PATTERN AND DRUG SENSITIVITY OF NON-SPECIFIC BACTERIAL POPULATION IN TUBERCULOSIS PATIENTS WITH MULTIPLE DRUG RESISTANCE

The objective of the study: in Tomsk Region, to establish the frequency of multiple drug resistance (MDR) of mycobacterium tuberculosis (MBT) in new tuberculosis patients with the reference to their HIV status and to assess their treatment outcomes.Subjects and methods. The presented results were obtained from a retrospective cohort study of 788 new tuberculosis patients who were registered for MDR TB treatment at Tomsk Phthisiopulmonology Medical Center from January 2017 to April 2019.Results. In Tomsk Region, the level of primary MDR reaches 31.3% in patients with TB/HIV co-infection, while in HIV negative tuberculosis patients, this rate is 24.2%. The incidence of primary MDR/XDR MTB reaches 40% among deceased patients with TB/HIV co-infection. Treatment efficacy in MDR/XDR TB patients with associated HIV infection is low – the effective treatment was achieved only in 7.3% of them. In general (excluding the data on MTB drug resistance and antiretroviral therapy), treatment efficacy of tuberculosis patients with HIV infection is significantly lower versus HIV negative tuberculosis patients: 37.7% and 61.9%, respectively, OR 0.38 [0.28; 0.50], p = 0.001.

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THE EFFECT OF DIFFERENT TB DRUGS AND ANTIMICROBIAL AGENTS ON THE EFFICIENCY OF TREATMENT OF TUBERCULOSIS PATIENTS WITH MULTIPLE DRUG RESISTANCE

Tuberculosis and lung diseases ◽

10.21292/2075-1230-2017-95-10-9-15 ◽

2017 ◽

Vol 95 (10) ◽

pp. 9-15 ◽

Cited By ~ 1

Author(s):

I. A. Vasilyeva ◽

◽

A. G. Samoylova ◽

O. V. Lovacheva ◽

L. N. Chernousovа ◽

...

Keyword(s):

Drug Resistance ◽

Antimicrobial Agents ◽

Multiple Drug Resistance ◽

Multiple Drug ◽

Tuberculosis Patients

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AUTOMATED PLASMAPHERESIS FOR MANAGEMENT OF HEPATOTOXIC REACTIONS TO CHEMOTHERAPY IN PULMONARY TUBERCULOSIS PATIENTS WITH MULTIPLE DRUG RESISTANCE INCLUDING THOSE WITH CONCURRENT VIRAL HEPATITIS

Tuberculosis and lung diseases ◽

10.21292/2075-1230-2018-96-10-13-19 ◽

2018 ◽

Vol 96 (10) ◽

pp. 13-19

Author(s):

E. V. VАNIEV ◽

◽

А. G. SАMOYLOVА1 ◽

А. E. ERGESHOV2 ◽

O. V. LOVАCHEVА ◽

...

Keyword(s):

Drug Resistance ◽

Pulmonary Tuberculosis ◽

Viral Hepatitis ◽

Multiple Drug Resistance ◽

Multiple Drug ◽

Tuberculosis Patients

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Comparison of Chest X-Ray Assessment in Multi-Drug Resistance to Drug- Sensitive Tuberculosis Patients

BioScientia Medicina ◽

10.32539/bsm.v5i1.185 ◽

2020 ◽

Vol 5 (1) ◽

pp. 135-143

Author(s):

Sari Afiah Miyuki Rifani ◽

Zen Ahmad ◽

M. Yusri ◽

Erial Bahar

Keyword(s):

Drug Resistance ◽

Pleural Effusion ◽

Multiple Drug Resistance ◽

Multidrug Resistant ◽

Multi Drug Resistance ◽

Bivariate Analysis ◽

Multiple Drug ◽

X Rays ◽

Tuberculosis Patients ◽

Resistant Tuberculosis

Introduction. Indonesia ranks third in tuberculosis cases, with 23,000 new dualdrug-resistant tuberculosis patients. The delay in predicting tuberculosis resistanceoccurs because sputum tools are not yet available. This study aimed to determinethe differences in chest x-rays for drug-sensitive multiple drug-resistanttuberculosis in Palembang. Method. A case-control design to compare theradiological characteristics of multiple drug resistance with drug-sensitive atPalembang during January-July 2020. One hundred thirty-eight patients consistedof cases of drug-sensitive tuberculosis and multidrug-resistant tuberculosis basedon the rapid molecular test that met the inclusion criteria, analyzed forposteroanterior chest X-rays by a radiologist without knowing the diagnosis—comparative chi-square using SPSS 22. Result. Multidrug resistance tuberculosishad more extensive or moderate lesions than drug-sensitive tuberculosis 89.8% vs72.4%. The multidrug-resistant group has more infiltrate detected, namely 84.1% vs69.6% and cavity 37.6% vs 30.4%. Atelectasis and pleural effusion are common indrug-resistant tuberculosis. Bivariate analysis showed that multidrug-resistanttuberculosis lesion infiltrates compared to drug-sensitive tuberculosis with p =0.025; OR 2,6 (CI 95% 1,1-6,0) sensitivity 85.5%, specificity 30.4%. Multivariateanalysis showed the presence of infiltrates p = 0.028; OR 2.58 (CI 95% 1.1-6.003).Consolidation, nodules, cavities, fibrosis, atelectasis, pleural effusion were notsignificant differences in the two groups. Conclusion. Multidrug-resistanttuberculosis has a more expansive lesion, the presence of infiltrates and cavities thatis more dominant than drug-sensitive tuberculosis.

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