scholarly journals Could miR34a be as a Potential Biomarker for Doxorubicin Induced Cardiotoxicity?

2021 ◽  
Author(s):  
Eda Caliskan Yildirim ◽  
Emre Gedik ◽  
Gurcan Gunaydin ◽  
Cem Coteli ◽  
Necla Ozer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Troponin I ◽  
Global Longitudinal Strain ◽  
Myocardial Deformation ◽  
Breast Cancer Patients ◽  
Cardiac Damage ◽  
Potential Biomarker ◽  
Before And After ◽  
Chemotherapy Patients

Abstract No biomarker is currently available for early detection of anthracycline-induced cardiotoxicity. The purpose of this study was to assess whether the plasma levels of microRNA34a (miR34a) could predict cardiotoxicity in breast cancer patients who received anthracycline-based chemotherapy.Forty-four breast cancer patients who received anthracycline-based chemotherapy for the first time were included in the study. Before and after taking chemotherapy, patients were examined for cardiac troponin-I, miR34a, and precursor miR34a levels, and echocardiographic strain analyses were performed. There was a statistically significant increase in troponin-I, miR34a, and pre-miR34a levels after treatment with anthracyclines. The mean increase in miR34a and pre-miR34a was 2.5 and 2.3 fold, respectively. Echocardiographic analysis of patients showed a significant decrease in global longitudinal strain (GLS) measurements compared to the baseline after anthracycline treatment. An increase in the levels of miR34a/pre-miR34a was detected in patients who were estimated to have cardiac damage according to GLS change, but this increase was not statistically significant. After doxorubicin treatment, an increase in miR34a level in plasma was demonstrated without correlation with cTn-I and GLS. A higher miR34a/pre-miR34a ratio was detected in patients with myocardial deformation than in those without myocardial deformation, but it was not statistically significant.

Immediate evaluation of global longitudinal strain at initiation of trastuzumab treatment in breast cancer patients

2021 ◽  
Author(s):  
Ann Banke ◽  
Morten Schou ◽  
Marianne Ewertz ◽  
Jordi Dahl ◽  
Peter Hartmund Frederiksen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Longitudinal Strain ◽  
Global Longitudinal Strain ◽  
Breast Cancer Patients ◽  
Trastuzumab Treatment

scholarly journals Cognitive and Psychological Impact of BRCA Genetic Counseling in Before and After Definitive Surgery Breast Cancer Patients

2012 ◽  
Vol 19 (13) ◽  
pp. 4003-4011 ◽  
Author(s):  
Juliette Christie ◽  
Gwendolyn P. Quinn ◽  
Teri Malo ◽  
Ji-Hyun Lee ◽  
Xiuhua Zhao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Genetic Counseling ◽  
Cancer Patients ◽  
Psychological Impact ◽  
Breast Cancer Patients ◽  
Before And After ◽  
Definitive Surgery

scholarly journals Breast Cancer: Preparing for Surgery

EDIS ◽  
2007 ◽  
Vol 2007 (15) ◽  
Author(s):  
Martha C. Monroe ◽  
Barbara F. Shea
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Medical Procedures ◽  
Breast Cancer Patients ◽  
Fact Sheet ◽  
Before And After ◽  
And Coping

FCS8829, a 4-page fact sheet by Martha C. Monroe and Barbara F. Shea, is intended for breast cancer patients who are preparing for their lumpectomy or mastectomy surgery. It helps patients understand what to expect before and after surgery. Includes information on understanding medical procedures and coping physically and psychologically. Also features quotes and experiences from other breast cancer patients. Published by the UF Department of Family, Youth and Community Sciences, April 2007.

scholarly journals Managing Cancer and Living Meaningfully (CALM) Intervention on Chemotherapy-Related Cognitive Impairment in Breast Cancer Survivors

2020 ◽  
Vol 19 ◽  
pp. 153473542093845
Author(s):  
Ke Ding ◽  
Xiuqing Zhang ◽  
Jingjing Zhao ◽  
He Zuo ◽  
Ziran Bi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cognitive Impairment ◽  
Psychological Distress ◽  
Cognitive Function ◽  
Cancer Therapy ◽  
Cancer Patients ◽  
Functional Assessment ◽  
Breast Cancer Survivors ◽  
Breast Cancer Patients ◽  
Before And After

