Current and ongoing research and experimentations in the creation, design and build of low-cost, high-value prototypes for novel and unconventional interaction devices (IxD) in combination with cyber-physical system (CPS) (i.e. hybrid design tools (HDT), blended spaces) tangible user interfaces (TUI) and use of sensor technology lead to a variety of novel interaction modalities, experiences and possibilities. In line with this research, we propose a first prototype Human Sensor Selection Tool (HSST) as a preliminary guide and guidelines for design and engineering domains. The HSST is based on and inspired by the ‘five human senses’ [1], a plethora in human body signals (e.g. proprioceptive, vestibular) and gestures (e.g. facial expression, (e-)motions) that could be integrated, translated, transformed, adapted or mimicked to enhance and enrich the interaction modalities with for example computer-aided design (CAD), computer-aided technologies (CAx), and effectively affective CPS.