ASSESSMENT OF EFFECTIVENESS OF THE EMPIRIC TREATMENT REGIMEN IN TUBERCULOSIS PATIENTS SUSPECTED WITH MULTIPLE DRUG RESISTANCE IN THE RUSSIAN FEDERATION

Salmonella isolates (n=124) were taken from animal food products in different regions of the Russian Federation and investigated. Serogroup was determined, as well as sensitivity to antibacterial drugs. High levels of resistance to fluoroquinolones were revealed (70,97% of isolates resistant to ciprofloxacin). Multiple drug resistance was determined (16,1% of multiresistant isolates). Data analysis was performed using the AMRcloud online platform.

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PATTERN AND DRUG SENSITIVITY OF NON-SPECIFIC BACTERIAL POPULATION IN TUBERCULOSIS PATIENTS WITH MULTIPLE DRUG RESISTANCE

Tuberculosis and lung diseases ◽

10.21292/2075-1230-2019-97-9-11-16 ◽

2019 ◽

Vol 97 (9) ◽

pp. 11-16

Author(s):

A. V. LАVRINENKO ◽

◽

I. S. АZIZOV ◽

S. I. KOLESNICHENKO ◽

M. T. KOZHАMURАTOV ◽

...

Keyword(s):

Drug Resistance ◽

Drug Sensitivity ◽

Bacterial Population ◽

Multiple Drug Resistance ◽

Multiple Drug ◽

Tuberculosis Patients

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Prevalence of tuberculosis in Russian Federation in 1970–2019 and factors influencing its level

Medical alphabet ◽

10.33667/2078-5631-2021-18-23-33 ◽

2021 ◽

pp. 23-33

Author(s):

M. V. Shilova

Keyword(s):

Drug Resistance ◽

Hiv Infection ◽

Russian Federation ◽

Tuberculosis Patients ◽

The Past ◽

Factors Influencing ◽

Number Of Patients ◽

The Russian Federation ◽

Detection Quality

The data on the prevalence of tuberculosis in the Russian Federation are presented. A decrease in the prevalence of tuberculosis over the past 49 years, from 1970 to 2019, and a decrease in the number of patients with tuberculosis are shown. The factors influencing the prevalence of tuberculosis infection in the Russian Federation are considered: timely detection, quality of diagnosis and treatment of tuberculosis patients, MBT drug resistance, HIV infection in tuberculosis patients. The reliability of indicators characterizing the prevalence of tuberculosis has been studied.

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ANTIBIOTIC RESISTANCE OF VIBRIO CHOLERAE O1 EL TOR ISOLATED ON THE TERRITORY OF THE RUSSIAN FEDERATION IN 2006-2015

Epidemiology and Infectious Diseases (Russian Journal) ◽

10.17816/eid40960 ◽

2017 ◽

Vol 22 (1) ◽

pp. 25-30

Author(s):

L. A Egiazaryan ◽

N. A Selyanskaya ◽

I. B Zakharova ◽

M. V Podshivalova ◽

E. A Bereznyak ◽

...

Keyword(s):

Antibiotic Resistance ◽

Vibrio Cholerae ◽

Russian Federation ◽

Molecular Mechanisms ◽

Multiple Drug Resistance ◽

Antibiotic Resistance Genes ◽

Multiple Drug ◽

Environmental Objects ◽

The Russian Federation ◽

El Tor

Aim of the study. The analysis of antibiotic resistance and molecular mechanisms of the persistence of Vibrio cholerae О1 El Tor strains, isolated from patients and environmental objects on the territory of the Russian Federation in 2006-2015. Material and Methods. The susceptibility of 34 V. cholerae El Tor strains to 13 antibacterial drugs was determined by the method of serial dilutions in a rich culture medium (Instructional Guidelines (МUК) 4.2.2495-09). Results. The strains showed resistance to 1-5 antibiotics (levomicetin, streptomycin, nalidixic acid, furazolidone, trimethoprim/sulfamethoxazole) and harbored SXT-element with antibiotic resistance genes. The emergence of quinolone resistance in V. cholerae O1 El Tor strains with accompanying multiple drug resistance limits the choice for drugs for etiotropic therapy and aggravates the possibility of unfavourable cholera outcome.

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HIV infection and multiple drug resistant tuberculosis: the frequency of co-infection and treatment efficacy

Tuberculosis and lung diseases ◽

10.21292/2075-1230-2021-99-2-45-51 ◽

2021 ◽

Vol 99 (2) ◽

pp. 45-51

Author(s):

O. V. Filinyuk ◽

A. S. Alliluev ◽

D. E. Аmichba ◽

P. N. Golubchikov ◽

Yu. S. Popelo ◽

...

