke recurrence and mortality in patients with acute first-ever ischemic stroke (FIS) without previous diabetes. Methods In total, 484,952 patients aged ≥20 years with FIS and nonprevious diabetes were retrieved from the 2000 to 2015 Taiwan’s National Health Insurance Research Database. Patients were categorized into the following cohorts: FIS without hyperglycemia (FISw/oHG), FIS with hyperglycemia without glycemic treatment (FISHGw/oGT), and FIS with hyperglycemia with glycemic treatment (FISHGw/GT). The short-term (within 1 year) and long-term (at the endpoint of 9.3 ± 8.6 years) prognostic effects of glycemic treatment and blood glucose monitoring on stroke recurrence and mortality among the cohorts were tested through Cox regression analysis.Results The mortality risk was lower in the FISHGw/GT cohort than in the FISHGw/oGT cohort at 3 months, 6 months, and 1 year (adjusted hazard ratio = 0.68, 0.62, 0.69, respectively, p < 0.001) as well as at the study endpoint, but no difference was observed in stroke recurrence at any time point (p > 0.05). Furthermore, compared with FISHGw/oGT without blood glucose monitoring, FISHGw/GT combined with blood glucose monitoring led to decreased risks of stroke recurrence within 1 year (p < 0.001) and mortality within 1 year and at the study endpoint (p < 0.001). Conclusion For optimal glycemic management in the acute phase and improved prognoses for patients with FIS and nonprevious diabetes with hyperglycemia, intensive blood glucose monitoring combined with glycemic treatment is needed.

2014 ◽  
Vol 609-610 ◽  
pp. 879-884
Author(s):  
Ya Xin Liu ◽  
Xiu Shan Song ◽  
Yu Feng Yao ◽  
Bo Huang ◽  
Ming Zhong

Considering the long-term, flexible blood glucose monitoring demand, a sensor monitoring system for interstitial fluid (ISF) ultrafiltration sampling and on-line monitoring of blood glucose is presented. In this paper, the glucose sensor chip used in this system will be introduced in detailed. This sensor chip was developed by MEMS technique and it has the advantages of less ISF consumption, smaller structures and easier integration. Otherwise, the silicon glucose sensor chip is provided with diffusion control of the analyte through a porous silicon membrane into a silicon etched cavity containing the agarose immobilised enzyme. First, glucose monitoring principle of this sensor system will be intrudouced briefly. Then, this paper focuses on the design and fabrication of the key component, which is the MEMS sensor chip with diffusion control. Finally, experiments were carried out, and results show that the sensor chips signal response time at increasing glucose concentrations is about 5s; The linear range is large enough to cover the required broad area of blood glucose (0.2 ~ 20 mmol / L), the sensitivity is 9.76 nA/mmol.L-1, and the correlation coefficient is 0.9954. In addition, experiments results of sensor chip with different pore membrane were compared with each other. We can see that different measuring range and sensitivity can be obtained, which agrees with the theoretical analysis.


1985 ◽  
Vol 2 (2) ◽  
pp. 33-35 ◽  
Author(s):  
I N Scobie ◽  
Beng Hey Tey ◽  
Vivien K Bowden ◽  
Sue L Judd ◽  
Clara Lowy ◽  
...  

2020 ◽  
Vol 2 (2) ◽  
pp. 83-90
Author(s):  
Mesa Sukmadani Rusdi

Diabetes mellitus (DM) is a metabolic disorder characterized by an increase in insulin due to decreased insulin secretion by pancreatic beta cells and/ or insulin resistance. Hypoglycemia is one of the main risks that DM patients often to suffer. in Type 2 DM, hypoglycemia is the most common side effect of the use of insulin and sulfonylureas. It is because of their modes of action . Hypoglycaemia presents a major barrier to satisfactory long term glycemic control and remains a feared complication of diabetes treatment. Acute and chronic complications of hypoglycemia can interfere with life, such as social interactions, sleep, sexual activity, driving, sports, and other activities. Blood glucose monitoring needs to be done to prevent the risk of hypoglycemia. Patients treated with insulin, sulfonylureas/glinides are advised to check blood glucose any time hypoglycemia is going to happen.


2016 ◽  
Vol 11 (1) ◽  
pp. 172-173 ◽  
Author(s):  
Michelle F. Magee ◽  
Evgenia Gourgari ◽  
Gretchen A. Youssef ◽  
Carine M. Nassar

Sign in / Sign up

Export Citation Format

Share Document