scholarly journals Rational design of non-toxic GOx-based biocatalytic nanoreactor for multimodal synergistic therapy and tumor metastasis suppression

Theranostics ◽  
2021 ◽  
Vol 11 (20) ◽  
pp. 10001-10011
Author(s):  
Lifeng Hang ◽  
Tao Zhang ◽  
Hua Wen ◽  
Meng Li ◽  
Lianbao Liang ◽  
...  
Keyword(s):  
Tumor Metastasis ◽  
Rational Design ◽  
Metastasis Suppression

Mechanism of Tumor Metastasis Suppression by the KA11 Gene

2007 ◽  
Author(s):  
Kounosuke Watabe
Keyword(s):  
Tumor Metastasis ◽  
Metastasis Suppression

Tetraspanin family member CD9 inhibits Aggrus/podoplanin-induced platelet aggregation and suppresses pulmonary metastasis

Blood ◽  
2008 ◽  
Vol 112 (5) ◽  
pp. 1730-1739 ◽  
Author(s):  
Youya Nakazawa ◽  
Shigeo Sato ◽  
Mikihiko Naito ◽  
Yukinari Kato ◽  
Kazuhiko Mishima ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Tumor Metastasis ◽  
Ectopic Expression ◽  
Metastasis Suppressor ◽  
Low Density ◽  
Hematogenous Spread ◽  
Lung Retention ◽  
Ht1080 Cells ◽  
Metastasis Suppression ◽  
The Relationship

Abstract CD9 has been reported to play a role in tumor metastasis suppression. However, it is not fully understood how CD9 affects the hematogenous spread of tumor cells. To clarify a new mechanism (or mechanisms), we generated HT1080 cells that had been transfected with a CD9-expressing plasmid. Ectopic expression of CD9 in HT1080 cells actually reduced their metastatic ability. CD9 expression reduced lung retention and platelet ag-gregation activity of the transfectants. Because HT1080 cells express the metastasis-promoting, platelet aggregation-inducing factor Aggrus/podoplanin on their surface, we examined the relationship between CD9 and Aggrus. We discovered that CD9 formed a complex with Aggrus via transmembrane domains 1 and 2 (TM1 and TM2) of CD9. Investigation of the interaction revealed that each CD9 and Aggrus interacted homophilically, and that they colocalized in low-density membrane fractions. Deleting TM1 and TM2 attenuated the ability of CD9 to interact homophilically or to localize in low-density membrane fractions. The expression of CD9–wild-type (WT), but not CD9 lacking TM1 and TM2, attenuated the platelet aggregation and metastasis induced by forced expression of Aggrus in CHO cells. Therefore, CD9 may act as a metastasis suppressor, at least in part, by neutralizing Aggrus-mediated platelet aggregation.

Metformin and Docosahexaenoic Acid Hybrid Micelles for Premetastatic Niche Modulation and Tumor Metastasis Suppression

Nano Letters ◽  
2019 ◽  
Vol 19 (6) ◽  
pp. 3548-3562 ◽  
Author(s):  
Tianze Jiang ◽  
Liang Chen ◽  
Yukun Huang ◽  
Jiahao Wang ◽  
Minjun Xu ◽  
...  
Keyword(s):  
Docosahexaenoic Acid ◽  
Tumor Metastasis ◽  
Premetastatic Niche ◽  
Metastasis Suppression

A dual-catalytic nanoreactor for synergistic chemodynamic-starvation therapy toward tumor metastasis suppression

2021 ◽  
Author(s):  
Huiwen Zhang ◽  
Fei Lu ◽  
Wei Pan ◽  
Yegang Ge ◽  
Bingjie Cui ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Tumor Metastasis ◽  
Metastatic Tumors ◽  
Metastasis Suppression ◽  
Effective Treatments

Tumor metastasis is extremely deadly for cancer patients and developing effective treatments for deep metastatic tumors remains a major challenge. In this study, we demonstrated a dual-catalytic nanoreactor for tumor...

Sequentially Triggered Bacterial Outer Membrane Vesicles for Macrophage Metabolism Modulation and Tumor Metastasis Suppression

ACS Nano ◽  
2021 ◽  
Author(s):  
Qin Guo ◽  
Xuwen Li ◽  
Wenxi Zhou ◽  
Yongchao Chu ◽  
Qinjun Chen ◽  
...  
Keyword(s):  
Outer Membrane ◽  
Tumor Metastasis ◽  
Membrane Vesicles ◽  
Outer Membrane Vesicles ◽  
Metastasis Suppression ◽  
Bacterial Outer Membrane

Rational Design of Nanoparticles with Deep Tumor Penetration for Effective Treatment of Tumor Metastasis

2018 ◽  
Vol 28 (40) ◽  
pp. 1801840 ◽  
Author(s):  
Zhiwen Zhang ◽  
Hong Wang ◽  
Tao Tan ◽  
Jie Li ◽  
Zhiwan Wang ◽  
...  
Keyword(s):  
Effective Treatment ◽  
Tumor Metastasis ◽  
Rational Design ◽  
Tumor Penetration

Molecular insights on the dynamic stability of peptide nucleic acid functionalized carbon and boron nitride nanotubes

2021 ◽  
Vol 23 (1) ◽  
pp. 219-228
Author(s):  
Nabanita Saikia ◽  
Mohamed Taha ◽  
Ravindra Pandey
Keyword(s):  
Nucleic Acid ◽  
Boron Nitride ◽  
Nucleic Acids ◽  
Dynamic Stability ◽  
Peptide Nucleic Acid ◽  
Rational Design ◽  
Peptide Nucleic Acids ◽  
Boron Nitride Nanotubes ◽  
Molecular Hybrids ◽  
Single Wall Nanotubes

The rational design of self-assembled nanobio-molecular hybrids of peptide nucleic acids with single-wall nanotubes rely on understanding how biomolecules recognize and mediate intermolecular interactions with the nanomaterial's surface.

Optimizing electron density of nickel sulfide electrocatalysts through sulfur vacancy engineering for alkaline hydrogen evolution

2020 ◽  
Vol 8 (35) ◽  
pp. 18207-18214
Author(s):  
Dongbo Jia ◽  
Lili Han ◽  
Ying Li ◽  
Wenjun He ◽  
Caichi Liu ◽  
...  
Keyword(s):  
Hydrogen Evolution ◽  
Electron Density ◽  
Rational Design ◽  
Nickel Sulfide ◽  
Catalytic Performance ◽  
Sulfide Catalysts ◽  
Sulfur Vacancy

A novel, rational design for porous S-vacancy nickel sulfide catalysts with remarkable catalytic performance for alkaline HER.

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