Thio and Seleno Rhodamine Derivatives as Reversal Agents of Multidrug Resistance in Breast Cancer

2005 ◽  
Author(s):  
Michael R. Detty ◽  
Scott L. Gibson
Keyword(s):  
Breast Cancer ◽  
Multidrug Resistance ◽  
Reversal Agents ◽  
Rhodamine Derivatives

Study of the mechanism responsible for multidrug resistance in breast cancer MCF-7 cell mediated by 14-3-3σ

2010 ◽  
Vol 34 (8) ◽  
pp. S47-S47
Author(s):  
Guopei Zheng ◽  
Sisi Yi ◽  
Yafei Li ◽  
Fangren Kong ◽  
Yanhui Yu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Multidrug Resistance ◽  
Mcf 7

Role of ABCB5 P-Glycoprotein in Breast Cancer Multidrug Resistance

2005 ◽  
Author(s):  
Markus H. Frank
Keyword(s):  
Breast Cancer ◽  
Multidrug Resistance ◽  
P Glycoprotein

scholarly journals Structure activity relationships and the binding mode of quinolinone-pyrimidine hybrids as reversal agents of multidrug resistance mediated by P-gp

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jerónimo Laiolo ◽  
Priscila Ailin Lanza ◽  
Oscar Parravicini ◽  
Cecilia Barbieri ◽  
Daniel Insuasty ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Molecular Complexes ◽  
Binding Mode ◽  
Reversal Agents ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Doxorubicin Toxicity ◽  
Key Residues ◽  
Nanomolar Range ◽  
Experimental Structure

AbstractP-gp-associated multidrug resistance is a major impediment to the success of chemotherapy. With the aim of finding non-toxic and effective P-gp inhibitors, we investigated a panel of quinolin-2-one-pyrimidine hybrids. Among the active compounds, two of them significantly increased intracellular doxorubicin and rhodamine 123 accumulation by inhibiting the efflux mediated by P-gp and restored doxorubicin toxicity at nanomolar range. Structure–activity relationships showed that the number of methoxy groups, an optimal length of the molecule in its extended conformation, and at least one flexible methylene group bridging the quinolinone to the moiety bearing the pyrimidine favored the inhibitory potency of P-gp. The best compounds showed a similar binding pattern and interactions to those of doxorubicin and tariquidar, as revealed by MD and hybrid QM/MM simulations performed with the recent experimental structure of P-gp co-crystallized with paclitaxel. Analysis of the molecular interactions stabilizing the different molecular complexes determined by MD and QTAIM showed that binding to key residues from TMH 4–7 and 12 is required for inhibition.

Co-delivery of doxorubicin and RNA using pH-sensitive poly (β-amino ester) nanoparticles for reversal of multidrug resistance of breast cancer

Biomaterials ◽  
2014 ◽  
Vol 35 (23) ◽  
pp. 6047-6059 ◽  
Author(s):  
Shan Tang ◽  
Qi Yin ◽  
Zhiwen Zhang ◽  
Wangwen Gu ◽  
Lingli Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Multidrug Resistance ◽  
Ph Sensitive ◽  
Amino Ester

Co-delivery of Poria cocos extract and doxorubicin as an ‘all-in-one’ nanocarrier to combat breast cancer multidrug resistance during chemotherapy

2020 ◽  
Vol 23 ◽  
pp. 102095
Author(s):  
Yanan Li ◽  
Xiaolian Li ◽  
Yang Lu ◽  
Birendra Chaurasiya ◽  
Gujie Mi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Multidrug Resistance ◽  
Poria Cocos

A Phase l/ll Study of Quinidine, a Potential Multidrug Resistance-Reversing Agent, in Combination with Pirarubicin in Patients with Advanced Refractory Breast Cancer

1993 ◽  
Vol 16 (6) ◽  
pp. 450-453 ◽  
Author(s):  
M. Raderer ◽  
D. Depisch ◽  
K. Haider ◽  
W. Kwasny ◽  
M. Djavanmard ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Multidrug Resistance
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