Vitamin D and Related Genes, Race, and Prostate Cancer Aggressiveness

2014 ◽  
Author(s):  
Susan E. Steck
Keyword(s):  
Prostate Cancer ◽  
Vitamin D ◽  
Cancer Aggressiveness

scholarly journals Associations Between Serum Vitamin D and Adverse Pathology in Men Undergoing Radical Prostatectomy

2016 ◽  
Vol 34 (12) ◽  
pp. 1345-1349 ◽  
Author(s):  
Yaw A. Nyame ◽  
Adam B. Murphy ◽  
Diana K. Bowen ◽  
Gregory Jordan ◽  
Ken Batai ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Vitamin D ◽  
Radical Prostatectomy ◽  
Univariate Analysis ◽  
Serum Vitamin ◽  
Serum Vitamin D ◽  
Cancer Aggressiveness ◽  
Increased Risk ◽  
Vitamin D Levels ◽  
The Relationship

Purpose Lower serum vitamin D levels have been associated with an increased risk of aggressive prostate cancer. Among men with localized prostate cancer, especially with low- or intermediate-risk disease, vitamin D may serve as an important biomarker of disease aggression. The aim of this study was to assess the relationship between adverse pathology at the time of radical prostatectomy and serum 25-hydroxyvitamin D (25-OH D) levels. Methods This cross-sectional study was carried out from 2009 to 2014, nested within a large epidemiologic study of 1,760 healthy controls and men undergoing prostate cancer screening. In total, 190 men underwent radical prostatectomy in the cohort. Adverse pathology was defined as the presence of primary Gleason 4 or any Gleason 5 disease, or extraprostatic extension. Descriptive and multivariate analyses were performed to assess the relationship between 25-OH D and adverse pathology at the time of prostatectomy. Results Eighty-seven men (45.8%) in this cohort demonstrated adverse pathology at radical prostatectomy. The median age in the cohort was 64.0 years (interquartile range, 59.0 to 67.0). On univariate analysis, men with adverse pathology at radical prostatectomy demonstrated lower median serum 25-OH D (22.7 v 27.0 ng/mL, P = .007) compared with their counterparts. On multivariate analysis, controlling for age, serum prostate specific antigen, and abnormal digital rectal examination, serum 25-OH D less than 30 ng/mL was associated with increased odds of adverse pathology (odds ratio, 2.64; 95% CI, 1.25 to 5.59; P = .01). Conclusion Insufficiency/deficiency of serum 25-OH D is associated with increased odds of adverse pathology in men with localized disease undergoing radical prostatectomy. Serum 25-OH D may serve as a useful biomarker in prostate cancer aggressiveness, which deserves continued study.

Serum Vitamin D is Not Helpful for Predicting Prostate Cancer Aggressiveness Compared with the Prostate Health Index

2016 ◽  
Vol 196 (3) ◽  
pp. 709-714 ◽  
Author(s):  
Carsten Stephan ◽  
Michael Lein ◽  
Julia Matalon ◽  
Ergin Kilic ◽  
Zhongwei Zhao ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Vitamin D ◽  
Serum Vitamin ◽  
Health Index ◽  
Serum Vitamin D ◽  
Cancer Aggressiveness ◽  
Prostate Health Index ◽  
Prostate Health

Abstract 806: SNPs in vitamin D-related genes are associated with prostate cancer aggressiveness in the North Carolina-Louisiana Prostate Cancer Project (PCaP)

2016 ◽  
Author(s):  
Susan E. Steck ◽  
Anna Woloszynska-Read ◽  
Samuel Antwi ◽  
Hongmei Zhang ◽  
Lenore Arab ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Vitamin D ◽  
North Carolina ◽  
The North ◽  
Cancer Aggressiveness ◽  
Cancer Project

418: Association between the Dihydrotestosterone Level in the Prostate and Prostate Cancer Aggressiveness Using the Gleason Score

2006 ◽  
Vol 175 (4S) ◽  
pp. 136-136
Author(s):  
Tsutomu Nishiyama ◽  
Toshihiko Ikarashi ◽  
Yutaka Hashimoto ◽  
Kazuya Suzuki ◽  
Kota Takahashi
Keyword(s):  
Prostate Cancer ◽  
Gleason Score ◽  
Cancer Aggressiveness

803: Interactions Between Ultraviolet Radiation and Polymorphisms in the Vitamin D Receptor Gene Mediate Prostate Cancer Susceptibility

2006 ◽  
Vol 175 (4S) ◽  
pp. 260-260
Author(s):  
Nicholas J. Rukin ◽  
Samuel J. Moon ◽  
Dhaval Bodiwala ◽  
Christopher J. Luscombe ◽  
Mark F. Saxby ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Vitamin D ◽  
Ultraviolet Radiation ◽  
Vitamin D Receptor ◽  
Cancer Susceptibility ◽  
Receptor Gene ◽  
Vitamin D Receptor Gene ◽  
Prostate Cancer Susceptibility

487: Vitamin D Receptor Gene Haplotypes and Prostate Cancer in Hispanic and Non-Hispanic White Men: Results from a Case-Control Genetic Association Study

2006 ◽  
Vol 175 (4S) ◽  
pp. 158-158
Author(s):  
Kathleen C. Torkko ◽  
Phuong Mai ◽  
Robin J. Leach ◽  
Betsy A. Higgins ◽  
Adrie Van Bokhoven ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Vitamin D ◽  
Association Study ◽  
Vitamin D Receptor ◽  
Genetic Association Study ◽  
Receptor Gene ◽  
White Men ◽  
Case Control ◽  
Vitamin D Receptor Gene ◽  
Hispanic White
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