Keyword(s):

Drug Resistance ◽

Hiv Infection ◽

Treatment Efficacy ◽

Multiple Drug Resistance ◽

Medical Center ◽

Multiple Drug ◽

Tuberculosis Patients ◽

Tomsk Region ◽

Mdr Tb ◽

Hiv Negative

The objective of the study: in Tomsk Region, to establish the frequency of multiple drug resistance (MDR) of mycobacterium tuberculosis (MBT) in new tuberculosis patients with the reference to their HIV status and to assess their treatment outcomes.Subjects and methods. The presented results were obtained from a retrospective cohort study of 788 new tuberculosis patients who were registered for MDR TB treatment at Tomsk Phthisiopulmonology Medical Center from January 2017 to April 2019.Results. In Tomsk Region, the level of primary MDR reaches 31.3% in patients with TB/HIV co-infection, while in HIV negative tuberculosis patients, this rate is 24.2%. The incidence of primary MDR/XDR MTB reaches 40% among deceased patients with TB/HIV co-infection. Treatment efficacy in MDR/XDR TB patients with associated HIV infection is low – the effective treatment was achieved only in 7.3% of them. In general (excluding the data on MTB drug resistance and antiretroviral therapy), treatment efficacy of tuberculosis patients with HIV infection is significantly lower versus HIV negative tuberculosis patients: 37.7% and 61.9%, respectively, OR 0.38 [0.28; 0.50], p = 0.001.

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THE EFFECT OF DIFFERENT TB DRUGS AND ANTIMICROBIAL AGENTS ON THE EFFICIENCY OF TREATMENT OF TUBERCULOSIS PATIENTS WITH MULTIPLE DRUG RESISTANCE

Tuberculosis and lung diseases ◽

10.21292/2075-1230-2017-95-10-9-15 ◽

2017 ◽

Vol 95 (10) ◽

pp. 9-15 ◽

Cited By ~ 1

Author(s):

I. A. Vasilyeva ◽

◽

A. G. Samoylova ◽

O. V. Lovacheva ◽

L. N. Chernousovа ◽

...

Keyword(s):

Drug Resistance ◽

Antimicrobial Agents ◽

Multiple Drug Resistance ◽

Multiple Drug ◽

Tuberculosis Patients

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AUTOMATED PLASMAPHERESIS FOR MANAGEMENT OF HEPATOTOXIC REACTIONS TO CHEMOTHERAPY IN PULMONARY TUBERCULOSIS PATIENTS WITH MULTIPLE DRUG RESISTANCE INCLUDING THOSE WITH CONCURRENT VIRAL HEPATITIS

Tuberculosis and lung diseases ◽

10.21292/2075-1230-2018-96-10-13-19 ◽

2018 ◽

Vol 96 (10) ◽

pp. 13-19

Author(s):

E. V. VАNIEV ◽

◽

А. G. SАMOYLOVА1 ◽

А. E. ERGESHOV2 ◽

O. V. LOVАCHEVА ◽

...

Keyword(s):

Drug Resistance ◽

Pulmonary Tuberculosis ◽

Viral Hepatitis ◽

Multiple Drug Resistance ◽

Multiple Drug ◽

Tuberculosis Patients

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Comparison of Chest X-Ray Assessment in Multi-Drug Resistance to Drug- Sensitive Tuberculosis Patients

BioScientia Medicina ◽

10.32539/bsm.v5i1.185 ◽

2020 ◽

Vol 5 (1) ◽

pp. 135-143

Author(s):

Sari Afiah Miyuki Rifani ◽

Zen Ahmad ◽

M. Yusri ◽

Erial Bahar

Keyword(s):

Drug Resistance ◽

Pleural Effusion ◽

Multiple Drug Resistance ◽

Multidrug Resistant ◽

Multi Drug Resistance ◽

Bivariate Analysis ◽

Multiple Drug ◽

X Rays ◽

Tuberculosis Patients ◽

Resistant Tuberculosis

Introduction. Indonesia ranks third in tuberculosis cases, with 23,000 new dualdrug-resistant tuberculosis patients. The delay in predicting tuberculosis resistanceoccurs because sputum tools are not yet available. This study aimed to determinethe differences in chest x-rays for drug-sensitive multiple drug-resistanttuberculosis in Palembang. Method. A case-control design to compare theradiological characteristics of multiple drug resistance with drug-sensitive atPalembang during January-July 2020. One hundred thirty-eight patients consistedof cases of drug-sensitive tuberculosis and multidrug-resistant tuberculosis basedon the rapid molecular test that met the inclusion criteria, analyzed forposteroanterior chest X-rays by a radiologist without knowing the diagnosis—comparative chi-square using SPSS 22. Result. Multidrug resistance tuberculosishad more extensive or moderate lesions than drug-sensitive tuberculosis 89.8% vs72.4%. The multidrug-resistant group has more infiltrate detected, namely 84.1% vs69.6% and cavity 37.6% vs 30.4%. Atelectasis and pleural effusion are common indrug-resistant tuberculosis. Bivariate analysis showed that multidrug-resistanttuberculosis lesion infiltrates compared to drug-sensitive tuberculosis with p =0.025; OR 2,6 (CI 95% 1,1-6,0) sensitivity 85.5%, specificity 30.4%. Multivariateanalysis showed the presence of infiltrates p = 0.028; OR 2.58 (CI 95% 1.1-6.003).Consolidation, nodules, cavities, fibrosis, atelectasis, pleural effusion were notsignificant differences in the two groups. Conclusion. Multidrug-resistanttuberculosis has a more expansive lesion, the presence of infiltrates and cavities thatis more dominant than drug-sensitive tuberculosis.

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