scholarly journals Simultaneous Bilateral Total Knee Arthroplasty Retrospective Case Control Study: Does Genicular Injection Application Yield a More Effective Pain Control Compared with Periarticular Injection?

2021 ◽  
Author(s):  
Abdullah Küçükalp ◽  
Bülent Özdemir
Keyword(s):  
Knee Arthroplasty ◽  
Pain Control ◽  
Case Control Study ◽  
Statistical Significance ◽  
Case Control ◽  
The Other ◽  
Control Group ◽  
Periarticular Injection ◽  
Bilateral Knee ◽  
Control Study

Abstract Background:The aim of the present study was to investigate the hypothesis that administering the analgesic solution prepared for periarticular injection as a genicular injection to patients undergoing bilateral knee arthroplasty has equivalent effect to periarticuler injection and provides equal or enhanced pain control. Thus, these two different practices were compared.Methods:This was a case control study, during which simultaneous bilateral knee arthroplasty patients were evaluated retrospectively. The analgesic solution prepared for periarticular injection was applied as a genicular injection to one knee of each of 30 patients operated on in the same session, and was applied as standard periarticular injection to the other knee. The study group comprised the patients operated on in the same session who were subject to genicular infiltration anaesthesia and the control group consisted of patients with standard periarticular infiltration anaesthesia administered to the other knee. The study data are summarized via descriptive statistics (mean, standard deviation, etc.). Statistical analyses were performed using SPSS 22.0 software. Wilcoxon’s signed-rank test was used for comparisons. The level of statistical significance was set at p < 0,05.Results:Pain scores were lower during the early postoperative period in the knees of patients who received the genicular injection (p<0.005). There were no statistically significant differences between the groups with regard to drainage volume, complications and range of joint motion.Conclusions:Genicular injection is a reliable and effective procedure for early postoperative pain control.

scholarly journals Minimally invasive total knee arthroplasty using the contralateral knee as a control group: a case-control study

2009 ◽  
Vol 34 (4) ◽  
pp. 491-495 ◽  
Author(s):  
Peter M. Bonutti ◽  
Michael G. Zywiel ◽  
Thorsten M. Seyler ◽  
Seung Yong Lee ◽  
Mike S. McGrath ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Minimally Invasive ◽  
Knee Arthroplasty ◽  
Case Control Study ◽  
Case Control ◽  
Control Group ◽  
Contralateral Knee ◽  
Group A ◽  
Total Knee ◽  
Control Study

Association of Dyslipidemia with Uterine Fibroid: A Case Control Study

2020 ◽  
Vol 33 (2) ◽  
pp. 100-106
Author(s):  
Shahzadi Afruza ◽  
AKM Azad Hossain ◽  
Jesmin Jahan ◽  
Asma Sharmin ◽  
Halima Naznin ◽  
...  
Keyword(s):  
Uterine Fibroid ◽  
Case Control Study ◽  
Statistical Significance ◽  
Hormonal Treatment ◽  
Case Control ◽  
Atherogenic Index ◽  
Control Group ◽  
Case Group ◽  
Control Study ◽  
Inpatient Department

Background & objective: Uterine fibroid (UF) is the most common gynaecological neoplasm. Despite the major public health impact of UF, little is known about their association. Some studies focused on the similarities between the common biological mechanisms underlying the development of UF and atherosclerotic plaques. So, it is possible to hypothesize that same atherogenic risk factors, such as dyslipidemia may play a role in UF pathogenesis. This study was carried out to investigate the lipid profile in patients with UF and to analyze the association of dyslipidemia with UF. Materials & Methods: This case-control study was carried out in the outpatient and inpatient Department of Obstetrics & Gynaecology, BSMMU, Shahbag, Dhaka over a period of 12 months between March 2017 to February 2018. Participants were 100 in number and aged between 18 and 45 years. Cases consisted of 50 women with uterine fibroids diagnosed by ultrasonography attending the outpatient and inpatient department of obstetrics and gynaecology, BSMMU, having no previous hormonal treatment. A similar number of age matched women without UF visiting the same gynaecological outpatient clinic for routine reasons were recruited as controls. Women who were postmenopausal, pregnant, diagnosed cases of malignant diseases, diagnosed cases of hypertension, diabetes mellitus, thyroid disease, CLD and CKD and women undergoing hormonal therapy were excluded from the study. Fasting lipid profiles were determined in blood samples taken from each participant. Atherogenic index was also calculated. Chi-square test was used for testing statistical significance. Statistical significance was set at p < 0⋅05. Results: Women with UF were found to have significantly higher levels of serum TC, TG and significantly lower level of HDL-C compared to the controls (p<0.05). The mean atherogenic index was 4.30±1.41 in case group and 2.86±0.97 in control group. The difference was statistically significant (p<0.05) between two groups. Conclusion: There is an association between dyslipidemia and UF. Women with UF have higher atherogenic index compared to women without UF. TAJ 2020; 33(2): 100-106

