Gene-Gene and Gene-Environment Interactions in the Etiology of Breast Cancer

2007 ◽  
Author(s):  
Dana R. Marshall ◽  
Olufemi J. Adegoke ◽  
Wei Zheng
Keyword(s):  
Breast Cancer ◽  
Gene Environment

Gene Environment Interactions in Women with Breast Cancer and Secondary Lung Cancer

2004 ◽  
Author(s):  
Meredith A. Tennis ◽  
Peter G. Shields
Keyword(s):  
Breast Cancer ◽  
Lung Cancer ◽  
Gene Environment

scholarly journals Gene-Environment Interactions Relevant to Estrogen and Risk of Breast Cancer: Can Gene-Environment Interactions Be Detected Only among Candidate SNPs from Genome-Wide Association Studies?

Cancers ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 2370
Author(s):  
JooYong Park ◽  
Ji-Yeob Choi ◽  
Jaesung Choi ◽  
Seokang Chung ◽  
Nan Song ◽  
...  
Keyword(s):  
Breast Cancer ◽  
High Risk ◽  
Environmental Factors ◽  
Minor Allele ◽  
Estrogen Metabolism ◽  
Age At Menarche ◽  
Genome Wide Association Studies ◽  
Estrogen Exposure ◽  
Gene Environment ◽  
Independent Population

In this study we aim to examine gene–environment interactions (GxEs) between genes involved with estrogen metabolism and environmental factors related to estrogen exposure. GxE analyses were conducted with 1970 Korean breast cancer cases and 2052 controls in the case-control study, the Seoul Breast Cancer Study (SEBCS). A total of 11,555 SNPs from the 137 candidate genes were included in the GxE analyses with eight established environmental factors. A replication test was conducted by using an independent population from the Breast Cancer Association Consortium (BCAC), with 62,485 Europeans and 9047 Asians. The GxE tests were performed by using two-step methods in GxEScan software. Two interactions were found in the SEBCS. The first interaction was shown between rs13035764 of NCOA1 and age at menarche in the GE|2df model (p-2df = 1.2 × 10−3). The age at menarche before 14 years old was associated with the high risk of breast cancer, and the risk was higher when subjects had homozygous minor allele G. The second GxE was shown between rs851998 near ESR1 and height in the GE|2df model (p-2df = 1.1 × 10−4). Height taller than 160 cm was associated with a high risk of breast cancer, and the risk increased when the minor allele was added. The findings were not replicated in the BCAC. These results would suggest specificity in Koreans for breast cancer risk.

scholarly journals Haplotype analysis on correlation between transcription factor 7-like 2 gene polymorphism and breast cancer risk

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yang Wang ◽  
Xiaojuan Men ◽  
Yongxue Gu ◽  
Huidong Wang ◽  
Zhicai Xu
Keyword(s):  
Breast Cancer ◽  
Transcription Factor ◽  
Logistic Regression ◽  
Abdominal Obesity ◽  
Haplotype Analysis ◽  
Environment Interaction ◽  
Nucleotide Polymorphisms ◽  
Chinese Han ◽  
Locus Model ◽  
Gene Environment

Abstract Background Up to now, limited researches focused on the association between transcription factor 7-like 2 gene (TF7L2) gene single nucleotide polymorphisms (SNPs) and breast cancer (BC) risk. The aim of this study was to evaluate the associations between TF7L2 and BC risk in Chinese Han population. Methods Logistic regression model was used to test the correlation between polymorphisms and BC risk. Strength of association was evaluated by odds ratio (OR) and 95% confidence interval (CI). Generalized multifactor dimensionality reduction (GMDR) was applied to analyze the SNP-SNP and gene-environment interaction. Results Logistic regression analysis indicated that the BC risk was obviously higher in carriers of rs1225404 polymorphism C allele than that in TT genotype carriers (TC or CC versus TT), adjusted OR (95%CI) =1.40 (1.09–1.72). Additionally, we also discovered that people with rs7903146- T allele had an obviously higher risk of BC than people with CC allele (CT or TT versus CC), adjusted OR (95%CI) =1.44 (1.09–1.82). GMDR model was used to research the effect of interaction among 4 SNPs and environmental factors on BC risk. We discovered an important two-locus model (p = 0.0100) including rs1225404 and abdominal obesity, suggesting a potential gene–environment correlation between rs1225404 and abdominal obesity. In general, the cross-validation consistency of two-locus model was 10 of 10, and the testing accuracy was 0.632. Compared with subjects with normal waist circumference (WC) value and rs1225404 TT genotype, abdominal obese subjects with rs1225404 TC or CC genotype had the highest BC risk. After covariate adjustment, OR (95%CI) was 2.23 (1.62–2.89). Haplotype analysis indicated that haplotype containing rs1225404-T and rs7903146-C alleles were associated with higher BC risk. Conclusions C allele of rs1225404 and T allele of rs7903146, interaction between rs1225404 and abdominal obesity, rs1225404-T and rs7903146-C haplotype were all related to increased BC risk.

