4,5-Di-substituted benzyl-imidazol-2-substituted amines as the structure template for the design and synthesis of reversal agents against P-gp-mediated multidrug resistance breast cancer cells

2014 ◽  
Vol 83 ◽  
pp. 74-83 ◽  
Author(s):  
Nan Zhang ◽  
Zhaohui Zhang ◽  
Iris L.K. Wong ◽  
Shengbiao Wan ◽  
Larry M.C. Chow ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Multidrug Resistance ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Reversal Agents ◽  
Design And Synthesis

scholarly journals Tamoxifen induces stem-like phenotypes and multidrug resistance by altering epigenetic regulators in ERα+ breast cancer cells

2020 ◽  
Vol 7 ◽  
pp. 20-20
Author(s):  
Aparna Kalyanaraman ◽  
Dhanavathy Gnanasampanthapandian ◽  
Prasad Shanmughan ◽  
Puneet Kishore ◽  
Satish Ramalingam ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Multidrug Resistance ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Epigenetic Regulators

Mitochondria-mediated apoptosis operating irrespective of multidrug resistance in breast cancer cells by the anticancer agent prodigiosin

2004 ◽  
Vol 68 (7) ◽  
pp. 1345-1352 ◽  
Author(s):  
Vanessa Soto-Cerrato ◽  
Esther Llagostera ◽  
Beatriz Montaner ◽  
George L. Scheffer ◽  
Ricardo Perez-Tomas
Keyword(s):  
Breast Cancer ◽  
Multidrug Resistance ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Anticancer Agent

EGFR-mediated G1/S transition contributes to the multidrug resistance in breast cancer cells

2011 ◽  
Vol 39 (5) ◽  
pp. 5465-5471 ◽  
Author(s):  
Shu-Jun Chen ◽  
Jing Luan ◽  
Hai-Shi Zhang ◽  
Can-Ping Ruan ◽  
Xin-Yun Xu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Multidrug Resistance ◽  
Cancer Cells ◽  
Breast Cancer Cells

scholarly journals Induction of multidrug resistance associated protein 2 in tamoxifen-resistant breast cancer cells

2007 ◽  
Vol 14 (2) ◽  
pp. 293-303 ◽  
Author(s):  
Hoo Kyun Choi ◽  
Jin Won Yang ◽  
Sang Hee Roh ◽  
Chang Yeob Han ◽  
Keon Wook Kang
Keyword(s):  
Breast Cancer ◽  
Multidrug Resistance ◽  
Cancer Cells ◽  
Transcriptional Activation ◽  
Breast Cancer Cells ◽  
Pregnane X Receptor ◽  
Pi3 Kinase ◽  
Gene Promoters ◽  
Breast Cancer Patients ◽  
Mcf 7

Acquired resistance to tamoxifen (TAM) is a serious therapeutic problem in breast cancer patients. The transition from chemotherapy-responsive breast cancer cells to chemotherapy-resistant cancer cells is mainly accompanied by the increased expression of multidrug resistance-associated proteins (MRPs). In this study, it was found that TAM-resistant MCF-7 (TAMR-MCF-7) cells expressed higher levels of MRP2 than control MCF-7 cells. Molecular analyses using MRP2 gene promoters supported the involvement of the pregnane X receptor (PXR) in MRP2 overexpression in TAMR-MCF-7 cells. Although CCAAT/enhancer-binding protein β was overexpressed continuously in TAMR-MCF-7 cells, this might not be responsible for the transcriptional activation of the MRP2 gene. In addition, the basal activities of phosphatidylinositol 3-kinase (PI3-kinase) were higher in the TAMR-MCF-7 cells than in the control cells. The inhibition of PI3-kinase significantly reduced both the PXR activity and MRP2 expression in TAMR-MCF-7 cells. Overall, MRP2 induction plays a role in the additional acquisition of chemotherapy resistance in TAM-resistant breast cancer.

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