scholarly journals PATHOMORPHOSIS OF EXTRAPULMONARY TUBERCULOSIS IN CHILDREN

2016 ◽  
Vol 5 ◽  
pp. 50-58
Author(s):  
Lidia Mykolyshyn ◽  
Zoriana Piskur
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Extrapulmonary Tuberculosis ◽  
Miliary Tuberculosis ◽  
Lethal Outcome ◽  
Ocular Tuberculosis ◽  
Clinical Forms ◽  
Peripheral Lymph ◽  
Skin Tuberculosis ◽  
Lymph Node Tuberculosis

Aim. To study clinical and epidemiological aspects of pathomorphosis of extrapulmonary tuberculosis clinical forms. Materials and Methods. Retrospective analysis of 138 case histories in children aged to 15 years, obtaining extrapulmonary tuberculosis treatment in a specialized children's hospital during 1988-2015 was carried out. Among them, in 103 children, clinical forms of extrapulmonary tuberculosis combined with respiratory tuberculosis and in 35 children independent forms of extrapulmonary tuberculosis were found. Studied stage (1988-2015) was divided into 3 periods: I – 1988-1997, II – 1998-2007, III – 2008-2015. During 2008-2015, incomparison to previous periods, the number of cases of peripheral lymph node tuberculosis (PLN), meninges and central nervous system tuberculosis, bones and joints tuberculosis, and ocular tuberculosis decreased. In 2008-2015, the share of combined forms of meninges and central nervous system tuberculosis and ocular tuberculosis remained at 1998-2007 level. During 2008-2015, skin tuberculosis was not diagnosed. Nevertheless, in 2008-2015, in6.8±10.2 % of cases extrapulmonary tuberculosis combined with miliary tuberculosis, and in 5.8±10.4 % of cases the process characterized by lethal outcome, moreover 4.9±10.7% from them – in recent years. It is important that during period I, in 19.6±13.2 % of cases extrapulmonary tuberculosis combined with respiratory tuberculosis in reverse development phases, during period II – in 12.9±19.3 % of cases, during period III – in 23.8±21.2 % of cases. Conclusion. Despite the reduction, extrapulmonary tuberculosis combined with severe forms of respiratory tuberculosis, which led to lethal outcome in children in 5.8±10.4% of cases. Tuberculosis epidemiological situation worsening, reversion of severe forms of tuberculosis with the development of extrapulmonary one and several organs injuries in children shows the necessity of social, preventive and therapeutic measures intensification among children.

scholarly journals The impact of HIV infection on spectrum of extrapulmonary tuberculosis in Siberia and Far East

2018 ◽  
Vol 10 (4) ◽  
pp. 89-95
Author(s):  
E. V. Kulchavenya
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Hiv Infection ◽  
Extrapulmonary Tuberculosis ◽  
Far East ◽  
Urogenital Tuberculosis ◽  
Peripheral Lymph ◽  
The Status ◽  
The Central Nervous System ◽  
The Impact

Introduction. Human immunodeficiency virus (HIV) infection is a risk factor for tuberculosis (TB), increasing the likelihood of its development in 20–37 times. The purpose of the study was to evaluate an influence of HIV infection on a spectrum of extrapulmonary tuberculosis (EPTB). Material and methods. Statistical reports of dispensaries on tuberculosis in Siberia and Far East were analyzed for 2016–2017 years. Of total 1227 patients with isolated EPTB (without pulmonary TB) who have the status of HIV infection were enrolled in the study. пациентов с изолированными формами ВЛТ, у которых определен статус ВИЧинфицирования. Results. In the overall spectrum of the incidence of EPTB in Siberia and the Far East, estimated independently from HIV infection, the leading form with a large predominance was the bone and joints TB (41,0%). The second-third place was divided by urogenital tuberculosis and tuberculosis of the central nervous system (19,4% and 18,7% respectively). The spectrum of the incidence of EPTB changed dramatically depending on HIV infection. If in HIV-infected patients most common form was TB of the central nervous system (43.8%), followed by the second – the bone and joints TB (34.5%), and TB of peripheral lymph node TB (11.7%). The proportion of urogenital tuberculosis in HIV-infected was negligible (1.9%). In the analyzed period, significant changes in the proportions of extrapulmonary tuberculosis localization in both HIV-infected and immunocompetent patients were not found. Conclusion. HIV infection dramatically changes the spectrum of the incidence of EPTB. We recommend making changes in the system of recording patients with EPTB, allocating HIV-infected to a separate group.