scholarly journals The lower methylation of RANK is associated with osteoporosis in male aged general population of Xinjiang: A Case-Control Study

2020 ◽  
Author(s):  
Junjing Shang ◽  
Hong xiang ◽  
Xue Bai ◽  
Buluhan Halan ◽  
Hongmei Wang
Keyword(s):  
Blood Pressure ◽  
General Population ◽  
Case Control Study ◽  
Statistical Significance ◽  
Multivariate Logistic Regression Analysis ◽  
Case Control ◽  
Control Group ◽  
Case Group ◽  
Methylation Rate ◽  
Control Study

Abstract Background RANK is a candidate gene for osteoporosis on both functional and genetic grounds. The study is to investigate the relationships between the methylation of RANK and osteoporosis in aged general population. Methods On the basis of an epidemiological investigation, we detect for methylation CpGs in promoter of RANK in 32 aged subjects (16 males and 16 females) firstly. Secondly, after considering the relationships among osteoporosis and the methylation rate of identified CpGs in male and female subjects, the selected representatives CpGs were detected in 90 male aged general subjects (43 controls and 47 cases) by bisulfite sequencing. Then a case-control study is conducted. Results Age and the prevalence of diabetes were significantly difference between the case patients and control individuals (P = 0. 025, P = 0. 005)., There was no statistical significance between the case group and the control group for the following values: systolic blood pressure, diastolic blood pressure, body mass index, 25-dihydroxyvitaminD3, folic acid, testosterone, creatinine, serum calcium concentration, and the prevalence of smoking, drinking and hypertension (P > 0.05). The methylation rate of RANK in control group was significant higher than that in osteoporosis group (P < 0.001). In addition, by covariance analysis to adjust age, prevalence of smoking, drinking, hypertension, and diabetes, the methylation rate of RANK in control group was significant higher than that in osteoporosis group in male aged general population of Xinjiang (P = 0.001). After adjusting for confounding factors (age, smoking, drinking, and diabetes), multivariate logistic regression analysis also showed that lower methylation of RNAK gene were significantly associated with osteoporosis (OR = 0.930, 95% CI = 0.886–0.976) Conclusions The lower methylation rate of RANK was associated with osteoporosis in male aged general population of Xinjiang. This confirms that lower methylation of RANK might be involved in the pathogenesis of osteoporosis

scholarly journals Impact of SARS-CoV-2 Infection During Pregnancy on Infant Neurobehavioral Development: A Case-Control Study

2021 ◽  
Vol 9 ◽  
Author(s):  
Yao Cheng ◽  
Haoyue Teng ◽  
Yue Xiao ◽  
Mengxin Yao ◽  
Jieyun Yin ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Case Control Study ◽  
Statistical Significance ◽  
Case Control ◽  
Control Group ◽  
Neurobehavioral Development ◽  
Ages And Stages Questionnaires ◽  
Group 5 ◽  
Larger Sample ◽  
Control Study

Background: Previous studies on the pneumonia outbreak caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have focused on the general population and pregnant women, while little is known about the effects of SARS-CoV-2 on retardation during and after pregnancy. The purpose of this study was to evaluate the potential influence of SARS-CoV-2 on infant neurobehavioral development.Methods: A case-control study was conducted in Wuhan Maternal and Child Health Hospital, China. Nine pregnant women with SARS-CoV-2 infection and 9 controls matched by maternal age, parity, and status of chronic disease were included. Infantile neurobehavioral development was assessed through the Ages and Stages Questionnaires Edition 3 (ASQ-3).Results: The majority of pregnant women with SARS-CoV-2 experienced cesarean section (7 of 9), which was higher than the control group (5 of 9). The throat swabs of all newborn were negative. We found that compared with the control group, neonates of mothers with SARS-CoV-2 infection during pregnancy had lower scores in communication, gross movement, fine movement, problem solving, and personal-social domains; but only fine movement domain yielded statistical significance (P = 0.031).Conclusion: Infection with SARS-CoV-2 during pregnancy may have a certain impact on infant neurobehavioral development. Further studies with larger sample size are warranted for validation.