scholarly journals Gene-environment interactions and predictors of breast cancer in family-based multi-ethnic groups

Oncotarget ◽  
2018 ◽  
Vol 9 (49) ◽  
pp. 29019-29035 ◽  
Author(s):  
Mildred C. Gonzales ◽  
James Grayson ◽  
Amanda Lie ◽  
Chong Ho Yu ◽  
Shyang-Yun Pamela K. Shiao
Keyword(s):  
Breast Cancer ◽  
Ethnic Groups ◽  
Gene Environment ◽  
Family Based

scholarly journals Evidence of Gene–Environment Interactions between Common Breast Cancer Susceptibility Loci and Established Environmental Risk Factors

PLoS Genetics ◽  
2013 ◽  
Vol 9 (3) ◽  
pp. e1003284 ◽  
Author(s):  
Stefan Nickels ◽  
Thérèse Truong ◽  
Rebecca Hein ◽  
Kristen Stevens ◽  
Katharina Buck ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Environmental Risk ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Environmental Risk Factors ◽  
Susceptibility Loci ◽  
Gene Environment

scholarly journals O-44 Gene–environment interactions in 7610 women with breast cancer: Prospective evidence from the Million Women Study

2010 ◽  
Vol 8 (6) ◽  
pp. 16-17
Author(s):  
Ruth C. Travis ◽  
Gillian K. Reeves ◽  
Jane Green ◽  
Diana Bull ◽  
Sarah J. Tipper ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Environment

scholarly journals Post-traumatic Stress Symptoms and Serotonin Transporter (5-HTTLPR) Polymorphism in Breast Cancer Patients

2021 ◽  
Vol 12 ◽  
Author(s):  
Luigi Zerbinati ◽  
Martino Belvederi Murri ◽  
Rosangela Caruso ◽  
Maria Giulia Nanni ◽  
Wendy Lam ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Serotonin Transporter ◽  
Traumatic Stress ◽  
Breast Cancer Patients ◽  
Post Traumatic Stress ◽  
Event Scale ◽  
Gene Environment ◽  
Post Traumatic ◽  
The Impact

Introduction: Post-traumatic Symptoms (PTSS) and Post-traumatic Stress Disorder (PTSD) have been reported to affect a quite significant proportion of cancer patients. No study has examined the relationship between serotonin transporter gene-linked polymorphic region (5-HTTLPR) and cancer, including Gene-Environment interactions between this polymorphism and specific causes of distress, such as cancer related problems (CRP) or life stressful events (SLE).Methods: One hundred and forty five breast cancer outpatients participated in the study and were assessed using the Impact of Event Scale (IES), the Problem List (PL) developed by the National Comprehensive Cancer Network (NCCN) Distress Management Guidelines and the Paykel's Life Events Interview to evaluate the exposure to SLE during the year before the cancer diagnosis. Each patient was genotyped for 5-HTTLPR polymorphism by analyzing genomic DNA obtained from whole blood cells. Gene-Environment interactions were tested through moderation analysis.Results: Twenty-six patients (17.7%) were classified as PTSS cases using the IES. Genotype and phenotype distributions did not differ across individuals with/without PTSS (genotype: χ2 = 1.5; df = 2; p = 0.3; phenotype χ2 = 0.9; df = 1; p = 0.2). For both the genotype and phenotype model, using CRP as a predictor showed significant gene-environment interactions with IES total score (p = 0.020 and p = 0.004, respectively), with individuals carrying the l/l allele showing a greater probability of experiencing PTSS. No interaction was found in relationship to SLE (p = 0.750).Conclusion: This study showed a significant GEI between CRP and PTSS in breast cancer patients, with carriers of the l/l allele showing indicators consistent with greater sensitivity to stress.

scholarly journals Gene-environment interactions involving functional variants: Results from the Breast Cancer Association Consortium

2017 ◽  
Vol 141 (9) ◽  
pp. 1830-1840 ◽  
Author(s):  
Myrto Barrdahl ◽  
Anja Rudolph ◽  
John L. Hopper ◽  
Melissa C. Southey ◽  
Annegien Broeks ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Functional Variants ◽  
Breast Cancer Association Consortium ◽  
Gene Environment

scholarly journals Reproductive risk factors in breast cancer and genetic hormonal pathways: a gene-environment interaction in the MCC-Spain project

BMC Cancer ◽  
2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Trinidad Dierssen-Sotos ◽  
Camilo Palazuelos-Calderón ◽  
José-Juan Jiménez-Moleón ◽  
Nuria Aragonés ◽  
Jone M. Altzibar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Environment Interaction ◽  
Reproductive Risk ◽  
Gene Environment Interaction ◽  
Gene Environment ◽  
Reproductive Risk Factors
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