scholarly journals The Clinical Features and Prognosis Analysis of Pregnant Women with Tuberculosis After in Vitro Fertilization and Embryo Transfer and Natural Fertilization

2021 ◽  
Author(s):  
Wei Huang ◽  
Tao Li ◽  
yang Yang ◽  
Ping Liu ◽  
Jinghua Liu ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Liver Injury ◽  
Pregnant Women ◽  
Embryo Transfer ◽  
Clinical Features ◽  
T Lymphocyte ◽  
Adverse Outcomes ◽  
Vitro Fertilization ◽  
Ivf Et

Abstract Objective: To investigate the clinical characteristics and prognosis of women with tuberculosis after in vitro fertilization and embryo transfer (IVF-ET) and natural pregnancy.Design/Methods: Ninety-five pregnant women with tuberculosis admitted to Shanghai Public Health Clinical Center between February 2013 and July 2020 were retrospectively analyzed. They were divided into 24 cases of IVF-ET with tuberculosis and 71 cases of natural pregnancy group with tuberculosis. Baseline demographic, medical history were collected. We used descriptive statistics to describe demographic, clinical features and prognosis of pregnant women with tuberculosis using Pearson chi-squared, Fisher’s exact tests, or Kruskal-Wallis.Results: The incidence of fever, hematogenous disseminated pulmonary, drug-induced liver injury and fetal adverse outcomes in IVF-ET group were higher than those in natural pregnancy group (p<0.05). The lymphocyte count, hemoglobin level, albumin level and the number of CD4+T lymphocyte、CD8+ T lymphocyte in IVF-ET group were significantly lower than that in natural pregnancy group (p<0.05).Conclusions: Pregnant women with tuberculosis after in vitro fertilization and embryo transfer have broader lung lesions, more prominent symptoms of systemic poisoning, larger proportion of severe tuberculosis, more prone to anti-tuberculosis drugs induced liver injury and higher proportion of spontaneous abortion and inevitable abortion, which calls for enough attentions.

scholarly journals Acute miliary tuberculosis in pregnancy after in vitro fertilization and embryo transfer: a report of seven cases

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Xiaoyan Gai ◽  
Hongbin Chi ◽  
Wenli Cao ◽  
Lin Zeng ◽  
Lixue Chen ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Pregnant Women ◽  
Embryo Transfer ◽  
Pregnancy Outcomes ◽  
Miliary Tuberculosis ◽  
Vitro Fertilization ◽  
Peking University ◽  
In Pregnancy ◽  
Ivf Et

Abstract Background While miliary tuberculosis (TB) in pregnancy is rare after in vitro fertilization and embryo transfer (IVF-ET), it poses a serious threat to the health of pregnant women and their fetuses. The present study aimed to describe the clinical features of miliary TB and pregnancy outcomes of patients after IVF-ET. Methods Data of infertile patients who received IVF-ET at Peking University Third Hospital between January 2012 and December 2017 were retrospectively analyzed. Patients who developed miliary TB during pregnancy were identified, and clinical characteristics of miliary TB were described. Results Out of 62,755 infertile women enrolled, 7137 (11.4 %) showed signs of prior pulmonary TB on chest X-ray (CXR). Among the 15,136 women (mean age: 33.2 ± 5.0 years) who successfully achieved clinical pregnancy, seven patients aged 28–35 years had miliary TB during pregnancy, with two patients having a complication of TB meningitis. All these patients presented with fever. Notably, old TB lesions were detected on CXR in six patients before IVF-ET; nevertheless, no anti-TB therapy was administered. Furthermore, salpingography revealed oviduct obstruction in all patients (7/7). Patients received anti-TB therapy following a diagnosis of miliary TB and were clinically cured. However, pregnancy was terminated due to spontaneous (4/7) and induced (3/7) abortion. Conclusions TB reactivation, mostly as miliary TB and TB meningitis, is severe in pregnant women after IVF-ET and deleterious to pregnancy outcomes. Signs of prior TB on CXR may be risk factors for TB reactivation during pregnancy.

Salivary oestradiol and progesterone after in vitro fertilization and embryo transfer using different luteal support regimens

1990 ◽  
Vol 2 (4) ◽  
pp. 351 ◽  
Author(s):  
YF Wong ◽  
EP Loong ◽  
KR Mao ◽  
PP Tam ◽  
NS Panesar ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Embryo Transfer ◽  
Luteal Phase ◽  
Biologically Active ◽  
Luteal Support ◽  
Vitro Fertilization ◽  
Group A ◽  
Group B ◽  
Ivf Et

Salivary oestradiol (E2) and progesterone (P) levels have been shown to reflect the biologically active fractions in the serum. The luteal-phase status of stimulated cycles was investigated after in vitro fertilization and embryo transfer (IVF-ET). Thirty patients were randomly allocated to one of three luteal therapy groups: group A had no support, group B had intramuscular P and group C had intramuscular P and human chorionic gonadotrophin (hCG). One pregnancy was achieved in group A, two in group B and three in group C. Significant correlations between salivary and serum levels of E2 and of P in matched samples during luteal phase were found. Salivary E2 levels from luteal day 8 through day 14 and P levels from day 3 through day 14 were significantly higher in the pregnant than in the nonpregnant cycles. Among the nonpregnant cycles, salivary E2 and P levels were significantly higher in group C than in group A or B. These findings suggest that, in stimulated cycles for IVF-ET, determination of salivary E2 and P levels may be used as reliable alternatives to serum concentrations for assessing the luteal phase. Also, the additional hCG has an enhanced luteotrophic effect, as reflected by the higher salivary E2 and P levels, which may lead to a better pregnancy rate.

scholarly journals Efficiency Comparison Between Dry And Humid Cultures For Clinical Outcome of The In Vitro Fertilization-Embryo Transfer

2021 ◽  
Author(s):  
Weihai Xu ◽  
Lin Zhang ◽  
Ling Zhang ◽  
Shishi Li ◽  
Jing Shu
Keyword(s):  
In Vitro Fertilization ◽  
Embryo Transfer ◽  
Implantation Rate ◽  
Fertilization Rate ◽  
Cleavage Rate ◽  
High Quality ◽  
Vitro Fertilization ◽  
Efficiency Comparison ◽  
Ivf Et

Abstract Background: In this study, we compared the in vitro embryo development, embryo transfer outcome and the offspring outcome in the in vitro fertilization-embryo transfer (IVF-ET) between dry culture (DC) and humid culture (HC). Methods: Our study was divided into two parts. Firstly, we determined the fertilization rate, cleavage rate and high-quality embryo rate from 21 cycles in the DC group (N=262 oocytes) and HC group (N=263 oocytes). Secondly, we determined the embryo transfer outcome and the offspring outcome in DC group (N=184 cycles) and HC group (N=136 cycles). Results: Compared with the HC group, significant increase was observed in the high-quality embryo rate (66.1.2% vs. 55.3%, p=0.037) and implantation rate (49.8% vs. 40.6%, p=0.027) in the DC group. No statistical differences were observed in the pregnant outcome and birth defect of the offspring (p>0.05). Compared with HC, DC was associated with a higher high-quality embryo rate and a higher implantation rate after embryo transfer. Conclusions: No statistical differences were noticed in the offspring conditions between the two culture modes. Taken together, DC may serve as a promising method for IVF-ET.

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