Objective: To evaluate the effectiveness and feasibility of Managing Cancer and Living Meaningfully (CALM), which is used to reduce chemotherapy-related cognitive impairment (CRCI), relieve psychological distress, and improve quality of life (QOL) in Chinese breast cancer survivors (BCs). Methods: Seventy-four BCs were enrolled in this study. All patients were randomly assigned to either the CALM group or the care as usual (CAU) group. All patients were evaluated by the Functional Assessment of Cancer Therapy–Cognitive Function (FACT-Cog), Distress Thermometer (DT), and the Functional Assessment of Cancer Therapy–Breast (FACT-B) before and after CALM or CAU application to BCs with CRCI. We compared the differences in all these scores between the CALM group and the control group and analyzed the correlation between cognitive function and QOL. Results: Compared with the CAU group, the performance of the CALM group on the FACT-Cog, DT, and FACT-B showed significant differences before and after CALM ( t = −18.909, −5.180, −32.421, P = .000, .000, .000, respectively). Finally, there was a positive correlation between cognitive function and QOL in breast cancer patients before ( r = 0.579, P = .000) and after ( r = 0.797, P = .000) treatment. Conclusions: The present results indicated that CALM has salutary effects on the improvement of cognitive impairment and QOL and relieves psychological distress in breast cancer patients, which may be due to a positive correlation between psychological distress and cognitive function or QOL.

scholarly journals Myocardial infarction, ischaemic stroke and pulmonary embolism before and after breast cancer hospitalisation

2011 ◽  
Vol 106 (07) ◽  
pp. 149-155 ◽  
Author(s):  
Sumitra Shantakumar ◽  
Pieter W. Kamphuisen ◽  
Fernie J. A. Penning-van Beest ◽  
Ron M. C. Herings ◽  
Myrthe P. P. van Herk-Sukel
Keyword(s):  
Breast Cancer ◽  
Myocardial Infarction ◽  
Pulmonary Embolism ◽  
Ischaemic Stroke ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
Increased Risk ◽  
Before And After ◽  
Receive Treatment ◽  
Free Women

SummaryWe studied the occurrence of myocardial infarction (MI), ischaemic stroke (IS) and pulmonary embolism (PE) before and after breast cancer hospitalisation compared with cancer-free controls. For this, women with a first breast cancer hospitalisation during 2000–2007 were selected from the PHARMO Record Linkage System, including drug use and hospitalisations of three million inhabitants in the Netherlands, and matched 1:10 by age to cancer-free women. The occurrence of MI, IS and PE were assessed in the 12 months before and after breast cancer hospitalisation. The study included 11,473 breast cancer patients, with a mean (± SD) age of 59 (± 14) years. Breast cancer patients were two to three times as likely as their cancer-free controls to have had a hospitalisation for PE, MI or IS in the 12 months before diagnosis, though prevalence was <1% in all groups. Breast cancer patients experienced an extreme high risk of PE in the first six months after diag- nosis (hazard ratio [HR] 23.5, 95% confidence interval [CI] 11.1–49.7 compared to controls), which declined gradually to a four times increased risk (HR 3.6, 95%CI 2.4–5.5) more than 12 months after breast cancer hospitalisation. However, incidence was low: less than five events per 1,000 person years during all time periods. For MI and IS we did not observe significant increased HRs after breast cancer hospitalisation compared to controls. Breast cancer patients seem to have a higher risk profile to develop MI and IS, and receive treatment that increases the risk of PE compared to cancer-free controls, although the frequency of hospitalisations was low.

scholarly journals Evaluation of breast cancer patients with genetic risk: Before and after a multidisciplinary heredofamiliar cancer unit implementation

2016 ◽  
Vol 27 ◽  
pp. vi465
Author(s):  
M. Lobo ◽  
S. Lopez-Tarruella ◽  
S. Luque ◽  
S. Lizarraga ◽  
P. Rincon ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Genetic Risk ◽  
Breast Cancer Patients ◽  
Before And After
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