Tuberculosis of the meninges and central nervous system. Experience of clinical diagnostics in St. Petersburg for 50 years

MedAlliance ◽  
2020 ◽  
Vol 8 (1) ◽  
pp. 14-24
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Medical Errors ◽  
Clinical Diagnostics ◽  
Lethal Outcome ◽  
Significant Difference ◽  
Group 2 ◽  
Allergic Vasculitis ◽  
Tuberculosis Meningitis ◽  
Group 1

The clinic and diagnostics of tuberculosis meningitis (TM) in 926 patients treated in St. Petersburg hospitals in 1965–1994 (group 1) and in 1995–2018 (group 2) is presented. The TM clinic is demonstrated to be determined by the form of tuberculosis and its characteristic generalization nature in the presence of repeated waves of bacteremia and allergic vasculitis of greater or lesser severity. There is clinical peculiarity of TM in primary pulmonary tuberculosis and its early large-focal and late miliar generalization, as well as in hematogenous tuberculosis. In patients of the 1st and 2nd groups the TM clinic shows in some respects a noticeable similarity, in others — a significant difference. Despite the typical symptoms, early diagnosis of TM took place in less than 20% of patients. Clinical examples illustrating the unusual development of TM, contrasting with its usual course, are given. A number of objective and subjective factors contributing to the adverse evolution of TM and its lethal outcome are discussed. These include the peculiarity of modern tuberculosis, especially when associated with HIV infection, as well as medical errors associated with ignorance of the pathogenesis of tuberculosis and failure to comply with the minimum examination for tuberculosis.

scholarly journals A scoring system to effectively evaluate central nervous system tuberculosis in patients with miliary tuberculosis

PLoS ONE ◽  
2017 ◽  
Vol 12 (5) ◽  
pp. e0176651 ◽  
Author(s):  
Yongjiu Xiao ◽  
Shuqing Yu ◽  
Qingliang Xue ◽  
Shan Lang ◽  
Junping Sun ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Scoring System ◽  
Miliary Tuberculosis

scholarly journals A case of miliary tuberculosis accompanied by central nervous system involvement

2016 ◽  
Vol 5 (3) ◽  
pp. 213-216
Author(s):  
Melike Demir ◽  
Mahsuk Taylan ◽  
Demet Arslan ◽  
Emel Aslan ◽  
Süreyya Yılmaz ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Miliary Tuberculosis ◽  
Central Nervous System Involvement ◽  
System Involvement

scholarly journals Miliary Tuberculosis with Postpartum Involvement of the Central Nervous System

2018 ◽  
Vol 24 (3) ◽  
pp. 273-274
Author(s):  
Mehmet Balal ◽  
Aslıhan Candevir Ulu ◽  
Meltem Demirkıran
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Miliary Tuberculosis ◽  
The Central Nervous System

Central nervous system tuberculosis after resolution of miliary tuberculosis

1998 ◽  
Vol 17 (6) ◽  
pp. 519-523 ◽  
Author(s):  
ANNE B. CHANG ◽  
KEITH GRIMWOOD ◽  
A. SIMON HARVEY ◽  
JEFFREY V. ROSENFELD ◽  
ANTHONY OLINSKY
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Miliary Tuberculosis

scholarly journals Extremely High Levels of Central Nervous System Involvement in Miliary Tuberculosis

2021 ◽  
Author(s):  
Guirong Wang ◽  
Ruixia Liang ◽  
Qing Sun ◽  
Xinlei Liao ◽  
Chenqian Wang ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Miliary Tuberculosis ◽  
Central Nervous System Involvement ◽  
Cns Involvement ◽  
Molecular Tests ◽  
Cerebral Computed Tomography ◽  
Magnetic Resonance Imaging Mri ◽  
Almost All ◽  
Csf Examination

Abstract BackgroundMiliary tuberculosis (TB) is one of the severest manifestations of TB that can be lethal when concomitant with the central nervous system (CNS) involvement. Bacteriological, biochemical and radiological methods for find CNS comorbidity in miliary TB was evaluated in this study.MethodsConsecutive miliary TB adults were retrospectively enrolled from two designated TB hospitals in China. The capacities of examinations of cerebrospinal fluid (CSF), cerebral computed tomography (CT) and magnetic resonance imaging (MRI) for diagnosis of CNS involvement were assessed.ResultsAssessment of CNS involvement with a lumbar puncture and/or neuroimaging was undertaken in 282 out of 392 of acute miliary TB. Of these 282 patients, 87.59% (247/282) had CNS involvement. Cerebral contrast-enhanced MRI (96.05%, 170/177) and MRI (93.15%, 204/219) yielded significantly higher sensitivities over CSF examination (71.92%, 146/203, P<0.001) and CT (34.69%, 17/49, P<0.001). The sensitivity of CSF examination was superior to CT scan (P<0.001). Although 59.65% (134/225) miliary TB patients acquired bacteriological evidence with sputum examination, the positivity was only 8.82% (21/238) for CSF examination by conventional and molecular tests.ConclusionAlmost all miliary TB had CNS involvement and MRI demonstrated outstanding potential over other methods. Therefore, a routinely screening of CNS TB should be strongly suggested in miliary TB and MRI could be used as the initial approach in resources rich settings.

Pediatric miliary tuberculosis presenting with stroke: contribution to the paper “Tuberculosis of the central nervous system in children”

2019 ◽  
Vol 35 (8) ◽  
pp. 1273-1275
Author(s):  
María Isabel Sánchez-Códez ◽  
Manuel Lubián-Gutiérrez ◽  
Carmen Fernández-Bravo ◽  
Myriam Ley-Martos
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Miliary Tuberculosis ◽  
The Central Nervous System
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