A case–control study on effects of the ATM, RAD51 and TP73 genetic variants on colorectal cancer risk

2019 ◽  
Vol 44 (6) ◽  
pp. 778-786
Author(s):  
Merve Yazici ◽  
Umit Yilmaz ◽  
Nesibe Yilmaz ◽  
Faruk Celik ◽  
Ece Gizem Isikoren ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Patient Group ◽  
Case Control Study ◽  
Statistical Significance ◽  
Turkish Population ◽  
Case Control ◽  
Control Group ◽  
Clinical Parameters ◽  
Allele Distribution ◽  
Control Study

Abstract Aim ATM, RAD51 and TP73 are genes that take part in DNA repair pathways. The aim of this prospective case-control study was to determine the genotype and allele distributions of the ATM 5′-UTR G/A, RAD51 135 G/C and TP73 GC/AT polymorphisms and their relationship with clinical parameters in Turkish colorectal cancer (CRC) patients. Material and methods One hundred and four CRC patients and 113 healthy individuals were included in this study as control. The polymerase chain reaction-restriction fragment length polymorphism techniques were used. Results The ATM 5′-UTR G/A polymorphism GG (p = 0.001) and AA (p = 0.0001) genotypes were found higher in the patient group, while the GA genotype (p = 0.0001) and A allele (p = 0.001) were significantly higher in the control group. Moreover, the GG genotype (p = 0.042) was higher among patients with advanced-stage cancer and, while GA genotype (p = 0.047) was increased in patients without perineural invasion. The RAD51 135 G/C polymorphism GC genotype (p = 0.0001) and C allele (p = 0.0001) were significantly higher in the patient group, while CC genotype (p = 0.0001) was higher in the control group. No statistical significance was observed between the TP73 GC/AT polymorphism genotype and allele distribution and the clinical parameters. Conclusion In the Turkish population, the ATM 5′-UTR GG and AA genotypes, and the RAD51 135 G/C GC genotype and the C allele presence may be risk factors for CRC.

scholarly journals Susceptibility to the novel coronavirus disease (COVID-19) is associated with ABO and Rh blood groups: a case-control study from Afghanistan

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Khyber Saify ◽  
Mohammad Sarwar Alborz ◽  
Mostafa Saadat
Keyword(s):  
Blood Group ◽  
Case Control Study ◽  
Statistical Significance ◽  
Case Control ◽  
Blood Groups ◽  
Control Group ◽  
North East ◽  
Group A ◽  
Novel Coronavirus ◽  
Control Study

Abstract Background There are preliminary studies about the association between COVID-19 and ABO phenotypes and the results are controversial. There are only two studies which investigated the association of Rh blood groups in addition to ABO with COVID-19; however, in the statistical analysis ABO and Rh blood groups have been considered separately. Therefore, the present case-control study was performed to determine the association of COVID-19 with ABO blood groups considering the Rh blood groups simultaneously. The study was conducted in Kunduz COVID-19 treatment specific center, Spin-Zar Hospital (Kunduz Province, North East Afghanistan). A total of 301 confirmed COVID-19 cases and 1039 healthy blood donors as control group were included in the study. Results The Rh− phenotype strongly increased the risk of COVID-19 (OR = 2.97, 95% CI 1.86–3.89, P < 0.001). Although blood group A increased the risk of developing COVID-19, the association did not reach statistical significance. In analysis of the combination phenotypes, the A− blood group remarkably increased the risk of COVID-19 (OR = 7.24, 95% CI 3.62–14.4, P < 0.001). Multivariate analysis revealed that the interaction of Rh and ABO is significant (P < 0.013). Conclusion These findings indicate that susceptibility to COVID-19 is strongly associated with A− blood group.

The effect of the duration between the previous ceserian section and the current pregnancy on the incidence of placenta accreta spectrum: A Case Control Study

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Rehab M Abdelrahman ◽  
Tarek Aly Raafat ◽  
Ahmed Gamal Abdelnasser ◽  
Safaa Bakr Farag Allah Elghatwary
Keyword(s):  
Short Duration ◽  
Caesarean Delivery ◽  
Case Control Study ◽  
Placenta Accreta ◽  
Statistical Significance ◽  
Case Control ◽  
Control Group ◽  
Severe Bleeding ◽  
Placenta Accreta Spectrum ◽  
Control Study

Abstract Background Placenta accreta spectrum is a serious obstetric disorder that is characterized by deeply penetrating villi which are abnormally attached to the myometrium of the uterus. This prevents its complete dissociation during the third stage of labor that may cause severe bleeding, with its marked risk on the mother life. All recent studies confirm that the occurrence of placenta accreta increased dramatically in the recent years with the increasing number of caesarean sections. The number of previous caesarean deliveries accompanied by placenta previa markedly increase the risk for placenta accreta. There is a continued need to study risk factors of abnormally adherent placenta to improve the antenatal diagnosis . Objective The current study aims to evaluate the effect of the short duration between the perior caesarean delivery and the current pregnancy on the occurence of placenta accreta spectrum. Patients and Methods a case control study which was performed in the Maternity Hospital of Ain Shams University. It compare the duration between the perior caesarean section and the current pregnancy in the placenta accreta cases and the matched controls to determine if it increases the occurrences of placenta accreta or not. It include all pregnant ladies with placenta accreta spectrum diagnosed radiologically or surgically in the period of the beginning of June 2019 to the beginning of December 2019 with in the inclusion criteria, also the matched controls. Results there was no difference with a statistical significance between control group and patients group regarding inter pregnancy interval. Conclusion this study reveals that there was no effect of the short duration between the previous caesarean delivery and the current pregnancy on the occurence of placenta accreta spectrum.

SERUM PROLACTINE LEVEL IN PATIENTS OF PSORIASIS VULGARIS AND ITS CORRELATION WITH DISEASE SEVERITY: A CASE-CONTROL STUDY

2019 ◽  
Vol 3 (6) ◽  
Author(s):  
Pawan Kumar Saini ◽  
Devendra Yadav ◽  
Rozy Badyal ◽  
Suresh Jain ◽  
Arti Singh ◽  
...  
Keyword(s):  
Disease Severity ◽  
Prolactin Level ◽  
Case Control Study ◽  
Statistical Significance ◽  
Case Control ◽  
Serum Prolactin ◽  
P Value ◽  
Serum Prolactin Level ◽  
R Value ◽  
Control Study

Background: Psoriasis is an autoimmune chronic inflammatory disorder affecting the skin mediated by T-lymphocytes resulting in production of cytokines which cause hyperproliferation of keratinocytes.  Several factors and hormones like Prolactin have an action similar to these cytokines in promoting the multiplication of keratinocytes and other cells like lymphocytes and epithelial cells may have a role on the etiopathogenesis of psoriasis. Aim:-The aim of study is to compare the serum Prolactin levels in patients of psoriasis with a control group. Setting and study design: This is a case-control study conducted in the department of Dermatology, Venereology and Leprosy GMC, Kota over a period of 1year from July 2017 to June 2018 Material and method: The study included 100 cases of psoriasis (60 males and 40 females) and 100 controls similar for age and sex. Serum Prolactin levels were measured by ECLIA and results were obtained. Statistical analysis: Mean and standard deviation were calculated for each variable. Statistical significance of the results was analyzed using correlation analysis (Pearson correlation coefficient) and independent samples t-test. Statistical significance was assumed at p value<0.05. Result: Serum Prolactin level was significantly higher in cases of psoriasis compared to controls (p-value <0.001). PASI score and serum Prolactin levels were found to have a positive correlation (r value = 0.337; p-value: 0.001). No significant  correlation was found between serum levels of Prolactin and duration of disease r value= -0.034, P value =0.733). Serum Prolactin level was higher in male patients compared to females patients. Conclusion:- High serum Prolactin may be a biological marker of disease severity in psoriasis and may have a role in the pathogenesis of psoriasis. Further studies with large sample size are required to confirm this hypothesis.

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